Opportunity Information: Apply for RFA GD 10 001
Apply for RFA GD 10 001
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Knowledge Synthesis Center for Evaluating Genomic Application in Practice and Prevention (U18)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.068 Chronic Diseases Research, Control, and Prevention.
- This funding opportunity was created on Apr 23, 2010 and posted on Apr 14, 2010.
- Applicants must submit their applications by Apr 30, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,200,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Public nonprofit organizations Private nonprofit organizations For profit organizations Small, minority, and women owned businesses Universities Colleges Research institutions Hospitals Community based organizations Faith based organizations Federally recognized or state recognized American Indian/Alaska Native tribal governments American Indian/Alaska Native tribally designated organizations Alaska Native health corporations Urban Indian health organizations Tribal epidemiology centers State and local governments or their Bona Fide Agents (this includes the District of Columbia, the Commonwealth of Puerto Rico, the Virgin Islands, the Commonwealth of the Northern Marianna Islands, American Samoa, Guam, the Federated States of Micronesia, the Republic of the Marshall Islands, and the Republic of Palau) Political subdivisions of States (in consultation with States) A Bona Fide Agent is an agency/organization identified by the state as eligible to submit an application under the state eligibility in lieu of a state application. If you are applying as a bona fide agent of a state or local government, you must provide a letter from the state or local government as documentation of your status. Attach this documentation behind the first page of your application form or for electronic applications, use a PDF file and attach as Other Documents and label as appropriate.
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Opportunity Summary:
The Centers for Disease Control and Prevention (CDC) announced this discretionary funding opportunity (RFA GD 10 001) to support a single Genomics Knowledge Synthesis Center through a research demonstration cooperative agreement mechanism (U18). The purpose of the Center is to help strengthen the evidence base behind genomic applications used in real-world practice and prevention by conducting systematic evidence reviews, updating them as new research emerges, and publishing the findings in a way that can inform evaluation and decision-making. In practical terms, the Center is meant to serve as a dedicated hub for rigorous, transparent evidence synthesis focused on how well specific genomic tests and related services perform and whether they are appropriate for use in healthcare and public health settings.
A key administrative note in the announcement is that the opportunity was reposted with a slightly revised funding opportunity number: it appears as RFA GD 10 001 (with a hyphen inserted between GD and 10) rather than RFA GD10 001. The reposting also extended the application deadline. Applicants who already submitted an application under the earlier listing were told they did not need to resubmit, which implies CDC intended continuity between the two postings while correcting the identifier and timing.
The work scope centers on systematic evidence reviews addressing selected evaluation questions about a set of health-related genomic tests and services. The announcement explicitly includes DNA-based tests, RNA-based tests, and proteomic tests, and it also points to family health history tools and other genomic services as eligible targets of evaluation. The emphasis on "evaluation" and "practice and prevention" signals that the reviews are expected to go beyond basic laboratory validity and look at issues that matter for implementation and population impact, such as the strength and consistency of evidence, applicability to real populations, and the implications for prevention strategies and clinical or public health use. The Center is expected not only to conduct reviews but also to update them over time, suggesting an ongoing, living-evidence approach rather than one-off reports.
From a funding and awards standpoint, CDC anticipated making one award under this FOA. The estimated total funding amount listed is $1,200,000, with an award ceiling of $500,000 and no stated award floor. There is no cost sharing or matching requirement, which reduces barriers for applicants that might not have flexible funds to contribute. The activity category is health, and the CFDA number provided is 93.068 (Chronic Diseases Research, Control, and Prevention), reflecting CDCs positioning of genomics evidence evaluation as part of chronic disease prevention and population health decision-making.
Eligibility is broad and includes public and private nonprofit organizations, for-profit organizations (including small, minority-owned, and women-owned businesses), universities and colleges, research institutions, hospitals, community-based and faith-based organizations, tribal governments and tribally designated organizations, Alaska Native and Urban Indian health organizations, tribal epidemiology centers, and state and local governments and their bona fide agents. The FOA includes a specific administrative requirement for applicants applying as a bona fide agent of a state or local government: they must provide documentation (a letter from the relevant government) confirming that status, attached with the application materials. This wide eligibility range suggests CDC was aiming to attract applicants with strong capacity in evidence synthesis, genomics, and translation to practice, regardless of organizational type, while still requiring clear proof of authority when a non-government entity applies on behalf of a government.
The timeline details show the posting date as April 14, 2010, with an original closing date of April 20, 2010 and a current closing date of April 30, 2010, and an archive date of May 30, 2010. The CDC is the sponsoring agency, and the contact provided for access issues is the CDC Procurement and Grants Office Technical Information Management Section (phone 770-488-2700). Overall, this opportunity was designed to fund a single, centralized, cooperative-agreement partner to produce and maintain high-quality systematic reviews that evaluate genomic tests and tools relevant to prevention and routine practice, giving policymakers, clinicians, and public health leaders a clearer evidence foundation for deciding which genomic applications should be used, when, and for whom.
