Opportunity Information: Apply for RFA RM 10 012
Apply for RFA RM 10 012
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Knockout Mouse Phenotyping Project Database (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.233 National Center on Sleep Disorders Research 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.310 Trans NIH Research Support 93.389 National Center for Research Resources 93.396 Cancer Biology Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Sep 10, 2010 and posted on Sep 10, 2010.
- Applicants must submit their applications by Nov 10, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $7,500,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Small businesses For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The NIH funding opportunity RFA-RM-10-012, titled "Knockout Mouse Phenotyping Project Database (U54)," supports the creation of a central Data Coordination Center and Database (DCCDB) for the Knockout Mouse Phenotyping Project (KOMP2). The core idea is to fund one organization to build and run the data backbone for a large, multi-site effort that produces knockout mouse lines and systematically measures their phenotypes. In practical terms, the awardee would be responsible for developing, hosting, and maintaining the databases that (1) track progress across the production pipeline that converts embryonic stem (ES) cell resources into knockout mice, (2) collect and manage phenotype data coming from multiple phenotyping centers, and (3) publish those results so they are usable by the broader research community.
A major emphasis of the announcement is coordination and integration. KOMP2 is not meant to operate in isolation, so the DCCDB is expected to coordinate closely with the International Mouse Phenotyping Consortium (IMPC). That means aligning data standards, formats, identifiers, and timelines so phenotype results generated across centers can be combined, compared, and queried in a consistent way. Just as important, the DCCDB is expected to serve multiple audiences at once: investigators within the KOMP2 network who need timely operational and scientific updates, NIH staff overseeing the program, and the public research community that relies on open access to well-organized datasets.
The deliverable the FOA keeps pointing to is a single, integrated web portal for phenotype information. Rather than having fragmented databases or center-specific websites, this project is intended to provide one place where users can discover which knockout lines have been produced, what phenotyping has been completed, and what the results show. That implies not only storage and retrieval, but also thoughtful user-facing tools: search and browse functions, clear gene and line pages, documentation of protocols and metadata, and interfaces that support both human users and programmatic access (for example, downloads or APIs), all while maintaining data quality and consistent provenance.
The mechanism is a U54 cooperative agreement, which generally signals that NIH expects substantial programmatic involvement and coordination throughout the project rather than a hands-off grant. This FOA was released in parallel with related KOMP2 solicitations under other mechanisms (including RFA-RM-10-011 and RFA-RM-10-013), indicating that the DCCDB is one component in a larger, coordinated set of awards that together make up the overall KOMP2 infrastructure.
Funding is capped at up to $1.5 million in total costs per year for up to five years, for an estimated total of about $7.5 million over the project period. The NIH anticipated making a single award, meaning this competition was essentially to select one group to serve as the central data hub for KOMP2. Applications would therefore be expected to demonstrate not just technical competence in database engineering, but also credibility in operating a national-scale resource: project management, uptime and security planning, scalable architecture, data submission workflows, quality control procedures, and a track record of collaborating across institutions and large consortia.
Eligibility was broad and included higher education institutions (public and private), nonprofits (including those with and without 501(c)(3) status, with noted exceptions), state governments, small businesses, for-profit organizations, and certain designated institution types such as HBCUs, Hispanic-serving institutions, Tribal colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, and even non-U.S. entities where applicable. No cost sharing or matching was required. The opportunity was posted September 10, 2010, with an original and current closing date of November 10, 2010, and it was archived December 11, 2010.
Overall, the grant is best understood as an infrastructure and coordination award aimed at making KOMP2 data findable, standardized, and broadly accessible. Success would be measured by whether the DCCDB can reliably track the production pipeline, ingest and curate high-volume phenotyping outputs from multiple centers, stay synchronized with international partners like IMPC, and deliver a stable, user-friendly portal that serves both consortium members and the wider biomedical research community.
FAQs: NIH RFA-RM-10-012 (Knockout Mouse Phenotyping Project Database, U54)
What is RFA-RM-10-012?
RFA-RM-10-012 is an NIH funding opportunity titled "Knockout Mouse Phenotyping Project Database (U54)." It supports building and operating a central Data Coordination Center and Database (DCCDB) for the Knockout Mouse Phenotyping Project (KOMP2).
What is the purpose of this funding opportunity?
The purpose is to fund one organization to create the central data backbone for KOMP2. This includes developing, hosting, and maintaining databases that track knockout mouse production progress, manage phenotype data from multiple centers, and publish integrated results for broad community use.
What does DCCDB stand for, and what does it do?
DCCDB stands for Data Coordination Center and Database. It is responsible for coordinating data across a multi-site program, running the core databases, and delivering an integrated web portal where users can find information about knockout mouse lines and phenotyping results.
How does this opportunity relate to KOMP2?
The DCCDB is a central component of KOMP2, which is a large, multi-site effort that produces knockout mouse lines and performs systematic phenotyping. The DCCDB is meant to connect the production pipeline and phenotyping outputs into a unified, accessible resource.
