Opportunity Information: Apply for PA 13 118
Apply for PA 13 118
- The National Institutes of Health in the education food and nutrition health income security and social services sector is offering a public funding opportunity titled "Mechanisms, Models, Measurement, Management in Pain Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Apr 9, 2013 and posted on Feb 15, 2013.
- Applicants must submit their applications by May 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments For profit organizations other than small businesses Native American tribal governments (Federally recognized) Small businesses State governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH Funding Opportunity Announcement PA-13-118, titled "Mechanisms, Models, Measurement, Management in Pain Research (R01)," is an investigator-initiated R01 grant opportunity designed to spur a broad range of pain research across NIH Institutes and Centers. Its main goal is to make clear the pain-related research interests spanning multiple NIH components and to encourage new basic, clinical, and translational studies that align with each participating Institute or Center's mission. The announcement emphasizes that pain remains a major unresolved health challenge: even with progress in mapping neural pathways and other biological underpinnings, pain is still experienced in highly individual ways, and treatment often remains difficult, inconsistent, or inadequate across patient populations.
A central scientific motivation in this FOA is the need for advances at every scale of analysis. On the "micro" end, the NIH is interested in molecular, cellular, and mechanistic work that can explain how pain is initiated, amplified, sustained, and resolved. On the "macro" end, it encourages behavioral, psychological, and social science approaches that examine how pain is perceived, reported, and managed in real-world contexts, including how pain interacts with environment, stress, cognition, mental health, family and community factors, and health systems. The FOA also highlights a particularly important gap: the field still does not adequately understand why some individuals recover after acute injury while others transition into chronic pain. Research that clarifies the biological, psychological, and social drivers of that transition, and that identifies predictive markers or modifiable risk factors, fits squarely within the stated priorities.
The scope is intentionally broad, covering mechanisms, models, measurement, and management. In practice, that means the FOA welcomes work developing or refining experimental models of pain (including preclinical and human models), improving measurement tools (such as more sensitive or meaningful pain assessments, biomarkers, imaging approaches, or patient-reported outcomes), and testing or optimizing management strategies (including pharmacologic, device-based, behavioral, rehabilitative, integrative, or multi-modal interventions). Because the FOA is framed to serve the missions of multiple NIH Institutes and Centers, it is well suited for projects that connect pain to specific diseases and conditions (for example cancer, arthritis and musculoskeletal conditions, neurologic disorders, diabetes and kidney disease, substance use, aging-related conditions, and child health), as reflected by the multiple CFDA program listings associated with the opportunity.
The announcement strongly encourages interdisciplinary and multidisciplinary teams, reflecting the reality that meaningful progress in pain research often requires integrating neuroscience, immunology, pharmacology, psychology, nursing science, rehabilitation, data science, clinical trial methodology, and health services research. It also explicitly encourages applications from investigators who are underrepresented in biomedical research, including minority investigators, investigators with disabilities, and women investigators, signaling an interest not only in scientific breadth but also in broad participation in the pain research workforce.
From an administrative standpoint, PA-13-118 is a discretionary NIH grant opportunity using the R01 mechanism, with no cost-sharing or matching requirement. The opportunity was posted February 15, 2013, created April 9, 2013, and had an original and final closing date of May 7, 2016, with an archive date of June 7, 2016. While the archived status indicates the specific FOA is no longer open for new submissions under that announcement, the summary still matters as a description of NIH pain research priorities and the kind of projects NIH has sought to stimulate under this umbrella.
Eligibility is broad and includes a wide range of applicant organizations: public and private institutions of higher education, nonprofits (both 501(c)(3) and certain non-501(c)(3) entities), small businesses and other for-profit organizations (other than small businesses are also listed as eligible), state, county, city or township governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The FOA also notes eligibility for specific institution types such as HBCUs, Hispanic-serving institutions, AANAPISI institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities, and faith-based or community-based organizations. Importantly, non-U.S. entities are eligible as well: foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are allowed.
The sponsoring agency is the National Institutes of Health, and the source announcement is available through the NIH Grants Guide page associated with PA-13-118. For technical issues accessing the announcement, the listed contact is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: NIH PA-13-118 - Mechanisms, Models, Measurement, Management in Pain Research (R01)
What is PA-13-118?
PA-13-118 is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) titled "Mechanisms, Models, Measurement, Management in Pain Research (R01)." It is an investigator-initiated opportunity using the R01 grant mechanism and is intended to stimulate a broad range of pain research across multiple NIH Institutes and Centers.
What is the main purpose of this FOA?
The FOA is meant to clarify pain-related research interests across participating NIH Institutes and Centers and encourage new basic, clinical, and translational pain studies that align with each Institute or Center's mission.
