Opportunity Information: Apply for PAR 08 249
Apply for PAR 08 249
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Mechanisms of Adverse Drug Reactions in Children (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 8, 2008 and posted on Oct 8, 2008.
- Applicants must submit their applications by May 23, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public housing authorities/Indian housing authorities County governments City or township governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Native American tribal governments (Federally recognized) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Mechanisms of Adverse Drug Reactions in Children (R03)" (Funding Opportunity Number PAR-08-249) is a National Institutes of Health (NIH) funding announcement led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Its main goal is to support research that explains why children experience adverse drug reactions by focusing on underlying molecular, cellular, and genetic mechanisms. In practical terms, the program is looking for studies that move beyond simply describing side effects and instead dig into the biological pathways and factors that cause harmful or unexpected responses to medications in pediatric populations. The emphasis on mechanisms suggests that projects should aim to clarify how and why these reactions occur, potentially laying groundwork for safer prescribing, improved monitoring, and better risk prediction for children.
This opportunity uses the NIH Small Research Grant (R03) mechanism, which is designed for smaller, more focused projects that can be completed in a relatively short time and with limited resources. The R03 mechanism commonly supports pilot studies and feasibility work, secondary analyses of existing datasets, small self-contained research projects, and efforts to develop or refine research methods or technologies. That framing matters because it signals what NIH expects: a tight, clearly scoped study that can produce meaningful preliminary evidence, validate an approach, or generate insights that can support larger future projects. The announcement also notes that this R03 runs in parallel with a separate but scientifically identical opportunity under the R01 mechanism (PAR-08-248), which is typically used for larger, more extended research programs. In other words, investigators who have a smaller, targeted mechanistic question may be best suited for the R03 track, while those planning a broader research effort might consider the R01 companion FOA.
Funding levels and the number of awards are not fixed in the announcement. Instead, NIH indicates that award size and duration will vary depending on the proposed research, and that the total number of awards and overall dollars awarded will depend on the number of applications received and their quality, budgets, and project periods. There is no cost sharing or matching requirement, which is typical for many NIH research grant programs and reduces financial barriers for applicants.
Eligibility is broad and includes a wide range of U.S. and non-U.S. organizations. Eligible applicants listed include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple levels of government such as state, county, city or township governments, and special district governments. The eligibility list also explicitly includes tribal entities and related organizations, such as federally recognized Native American tribal governments, other tribal governments, tribally controlled colleges and universities (TCCUs), and Native American tribal organizations. The FOA also highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), faith-based and community-based organizations, U.S. territories or possessions, and even non-domestic (non-U.S.) entities and foreign organizations, along with regional organizations and eligible federal agencies. This wide net indicates NIH interest in encouraging diverse institutional participation and leveraging different research environments and patient populations relevant to pediatric drug safety.
From an administrative standpoint, the opportunity falls under the NIH, is categorized as a discretionary grant, and is associated with CFDA number 93.865 (Child Health and Human Development Extramural Research). The announcement was posted on October 8, 2008, and the final closing date listed is May 23, 2010, with an archive date of June 23, 2010. The full announcement was made available through NIHs grants policy and guidance website, and NIH provided support contacts through the NIH Office of Extramural Research (OER) webmaster for access or linking issues. Overall, the program is essentially a targeted NIH small-grant pathway for investigators who want to produce mechanistic insights into pediatric adverse drug reactions, especially studies that are feasible within limited time and budget but still contribute meaningful evidence that can improve child health and medication safety.
Frequently Asked Questions (FAQs): Mechanisms of Adverse Drug Reactions in Children (R03) - PAR-08-249
What is the name of this grant opportunity?
The opportunity is titled "Mechanisms of Adverse Drug Reactions in Children (R03)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-08-249.
Which agency is offering this funding?
This is a National Institutes of Health (NIH) funding announcement.
Which NIH institute is leading the opportunity?
The opportunity is led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What is the main purpose of this FOA?
The primary goal is to support research that explains why children experience adverse drug reactions by focusing on underlying molecular, cellular, and genetic mechanisms.
What does NIH mean by focusing on "mechanisms" of adverse drug reactions?
The emphasis on mechanisms means projects should go beyond simply describing or listing side effects. Instead, studies are expected to investigate the biological pathways and contributing factors that cause harmful or unexpected responses to medications in pediatric populations.
What kinds of research projects are a good fit for this announcement?
Projects that are well aligned are those designed to clarify how and why adverse drug reactions occur in children, potentially generating insights that could support safer prescribing, improved monitoring, and better risk prediction for pediatric medication use.
What grant mechanism does this opportunity use?
This opportunity uses the NIH Small Research Grant (R03) mechanism.
What is the R03 mechanism intended for?
The R03 is designed for smaller, focused projects that can be completed in a relatively short time with limited resources. It commonly supports:
- Pilot studies and feasibility studies
- Secondary analyses of existing datasets
- Small, self-contained research projects
- Development or refinement of research methods or technologies
Is there a related NIH opportunity for larger projects on the same topic?
Yes. This R03 FOA runs in parallel with a separate but scientifically identical opportunity under the R01 mechanism: PAR-08-248. The R03 is intended for smaller targeted studies, while the R01 typically supports larger and longer research efforts.
Are the funding amount and number of awards fixed?
No. The announcement indicates that award size and duration will vary depending on the proposed research. The number of awards and the total dollars awarded depend on factors such as the number of applications received, application quality, proposed budgets, and project periods.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes a wide range of U.S. and non-U.S. organizations. Eligible applicants listed include:
- Public and private institutions of higher education
- Nonprofit organizations (with or without 501(c)(3) status)
- For-profit organizations (other than small businesses)
- Small businesses
- State, county, city or township governments
- Special district governments
- Eligible federal agencies
- U.S. territories or possessions
- Non-domestic (non-U.S.) entities, foreign organizations, and regional organizations
Are tribal entities and tribal-serving institutions eligible?
Yes. The eligibility list explicitly includes:
- Federally recognized Native American tribal governments
- Other tribal governments
- Tribally controlled colleges and universities (TCCUs)
- Native American tribal organizations
Are minority-serving and community-based institutions included as eligible applicants?
Yes. The FOA highlights eligibility for organizations such as:
- Alaska Native and Native Hawaiian Serving Institutions
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Faith-based and community-based organizations
What type of grant is this categorized as?
The opportunity is under NIH and is categorized as a discretionary grant.
What CFDA number is associated with this program?
The FOA is associated with CFDA 93.865, titled Child Health and Human Development Extramural Research.
When was this announcement posted?
The announcement was posted on October 8, 2008.
What is the final closing date for applications?
The final closing date listed is May 23, 2010.
When was the opportunity archived?
The archive date is June 23, 2010.
Where was the full announcement made available?
The full announcement was made available through NIH's grants policy and guidance website.
Who should be contacted for access or linking issues related to the announcement?
NIH provided support contacts through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
What is the practical takeaway for applicants deciding between the R03 and the companion R01?
Based on how the FOA frames the mechanisms, applicants with a smaller, tightly scoped mechanistic question may be best suited to the R03 (PAR-08-249), while applicants planning a broader, longer research effort might consider the companion R01 (PAR-08-248).
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