Opportunity Information: Apply for RFA DK 12 502
Apply for RFA DK 12 502
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of Look AHEAD (Action for Health in Diabetes) Consortium (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Sep 28, 2012 and posted on Jun 1, 2012.
- Applicants must submit their applications by Dec 20, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $23,058,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 16 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education Private institutions of higher education.
- Other Eligible Applicants include the following Only organizations which are currently participating in Look AHEAD are eligible to apply under this FOA.
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Opportunity Summary:
The funding opportunity titled "Limited Competition for the Continuation of Look AHEAD (Action for Health in Diabetes) Consortium (U01)" (Funding Opportunity Number RFA DK 12 502) is a National Institutes of Health (NIH) request for applications issued jointly by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung, and Blood Institute (NHLBI). It is a discretionary, limited-competition Request for Applications (RFA) that uses the cooperative agreement mechanism (U01), meaning the funded work is expected to be carried out with substantial NIH scientific and programmatic involvement rather than as a fully independent investigator-initiated grant.
The scientific and public health focus is the continuation of the Look AHEAD (Action for Health in Diabetes) Consortium, a major clinical trial evaluating the long-term health effects of an intensive lifestyle intervention aimed at achieving and maintaining weight loss in adults who are overweight or obese and who have type 2 diabetes. Look AHEAD is designed to assess how a structured lifestyle program influences long-term outcomes, with relevance to diabetes management and cardiovascular and related health risks that commonly accompany type 2 diabetes and obesity. In practical terms, this FOA is not proposing a brand-new trial; it is specifically supporting continued follow-up to extend the evidence base on long-term outcomes in an already-established cohort.
The central purpose of this particular limited competition is to fund an additional two-year follow-up period for all currently enrolled participants. That emphasis on continued follow-up signals that the funders viewed the existing enrolled population, study infrastructure, and accumulated data as uniquely valuable, and that extending observation time would meaningfully strengthen the trial's ability to detect longer-term effects of the lifestyle intervention. The continuation period would typically involve maintaining participant engagement, collecting follow-up clinical endpoints and other outcomes, ensuring high-quality data capture, and preserving the operational capacity needed to complete the extended observation window.
Eligibility is narrowly restricted. While the general applicant categories listed include public and state-controlled institutions of higher education and private institutions of higher education, the FOA explicitly limits eligibility to organizations that are already participating in the Look AHEAD Consortium. This makes it a true continuation opportunity intended to support existing trial sites and consortium components rather than open competition among new entrants. Investigators or institutions not already part of Look AHEAD would not be eligible to apply under this announcement.
From a funding and administrative standpoint, NIH anticipated making about 16 awards under this FOA, with an estimated total funding level of approximately $23,058,000. The FOA states there is no cost sharing or matching requirement. The activity aligns with health-related research categories such as food and nutrition and broader biomedical domains covered by the listed CFDA numbers, including diabetes, digestive and kidney diseases extramural research, cardiovascular diseases, lung diseases, blood diseases, and sleep disorders research, reflecting the cross-cutting health implications of obesity, diabetes, and lifestyle interventions.
Key dates indicate the opportunity was posted June 1, 2012, with an original application due date of November 20, 2012, later updated to a current closing date of December 20, 2012. The archive date was January 21, 2013, indicating the solicitation is no longer active, but the details remain useful for understanding how NIH structures limited competitions to extend large, multi-site clinical trials when additional follow-up is scientifically justified.
Overall, this FOA is best understood as a targeted, consortium-only continuation mechanism to preserve and extend the value of an ongoing landmark lifestyle intervention trial in type 2 diabetes by enabling two additional years of participant follow-up, using a cooperative agreement structure that supports close coordination between NIH and the established Look AHEAD research network.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Limited Competition for the Continuation of Look AHEAD (Action for Health in Diabetes) Consortium (U01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA DK 12 502.
Which agencies issued this request for applications?
This request for applications (RFA) was issued by the National Institutes of Health (NIH) and is jointly associated with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung, and Blood Institute (NHLBI).
What type of funding announcement is this?
It is a discretionary, limited-competition Request for Applications (RFA).
What funding mechanism does this opportunity use?
This opportunity uses the cooperative agreement mechanism (U01).
What does a U01 cooperative agreement imply for how the work is conducted?
A U01 indicates substantial NIH scientific and programmatic involvement is expected during the project, rather than the project being carried out as a fully independent investigator-initiated grant.
What is the overall scientific focus of this opportunity?
The focus is the continuation of the Look AHEAD (Action for Health in Diabetes) Consortium, a major clinical trial studying the long-term health effects of an intensive lifestyle intervention aimed at achieving and maintaining weight loss in adults who are overweight or obese and who have type 2 diabetes.
Is this funding opportunity intended to start a new clinical trial?
No. The opportunity is specifically intended to support continued follow-up in an already-established Look AHEAD cohort, rather than proposing a brand-new trial.
What is the central purpose of this limited competition?
The central purpose is to fund an additional two-year follow-up period for all currently enrolled participants in the Look AHEAD study.
How long is the continuation follow-up period supported by this FOA?
The FOA emphasizes supporting two additional years of follow-up for currently enrolled participants.
Why is the follow-up extension considered important in the description?
The description indicates that extending the observation time would strengthen the trial's ability to detect longer-term effects of the lifestyle intervention, leveraging the unique value of the existing cohort, infrastructure, and accumulated data.
