Opportunity Information: Apply for PA 10 008
Apply for PA 10 008
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Mechanisms, Models, Measurement, and Management in Pain Research (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Oct 5, 2009 and posted on Oct 5, 2009.
- Applicants must submit their applications by Jan 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Private institutions of higher education Small businesses For profit organizations other than small businesses Public housing authorities/Indian housing authorities State governments County governments Independent school districts Special district governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH Funding Opportunity Announcement PA-10-008, titled "Mechanisms, Models, Measurement, and Management in Pain Research (R03)," is a discretionary grant program led by the National Institute of Nursing Research (NINR) in partnership with multiple NIH Institutes and Centers through the NIH Pain Consortium. Its central goal is to stimulate a broad range of pain research that matches the varied missions of participating NIH components, spanning basic, clinical, and translational science. The announcement emphasizes that major gaps remain in understanding and treating pain, even with progress in areas like mapping neural pathways. Pain is highlighted as highly individual in both experience and treatment response, and the FOA calls special attention to the limited understanding of how some people move from an acute pain episode to a chronic pain condition, a transition that has major health, functional, and quality-of-life implications.
The FOA intentionally casts a wide net across scientific levels of analysis, encouraging work from the "micro" end of the spectrum, such as molecular and mechanistic studies, to the "macro" end, including behavioral, social, and other biopsychosocial approaches. It invites research that advances pain mechanisms, improves experimental and clinical models of pain, strengthens pain measurement (including assessment tools and methodologies), and develops or evaluates pain management strategies. A key theme is the need for new advances in essentially every area of pain science, with encouragement for projects that can clarify why pain differs so dramatically between individuals and how those differences can be predicted or addressed.
This opportunity uses the NIH Small Research Grant (R03) mechanism, which is designed for smaller, focused projects that can be completed in a relatively short period with limited resources. The R03 is positioned as a practical pathway for early-stage or tightly scoped work, including pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, development of research methodology, and development of new research technology relevant to pain research. In other words, it supports studies that can generate preliminary data, test a new approach, validate a measure, or produce proof-of-concept findings that may later justify larger-scale funding.
The FOA also stresses the value of interdisciplinary and multidisciplinary research teams, reflecting the reality that pain is rarely explained or solved within a single discipline. In addition, it explicitly encourages applications from investigators who are underrepresented in biomedical research, including underrepresented minority investigators, investigators with disabilities, and women investigators, aligning with NIH-wide goals to broaden participation and perspectives in the research workforce.
Administratively, PA-10-008 runs in parallel with two companion announcements of the same scientific scope that support larger or different kinds of projects: PA-10-006 (R01) for full-scale research projects and PA-10-007 (R21) for exploratory/developmental work. This structure allows applicants to select a mechanism that matches the maturity, scale, and risk profile of their proposed pain research, while keeping the scientific priorities consistent across mechanisms.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants listed include private and public institutions of higher education, small businesses and other for-profit organizations, nonprofits (including those with and without 501(c)(3) status), various units of government (state, county, city/township, special districts), public housing authorities, independent school districts, and tribal governments and tribal organizations. The FOA also notes eligibility for entities such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and foreign organizations. There is no cost sharing or matching requirement.
Funding levels and the number of awards are not fixed in the announcement because awards are expected to vary depending on the scope, duration, and budget needs of individual applications. The FOA indicates that overall award totals and counts depend on the number of applications received, their scientific quality, the requested costs, and the availability of funds across participating NIH components. The opportunity was originally posted on October 5, 2009, with a closing date of January 7, 2013, and it was archived on February 7, 2013. For full details, the FOA points to the NIH Grants Guide link (PA-10-008) and provides NIH Office of Extramural Research (OER) webmaster contacts for access or technical issues.
FAQs: NIH PA-10-008 - Mechanisms, Models, Measurement, and Management in Pain Research (R03)
What is PA-10-008?
PA-10-008 is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) titled "Mechanisms, Models, Measurement, and Management in Pain Research (R03)." It uses the NIH Small Research Grant (R03) mechanism to support smaller, focused pain research projects.
Which NIH Institute leads this opportunity?
This discretionary grant program is led by the National Institute of Nursing Research (NINR), in partnership with multiple NIH Institutes and Centers through the NIH Pain Consortium.
What is the main goal of this FOA?
The central goal is to stimulate a broad range of pain research aligned with the varied missions of participating NIH components, spanning basic, clinical, and translational science.
Why does the FOA emphasize the need for more pain research?
