Opportunity Information: Apply for PA 10 007
Apply for PA 10 007
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Mechanisms, Models, Measurement, and Management in Pain Research (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Oct 5, 2009 and posted on Oct 5, 2009.
- Applicants must submit their applications by Jan 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Private institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments For profit organizations other than small businesses State governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH funding opportunity titled "Mechanisms, Models, Measurement, and Management in Pain Research (R21)" (Funding Opportunity Number PA-10-007) is an exploratory/developmental research grant announcement designed to push forward new ideas and early-stage studies in pain research. It is led by the National Institute of Nursing Research (NINR) in collaboration with members of the NIH Pain Consortium, and it is meant to both clarify the pain-related priorities across multiple NIH Institutes and Centers and actively stimulate a broad pipeline of basic, clinical, and translational research aligned with those missions. The overall message of the announcement is that meaningful gaps remain across the full spectrum of pain science, from molecular and cellular mechanisms through systems neuroscience, clinical presentation, treatment response, and the behavioral and social dimensions of pain.
A key emphasis is the need for advances at every level of analysis. On the "micro" end, that includes foundational work in molecular science and related mechanistic approaches that can explain how pain starts, how it is maintained, and how it varies across individuals. On the "macro" end, it includes behavioral, psychological, social, and environmental factors that shape pain experience, disability, and treatment outcomes. Even though the field has made important progress in certain areas, such as mapping neural pathways involved in pain processing, the FOA underscores that pain remains highly individualized and that effective treatment is still a major unresolved challenge. In particular, the NIH highlights an important unmet need: understanding how and why some people transition from acute pain after an injury or insult into persistent or chronic pain, while others recover. Applications that can shed light on that transition, including contributing biological mechanisms, patient-level risk factors, and contextual influences, fit squarely within the intent of the program.
This FOA uses the NIH R21 mechanism, which is generally intended for exploratory or developmental projects that may be higher risk but have the potential to open up new directions, generate compelling preliminary data, or test novel concepts, models, tools, or approaches. The announcement also notes that it is part of a set of parallel opportunities with the same scientific scope offered under other mechanisms: an R01 version (PA-10-006) for full research projects and an R03 version (PA-10-008) for smaller, more limited-scope studies. In practice, that means applicants should select the mechanism that best matches the maturity of their idea, the level of preliminary evidence, and the scale of work being proposed, with PA-10-007 positioned for early-stage, innovative efforts.
The announcement encourages interdisciplinary and multidisciplinary team science, reflecting how complex pain is and how often progress depends on integrating perspectives across fields (for example, neuroscience, nursing science, medicine, rehabilitation, pharmacology, psychology, epidemiology, engineering, data science, and public health). It also explicitly encourages applications from investigators who are underrepresented in biomedical research, including minority, disabled, and women investigators, signaling a priority for broadening participation and perspectives in pain research.
In terms of funding, the FOA sets an award ceiling of $200,000, and it states that the size and duration of awards will vary depending on the scope and needs of the proposed project. Rather than guaranteeing a fixed number of awards, NIH explains that the total number and total dollars awarded depend on the mix of applications received, their scientific quality, the requested budgets, and program priorities at the participating Institutes and Centers. There is no cost-sharing or matching requirement, which is typical for NIH research grants.
Eligibility is broad and includes many types of domestic and non-domestic entities. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profit entities), state and local governments, independent school districts, special district governments, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The FOA also specifies eligibility for a range of institution types and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions, as well as foreign (non-U.S.) organizations.
Administratively, the opportunity was posted on October 5, 2009, and the final closing date listed is January 7, 2013, with an archive date of February 7, 2013, meaning it is no longer active as a current competition but remains an important reference for NIH priorities and for understanding how NIH framed pain research needs during that period. The sponsoring agency is the National Institutes of Health, and the full announcement was hosted through the NIH grants guide, with technical support routed through the NIH Office of Extramural Research (OER) webmaster contact.
Overall, PA-10-007 can be summed up as an NIH-wide call, coordinated through NINR and the NIH Pain Consortium, for creative, early-stage pain research projects that build new mechanisms, models, measurement strategies, or management approaches. It is especially focused on closing persistent gaps in how pain is experienced and treated across individuals and on unraveling the poorly understood pathways that lead from acute pain to chronic pain, using cross-disciplinary science and inclusive participation from a wide range of investigators and institutions.
FAQs: Mechanisms, Models, Measurement, and Management in Pain Research (R21) (PA-10-007)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Mechanisms, Models, Measurement, and Management in Pain Research (R21)" and the Funding Opportunity Number is PA-10-007.
