Opportunity Information: Apply for PA 14 222
Apply for PA 14 222
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Long Term Retention in Care for U.S. Substance Using Populations (R34)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on May 15, 2014 and posted on May 14, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $225,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) County governments Special district governments For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public and State controlled institutions of higher education Private institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The NIH grant opportunity PA-14-222, titled "Long Term Retention in Care for U.S. Substance Using Populations (R34)," is a discretionary grant program focused on improving long-term HIV care outcomes for people living with HIV who also use substances. The core idea behind the announcement is straightforward: because HIV still requires lifelong treatment and monitoring, the biggest gains in public health and individual health depend not only on getting people into care once, but on keeping them engaged in care over many years. The FOA specifically encourages research that targets long-term retention in HIV care as the pathway to sustained viral suppression, with particular attention to individuals whose substance use increases the risk of dropping out of care, interrupting treatment, and losing viral suppression.
This opportunity uses the NIH R34 mechanism, which is typically designed for pilot or developmental clinical research projects that help generate early evidence and feasibility data needed before moving to larger-scale studies. In practice, that means applicants are expected to propose projects that develop, refine, or test approaches intended to keep substance-using populations consistently connected to HIV medical care and supportive services over time. The emphasis is on retention as a long-term, ongoing process rather than a short-term re-engagement effort, and on outcomes that matter clinically and epidemiologically, especially sustained viral suppression. While the short description in the listing is brief, the intent is to stimulate practical, testable strategies that can be measured and eventually scaled, such as service delivery models, care coordination methods, behavioral or systems interventions, or other approaches that address barriers common in substance-using populations (for example, unstable housing, co-occurring mental health conditions, stigma, transportation and access issues, incarceration involvement, or fragmented service systems).
Administratively, this is an NIH program announcement (Funding Opportunity Number PA-14-222) under the catalog area 93.279, Drug Abuse and Addiction Research Programs, and it sits at the intersection of HIV care and substance use research. The funding instrument is a grant, and the activity category is listed under Education and Health, reflecting the health services and public health nature of the work. The award ceiling is $225,000, and there is no cost sharing or matching requirement, which lowers the financial barrier for applicants and allows proposed budgets to focus on study execution rather than securing outside matching funds.
Eligibility is broad and includes many types of U.S.-based organizations and governments. Eligible applicants include state, county, city or township, and special district governments; federally recognized and other tribal governments; public housing authorities and Indian housing authorities; public and state-controlled and private institutions of higher education; independent school districts; small businesses and other for-profit organizations (other than small businesses are also explicitly listed as eligible); and nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories). The FOA also calls out additional eligible applicant types such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs), as well as faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. At the same time, it clearly excludes foreign institutions and other non-U.S. entities, along with non-domestic components of U.S. organizations, and it does not allow foreign components as defined by NIH policy.
Key dates show that the opportunity was posted May 14, 2014, created May 15, 2014, and had an original and final closing date of May 7, 2017, with an archive date of June 7, 2017. In other words, it was an active NIH funding opportunity for several years and is now closed and archived, but it remains a useful reference point for the kinds of retention-in-care questions NIH has prioritized in the context of HIV and substance use. For those needing the full archived announcement details, NIH provided an additional information link to the Grants Guide page (http://grants.nih.gov/grants/guide/pa-files/PA-14-222.html) and directed technical access or linking issues to the NIH Office of Extramural Research webmaster via FBOWebmaster@OD.NIH.GOV.
Overall, the FOA is centered on one practical public health problem: many people living with HIV can reach viral suppression with modern treatment, but substance use can make consistent engagement in care harder to maintain over the long term. This R34 opportunity was meant to build the evidence base for interventions and care models that keep people in HIV care for years, not just months, so that viral suppression can be sustained and both individual health outcomes and HIV transmission risks improve over time.
FAQs: NIH PA-14-222 - Long Term Retention in Care for U.S. Substance Using Populations (R34)
What is the grant opportunity called?