The FOA highlights that major gaps remain in understanding and treating pain, even with progress in areas such as mapping neural pathways. It also emphasizes that pain is highly individual, both in how it is experienced and how people respond to treatment.
Does the FOA call out any specific scientific problem areas?
Yes. A specific area of emphasis is the limited understanding of how some individuals transition from an acute pain episode to a chronic pain condition, a shift with major health, functional, and quality-of-life implications.
What types of pain research are encouraged?
The FOA intentionally casts a wide net and encourages work across many levels of analysis. It invites research that advances pain mechanisms, improves experimental and clinical models of pain, strengthens pain measurement, and develops or evaluates pain management strategies.
Does the FOA focus only on biological mechanisms?
No. It encourages research ranging from "micro" approaches (for example, molecular and mechanistic studies) to "macro" approaches (including behavioral, social, and other biopsychosocial approaches).
What does "mechanisms" mean in the context of this FOA?
In this FOA, mechanisms refers broadly to research aimed at understanding how pain works, including mechanistic and molecular studies as well as other scientific approaches that explain pain processes.
What does the FOA mean by "models" of pain?
The FOA encourages improvements to experimental and clinical models of pain, meaning research approaches and systems used to study pain in ways that can support stronger understanding and better translation to clinical care.
What kinds of "measurement" work does the FOA encourage?
It encourages work that strengthens pain measurement, including pain assessment tools and methodologies.
What does "management" cover under this FOA?
Management refers to developing or evaluating strategies for pain management, consistent with the FOA's broad scope across basic, clinical, and translational science.
Is the FOA interested in differences between individuals?
Yes. A key theme is the need for advances that help clarify why pain differs so dramatically between individuals and how those differences can be predicted or addressed.
What grant mechanism does PA-10-008 use?
PA-10-008 uses the NIH Small Research Grant (R03) mechanism.
What is an R03 intended for?
The R03 mechanism is designed for smaller, focused projects that can be completed in a relatively short period with limited resources. It is described as a practical pathway for early-stage or tightly scoped work.
What types of projects are specifically mentioned as appropriate for the R03 under this FOA?
The FOA notes that R03s may support pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, development of research methodology, and development of new research technology relevant to pain research.
What is the R03 expected to produce?
The FOA frames the R03 as supporting studies that can generate preliminary data, test a new approach, validate a measure, or produce proof-of-concept findings that may later justify larger-scale funding.
Are interdisciplinary or multidisciplinary teams encouraged?
Yes. The FOA stresses the value of interdisciplinary and multidisciplinary research teams, reflecting the idea that pain is rarely explained or solved within a single discipline.
Does the FOA encourage applications from underrepresented investigators?
Yes. It explicitly encourages applications from investigators who are underrepresented in biomedical research, including underrepresented minority investigators, investigators with disabilities, and women investigators.
Are there companion funding opportunities with the same scientific scope?
Yes. PA-10-008 runs in parallel with two companion announcements of the same scientific scope: PA-10-006 (R01) for full-scale research projects and PA-10-007 (R21) for exploratory/developmental work.
How should an applicant choose between R03, R21, and R01 for this pain research topic?
The FOA explains that the structure allows applicants to select a mechanism that matches the maturity, scale, and risk profile of their proposed pain research, while keeping the scientific priorities consistent across mechanisms.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants listed include private and public institutions of higher education, small businesses and other for-profit organizations, nonprofits (with and without 501(c)(3) status), and multiple units of government (state, county, city/township, special districts), as well as public housing authorities, independent school districts, tribal governments, and tribal organizations.
Are specific institution types called out as eligible?
Yes. The FOA notes eligibility for entities such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and foreign organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. The FOA states that eligibility includes non-domestic (foreign) organizations.
Is cost sharing or a matching contribution required?
No. The FOA states there is no cost sharing or matching requirement.
How many awards will be made and what is the funding level?
The FOA does not set a fixed number of awards or a fixed funding level. It indicates that awards are expected to vary based on the scope, duration, and budget needs of individual applications.
What factors determine the total number of awards and overall funding?
The FOA indicates totals depend on the number of applications received, the scientific quality of those applications, the requested costs, and the availability of funds across participating NIH components.
When was PA-10-008 posted and when did it close?
The opportunity was originally posted on October 5, 2009, with a closing date of January 7, 2013.
Is this FOA still active?
No. The FOA was archived on February 7, 2013.
Where can someone find the official FOA details?
The FOA points to the NIH Grants Guide link for PA-10-008 for full details.
Who is listed for help with access or technical issues?
The FOA provides NIH Office of Extramural Research (OER) webmaster contacts for access or technical issues.
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