What kinds of pain research does the FOA aim to encourage?
The scope is intentionally broad and covers "mechanisms, models, measurement, and management" in pain research. It invites studies ranging from molecular and cellular work through clinical, behavioral, psychological, and social science research, including translational approaches.
Why does NIH consider pain research a priority in this announcement?
The announcement highlights pain as a major unresolved health challenge. Even with progress in understanding biological pathways, pain is still experienced in highly individual ways and treatment remains difficult, inconsistent, or inadequate for many patient populations.
Does the FOA focus only on biological mechanisms of pain?
No. While it includes strong interest in biological and mechanistic research, it also explicitly encourages behavioral, psychological, and social science approaches that examine how pain is perceived, reported, and managed in real-world settings.
What does the FOA mean by advances at every scale of analysis?
It signals interest in both "micro" and "macro" levels of research: from molecular, cellular, and mechanistic studies of how pain is initiated, amplified, sustained, and resolved, to broader investigations of behavior, cognition, stress, mental health, family and community factors, environment, and health systems that shape pain experience and care.
Is the transition from acute pain to chronic pain a specific area of interest?
Yes. The FOA calls out a major gap in understanding why some individuals recover after acute injury while others develop chronic pain. Studies that clarify biological, psychological, and social drivers of this transition, and that identify predictive markers or modifiable risk factors, fit squarely within the stated priorities.
What does "mechanisms" refer to in the scope?
Within the FOA, "mechanisms" includes molecular, cellular, and other mechanistic work aimed at explaining how pain is initiated, amplified, sustained, and resolved.
What does "models" refer to in the scope?
"Models" includes developing or refining experimental models of pain, including both preclinical models and human models.
What does "measurement" refer to in the scope?
"Measurement" includes improving pain measurement tools such as more sensitive or meaningful pain assessments, biomarkers, imaging approaches, and patient-reported outcomes.
What does "management" refer to in the scope?
"Management" includes testing or optimizing pain management strategies, including pharmacologic, device-based, behavioral, rehabilitative, integrative, or multi-modal interventions.
Does this FOA support basic, clinical, and translational research?
Yes. The FOA explicitly encourages new basic, clinical, and translational studies in pain research.
Is the FOA tied to specific diseases or conditions?
It is well suited for projects that connect pain to specific diseases and conditions and notes examples such as cancer, arthritis and musculoskeletal conditions, neurologic disorders, diabetes and kidney disease, substance use, aging-related conditions, and child health. The FOA also references multiple CFDA program listings, reflecting participation across NIH components.
Does the FOA encourage interdisciplinary or multidisciplinary teams?
Yes. It strongly encourages interdisciplinary and multidisciplinary teams, recognizing that progress in pain research often requires integrating multiple fields and approaches.
Which disciplines are explicitly mentioned as relevant for team-based research?
The FOA highlights integration across areas including neuroscience, immunology, pharmacology, psychology, nursing science, rehabilitation, data science, clinical trial methodology, and health services research.
Does the FOA encourage applications from underrepresented investigators?
Yes. It explicitly encourages applications from investigators underrepresented in biomedical research, including minority investigators, investigators with disabilities, and women investigators.
What grant mechanism is used for PA-13-118?
The FOA uses the NIH R01 mechanism and is described as an investigator-initiated opportunity.
Is cost-sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
Who is the sponsoring agency for this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Is PA-13-118 still open for new applications?
No. The FOA is archived and is no longer open for new submissions under that specific announcement.
What were the key dates for this FOA?
The FOA was posted on February 15, 2013, created on April 9, 2013, and had an original and final closing date of May 7, 2016. The archive date is June 7, 2016.
Why might the archived FOA still be useful?
Even though it is closed, the summary remains useful as a description of NIH pain research priorities and the types of projects NIH sought to stimulate under this umbrella.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including public and private institutions of higher education, nonprofits (501(c)(3) and certain non-501(c)(3) entities), small businesses, other for-profit organizations (including those other than small businesses), state/county/city/township governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations.
Are minority-serving institutions and specific institution types listed as eligible?
Yes. The FOA notes eligibility for institution types such as HBCUs, Hispanic-serving institutions, AANAPISI institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities, and faith-based or community-based organizations.
Are non-U.S. organizations eligible to apply?
Yes. The FOA states that foreign organizations and foreign institutions may apply. It also allows non-U.S. components of U.S. organizations and permits foreign components (as defined by NIH policy).
Where can the source announcement be found?
The source announcement is available through the NIH Grants Guide page associated with PA-13-118.
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement, the listed contact is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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