Opportunity Information: Apply for RFA AA 16 003

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition Consortia for HIV/AIDS and Alcohol Related Research Trials (CHAART) Resource Core (U24)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
  • This funding opportunity was created on Jul 8, 2015 and posted on Jul 8, 2015.
  • Applicants must submit their applications by Jan 15, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $7,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $250,000.00 in funding.
  • The number of recipients for this funding is limited to 12 candidate(s).
  • Eligible applicants include: Private institutions of higher education Public and State controlled institutions of higher education.
Apply for RFA AA 16 003

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Opportunity Summary:

The Limited Competition Consortia for HIV/AIDS and Alcohol Related Research Trials (CHAART) Resource Core (U24) funding opportunity (RFA-AA-16-003) was a National Institutes of Health cooperative agreement designed to strengthen and coordinate research focused on the intersection of alcohol use and HIV/AIDS outcomes. The central idea behind the announcement was to build and support a shared scientific "core" that could serve multiple research projects within CHAART consortia, helping investigators run more rigorous, harmonized, and operationally effective studies that examine how alcohol influences HIV-related morbidity, mortality, disease progression, and transmission, and how targeted interventions can reduce alcohol-related harms in people affected by HIV.

A major emphasis of the FOA was advancing operations and implementation research, meaning it was not just about testing a clinical hypothesis in isolation, but about improving how evidence-based approaches are deployed in real-world systems of care and community settings. The opportunity highlighted two complementary goals: first, developing broader systems for monitoring and understanding the complicated and interlocking patterns of HIV and alcohol-related illness and death; and second, designing and evaluating interventions that reduce the negative effects of alcohol on HIV disease progression and on transmission risk. In practice, this points to work such as improving surveillance and measurement frameworks, standardizing data elements across sites, strengthening analytic approaches for complex outcomes, and supporting intervention studies that can be implemented and sustained within health systems.

This announcement was explicitly aligned with priorities in the Trans-NIH Plan for HIV-Related Research, signaling that the work was intended to fit into a larger, cross-institute federal research strategy rather than operate as a standalone program. The "resource core" structure indicates that the funded activity was meant to provide enabling infrastructure and expertise that individual research projects in the consortia could draw upon. While the FOA text in the provided excerpt does not list specific core components, scientific cores in this context commonly include functions such as data management and informatics support, coordination of multi-site operations, development and dissemination of common protocols and measures, biostatistics and methodological consultation, support for monitoring outcomes across heterogeneous settings, and facilitation of collaboration and communication across research teams. Because the mechanism is a U24 cooperative agreement, NIH would typically maintain substantial programmatic involvement, with the award functioning as a partnership where NIH staff may help guide priorities, integration, and performance expectations to ensure the core serves consortium-wide needs.

In terms of who could apply, eligibility was limited to institutions of higher education, including private universities and public or state-controlled universities. The FOA did not require cost sharing or matching funds. It was categorized as discretionary funding, with the funding instrument being a cooperative agreement and the activity area being health. The NIH listed an expected 12 awards, with an estimated total funding amount of $7,000,000 and an award ceiling of $250,000. The program fell under CFDA 93.273, Alcohol Research Programs, which reflects the role of alcohol research as the anchor theme even as the work directly addresses HIV/AIDS outcomes.

From an administrative standpoint, the opportunity was posted on July 8, 2015, with an original and final closing date of January 15, 2016, and an archive date of February 15, 2016. Additional details and full application requirements were provided through the NIH Grants Guide link associated with the announcement. For technical issues accessing the announcement or linking problems, the contact point listed was the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).

FAQs: Limited Competition Consortia for HIV/AIDS and Alcohol Related Research Trials (CHAART) Resource Core (U24) - RFA-AA-16-003

What is this funding opportunity?

This opportunity, titled "Limited Competition Consortia for HIV/AIDS and Alcohol Related Research Trials (CHAART) Resource Core (U24)" (RFA-AA-16-003), was a National Institutes of Health (NIH) cooperative agreement intended to strengthen and coordinate research at the intersection of alcohol use and HIV/AIDS outcomes by supporting a shared "resource core" within CHAART consortia.

