Opportunity Information: Apply for PA 08 221
Apply for PA 08 221
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Investigational Nutrigenetic Studies for Cancer Prevention (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research 93.399 Cancer Control.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 30, 2008.
- Applicants must submit their applications by Sep 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses State governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Hispanic serving Institutions Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations U.S. Territory or Possession.
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Opportunity Summary:
Investigational Nutrigenetic Studies for Cancer Prevention (R21) (Funding Opportunity Number PA-08-221) was a National Institutes of Health (NIH) grant opportunity led by the National Cancer Institute (NCI) in partnership with the National Institute of Nursing Research (NINR) and the Office of Dietary Supplements (ODS). The central aim was to fund early-stage, exploratory research that tests how inherited genetic differences influence the way individuals respond to specific dietary components that are believed to affect cancer-related biological processes. In practical terms, the FOA encouraged small, pilot dietary intervention studies that use human genetic variation data, including insights generated by the Human Genome Project and the International HapMap Project, to see whether certain genetic variants can help predict who benefits (or does not benefit) from particular dietary exposures relevant to cancer prevention. The long-term vision behind this program was to move toward personalized, genetics-informed dietary prevention strategies, especially for people who may be genetically more susceptible to cancer.
A key feature of the announcement is what it would not support. The FOA explicitly excluded purely associational work and non-interventional, epidemiology-only studies. That means projects that only look for correlations in existing population datasets, without actually testing a dietary change or intervention in a controlled way, were not considered responsive. The emphasis was on intervention-oriented, hypothesis-generating studies that connect genotype to a measurable response to a dietary component, with relevance to cancer processes and prevention.
The award mechanism was the NIH R21, which is designed for exploratory and developmental research and commonly supports pilot work used to justify larger trials or more definitive studies later. This FOA ran in parallel with a companion announcement of the same scientific scope using the R01 mechanism (PA-08-220), which is NIH's standard mechanism for larger, more mature research projects. In other words, PA-08-221 targeted smaller, earlier proof-of-concept nutrigenetics intervention studies, while PA-08-220 provided a pathway for more extensive follow-on work.
In terms of funding parameters, the listed award ceiling was $200,000, and there was no cost-sharing or matching requirement. The number of awards was not specified because awards were dependent on available funds and the quantity and quality of applications received. The opportunity was categorized as discretionary grant funding within health and education-related activity areas and was associated with CFDA numbers 93.393 (Cancer Cause and Prevention Research), 93.396 (Cancer Biology Research), and 93.399 (Cancer Control).
Eligibility was broad and included many organization types. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (other than small businesses), small businesses, and state governments. The eligibility language also extended to additional categories such as eligible federal agencies, Hispanic-serving institutions, non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions, reflecting NIH's typical openness to a wide range of qualified research institutions and partners.
Administratively, the FOA was posted on July 30, 2008, created on December 5, 2008, and had an original and final closing date of September 7, 2011, with an archive date of October 8, 2011. The full announcement was available through NIH's grants guide, and technical access questions were directed to the NIH Office of Extramural Research (OER) webmaster contact.
FAQs: Investigational Nutrigenetic Studies for Cancer Prevention (R21) - PA-08-221
What is the name of this grant opportunity?
The opportunity is titled Investigational Nutrigenetic Studies for Cancer Prevention (R21).
What is the funding opportunity number (FOA number)?
The funding opportunity number is PA-08-221.
Which agency offered this opportunity?
This was a National Institutes of Health (NIH) grant opportunity led by the National Cancer Institute (NCI).
Were other NIH entities involved?
Yes. NCI led the program in partnership with the National Institute of Nursing Research (NINR) and the Office of Dietary Supplements (ODS).
What was the main goal of this FOA?
The central aim was to support early-stage, exploratory research that tests how inherited genetic differences influence how individuals respond to specific dietary components believed to affect cancer-related biological processes.
What kinds of studies were encouraged?
The FOA encouraged small, pilot dietary intervention studies that incorporate human genetic variation data to evaluate whether specific genetic variants can help predict who benefits (or does not benefit) from dietary exposures relevant to cancer prevention.
What does "nutrigenetic" mean in the context of this FOA?
In this program, nutrigenetics refers to studying how differences in a person's inherited genetics can change their biological response to particular dietary components in ways that may relate to cancer processes and prevention.
What was the long-term vision behind the program?
The long-term vision was to move toward personalized, genetics-informed dietary prevention strategies, particularly for individuals who may be genetically more susceptible to cancer.
How were human genetics resources expected to be used?
The FOA referenced the use of insights from resources such as the Human Genome Project and the International HapMap Project to inform the selection and study of genetic variants relevant to dietary response.
Did the FOA require an intervention component?
Yes. The emphasis was on intervention-oriented and hypothesis-generating studies that connect genotype to a measurable response to a dietary component relevant to cancer processes and prevention.
What types of projects were explicitly not supported?
The FOA explicitly excluded purely associational work and non-interventional, epidemiology-only studies. Projects that only looked for correlations in existing datasets, without actually testing a dietary change or intervention in a controlled way, were not considered responsive.
What award mechanism was used for this opportunity?
This FOA used the NIH R21 mechanism, which is intended for exploratory and developmental research (often pilot or proof-of-concept work that can support later, larger studies).
Was there a related opportunity using a different mechanism?
Yes. This FOA ran in parallel with a companion announcement covering the same scientific scope under the R01 mechanism: PA-08-220.
How did PA-08-221 (R21) differ from the companion PA-08-220 (R01)?
PA-08-221 targeted smaller, earlier proof-of-concept nutrigenetics intervention studies using the R21 mechanism, while PA-08-220 provided a pathway for larger, more mature projects under the R01 mechanism.
What was the maximum award amount listed?
The listed award ceiling was $200,000.
Was cost sharing or matching required?
No. The FOA stated there was no cost-sharing or matching requirement.
How many awards were expected to be made?
The number of awards was not specified. Awards depended on available funds and the quantity and quality of applications received.
How was this opportunity categorized from a funding type perspective?
It was categorized as discretionary grant funding within health and education-related activity areas.
Which CFDA numbers were associated with this FOA?
The opportunity was associated with CFDA numbers 93.393 (Cancer Cause and Prevention Research), 93.396 (Cancer Biology Research), and 93.399 (Cancer Control).
Who was eligible to apply?
Eligibility was broad and included: public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and state governments.
Were non-U.S. organizations eligible?
Yes. The eligibility language included non-U.S. entities (foreign organizations).
Did eligibility include specialized organization categories?
Yes. The FOA also referenced eligibility categories such as Hispanic-serving institutions, regional organizations, U.S. territories or possessions, and eligible federal agencies, reflecting NIH's broad eligibility approach for qualified research applicants.
When was the FOA posted?
The FOA was posted on July 30, 2008.
When was the FOA created?
The FOA record indicates it was created on December 5, 2008.
What were the closing dates for this opportunity?
The FOA had an original and final closing date of September 7, 2011.
When was the FOA archived?
The archive date was October 8, 2011.
Where could applicants find the full announcement?
The full announcement was available through the NIH Grants Guide.
Who handled technical access questions about the announcement?
Technical access questions were directed to the NIH Office of Extramural Research (OER) webmaster contact.
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