Opportunity Information: Apply for RFA RM 09 002

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "National Centers for Biomedical Computing (U54)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
  • This funding opportunity was created on Nov 10, 2009 and posted on Nov 10, 2009.
  • Applicants must submit their applications by Jan 7, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $62,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $2,330,000.00 in funding.
  • Eligible applicants include: For profit organizations other than small businesses Independent school districts Native American tribal governments (Federally recognized) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
Apply for RFA RM 09 002

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Opportunity Summary:

The National Centers for Biomedical Computing (NCBC) (U54) funding opportunity (RFA-RM-09-002) is an NIH Common Fund initiative designed to continue and expand a national network of large, coordinated centers focused on biomedical computing. The main aim is to strengthen the computational infrastructure that biomedical and behavioral researchers rely on, not just by supporting cutting-edge computational science research, but also by delivering practical tools, platforms, and shared resources that help researchers analyze data, model biological systems, and carry out modern, computation-heavy studies. In other words, these centers are intended to serve as both innovation engines (advancing the underlying science of biomedical computation) and as service-oriented hubs (turning those advances into usable software, methods, and community resources).

A central theme of the program is collaboration and networking. The NCBCs are expected to work in concert with individual investigator awards and with each other, creating a connected national effort rather than isolated projects. The idea is to accelerate progress by coordinating development, promoting interoperability, and ensuring that computational advances can be broadly adopted across the research community. The scope is intentionally broad, covering "all facets of biomedical computing," which can range from fundamental algorithm and method development to applied systems that support real-world biomedical research workflows.

Beyond research and tool-building, the FOA places clear emphasis on education and workforce development. Each center is expected to play a major role in training and educating researchers to engage in biomedical computing. This typically implies activities such as developing training materials, hosting workshops or short courses, supporting cross-disciplinary trainees, and generally helping biomedical scientists and computational experts learn to work together effectively. The training component is presented as a core expectation, not an optional add-on, reflecting NIH's interest in building long-term national capacity in biomedical computing.

The mechanism of support is a U54 cooperative agreement, which signals a substantial, multi-component center-style award with significant NIH involvement. Unlike a standard grant where the funded team operates with relatively more independence, a cooperative agreement typically involves ongoing collaboration with NIH program staff and coordination across the broader program. This structure fits the program's networked-center model and its interest in shared infrastructure, common standards, and coordinated deliverables.

In terms of funding, the NIH Common Fund committed an estimated total of $62,000,000 to be distributed over the first four years of the program. The announcement anticipates up to seven center awards. In addition to the Common Fund investment, participating NIH Institutes and Centers (ICs) were expected to contribute additional funding for each award, and the FOA notes that these participating ICs would provide 100 percent of the funding in the final year of the program. The listed award ceiling is $2,330,000, which reflects an upper bound for individual awards under the solicitation as presented in the source data.

Eligibility is broad and includes many types of applicant organizations. Eligible applicants span public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district governments, and certain housing authorities). The FOA also includes a wide range of other eligible entities such as federally recognized and other tribal organizations, tribally controlled colleges and universities, historically black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and U.S. territories or possessions. Notably, the eligibility list also includes non-U.S. entities (foreign organizations) and regional organizations, indicating the program was open to participation beyond domestic U.S. institutions, consistent with NIH policies that sometimes allow foreign involvement when scientifically justified.

Administratively, this is a discretionary funding opportunity from the National Institutes of Health, categorized under health and associated with CFDA number 93.310 (Trans-NIH Research Support). There is no cost-sharing or matching requirement. The opportunity was posted on November 10, 2009, with an original and current closing date of January 7, 2010, and an archive date of February 7, 2010. For applicants or interested parties seeking the full details, NIH provided an additional information link to the full announcement on the NIH grants site and designated the NIH Office of Extramural Research (OER) webmaster contacts for access and technical issues.

Frequently Asked Questions (FAQs)

What is the NCBC (U54) funding opportunity (RFA-RM-09-002)?