What kinds of activities are implied during the continuation period?
Activities implied include maintaining participant engagement, collecting follow-up clinical endpoints and other outcomes, ensuring high-quality data capture, and preserving the operational capacity needed to complete the extended observation window.
Who is eligible to apply for this limited competition?
Eligibility is narrowly restricted to organizations that are already participating in the Look AHEAD Consortium.
Are new institutions or investigators outside the Look AHEAD Consortium eligible to apply?
No. The FOA explicitly limits eligibility to existing Look AHEAD Consortium participants, so institutions or investigators not already part of Look AHEAD would not be eligible under this announcement.
What applicant organization types are mentioned in the description?
The description notes general applicant categories such as public and state-controlled institutions of higher education and private institutions of higher education, while also stating that eligibility is explicitly limited to current Look AHEAD Consortium participants.
How many awards did NIH anticipate making under this FOA?
NIH anticipated making about 16 awards.
What was the estimated total funding level for this FOA?
The estimated total funding level was approximately $23,058,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What health and research areas does this opportunity relate to?
The activity aligns with health-related research areas such as food and nutrition and broader biomedical domains reflected in the listed CFDA areas, including diabetes, digestive and kidney diseases extramural research, cardiovascular diseases, lung diseases, blood diseases, and sleep disorders research.
How does this FOA connect diabetes, obesity, and cardiovascular risk?
The described trial focuses on an intensive lifestyle intervention for weight loss in adults with type 2 diabetes who are overweight or obese, with relevance to diabetes management and cardiovascular and related health risks that commonly accompany type 2 diabetes and obesity.
When was this funding opportunity posted?
The opportunity was posted on June 1, 2012.
What was the original application due date?
The original application due date was November 20, 2012.
Was the closing date changed?
Yes. The description notes the due date was later updated to a current closing date of December 20, 2012.
What is the archive date and what does it indicate?
The archive date was January 21, 2013, indicating the solicitation is no longer active.
Is this FOA currently open for applications?
No. Based on the archive date provided (January 21, 2013), the solicitation is no longer active.
How is this FOA best described in practical terms?
It is a targeted, consortium-only continuation mechanism designed to preserve and extend the value of a large, multi-site clinical trial by supporting two additional years of participant follow-up under a cooperative agreement structure with close NIH coordination.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA DK 12 502) also looked into and applied for these:
| Funding Opportunity |
|---|
| Renal Function and Chronic Kidney Disease in Aging (R01) Apply for PA 12 211 Funding Number: PA 12 211 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| George M. OBrien Kidney Research Core Centers (P30) Apply for RFA DK 12 008 Funding Number: RFA DK 12 008 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $750,000 |
| Research Enhancement for NIDDK Hematology Grantees (Admin Supp) Apply for PA 12 242 Funding Number: PA 12 242 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| New Technologies for the Study of Lymphatics in the Digestive and Urinary Systems (R43/R44) Apply for PA 12 258 Funding Number: PA 12 258 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01) Apply for PAR 12 259 Funding Number: PAR 12 259 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $250,000 |
| Lymphatics in Health and Disease in the Digestive, Cardiovascular and Pulmonary Systems (R21) Apply for PAR 12 260 Funding Number: PAR 12 260 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $125,000 |
| Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) Apply for PAR 12 265 Funding Number: PAR 12 265 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Assessment, Serial Evaluation and Subsequent Sequelae of Acute Kidney Injury (ASSESS AKI) Study (U01) Apply for RFA DK 12 509 Funding Number: RFA DK 12 509 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Pilot Studies of Candidate Therapies for Chronic Kidney Disease (CKD) (U01) Apply for RFA DK 12 016 Funding Number: RFA DK 12 016 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) (U01) Apply for RFA DK 12 017 Funding Number: RFA DK 12 017 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01) Apply for RFA DK 12 508 Funding Number: RFA DK 12 508 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Advancing Clinical Research in Primary Glomerular Diseases (UM1) Apply for RFA DK 12 014 Funding Number: RFA DK 12 014 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Novel Interventions to Reduce Morbidity and Mortality of Hemodialysis Patients Safety and Other Early Phase Studies (U01) Apply for RFA DK 12 010 Funding Number: RFA DK 12 010 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Multidisciplinary K12 Urologic Research (KURe) Career Development Program Apply for RFA DK 12 013 Funding Number: RFA DK 12 013 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $600,000 |
| Limited Competition Small Grant Program for NIDDK K01/K08/K23 Recipients (R03) Apply for PAR 12 285 Funding Number: PAR 12 285 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $50,000 |
| George M. OBrien Urology Cooperative Research Centers Program (U54) Apply for RFA DK 12 009 Funding Number: RFA DK 12 009 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $650,000 |
| Ancillary Studies of Acute Kidney Injury, Chronic Kidney Disease, and End Stage Renal Disease Accessing Information from Clinical Trials, Epidemiological Studies, and Databases (R01) Apply for PA 12 299 Funding Number: PA 12 299 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Early Stage Pharmacological Validation of Novel Targets and Accompanying Pre Therapeutic Leads for Diseases of Interest to the NIDDK (R01) Apply for PAR 13 007 Funding Number: PAR 13 007 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| New Directions in Hematology Research (SHINE II) (R01) Apply for PAS 13 006 Funding Number: PAS 13 006 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| Limited Competition Data Coordinating Center for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (UC4) Apply for RFA DK 12 510 Funding Number: RFA DK 12 510 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
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