Opportunity Information: Apply for RFA MH 10 030
Apply for RFA MH 10 030
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Leveraging Existing Health care Networks to Transform Effectiveness Research (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Nov 10, 2009 and posted on Nov 10, 2009.
- Applicants must submit their applications by Jan 12, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Native American tribal governments (Federally recognized) Private institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments Small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Leveraging Existing Health care Networks to Transform Effectiveness Research (U19)" (Funding Opportunity Number RFA-MH-10-030) is a National Institute of Mental Health (NIMH) Funding Opportunity Announcement designed to create and support a Mental Health Research Network (MHRN) through a three-year cooperative agreement. The central idea is to build a practical, shared research infrastructure that sits on top of large, integrated health care delivery systems so researchers can run real-world mental health effectiveness studies faster, at larger scale, and with better consistency across sites than is typically possible when each study builds its own separate setup from scratch.
A major focus of the FOA is infrastructure development that makes large, multi-site effectiveness research feasible inside routine care environments. Applicants are expected to show they can identify, recruit, and enroll large patient populations into effectiveness trials using the reach of participating health systems. The expectation is not just that trials can be conducted, but that they can be conducted efficiently and repeatedly because the underlying network capabilities (governance, data pipelines, recruitment workflows, regulatory coordination, and operational partnerships with clinical settings) are built to last and to support multiple projects over time.
The announcement places heavy emphasis on using electronic medical records (EMRs) and other system-generated data as a backbone for research. A key deliverable is the ability to harmonize EMR data across multiple integrated systems so that data elements are defined consistently enough for research use, including cross-site comparisons and combined analyses. The network is expected to be capable of pooling data for common analyses, which implies developing shared data standards, methods for data quality assessment, and processes to handle privacy, security, and appropriate data sharing. This is aimed at enabling large sample sizes, improving statistical power, and making it possible to study outcomes and service patterns that would be hard to capture in smaller or single-system studies.
Beyond clinical and administrative data, the FOA also calls for building capacity to collect and store biologic materials. In practice, this means putting in place the operational and technical ability to obtain biological specimens (as appropriate to the research aims), manage consent and tracking, and store samples in a way that supports future analyses. The intent is to broaden the kinds of questions the network can answer, including those that may benefit from linking biologic measures with clinical outcomes and health system data.
In addition to building the network infrastructure, the MHRN is expected to actively conduct collaborative, multi-site mental health research using these integrated data systems. The FOA specifically requires at least one pilot intervention effectiveness study, signaling that NIMH wants the funded network to demonstrate early, tangible research output rather than operating only as a planning or capacity-building effort. The program is also expected to be able to perform short-term investigations of emerging mental health issues within health care systems, which suggests a need for rapid-response capability, such as quickly defining cohorts, analyzing trends, or evaluating urgent operational or public health concerns as they arise in real-world care settings.
The funding mechanism is an NIH Multi-Project Cooperative Agreement (U19). A cooperative agreement generally means there is substantial involvement from the funding agency compared with a standard research project grant, so the work is typically carried out in partnership with NIMH program staff through ongoing coordination, milestones, and joint problem-solving. The FOA falls under the Health activity category and is associated with CFDA number 93.242 (Mental Health Research Grants).
In terms of scale and competitiveness, NIMH indicated it planned to commit about $3.0 million in FY 2010 to support one new award in response to this announcement, contingent on available funds and on receiving enough high-quality applications. The opportunity was posted November 10, 2009, with an original and current closing date of January 12, 2010, and an archive date of February 12, 2010.
Eligibility is broad and includes many types of domestic organizations and governmental entities, such as public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (including small businesses), state and local governments, tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, and special district governments. The FOA also explicitly mentions additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Cost sharing or matching is not required.
Overall, this FOA is aimed at transforming mental health effectiveness research by anchoring it in the everyday operations of large health care delivery systems, building shared tools and standards for multi-site data use, and proving the network can generate actionable evidence through pilot intervention testing and rapid investigations of emerging issues.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Leveraging Existing Health care Networks to Transform Effectiveness Research (U19)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-MH-10-030.
Which agency is offering this opportunity?
This is a National Institute of Mental Health (NIMH) Funding Opportunity Announcement.
What is the main purpose of the award?
The purpose is to create and support a Mental Health Research Network (MHRN) that can run real-world mental health effectiveness studies efficiently across multiple large, integrated health care delivery systems by building shared, durable research infrastructure.
What funding mechanism is being used?
The mechanism is an NIH Multi-Project Cooperative Agreement (U19).
What does a cooperative agreement (U19) imply for how the project is run?
A cooperative agreement typically involves substantial involvement from the funding agency. In this FOA, the work is expected to be carried out in partnership with NIMH program staff through ongoing coordination, milestones, and joint problem-solving.
How long is the project period?
The announcement describes a three-year cooperative agreement.
What is the central idea behind the Mental Health Research Network (MHRN)?
