Lasker Clinical Research Scholars Program (SI2) | Apply Online

Opportunity Summary:

The Lasker Clinical Research Scholars Program (SI2) is a National Institutes of Health (NIH) funding opportunity designed to support early-stage, independent clinical researchers as they build and launch their research careers. The core aim is to provide substantial, stable backing for research activities at a career-defining time, while also creating a structured pathway that connects the NIH Intramural Research Program with the broader extramural research community. In practice, the program is meant to function as a bridge: it gives scholars the chance to establish themselves as independent investigators inside NIH and then, if they choose and are successful, transition to an external research environment with continued NIH support.

A defining feature of this opportunity is its two-phase structure. In Phase 1, selected Lasker Scholars receive an appointment as tenure-track investigators within the NIH Intramural Research Program. This intramural phase can last up to 5 to 7 years and includes independent research budgets, allowing scholars to run their own programs rather than working under a senior investigator. The tenure-track framing signals that the program is oriented toward independence and long-term scientific leadership, not short-term training. The emphasis is on enabling scholars to pursue clinically oriented research questions with the resources and institutional setting of NIH intramural laboratories and clinical infrastructure.

Phase 2 is structured as a continuation pathway for scholars who progress successfully through the intramural period. At that point, scholars become eligible to apply for up to 5 additional years of NIH support to continue their research at an extramural research facility, such as a university or academic medical center. Alternatively, the program also allows for the possibility that a scholar may be considered to remain within the intramural program as an NIH investigator rather than moving outside. This second phase is a major part of what makes the program distinct: it is not only an intramural appointment, and it is not only an extramural grant, but a career bridge that supports either a transition outward with funding or continued intramural development depending on the scholar and NIH decisions.

From an administrative standpoint, this opportunity was posted by NIH under Funding Opportunity Number RFA-OD-11-001 and is categorized under “Other” rather than a standard grant mechanism, reflecting its hybrid structure as both an appointment-based intramural role and a potential later-stage extramural support mechanism. The associated CFDA number is 93.140 (Intramural Research Training Award). The funding listing indicates an award ceiling of $500,000 and specifies that there is no cost sharing or matching requirement. Unlike many federal funding opportunities that must be submitted through an applicant organization, eligibility and submission for this program are individual-based: applications are submitted directly by the individual principal investigator (PI), not by an institution on the applicant’s behalf. The eligible applicants category is listed broadly as “Others,” with additional eligibility details referenced in the full announcement.

Key timing details in the source data show the opportunity was posted on February 2, 2011, with an original and current closing date of April 4, 2011, and an archive date of May 5, 2011, meaning it is no longer open under that specific announcement. Applicants or interested parties were directed to the full FOA text via the NIH Grants Guide link, and NIH provided contact support through the NIH Office of Extramural Research (OER) webmaster for access or technical linking issues.

Overall, the Lasker Clinical Research Scholars Program (SI2) is best understood as a competitive NIH career-launch platform for independent clinical researchers that combines a multi-year tenure-track intramural appointment and research budget with the possibility of extended NIH-backed research support during a later move to an extramural institution or continued intramural work. Its structure is intentionally built to reduce the usual barriers between intramural and extramural career paths and to give promising clinical investigators a longer runway to establish high-impact, independent research programs.

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