The funding opportunity is titled "Long Term Retention in Care for U.S. Substance Using Populations (R34)" and is identified by NIH as PA-14-222.
Which agency is offering this opportunity?
This opportunity is offered by the National Institutes of Health (NIH).
What is the main goal of PA-14-222?
The main goal is to support research that improves long-term retention in HIV care for people living with HIV in the United States who also use substances, with retention serving as a pathway to sustained viral suppression.
Why does this FOA focus on long-term retention in HIV care (not just linkage or re-engagement)?
The FOA is built on the idea that HIV requires lifelong treatment and monitoring, so the largest health and public health gains depend on keeping people consistently engaged in care for years. It emphasizes retention as an ongoing, long-term process rather than a short-term effort to bring people back into care.
Who is the target population for the proposed research?
The target population is U.S. people living with HIV whose substance use increases the risk of dropping out of care, interrupting treatment, and losing viral suppression.
What outcomes does the announcement emphasize?
The FOA emphasizes outcomes that matter clinically and epidemiologically, especially sustained viral suppression, supported by long-term retention in HIV medical care and related supportive services.
What types of projects are encouraged under the R34 mechanism?
The opportunity uses the NIH R34 mechanism, which is typically intended for pilot or developmental clinical research. Applicants are expected to propose projects that develop, refine, or test approaches and generate early evidence and feasibility data that could support later, larger-scale studies.
What kinds of approaches or interventions does the FOA intend to stimulate?
Based on the description provided, the FOA is meant to stimulate practical, testable strategies that can be measured and potentially scaled, such as service delivery models, care coordination methods, behavioral or systems interventions, or other approaches that address common barriers for substance-using populations.
What barriers does the FOA suggest may contribute to poor retention in care?
The FOA notes barriers common in substance-using populations, including unstable housing, co-occurring mental health conditions, stigma, transportation and access issues, incarceration involvement, and fragmented service systems.
What is the funding instrument and award type?
The funding instrument is a grant, and the activity category is listed under Education and Health.
What is the maximum award amount (ceiling)?
The award ceiling is $225,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What is the Catalog of Federal Domestic Assistance (CFDA) / catalog area listed for this opportunity?
The catalog area is 93.279, Drug Abuse and Addiction Research Programs.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and governments. Eligible applicants include state, county, city or township, and special district governments; federally recognized and other tribal governments; public housing authorities and Indian housing authorities; public and state-controlled and private institutions of higher education; independent school districts; small businesses; other for-profit organizations (with for-profits other than small businesses explicitly listed as eligible); and nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories).
Are specific institution types explicitly called out as eligible?
Yes. The FOA also calls out additional eligible types including historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs), as well as faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
Are foreign organizations or non-U.S. components eligible?
No. The FOA excludes foreign institutions and other non-U.S. entities, as well as non-domestic components of U.S. organizations. It also does not allow foreign components as defined by NIH policy.
Is this funding opportunity still open?
No. The opportunity is closed and archived. It had an original and final closing date of May 7, 2017, and an archive date of June 7, 2017.
When was the opportunity posted?
The opportunity was posted May 14, 2014, and created May 15, 2014.
Where can applicants find the archived NIH announcement page?
The archived announcement details are available through the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PA-14-222.html.
Who should be contacted for technical access or linking issues related to the NIH page?
The FOA directs technical access or linking issues to the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
What is the broader public health problem this FOA is trying to address?
The FOA is centered on the challenge that many people living with HIV can reach viral suppression with modern treatment, but substance use can make consistent engagement in care harder to maintain over the long term. It aims to build evidence for interventions and care models that keep people in HIV care for years so viral suppression can be sustained and health outcomes and HIV transmission risks improve over time.
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| Innovative Research in Cancer Nanotechnology (IRCN) (U01) Apply for PAR 14 285 Funding Number: PAR 14 285 Agency: National Institutes of Health Category: Education Health Funding Amount: $450,000 |
| Centers of Cancer Nanotechnology Excellence (CCNEs) (U54) Apply for RFA CA 14 013 Funding Number: RFA CA 14 013 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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