The National Centers for Biomedical Computing (NCBC) (U54) funding opportunity (RFA-RM-09-002) is an NIH Common Fund initiative to continue and expand a national network of large, coordinated centers focused on biomedical computing.

What is the main goal of the NCBC program?

The main goal is to strengthen the computational infrastructure that biomedical and behavioral researchers rely on by supporting cutting-edge biomedical computing research and by delivering practical tools, platforms, and shared resources for data analysis, biological modeling, and computation-heavy studies.

What kinds of activities are NCBC centers expected to do?

NCBC centers are expected to operate as both innovation engines and service-oriented hubs. That includes advancing the underlying science of biomedical computation and turning those advances into usable software, methods, tools, platforms, and community resources.

Does the program emphasize collaboration between centers?

Yes. A central theme is collaboration and networking. NCBCs are expected to work in concert with individual investigator awards and with each other to create a connected national effort rather than isolated projects.

How broad is the scientific scope of the NCBC program?

The scope is intentionally broad and covers "all facets of biomedical computing." This can include fundamental algorithm and method development as well as applied systems that support real-world biomedical research workflows.

Are tool-building and shared resources part of the program expectations?

Yes. The FOA emphasizes delivering practical tools, platforms, and shared resources that help researchers analyze data, model biological systems, and conduct modern computational studies.

Is education and training required as part of an NCBC center?

Yes. The FOA places clear emphasis on education and workforce development as a core expectation. Centers are expected to play a major role in training and educating researchers to engage in biomedical computing.

What kinds of training activities are implied for NCBC centers?

The description implies activities such as developing training materials, hosting workshops or short courses, supporting cross-disciplinary trainees, and helping biomedical scientists and computational experts learn to work together effectively.

What funding mechanism is used for this opportunity?

This opportunity uses a U54 cooperative agreement mechanism, which is a substantial, multi-component center-style award.

What does it mean that this is a cooperative agreement (U54)?

A cooperative agreement typically involves significant NIH involvement and ongoing collaboration with NIH program staff, which aligns with the program's networked-center model and interest in shared infrastructure, common standards, and coordinated deliverables.

How much funding is available overall?

The NIH Common Fund committed an estimated total of $62,000,000 to be distributed over the first four years of the program.

How many awards does the announcement anticipate?

The announcement anticipates up to seven center awards.

Is there an award ceiling for individual awards?

Yes. The listed award ceiling is $2,330,000 as presented in the source information.

Are NIH Institutes and Centers (ICs) involved in funding the awards?

Yes. In addition to the NIH Common Fund investment, participating NIH Institutes and Centers (ICs) were expected to contribute additional funding for each award, and the FOA notes that participating ICs would provide 100 percent of the funding in the final year of the program.

Is cost sharing or matching required?

No. The opportunity specifies that there is no cost-sharing or matching requirement.

Who is eligible to apply?

Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district governments, and certain housing authorities).

Are tribal organizations and minority-serving institutions eligible?

Yes. The eligibility list includes federally recognized and other tribal organizations, tribally controlled colleges and universities, historically black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and U.S. territories or possessions.

Are foreign organizations eligible to apply?

Yes. The eligibility list includes non-U.S. entities (foreign organizations) and regional organizations.

What agency is offering this funding opportunity?

This is a discretionary funding opportunity from the National Institutes of Health (NIH) and is described as an NIH Common Fund initiative.

What is the CFDA number associated with this opportunity?

The CFDA number listed is 93.310 (Trans-NIH Research Support).

What are the key dates for this opportunity?

The opportunity was posted on November 10, 2009. The original and current closing date is January 7, 2010. The archive date is February 7, 2010.

Where can applicants find the full announcement details?

NIH provided an additional information link to the full announcement on the NIH grants site.

Who is listed for access or technical issues related to the announcement?

The NIH Office of Extramural Research (OER) webmaster contacts are designated for access and technical issues.

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