What kinds of data systems are expected to be built and maintained?
The FOA emphasizes databases that (1) track progress across the production pipeline converting embryonic stem (ES) cell resources into knockout mice, (2) collect and manage phenotype data from multiple phenotyping centers, and (3) publish those results so they are usable by the broader research community.
What is meant by tracking the production pipeline?
Tracking the production pipeline refers to maintaining data systems that monitor and report progress as ES cell resources are converted into knockout mouse lines, including status tracking across stages and sites so the consortium and NIH can see what has been produced and what is in progress.
What is the main deliverable highlighted by the FOA?
A major deliverable is a single, integrated web portal for phenotype information, replacing fragmented databases or center-specific websites. The portal should enable users to discover which knockout lines exist, what phenotyping has been completed, and what the results show.
Who are the expected users of the DCCDB and portal?
The DCCDB is expected to serve multiple audiences: investigators within the KOMP2 network who need operational and scientific updates, NIH staff overseeing the program, and the public research community that relies on open access to organized datasets.
Is this project expected to provide open access to data?
Yes. The description emphasizes publishing results so they are usable by the broader research community and providing a stable, user-friendly portal that supports broad access to well-organized datasets.
What kind of coordination is required with international efforts?
The FOA emphasizes close coordination with the International Mouse Phenotyping Consortium (IMPC). This includes aligning data standards, formats, identifiers, and timelines so results across centers can be combined, compared, and queried consistently.
What does "integration" mean in the context of this opportunity?
Integration refers to unifying data coming from multiple production and phenotyping sites into consistent structures and user experiences. It also includes harmonizing standards with IMPC so cross-center and international comparisons are possible.
What user-facing features does the FOA imply for the portal?
The FOA implies features such as search and browse functions; clear gene and line pages; documentation for protocols and metadata; and interfaces that support both human users and programmatic access, such as downloads or APIs.
Does the FOA mention programmatic access like APIs or bulk downloads?
Yes. The announcement explicitly points to interfaces that support programmatic access, for example downloads or APIs, in addition to web interfaces for human users.
How important are data quality and provenance?
They are central expectations. The FOA calls for maintaining data quality and consistent provenance while ingesting high-volume phenotyping outputs across multiple centers and publishing integrated results.
What is the funding mechanism for this opportunity?
The mechanism is a U54 cooperative agreement.
What does a U54 cooperative agreement imply for NIH involvement?
A U54 cooperative agreement generally signals substantial NIH programmatic involvement and coordination throughout the project, rather than a hands-off approach.
Is NIH expecting multiple awards or a single award?
NIH anticipated making a single award. The competition was essentially to select one group to serve as the central data hub for KOMP2.
How much funding is available?
Funding is capped at up to $1.5 million in total costs per year for up to five years, for an estimated total of about $7.5 million over the full project period.
How long can the project be funded?
The project can be funded for up to five years.
Is cost sharing or matching required?
No. The opportunity states that no cost sharing or matching is required.
Which organizations are eligible to apply?
Eligibility is broad and includes higher education institutions (public and private), nonprofits (including those with and without 501(c)(3) status, with noted exceptions), state governments, small businesses, and for-profit organizations. It also includes designated institution types such as HBCUs, Hispanic-serving institutions, Tribal colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, and non-U.S. entities where applicable.
Are non-U.S. organizations eligible?
The eligibility description indicates that non-U.S. entities may be eligible where applicable.
What related funding opportunities were mentioned alongside this FOA?
This FOA was released in parallel with other KOMP2 solicitations, including RFA-RM-10-011 and RFA-RM-10-013, indicating the DCCDB award is one component of a larger coordinated set of awards that together form KOMP2 infrastructure.
What are the key capabilities an applicant would be expected to demonstrate?
Applications would be expected to show strong technical and operational capacity, including database engineering, national-scale resource operations, project management, uptime and security planning, scalable architecture, data submission workflows, and quality control procedures. The FOA also highlights the need for a track record of collaborating across institutions and large consortia.
What does "scalable architecture" refer to here?
In this context it refers to designing systems that can handle high-volume, multi-center data submission and growth over time while maintaining performance and reliability for both consortium members and public users.
What is meant by "data submission workflows"?
Data submission workflows refer to the processes and systems used to receive phenotype and production status data from multiple centers, manage ingestion, apply validation and quality control, and prepare the information for publication through the portal.
When was this opportunity posted, and what were the closing dates?
The opportunity was posted on September 10, 2010. The original and current closing date was November 10, 2010.
What does it mean that the opportunity was archived?
It means the FOA is no longer active. The listing indicates it was archived on December 11, 2010.
How would success be measured for the funded DCCDB?
Success is described in operational and community terms: reliably tracking the production pipeline, ingesting and curating high-volume phenotyping outputs from multiple centers, staying synchronized with IMPC standards and timelines, and delivering a stable, user-friendly portal that serves consortium members, NIH oversight needs, and the broader biomedical research community.
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