Opportunity Information: Apply for PA 08 253
Apply for PA 08 253
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Unique Interactions Between Tobacco Use and HIV/AIDS (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs 93.989 International Research and Research Training.
- This funding opportunity was created on Oct 3, 2008 and posted on Oct 3, 2008.
- Applicants must submit their applications by Jan 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public and State controlled institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Small businesses Private institutions of higher education Public housing authorities/Indian housing authorities County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity titled "Unique Interactions Between Tobacco Use and HIV/AIDS (R01)" (Funding Opportunity Number PA-08-253) is an NIH discretionary grant announcement designed to expand research on how cigarette smoking and HIV/AIDS interact to shape health outcomes. It is sponsored by the National Institute on Drug Abuse (NIDA) in partnership with the Fogarty International Center (FIC), reflecting both a substance use/public health focus and an interest in research that may include international or global health dimensions. The central aim is to stimulate rigorous scientific work that looks beyond treating tobacco use and HIV as separate issues, and instead examines their combined or synergistic effects, including how smoking may worsen HIV-related disease progression, complications, treatment outcomes, and overall morbidity and mortality among people living with HIV.
This announcement uses the NIH Research Project Grant (R01) mechanism, which is typically intended for well-developed, hypothesis-driven projects that can support a substantial, multi-year research plan. The FOA is paired with a parallel announcement of the same scientific scope that uses a smaller grant mechanism (R03, PA-08-254), meaning applicants should choose the mechanism that best fits the maturity, scale, and budget needs of their proposed work. The R01 track is generally appropriate for more comprehensive studies, such as larger observational cohorts, clinical or behavioral intervention trials, mechanistic studies, or multi-site projects aimed at clarifying causal pathways and real-world health impacts.
Funding levels and the number of awards are not fixed in advance. NIH notes that award size and project duration will vary depending on the nature and scope of the research proposed, and that total awards will ultimately depend on the quality of applications received, requested budgets, project timelines, and program priorities. In other words, this FOA does not promise a specific set-aside amount or a guaranteed number of awards; it functions as an open program announcement where strong applications compete based on scientific merit and relevance.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations other than small businesses, small businesses, local and state governmental entities, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility language also explicitly includes a range of mission-specific and community-rooted institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), certain tribal governments and tribal organizations (including some not federally recognized), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and foreign (non-U.S.) entities. This broad eligibility aligns with the public health nature of the topic and the need to reach diverse populations affected by both tobacco use and HIV.
From an administrative standpoint, the opportunity was posted on October 3, 2008, and the original and final closing date listed is January 7, 2012, with an archive date of February 7, 2012, meaning the announcement is no longer active but remains a useful reference for understanding NIH priorities at the intersection of tobacco and HIV research during that period. The CFDA listings associated with this FOA are 93.279 (Drug Abuse and Addiction Research Programs) and 93.989 (International Research and Research Training). There is no cost sharing or matching requirement, which is consistent with many NIH research project grants.
Overall, PA-08-253 is best understood as an NIH R01 invitation for researchers to develop substantial projects that clarify and address the compounded health burden that can arise when tobacco use and HIV/AIDS co-occur. The FOA emphasizes the importance of studying the interactive health effects rather than treating smoking as a generic comorbidity, with the expectation that improved scientific understanding can inform better prevention, cessation strategies, clinical management, and public health interventions tailored to people living with HIV in the U.S. and potentially in international settings as well.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Unique Interactions Between Tobacco Use and HIV/AIDS (R01)" and the Funding Opportunity Number is PA-08-253.
Which agency and institutes sponsor this funding opportunity?
This is an NIH discretionary grant announcement sponsored by the National Institute on Drug Abuse (NIDA) in partnership with the Fogarty International Center (FIC).
What is the main purpose of PA-08-253?
The central aim is to expand research on how cigarette smoking and HIV/AIDS interact to shape health outcomes. It encourages studies that look at combined or synergistic effects rather than treating tobacco use and HIV as separate issues.
What kinds of interactions or outcomes is the FOA trying to better understand?
The announcement emphasizes research on how smoking may worsen HIV-related disease progression, complications, treatment outcomes, and overall morbidity and mortality among people living with HIV.
What grant mechanism does this opportunity use?
PA-08-253 uses the NIH Research Project Grant (R01) mechanism, which is typically used for well-developed, hypothesis-driven projects that support a substantial, multi-year research plan.
Is there a related funding opportunity with a different grant mechanism?
Yes. The FOA is paired with a parallel announcement of the same scientific scope using the smaller R03 mechanism (PA-08-254). Applicants are expected to choose the mechanism that best fits the maturity, scale, and budget needs of their work.
When is an R01 generally the better fit than the parallel R03?
Based on the description provided, the R01 track is generally appropriate for more comprehensive studies, including larger observational cohorts, clinical or behavioral intervention trials, mechanistic studies, or multi-site projects aimed at clarifying causal pathways and real-world health impacts.
Does this FOA have a fixed budget amount or a guaranteed number of awards?
No. Funding levels and the number of awards are not fixed in advance. NIH indicates that award size and project duration will vary depending on the proposed research, and total awards will depend on application quality, requested budgets, timelines, and program priorities.