The central idea is to build a practical, shared research infrastructure that sits on top of large, integrated health care delivery systems so researchers can run effectiveness studies faster, at larger scale, and with greater consistency across sites than when each study builds its own stand-alone infrastructure.
Is this FOA primarily about funding individual studies or building infrastructure?
A major focus is infrastructure development that makes large, multi-site effectiveness research feasible inside routine care environments. The network is expected to support multiple projects over time rather than being built only for a single study.
What kinds of research activities are expected beyond infrastructure development?
In addition to building the network infrastructure, the MHRN is expected to actively conduct collaborative, multi-site mental health research using integrated data systems.
Is a pilot study required?
Yes. The FOA specifically requires at least one pilot intervention effectiveness study, indicating the network should demonstrate early, tangible research output.
What does the FOA mean by "effectiveness research" in this context?
Based on the description, the focus is on real-world studies conducted within routine care environments in large health care delivery systems, emphasizing practicality, scale, and cross-site consistency.
What capabilities are applicants expected to demonstrate regarding patient populations?
Applicants are expected to show they can identify, recruit, and enroll large patient populations into effectiveness trials using the reach of participating health systems.
Why does the FOA emphasize doing research inside routine care environments?
The intent is to anchor research in the everyday operations of large delivery systems so studies can be run repeatedly and efficiently using lasting governance, workflows, and partnerships with clinical settings.
What role do electronic medical records (EMRs) play in this network?
EMRs and other system-generated data are emphasized as a backbone for research. A key deliverable is the ability to harmonize EMR data across multiple integrated systems so data elements are defined consistently enough for research use.
What does "harmonizing EMR data across sites" involve, according to the FOA description?
It implies developing shared data standards, methods for data quality assessment, and processes to handle privacy, security, and appropriate data sharing so cross-site comparisons and pooled analyses are feasible.
Is the network expected to pool data across health systems?
Yes. The network is expected to be capable of pooling data for common analyses, supporting combined analyses and cross-site comparisons.
Why is pooling data across systems important in this FOA?
The stated aims include enabling large sample sizes, improving statistical power, and making it possible to study outcomes and service patterns that would be hard to capture in smaller or single-system studies.
Does the FOA address privacy and data security?
Yes. The description notes the need for processes to handle privacy, security, and appropriate data sharing as part of making multi-site, pooled EMR-based research feasible.
What kinds of non-EMR resources does the FOA expect the network to support?
Beyond clinical and administrative data, the FOA calls for building capacity to collect and store biologic materials, including the operational and technical ability to obtain specimens as appropriate, manage consent and tracking, and store samples to support future analyses.
Does the FOA require biological specimen collection for every project?
The description indicates specimens would be obtained "as appropriate to the research aims," and emphasizes building the capacity to collect and store biologic materials rather than stating that every project must collect them.
What is the intended benefit of linking biologic materials with health system data?
The intent is to broaden the kinds of questions the network can answer, including questions that may benefit from linking biologic measures with clinical outcomes and health system data.
What is meant by "rapid-response" or short-term investigations of emerging issues?
The FOA indicates the program should be able to perform short-term investigations of emerging mental health issues within health care systems, implying the ability to quickly define cohorts, analyze trends, or evaluate urgent operational or public health concerns as they arise in real-world care settings.
How many awards did NIMH plan to make under this announcement?
NIMH indicated it planned to support one new award in response to this announcement (contingent on available funds and receipt of high-quality applications).
What was the planned funding level?
NIMH indicated it planned to commit about $3.0 million in FY 2010 to support one new award, contingent on available funds and sufficient high-quality applications.
What is the CFDA number associated with this opportunity?
The FOA is associated with CFDA 93.242 (Mental Health Research Grants).
When was the opportunity posted?
The opportunity was posted on November 10, 2009.
What was the application due date?
The original and current closing date listed is January 12, 2010.
When was the archive date?
The archive date is February 12, 2010.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic organizations and governmental entities, including public and private institutions of higher education; nonprofits (with and without 501(c)(3) status); for-profit organizations (including small businesses); state and local governments; tribal governments and tribal organizations; public housing authorities/Indian housing authorities; independent school districts; and special district governments.
Are specific institution types explicitly mentioned as eligible?
Yes. The FOA explicitly mentions Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Does the FOA indicate what kind of health systems the network should build on?
Yes. The network is intended to sit on top of large, integrated health care delivery systems and leverage their reach to support large-scale, real-world effectiveness research.
What types of infrastructure components are highlighted as important?
The description highlights durable network capabilities such as governance, data pipelines, recruitment workflows, regulatory coordination, and operational partnerships with clinical settings.
What is the overall goal of this FOA in practical terms?
The FOA aims to transform mental health effectiveness research by anchoring it in large health care delivery systems, building shared tools and standards for multi-site data use, and demonstrating actionable evidence generation through pilot intervention testing and rapid investigations of emerging issues.
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