Opportunity Information: Apply for RFA ES 09 008
Apply for RFA ES 09 008
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Limited Competition Continuation of Studies on Early Environmental Exposures and Human Puberty (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research 93.399 Cancer Control.
- This funding opportunity was created on Oct 23, 2009 and posted on Oct 23, 2009.
- Applicants must submit their applications by Dec 23, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,900,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $650,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments County governments For profit organizations other than small businesses City or township governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government.
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Opportunity Summary:
This grant opportunity, RFA ES 09 008, is a limited competition Funding Opportunity Announcement from the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI) that supports the continuation of existing longitudinal research on early-life environmental exposures and female pubertal development, with the longer-term aim of improving understanding of breast cancer risk. It uses the NIH cooperative agreement mechanism (U01), which means the funded projects are expected to be carried out with substantial scientific involvement from NIH staff, not as fully independent investigator-initiated awards. The FOA is specifically restricted to investigators who were already supported under Project 2 (the epidemiology project) of the earlier Breast Cancer and the Environment Research Center (BCERC) grants (RFA ES 03 001), so it is not broadly open to new applicant teams proposing entirely new cohorts.
The core purpose is to keep following the cohorts of girls who were enrolled in the original BCERC epidemiological studies. By continuing follow-up rather than starting over, the program seeks to protect and extend the value of the original investment in building these rare, well-characterized cohorts and to increase statistical power for detecting meaningful relationships between early environmental determinants and pubertal timing and progression. The ongoing research focus spans a wide set of influences, including environmental exposures and stressors, genetic variation, biologic factors, lifestyle characteristics, and socioeconomic conditions, all examined in relation to pubertal endpoints and how those developmental patterns may connect to later breast cancer risk. The FOA emphasizes that data collection should continue using methods similar to those already established across the centers, supporting consistency over time and comparability across sites.
A major program expectation is cross-site collaboration and pooled analyses across the three study locations. In practice, that means awardees are expected to contribute compatible measures and participate in network-level analysis plans that combine data to strengthen inference and improve the ability to examine subgroup effects, exposure mixtures, gene-environment interactions, and other questions that typically require larger sample sizes than a single site can provide. The FOA also reinforces the broader Breast Cancer and the Environment Program (BCERP) network structure, noting that this announcement runs in parallel with two related FOAs (RFA ES 09 009 and RFA ES 09 010) that together make up the BCERP network, so successful applicants should be prepared to operate as part of a coordinated multi-award program.
An additional defining feature is the required, ongoing partnership with a local Community Outreach and Translation Core (COTC). The COTC role is not peripheral; it is positioned as essential to meeting the scientific and public-facing goals of the program. Key responsibilities include helping with participant retention (critical for longitudinal follow-up), strengthening partnerships among researchers, community members, advocates, and other stakeholders, and ensuring that breast cancer advocate perspectives meaningfully shape research questions and priorities. The COTC is also expected to develop and implement communication tools and materials to translate findings for the public and for policy makers, reflecting the program emphasis on moving results beyond academic publication toward broader understanding and potential public health impact.
In terms of funding, NIEHS and NCI projected a total of about $2.9 million per year for five years for this FOA, with up to three awards anticipated. The listed award ceiling is $650,000. There is no cost sharing or matching requirement. The opportunity was posted October 23, 2009, with an original and current closing date of December 23, 2009, and an archive date of January 23, 2010, indicating it is a past, time-limited solicitation rather than an open, ongoing program.
Eligibility in the source listing includes a range of applicant types such as state, county, and city or township governments, and for-profit organizations other than small businesses, with additional eligibility details pointing back to the FOA text. However, the practical eligibility constraint is the limited-competition requirement: only investigators already supported under the specified BCERC epidemiology project component were invited to apply for continuation under this mechanism. The program is cataloged under multiple CFDA numbers reflecting its environmental health and cancer research scope (93.113, 93.393, 93.396, 93.399).
FAQs: RFA ES 09 008 (NIEHS/NCI) - Early-Life Environmental Exposures and Female Pubertal Development
What is RFA ES 09 008?
RFA ES 09 008 is a limited competition Funding Opportunity Announcement (FOA) from the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI). It supports the continuation of existing longitudinal research examining early-life environmental exposures and female pubertal development, with a longer-term aim of improving understanding of breast cancer risk.
What is the main goal of this FOA?
The central goal is to continue following the cohorts of girls enrolled in the original Breast Cancer and the Environment Research Center (BCERC) epidemiology studies. By continuing follow-up rather than initiating new cohorts, the program aims to preserve and extend the value of the original investment in these rare, well-characterized longitudinal cohorts and increase statistical power to detect meaningful relationships between early environmental determinants and pubertal timing and progression.