What is the purpose of PA-10-007?
This Funding Opportunity Announcement (FOA) is designed to stimulate exploratory and developmental pain research projects that push forward new ideas, early-stage studies, and novel approaches. It emphasizes closing meaningful gaps across the full spectrum of pain science, from molecular and cellular mechanisms to clinical presentation, treatment response, and behavioral/social dimensions of pain.
Which NIH Institute leads this FOA, and who else is involved?
The FOA is led by the National Institute of Nursing Research (NINR) in collaboration with members of the NIH Pain Consortium.
What kinds of research areas does the FOA aim to advance?
The FOA aims to advance basic, clinical, and translational pain research. It highlights needs spanning mechanistic biology ("micro" levels like molecular and cellular mechanisms) through "macro" influences such as behavioral, psychological, social, and environmental factors that shape pain experience, disability, and treatment outcomes.
What major scientific gap does the FOA emphasize?
A major unmet need highlighted in the FOA is understanding how and why some people transition from acute pain after an injury or insult into persistent or chronic pain, while others recover. Projects that can clarify contributing biological mechanisms, patient-level risk factors, and contextual influences are strongly aligned with the FOA's intent.
What grant mechanism does PA-10-007 use?
PA-10-007 uses the NIH R21 mechanism, which supports exploratory/developmental research. R21 projects are commonly used for early-stage, innovative, and potentially higher-risk ideas that could open new directions, generate preliminary data, or test novel concepts, models, tools, or approaches.
Are there related NIH opportunities with the same scientific scope?
Yes. The FOA notes parallel opportunities with the same scientific scope under different mechanisms: an R01 version (PA-10-006) for full research projects and an R03 version (PA-10-008) for smaller, limited-scope studies.
How should an applicant choose between the R21 (PA-10-007), R01 (PA-10-006), and R03 (PA-10-008) options?
Based on the FOA description, applicants should select the mechanism that best matches the maturity of their idea, the level of preliminary evidence available, and the overall scale of work proposed. PA-10-007 (R21) is positioned for early-stage, innovative efforts.
Does the FOA encourage interdisciplinary or multidisciplinary research teams?
Yes. The FOA encourages interdisciplinary and multidisciplinary team science, reflecting the complexity of pain and the value of integrating multiple perspectives (for example, neuroscience, nursing science, medicine, rehabilitation, pharmacology, psychology, epidemiology, engineering, data science, and public health).
Does the FOA encourage applications from underrepresented investigators?
Yes. The FOA explicitly encourages applications from investigators underrepresented in biomedical research, including minority, disabled, and women investigators.
What is the maximum award amount mentioned in the FOA?
The FOA sets an award ceiling of $200,000.
Are the award size and duration fixed?
No. The FOA states that the size and duration of awards will vary depending on the scope and needs of the proposed project.
Does NIH guarantee a specific number of awards under PA-10-007?
No. The FOA indicates that the total number of awards and total dollars awarded depend on factors such as the mix of applications received, scientific quality, requested budgets, and program priorities across participating NIH Institutes and Centers.
Is there a cost-sharing or matching requirement?
No. The FOA states there is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-domestic entity types. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profit entities), state and local governments, independent school districts, special district governments, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations.
Are specific institution types and communities explicitly included in the eligibility language?
Yes. The FOA specifically includes eligibility for institution types and communities such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, U.S. territories or possessions, and foreign (non-U.S.) organizations.
Is PA-10-007 still an active funding opportunity?
No. The FOA was posted on October 5, 2009, with a final closing date of January 7, 2013, and an archive date of February 7, 2013. That means it is no longer active as a current competition, though it remains a useful reference for NIH pain research priorities as framed during that period.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Where was the full announcement hosted, and where is technical support directed?
The full announcement was hosted through the NIH grants guide, and technical support was routed through the NIH Office of Extramural Research (OER) webmaster contact.
How does the FOA describe the overall message or theme of the program?
The FOA frames pain as highly individualized and emphasizes that effective treatment remains a major unresolved challenge. It calls for creative research that can improve understanding and management of pain across individuals by developing new mechanisms, models, measurements, or management approaches, including work that addresses the transition from acute to chronic pain.
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| NIH Blueprint for Neuroscience Research Competitive Revisions for Studies Focused on Neuropathic Pain or Neural Plasticity to Promote Collaborative Pain Research (R01) Apply for PAR 10 204 Funding Number: PAR 10 204 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $75,000 |
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