Opportunity Information: Apply for PA 08 220
Apply for PA 08 220
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Investigational Nutrigenetic Studies for Cancer Prevention (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research 93.399 Cancer Control.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 30, 2008.
- Applicants must submit their applications by Sep 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Hispanic serving Institutions Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations U.S. Territory or Possession.
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Opportunity Summary:
Investigational Nutrigenetic Studies for Cancer Prevention (R01) (Funding Opportunity Number PA-08-220) was a National Institutes of Health funding opportunity led by the National Cancer Institute, with participation from the National Institute of Nursing Research and the Office of Dietary Supplements. The program was designed to support research that connects nutrigenetics and cancer prevention by using established human genetic variation resources, specifically information generated through the Human Genome Project and the International HapMap Project. The central idea behind the announcement was that people do not respond to diet in the same way, and that inherited genetic differences may help explain why certain dietary components reduce cancer-related processes for some individuals but not for others. By identifying genetic variants that predict response to specific nutrients or dietary patterns, the research supported under this opportunity aimed to move cancer prevention toward more personalized, targeted dietary strategies, especially for individuals with higher genetic susceptibility to cancer.
A key feature of the opportunity was its emphasis on dietary intervention work rather than purely observational research. The NIH specifically sought projects that would conduct small, pilot-style dietary interventions informed by genetic variation data, with the goal of testing whether particular genotypes are associated with measurable differences in biological responses relevant to cancer development or progression. In practical terms, that meant applicants were expected to go beyond population-level associations and instead implement controlled, interventional studies where diet or dietary components are deliberately modified and outcomes related to cancer processes are measured. The announcement clearly stated that associational studies and non-interventional, epidemiology-only projects were not supported under this FOA, reinforcing that the focus was on experimental testing of gene-by-diet interactions rather than retrospective or correlational analyses.
The mechanism of support was the NIH R01 Research Project Grant, which is the standard multi-year mechanism for hypothesis-driven research projects. This R01 announcement ran in parallel with a companion FOA of identical scientific scope that used the R21 Exploratory/Developmental Grant mechanism (PA-08-221), giving investigators the option to pursue either a fuller R01 project or a more preliminary, exploratory R21 approach depending on readiness and scope. Funding and the number of awards were not guaranteed; awards were contingent on the availability of NIH funds and on receiving a sufficient number of high-quality, meritorious applications.
Eligibility for applicants was broad and included many common NIH-eligible organization types. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with specific distinctions noted), for-profit organizations other than small businesses, small businesses, and state governments. The announcement also indicated additional eligible applicants such as federal agencies, Hispanic-serving institutions, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations), signaling that international participation and a wide variety of institutional settings were permitted so long as they met NIH requirements.
Administratively, the opportunity was categorized as a discretionary grant in the health and education-related activity areas, and it was associated with CFDA numbers spanning nursing research and multiple cancer research categories (including cancer cause and prevention research, cancer biology research, and cancer control). The FOA was posted July 30, 2008, and it ultimately closed on September 7, 2011, with an archive date of October 8, 2011. The full original announcement was hosted through the NIH grants guide, and NIH’s Office of Extramural Research provided web support contacts for access or linking issues.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled Investigational Nutrigenetic Studies for Cancer Prevention (R01) and the Funding Opportunity Number is PA-08-220.
Which NIH institute led this funding opportunity?
The opportunity was led by the National Cancer Institute (NCI).
Were other NIH components involved?
Yes. The announcement listed participation from the National Institute of Nursing Research (NINR) and the Office of Dietary Supplements (ODS).
What was the main purpose of PA-08-220?
The program was designed to support research that connects nutrigenetics and cancer prevention by leveraging established human genetic variation resources, particularly data generated through the Human Genome Project and the International HapMap Project.
What core scientific idea motivated this FOA?
The central idea was that people do not respond to diet in the same way, and that inherited genetic differences may help explain why certain dietary components reduce cancer-related processes for some individuals but not for others.
What kind of outcomes was the supported research aiming to achieve?
The research aimed to identify genetic variants that predict response to specific nutrients or dietary patterns, with the longer-term goal of moving cancer prevention toward more personalized, targeted dietary strategies, especially for individuals with higher genetic susceptibility to cancer.
Did this FOA emphasize interventions or observational studies?
This FOA emphasized dietary intervention research rather than purely observational work.
What type of study design was NIH specifically seeking under this announcement?
NIH sought projects that would conduct small, pilot-style dietary interventions informed by genetic variation data, testing whether particular genotypes are associated with measurable differences in biological responses relevant to cancer development or progression.
What does it mean that studies needed to go beyond population-level associations?
It means applicants were expected to implement controlled, interventional studies where diet or dietary components are deliberately modified and outcomes related to cancer processes are measured, rather than relying only on correlations or retrospective associations.
