Opportunity Information: Apply for PA 10 006
Apply for PA 10 006
- The National Institutes of Health in the education food and nutrition health income security and social services sector is offering a public funding opportunity titled "Mechanisms, Models, Measurement, and Management in Pain Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.213 Research and Training in Complementary and Integrative Health 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Oct 5, 2009 and posted on Oct 5, 2009.
- Applicants must submit their applications by Jan 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses City or township governments State governments Private institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts County governments For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Mechanisms, Models, Measurement, and Management in Pain Research (R01) (Funding Opportunity Number PA-10-006) is an NIH funding opportunity led by the National Institute of Nursing Research (NINR) in partnership with multiple NIH Institutes and Centers through the NIH Pain Consortium. Its central aim is to stimulate a broad pipeline of pain research that fits the missions of the participating NIH components, spanning basic, clinical, and translational science. The announcement is framed around the idea that meaningful progress in pain will require advances at many levels, from molecular and neural mechanisms to behavioral, social, and health services dimensions, because pain remains highly individualized and many treatment challenges are still unresolved.
A major scientific emphasis is improving understanding of how pain works and how it can be better studied and treated. The FOA highlights persistent gaps such as why pain experiences vary so much across individuals and, critically, how and why some people transition from acute pain after an injury or insult into a chronic pain state. The scope is intentionally wide and welcomes studies that develop or refine mechanisms (biological and psychosocial), experimental and clinical models of pain, improved approaches to measurement (including how pain is assessed, quantified, and tracked), and management strategies (which can include interventions and approaches to prevention, treatment, and long-term care). Because pain research often crosses disciplines, the FOA strongly encourages interdisciplinary and multidisciplinary teams.
The funding mechanism is the NIH Research Project Grant (R01), which generally supports mature, hypothesis-driven projects with a defined scope and a clear plan for producing impactful results. This FOA is described as running in parallel with two companion announcements of the same scientific scope that use different mechanisms: PA-10-008 for the R03 (small research grants, typically for more limited projects or pilot work) and PA-10-007 for the R21 (exploratory/developmental projects that are often higher-risk and earlier-stage). Applicants are expected to select the mechanism that best matches the maturity and scale of their proposed work.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants listed include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), and a wide range of government entities (state, county, city/township, special district). The FOA also includes tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, and additional categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign (non-U.S.) entities. In line with NIH-wide priorities around workforce diversity, the announcement explicitly encourages applications from underrepresented investigators, including minority, disabled, and women investigators.
Funding decisions under this FOA are contingent on the availability of funds and on receiving a sufficient number of high-quality, meritorious applications, rather than guaranteeing a specific award count. The opportunity was posted October 5, 2009, and the original/current closing date was January 7, 2013, with an archive date of February 7, 2013, meaning it is no longer active as a current open solicitation but remains relevant as a reference point for NIH pain research priorities and the structure of similar NIH Pain Consortium-aligned announcements.
Administratively, the opportunity is categorized as a discretionary grant and is associated with multiple CFDA program areas reflecting the cross-cutting nature of pain research, including oral health, complementary and integrative health, drug abuse and addiction, nursing research, cancer, arthritis and musculoskeletal conditions, diabetes/digestive/kidney diseases, neurosciences and neurological disorders, child health and human development, and aging. Taken together, those listings underscore that the FOA is meant to support pain research wherever it intersects with major disease areas and populations, rather than limiting applicants to a single narrow domain.
Frequently Asked Questions (FAQs)
What is the funding opportunity?
This opportunity is "Mechanisms, Models, Measurement, and Management in Pain Research (R01)" (Funding Opportunity Number PA-10-006), an NIH Research Project Grant (R01) announcement focused on advancing pain research across basic, clinical, and translational science.
Which NIH organization leads this FOA?
The opportunity is led by the National Institute of Nursing Research (NINR), in partnership with multiple NIH Institutes and Centers through the NIH Pain Consortium.
What is the main purpose of this FOA?
The central aim is to stimulate a broad pipeline of pain research that aligns with the missions of the participating NIH components. The FOA emphasizes that progress in pain research requires advances at multiple levels, from molecular and neural mechanisms to behavioral, social, and health services dimensions.