How does NIH decide the size and duration of awards under this program announcement?
According to the provided information, award size and project duration vary based on the nature and scope of the research proposed, and are influenced by factors such as scientific merit, requested budget, project timelines, and NIH program priorities.
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations); for-profit organizations other than small businesses; small businesses; local and state governments; special district governments; independent school districts; and public housing authorities/Indian housing authorities.
Are minority-serving institutions and community-based organizations explicitly included as eligible applicants?
Yes. The eligibility language explicitly includes institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), certain tribal governments and tribal organizations (including some not federally recognized), as well as faith-based or community-based organizations and regional organizations.
Are U.S. territories and foreign (non-U.S.) organizations eligible?
Yes. The eligibility description includes U.S. territories or possessions and foreign (non-U.S.) entities.
Is this funding opportunity focused only on the United States?
Not necessarily. While it addresses public health needs relevant to people living with HIV, the sponsorship partnership includes the Fogarty International Center (FIC) and the eligibility explicitly includes foreign entities, which supports research that may include international or global health dimensions.
Is cost sharing or matching required?
No. The FOA states that there is no cost sharing or matching requirement.
What are the CFDA numbers associated with this announcement?
The CFDA listings associated with this FOA are 93.279 (Drug Abuse and Addiction Research Programs) and 93.989 (International Research and Research Training).
When was this opportunity posted, and is it still active?
The opportunity was posted on October 3, 2008. The original and final closing date listed is January 7, 2012, and the archive date is February 7, 2012. Based on these dates, the announcement is no longer active.
What does it mean that this is an NIH program announcement without a set-aside?
As described, it does not promise a specific set-aside amount or a guaranteed number of awards. Instead, it operates as an open program announcement where strong applications compete based on scientific merit and relevance, with awards shaped by NIH priorities and available support.
What is the overarching research emphasis of PA-08-253?
The emphasis is on studying interactive health effects when tobacco use and HIV/AIDS co-occur, rather than treating smoking as a generic comorbidity. The intent is to generate evidence that can inform better prevention, cessation strategies, clinical management, and public health interventions tailored to people living with HIV.
Browse more opportunities from the same agency: National Institutes of Health
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 08 253) also looked into and applied for these:
| Funding Opportunity |
|---|
| Unique Interactions Between Tobacco Use and HIV/AIDS (R03) Apply for PA 08 254 Funding Number: PA 08 254 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Health Services Research on the Prevention and Treatment of Drug and Alcohol Abuse (R01) Apply for PA 08 263 Funding Number: PA 08 263 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Small Grants for Behavioral Research in Cancer Control (R03) Apply for PAR 09 003 Funding Number: PAR 09 003 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Understanding the Effects of Emerging Cellular, Molecular, and Genomic Technologies on Cancer Health Care Delivery(R01) Apply for PA 09 004 Funding Number: PA 09 004 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Understanding the Effects of Emerging Cellular, Molecular, and Genomic Technologies on Cancer Health Care Delivery (R21) Apply for PA 09 005 Funding Number: PA 09 005 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Health Services Research on the Prevention and Treatment of Drug and Alcohol Abuse (R21) Apply for PA 08 264 Funding Number: PA 08 264 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Health Services Research on the Prevention and Treatment of Drug and Alcohol Abuse (R03) Apply for PA 08 265 Funding Number: PA 08 265 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Exploratory Studies in Cancer Detection, Diagnosis, and Prognosis (R21) Apply for PA 08 267 Funding Number: PA 08 267 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Interactions between Physical Activity and Drug Abuse (R01) Apply for RFA DA 09 013 Funding Number: RFA DA 09 013 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Interactions between Physical Activity and Drug Abuse (R03) Apply for RFA DA 09 014 Funding Number: RFA DA 09 014 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Basic and Preclinical Research on Complementary and Alternative Medicine (CAM) (R01) Apply for PA 09 010 Funding Number: PA 09 010 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| The Mouse Gene Development Initiative (R01) Apply for RFA DA 09 015 Funding Number: RFA DA 09 015 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Medical Management of Older Patients with HIV/AIDS (R01) Apply for PA 09 017 Funding Number: PA 09 017 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| International Research Collaboration on Drug Abuse and Addiction Research (R01) Apply for PA 09 020 Funding Number: PA 09 020 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| International Research Collaboration on Drug Abuse and Addiction Research (R21) Apply for PA 09 021 Funding Number: PA 09 021 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| International Research Collaboration on Drug Abuse and Addiction Research (R03) Apply for PA 09 022 Funding Number: PA 09 022 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R21) Apply for RFA DA 09 018 Funding Number: RFA DA 09 018 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Secondary Data Analyses for Substance Abuse Research (R21/R33) Apply for RFA DA 09 020 Funding Number: RFA DA 09 020 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Brain Imaging Studies of Negative Reinforcement in Humans (R01) Apply for RFA DA 09 008 Funding Number: RFA DA 09 008 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
| Brain Imaging Studies of Negative Reinforcement in Humans (R21) Apply for RFA DA 09 009 Funding Number: RFA DA 09 009 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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