Were associational or epidemiology-only projects allowed?
No. The announcement stated that associational studies and non-interventional, epidemiology-only projects were not supported under this FOA.
What grant mechanism was used for PA-08-220?
The mechanism of support was the NIH R01 Research Project Grant, described as the standard multi-year mechanism for hypothesis-driven research projects.
Was there a companion funding opportunity with the same scientific scope?
Yes. PA-08-220 ran in parallel with a companion FOA of identical scientific scope using the R21 Exploratory/Developmental Grant mechanism: PA-08-221.
How should an investigator choose between the R01 (PA-08-220) and the R21 companion FOA?
Based on the information provided, the choice was positioned around readiness and scope: investigators could pursue a fuller R01 project or a more preliminary, exploratory R21 approach depending on what best fit their proposed work.
Was funding guaranteed under this opportunity?
No. Funding and the number of awards were not guaranteed. Awards were contingent on the availability of NIH funds and on receiving a sufficient number of high-quality, meritorious applications.
What types of organizations were eligible to apply?
Eligibility was broad and included many common NIH-eligible organization types, including:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (including those with and without 501(c)(3) status, with specific distinctions noted)
- For-profit organizations other than small businesses
- Small businesses
- State governments
Were federal agencies eligible applicants?
Yes. The announcement indicated that federal agencies were among the additional eligible applicants.
Were Hispanic-serving institutions eligible?
Yes. The FOA indicated Hispanic-serving institutions as eligible applicants.
Were U.S. territories or possessions eligible to apply?
Yes. The announcement indicated that U.S. territories or possessions were eligible applicant types.
Were regional organizations eligible applicants?
Yes. The announcement included regional organizations among eligible applicants.
Were non-U.S. (foreign) organizations allowed to apply?
Yes. The announcement indicated that non-U.S. entities (foreign organizations) were eligible, signaling that international participation was permitted so long as NIH requirements were met.
How was this opportunity categorized administratively?
Administratively, the opportunity was categorized as a discretionary grant in health and education-related activity areas.
What CFDA categories were associated with this FOA?
The FOA was associated with CFDA numbers spanning nursing research and multiple cancer research categories, including cancer cause and prevention research, cancer biology research, and cancer control.
When was PA-08-220 posted?
The FOA was posted on July 30, 2008.
When did PA-08-220 close?
The FOA ultimately closed on September 7, 2011.
When was the opportunity archived?
The archive date was October 8, 2011.
Where was the original announcement hosted?
The full original announcement was hosted through the NIH grants guide.
Who provided support for web access or linking issues?
The information provided indicates that NIH’s Office of Extramural Research provided web support contacts for access or linking issues.
Browse more opportunities from the same category: Education Health
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 08 220) also looked into and applied for these:
| Funding Opportunity |
|---|
| Investigational Nutrigenetic Studies for Cancer Prevention (R21) Apply for PA 08 221 Funding Number: PA 08 221 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Etiology, Prevention, and Treatment of Hepatocellular Carcinoma(R21) Apply for PA 08 244 Funding Number: PA 08 244 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R03) Apply for RFA DA 09 019 Funding Number: RFA DA 09 019 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R01) Apply for RFA DA 09 017 Funding Number: RFA DA 09 017 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Physical Science Oncology Centers (U54) Apply for RFA CA 09 009 Funding Number: RFA CA 09 009 Agency: National Institutes of Health Category: Education Health Funding Amount: $2,250,000 |
| NINR Mentored Research Scientist Development Award for Underrepresented or Disadvantaged Investigators (K01) Apply for PAR 05 135 Funding Number: PAR 05 135 Agency: National Institutes of Health Category: Education Health Funding Amount: $20,000 |
| NCI Transition Career Development Award to Promote Diversity (K22) Apply for PAR 08 047 Funding Number: PAR 08 047 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NINR Career Transition Award (K22) Apply for PAR 08 148 Funding Number: PAR 08 148 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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| NCI Mentored Career Development Award to Promote Diversity (K01) Apply for PAR 06 220 Funding Number: PAR 06 220 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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| The NCI Transition Career Development Award (K22) Apply for PAR 06 455 Funding Number: PAR 06 455 Agency: National Institutes of Health Category: Education Health Funding Amount: $125,000 |
| Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (F31) Apply for PA 07 002 Funding Number: PA 07 002 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Feasibility Studies for Collaborative Interaction for Minority Institution/Cancer Center Partnership (P20) Apply for PAR 07 230 Funding Number: PAR 07 230 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIDA Mentored Clinical Scientists Development Program Award in Drug Abuse and Addiction (K12) Apply for PAR 07 346 Funding Number: PAR 07 346 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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