What scientific areas does the FOA emphasize?
The FOA emphasizes improving understanding of how pain works and how it can be better studied and treated. It highlights persistent gaps, including why pain varies so much across individuals and how and why some people transition from acute pain to chronic pain.
What types of projects are within scope?
The scope is intentionally broad and welcomes studies that develop or refine:
- Mechanisms of pain (biological and psychosocial)
- Experimental and clinical models of pain
- Approaches to measurement (assessing, quantifying, and tracking pain)
- Management strategies (including prevention, treatment, and long-term care approaches)
Does this FOA support basic, clinical, and translational research?
Yes. The announcement explicitly spans basic, clinical, and translational science.
Is interdisciplinary research encouraged?
Yes. Because pain research often crosses disciplines, the FOA strongly encourages interdisciplinary and multidisciplinary teams.
What grant mechanism is used for this announcement?
This FOA uses the NIH Research Project Grant (R01) mechanism, which generally supports mature, hypothesis-driven projects with a defined scope and a clear plan for producing impactful results.
Are there related NIH opportunities with the same scientific scope?
Yes. The FOA is described as running in parallel with two companion announcements with the same scientific scope but different mechanisms:
- PA-10-008 (R03): small research grants, typically for limited projects or pilot work
- PA-10-007 (R21): exploratory/developmental projects, often higher-risk and earlier-stage
How should an applicant choose between R01, R03, and R21 for this topic area?
Applicants are expected to select the mechanism that best matches the maturity and scale of their proposed work. The R01 is generally positioned for more mature, hypothesis-driven projects, while the R03 and R21 are positioned for smaller or more exploratory efforts.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations, including:
- Public and private institutions of higher education
- Nonprofits with and without 501(c)(3) status
- For-profit organizations (including small businesses and other for-profits)
- Government entities (state, county, city/township, special district)
- Tribal governments and tribal organizations
- Public housing authorities/Indian housing authorities
- Independent school districts
- U.S. territories or possessions and regional organizations
- Eligible federal agencies
- Foreign (non-U.S.) entities
Are minority-serving institutions and other special categories included in eligibility?
Yes. The FOA includes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs), among others.
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are listed among eligible applicant types.
Does the FOA encourage applications from underrepresented investigators?
Yes. In line with NIH-wide priorities around workforce diversity, the announcement explicitly encourages applications from underrepresented investigators, including minority, disabled, and women investigators.
Is this opportunity still active?
No. The FOA is no longer active as a current open solicitation. It was posted October 5, 2009, had an original/current closing date of January 7, 2013, and an archive date of February 7, 2013.
If it is archived, why does it still matter?
Based on the information provided, it remains relevant as a reference point for NIH pain research priorities and for understanding the structure of similar NIH Pain Consortium-aligned announcements.
Are awards guaranteed under this FOA?
No. Funding decisions are contingent on the availability of funds and on receiving a sufficient number of high-quality, meritorious applications, rather than guaranteeing a specific number of awards.
How is this funding opportunity categorized?
Administratively, it is categorized as a discretionary grant.
What does the CFDA listing suggest about the scope?
The FOA is associated with multiple CFDA program areas, reflecting the cross-cutting nature of pain research. The listings underscore that the FOA is intended to support pain research wherever it intersects with major disease areas and populations rather than restricting applicants to a single narrow domain.
Which broad health and research areas are connected to this FOA through CFDA program areas?
The CFDA associations include areas such as oral health, complementary and integrative health, drug abuse and addiction, nursing research, cancer, arthritis and musculoskeletal conditions, diabetes/digestive/kidney diseases, neurosciences and neurological disorders, child health and human development, and aging.
What kinds of pain-related challenges does the FOA call out as unresolved?
The FOA notes that pain remains highly individualized and that many treatment challenges are still unresolved, highlighting the need for advances in mechanisms, models, measurement, and management.
Does the FOA limit pain research to one disease area or population?
No. The information provided indicates the FOA is designed to be cross-cutting and applicable to pain research across many disease areas and populations.
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