Opportunity Information: Apply for PAR 08 248
Apply for PAR 08 248
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Mechanisms of Adverse Drug Effects in Children (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 3, 2008 and posted on Oct 3, 2008.
- Applicants must submit their applications by May 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education Native American tribal governments (Federally recognized) Small businesses Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity titled "Mechanisms of Adverse Drug Effects in Children (R01)" (Funding Opportunity Number PAR-08-248) is a National Institutes of Health (NIH) discretionary grant solicitation aimed at improving what is known about why children experience harmful or unexpected reactions to medications. The central purpose is to support research that digs into the underlying biology of adverse drug reactions in pediatric populations, with a strong emphasis on molecular and cellular pathways as well as genetic and epigenetic contributors. In practical terms, the NIH is looking for studies that can explain the mechanisms behind adverse drug effects in children rather than simply describing clinical outcomes, with the broader goal of building scientific knowledge that can eventually inform safer and more effective pediatric drug use.
This opportunity uses the NIH Research Project Grant (R01) mechanism, which typically supports substantial, hypothesis-driven research projects that may require multi-year, in-depth investigation. The announcement notes that it runs in parallel with a separate but scientifically identical funding opportunity (PAR-08-249) that uses the R03 mechanism, which is generally intended for smaller, shorter, or more exploratory projects. Applicants who have a larger, more comprehensive plan would generally align with the R01 version, while those pursuing a more limited scope of work might consider the companion R03. The focus in both cases remains the same: clarifying the mechanistic basis of adverse drug reactions in children through modern biomedical approaches, including genetics and epigenetics.
Funding levels and the anticipated number of awards are not fixed in advance. Instead, awards under this FOA are explicitly contingent on the availability of NIH funds and on the quality and quantity of applications submitted. The announcement also emphasizes that because proposed projects can vary widely in scope, the size and duration of awards will vary as well. In other words, NIH is leaving room for a range of project designs and budgets, with final decisions depending on scientific merit, project period, and total requested costs across the pool of applications received.
From an administrative standpoint, this is categorized as a grant in the health domain (Funding Activity Category listed as Health, Income Security and Social Services) and is associated with CFDA number 93.865, which corresponds to Child Health and Human Development Extramural Research. There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds to be eligible or competitive under the stated terms of the opportunity.
Eligibility is broad and includes many types of organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, state governments, federally recognized Native American tribal governments, Native American tribal organizations (including those other than federally recognized tribal governments), small businesses, for-profit organizations (other than small businesses), and nonprofits both with and without 501(c)(3) status (with the nonprofit categories specifically excluding institutions of higher education where noted). The eligibility language also explicitly includes a range of institution types and communities often highlighted for inclusion in federal research programs, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and U.S. territories or possessions. The listing also indicates that non-U.S. entities (foreign organizations) are eligible, which is important for international research teams or collaborations that bring specialized expertise or access to relevant populations or data.
Key dates show that the opportunity was posted and created on October 3, 2008, with an original and current closing date of May 20, 2010, and an archive date of June 20, 2010. That timeline indicates the FOA is no longer active today, but the content remains useful as a reference for the kinds of pediatric pharmacology and adverse event mechanism research NIH has sought to fund, and it may resemble priorities that appear in newer NIH pediatric drug safety or pharmacogenomics solicitations.
For applicants or readers who need the full text, the opportunity provides an NIH grants guide link (http://grants.nih.gov/grants/guide/pa-files/PAR-08-248.html). For access or technical linking issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Mechanisms of Adverse Drug Effects in Children (R01)" and the Funding Opportunity Number is PAR-08-248.
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) discretionary grant solicitation.
What is the main purpose of this funding opportunity?
The purpose is to support research that improves what is known about why children experience harmful or unexpected reactions to medications, with an emphasis on understanding the underlying biological mechanisms.
What type of research is NIH looking to fund under this FOA?
NIH is looking for mechanistic studies of adverse drug effects in pediatric populations, particularly work that investigates molecular and cellular pathways and genetic and epigenetic contributors to adverse drug reactions.
Is this FOA focused on clinical outcomes or on biological mechanisms?
The emphasis is on explaining mechanisms behind adverse drug effects in children rather than simply describing clinical outcomes.
What grant mechanism does this opportunity use?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which typically supports substantial, hypothesis-driven research projects that may require multi-year, in-depth investigation.
Is there a related or companion funding opportunity?
Yes. The announcement notes a separate but scientifically identical opportunity, PAR-08-249, that uses the R03 mechanism.
How does the R01 version (PAR-08-248) differ from the companion R03 version (PAR-08-249)?
Both focus on the same scientific topic (mechanisms of adverse drug reactions in children), but the R01 is generally aligned with larger, more comprehensive projects, while the R03 is generally intended for smaller, shorter, or more exploratory projects.
Are funding amounts and the number of awards predetermined?
No. Funding levels and the anticipated number of awards are not fixed in advance and depend on the availability of NIH funds and the quality and quantity of applications received.
Will award size and duration be the same for all projects?
No. The announcement indicates that proposed projects can vary widely in scope, so the size and duration of awards will also vary.
What factors affect whether an award is made?
Awards are contingent on the availability of NIH funds and on the scientific merit and competitiveness of the applications submitted, as reflected by the quality and quantity of applications in the pool.
Is there a cost sharing or matching requirement?
No. The opportunity states there is no cost sharing or matching requirement, so applicants are not required to contribute non-federal funds under the stated terms.
What is the funding activity category listed for this opportunity?
The funding activity category is listed as Health, Income Security and Social Services.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA number 93.865, corresponding to Child Health and Human Development Extramural Research.
Who is eligible to apply?
Eligibility is broad and includes: public and state-controlled institutions of higher education; private institutions of higher education; state governments; federally recognized Native American tribal governments; Native American tribal organizations (including those other than federally recognized tribal governments); small businesses; for-profit organizations (other than small businesses); and nonprofits both with and without 501(c)(3) status (with certain nonprofit categories excluding institutions of higher education where noted).
Are minority-serving institutions and U.S. territories mentioned as eligible?
Yes. The eligibility language explicitly includes institution types and communities often highlighted for inclusion in federal research programs, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The listing indicates that non-U.S. entities (foreign organizations) are eligible.
When was this funding opportunity posted and created?
The opportunity was posted and created on October 3, 2008.
What were the closing and archive dates for this FOA?
The original and current closing date is listed as May 20, 2010, and the archive date is June 20, 2010.
Is this funding opportunity still active?
Based on the closing date (May 20, 2010) and archive date (June 20, 2010), this FOA is no longer active.
Why might this archived FOA still be useful to researchers?
Even though it is no longer active, it can serve as a reference for the kinds of pediatric pharmacology and adverse event mechanism research NIH has sought to fund, and it may resemble priorities that appear in newer NIH pediatric drug safety or pharmacogenomics solicitations.
Where can someone find the full text of the opportunity?
The full text is available via the NIH Grants Guide link: http://grants.nih.gov/grants/guide/pa-files/PAR-08-248.html
Who is the contact for access issues or technical linking problems?
The contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 08 248) also looked into and applied for these:
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