What is the main purpose of the CHAART Resource Core?

The central purpose was to build and support shared scientific infrastructure that multiple research projects within CHAART consortia could use. The goal was to help investigators run more rigorous, harmonized, and operationally effective studies examining how alcohol affects HIV-related morbidity, mortality, disease progression, and transmission, and how interventions can reduce alcohol-related harms for people affected by HIV.

What kind of research focus did the FOA emphasize?

The FOA emphasized operations and implementation research. This means the intent went beyond testing a clinical hypothesis in isolation and focused on improving how evidence-based approaches are deployed in real-world systems of care and community settings.

What were the two complementary goals highlighted in the announcement?

The opportunity highlighted two related goals: (1) developing broader systems for monitoring and understanding complex and interlocking patterns of HIV and alcohol-related illness and death; and (2) designing and evaluating interventions that reduce alcohol's negative effects on HIV disease progression and transmission risk.

What types of activities does this imply in practice?

Based on the description provided, this points to work such as improving surveillance and measurement frameworks, standardizing data elements across sites, strengthening analytic approaches for complex outcomes, and supporting intervention studies that can be implemented and sustained within health systems.

How does this opportunity relate to broader NIH priorities?

The announcement was explicitly aligned with priorities in the Trans-NIH Plan for HIV-Related Research. That alignment indicates the work was intended to fit into a larger, cross-institute federal research strategy rather than operate as a standalone program.

What does it mean that this is a "resource core"?

A "resource core" structure indicates the funded activity was meant to provide enabling infrastructure and expertise that individual research projects in the CHAART consortia could draw upon, helping promote consistency, coordination, and efficiency across studies.

Did the excerpt list specific required core components?

No. The provided excerpt does not list specific core components required by the FOA.

What kinds of functions are commonly included in scientific cores in this context?

While not listed as required components in the excerpt, scientific cores in this context commonly include functions such as data management and informatics support, coordination of multi-site operations, development and dissemination of common protocols and measures, biostatistics and methodological consultation, support for monitoring outcomes across heterogeneous settings, and facilitation of collaboration and communication across research teams.

What is the funding mechanism for this opportunity?

The funding mechanism was a U24 cooperative agreement.

What does a U24 cooperative agreement imply about NIH involvement?

Because the mechanism is a cooperative agreement, NIH would typically have substantial programmatic involvement. The award generally functions as a partnership in which NIH staff may help guide priorities, integration, and performance expectations to ensure the core serves consortium-wide needs.

Who was eligible to apply?

Eligibility was limited to institutions of higher education, including private universities and public or state-controlled universities.

Was cost sharing or matching required?

No. The FOA did not require cost sharing or matching funds.

What type of funding was this categorized as?

It was categorized as discretionary funding.

What is the activity area for this opportunity?

The activity area was health.

How many awards were expected?

The NIH listed an expected 12 awards.

What was the estimated total funding amount?

The estimated total funding amount was $7,000,000.

What was the award ceiling?

The award ceiling was $250,000.

What CFDA program was associated with this opportunity?

The program fell under CFDA 93.273, Alcohol Research Programs.

Why does CFDA 93.273 matter if the work addresses HIV/AIDS outcomes?

CFDA 93.273 reflects that alcohol research was the anchor theme for the program, even though the described research directly addresses HIV/AIDS outcomes and the interaction between alcohol use and HIV-related morbidity, mortality, progression, and transmission.

When was the opportunity posted?

The opportunity was posted on July 8, 2015.

What were the application due dates?

The original and final closing date was January 15, 2016.

When was the opportunity archived?

The archive date was February 15, 2016.

Where could applicants find the full requirements and details?

Additional details and full application requirements were provided through the NIH Grants Guide link associated with the announcement.

Who should be contacted for technical issues accessing the announcement?

For technical issues accessing the announcement or for linking problems, the contact listed was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

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