Frequently Asked Questions (FAQs)
What is this CDC funding opportunity?
This is a CDC discretionary funding opportunity (RFA GD 10 001) to support a single Genomics Knowledge Synthesis Center through a research demonstration cooperative agreement mechanism (U18).
What is the main purpose of the Genomics Knowledge Synthesis Center?
The Center is intended to strengthen the evidence base behind genomic applications used in real-world practice and prevention. It will do this by conducting systematic evidence reviews, updating those reviews as new research emerges, and publishing findings in a way that supports evaluation and decision-making in healthcare and public health settings.
What does "knowledge synthesis" mean in the context of this opportunity?
In this opportunity, knowledge synthesis refers to performing rigorous, transparent systematic evidence reviews that assess how well specific genomic tests and related services perform and whether they are appropriate for use in healthcare and public health practice and prevention.
What kind of award mechanism will CDC use?
CDC plans to fund the Center through a cooperative agreement mechanism (U18), described as a research demonstration cooperative agreement.
How many awards does CDC expect to make?
CDC anticipated making one award under this funding opportunity.
How much funding is available?
The estimated total funding amount is $1,200,000. The award ceiling is $500,000, and no award floor is stated.
Is there a cost sharing or matching requirement?
No. The announcement states there is no cost sharing or matching requirement.
What is the activity category and CFDA number for this opportunity?
The activity category is health. The CFDA number listed is 93.068 (Chronic Diseases Research, Control, and Prevention).
What types of topics or technologies are included in the review scope?
The scope includes systematic evidence reviews addressing selected evaluation questions about health-related genomic tests and services. The announcement explicitly includes DNA-based tests, RNA-based tests, and proteomic tests, and also points to family health history tools and other genomic services as eligible targets of evaluation.
Is the Center expected to focus only on lab performance of tests?
No. The emphasis on evaluation in real-world practice and prevention indicates the reviews are expected to address issues relevant to implementation and population impact (for example, strength and consistency of evidence, applicability to real populations, and implications for prevention strategies and clinical or public health use), not just basic laboratory validity.
Are the evidence reviews expected to be updated over time?
Yes. The Center is expected not only to conduct systematic reviews but also to update them as new research emerges, suggesting an ongoing approach rather than one-time reports.
What does CDC mean by publishing findings "in a way that can inform evaluation and decision-making"?
Based on the announcement description, the Center is expected to produce and share review findings so they can be used by decision-makers to evaluate genomic applications for use in healthcare and public health settings. The intent is to make the evidence base clearer for decisions about which genomic applications should be used, when, and for whom.
Who is eligible to apply?
Eligibility is broad and includes public and private nonprofit organizations; for-profit organizations (including small, minority-owned, and women-owned businesses); universities and colleges; research institutions; hospitals; community-based and faith-based organizations; tribal governments and tribally designated organizations; Alaska Native and Urban Indian health organizations; tribal epidemiology centers; and state and local governments and their bona fide agents.
Can for-profit organizations apply?
Yes. For-profit organizations are explicitly included in the eligibility list, including small, minority-owned, and women-owned businesses.
Can tribal governments and tribal organizations apply?
Yes. The eligibility list includes tribal governments and tribally designated organizations, Alaska Native and Urban Indian health organizations, and tribal epidemiology centers.
What is a "bona fide agent" of a state or local government, and is there special documentation required?
The announcement includes a specific administrative requirement for applicants applying as a bona fide agent of a state or local government: they must provide documentation (a letter from the relevant government) confirming that status, and the letter must be attached with the application materials.
Why does the opportunity mention being reposted and a revised funding opportunity number?
The announcement notes the opportunity was reposted with a slightly revised funding opportunity number: it appears as RFA GD 10 001 (with a hyphen inserted between GD and 10) rather than RFA GD10 001. The reposting also extended the application deadline.
If an applicant already submitted under the earlier listing, do they need to resubmit?
No. The announcement states that applicants who already submitted an application under the earlier listing were told they did not need to resubmit, implying CDC intended continuity between the two postings while correcting the identifier and timing.
What are the key dates for this opportunity?
The posting date is April 14, 2010. The original closing date was April 20, 2010, and the current closing date is April 30, 2010. The archive date is May 30, 2010.
Which federal agency is sponsoring this opportunity?
The sponsoring agency is the Centers for Disease Control and Prevention (CDC).
Who should be contacted for access issues related to the opportunity?
The contact provided for access issues is the CDC Procurement and Grants Office Technical Information Management Section at 770-488-2700.
What is the practical role of the Center in the genomics landscape?
In practical terms, the Center is meant to serve as a dedicated hub for rigorous, transparent evidence synthesis focused on how well specific genomic tests and related services perform and whether they are appropriate for use in healthcare and public health settings, particularly for practice and prevention decisions.
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