Is this grant meant to create new cohorts or studies?
No. This FOA is focused on continued follow-up of the existing BCERC epidemiological cohorts, not on creating entirely new cohorts or launching unrelated new applicant teams.
What research topics and factors are included under this FOA?
The FOA describes a broad research focus that includes environmental exposures and stressors, genetic variation, biologic factors, lifestyle characteristics, and socioeconomic conditions. These factors are examined in relation to pubertal endpoints and developmental patterns that may connect to later breast cancer risk.
What types of outcomes or endpoints are being studied?
The program emphasizes pubertal endpoints, including timing and progression of puberty, and how these developmental patterns may relate to later breast cancer risk.
What is the funding mechanism used for this opportunity?
This FOA uses the NIH cooperative agreement mechanism (U01). Under a cooperative agreement, funded projects are expected to be carried out with substantial scientific involvement from NIH staff, rather than being fully independent investigator-initiated awards.
What does "limited competition" mean for eligibility?
"Limited competition" means the FOA is not broadly open to all potential applicants. In practice, this opportunity is restricted to investigators who were already supported under Project 2 (the epidemiology project) of the earlier BCERC grants (RFA ES 03 001) and were invited to apply for continuation.
Who is practically eligible to apply?
Although the source listing includes multiple applicant types (such as state, county, and city or township governments, and for-profit organizations other than small businesses), the key practical eligibility constraint is the FOA restriction: only investigators already supported under the specified BCERC epidemiology project component (Project 2 under RFA ES 03 001) could apply for continuation.
Does the FOA require continuation of existing data collection methods?
Yes. The FOA emphasizes that data collection should continue using methods similar to those already established across the centers. This supports consistency over time and comparability across sites.
Is cross-site collaboration required?
Yes. A major program expectation is cross-site collaboration and pooled analyses across the three study locations. Awardees are expected to contribute compatible measures and participate in network-level analysis plans that combine data.
Why does the FOA emphasize pooled analyses?
Pooled analyses are emphasized to strengthen inference and improve the ability to evaluate questions that often require larger sample sizes than a single site can provide. This includes examining subgroup effects, exposure mixtures, and gene-environment interactions.
How does this FOA relate to the broader Breast Cancer and the Environment Program network?
This announcement is described as running in parallel with two related FOAs (RFA ES 09 009 and RFA ES 09 010). Together, these FOAs make up the Breast Cancer and the Environment Program (BCERP) network, so successful applicants are expected to operate as part of a coordinated multi-award program.
Is a Community Outreach and Translation Core (COTC) required?
Yes. The FOA requires an ongoing partnership with a local Community Outreach and Translation Core (COTC). The COTC is positioned as essential, not optional or peripheral.
What is the role of the COTC in this program?
The COTC is expected to help with participant retention for longitudinal follow-up, strengthen partnerships among researchers, community members, advocates, and other stakeholders, and ensure that breast cancer advocate perspectives meaningfully shape research questions and priorities.
Does the FOA expect communication or translation of findings beyond academic publications?
Yes. The COTC is expected to develop and implement communication tools and materials to translate findings for the public and for policy makers, reflecting an emphasis on moving results beyond academic publication toward broader understanding and potential public health impact.
How much funding was projected for this FOA?
NIEHS and NCI projected total funding of about $2.9 million per year for five years under this FOA.
How many awards were anticipated?
Up to three awards were anticipated.
What is the maximum award amount mentioned?
The listed award ceiling is $650,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
When was this FOA posted and when did it close?
The opportunity was posted on October 23, 2009. The original and current closing date was December 23, 2009, and the archive date was January 23, 2010.
Is this an open opportunity today?
No. Based on the provided dates (closing date in 2009 and archive date in 2010), this was a past, time-limited solicitation rather than an open, ongoing program.
Which agencies sponsored this FOA?
The FOA is sponsored by the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI).
Which CFDA numbers are associated with this program?
The program is cataloged under multiple CFDA numbers reflecting its environmental health and cancer research scope: 93.113, 93.393, 93.396, and 93.399.
What earlier grant program is this FOA continuing?
This FOA is specifically tied to continuation of research supported under the earlier Breast Cancer and the Environment Research Center (BCERC) grants, referenced as RFA ES 03 001, specifically Project 2 (the epidemiology project).
What is the long-term public health purpose described for this research?
The longer-term purpose described is to improve understanding of breast cancer risk by studying how early-life environmental determinants and related factors influence female pubertal development and associated endpoints.
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Previous opportunity: Coordinating Center for the Breast Cancer and the Environment Research Program (U01)
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