Opportunity Information: Apply for PA 13 194

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanisms of Alcohol and Nicotine Co Addiction (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
  • This funding opportunity was created on Apr 24, 2013 and posted on Apr 12, 2013.
  • Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Independent school districts Native American tribal governments (Federally recognized) City or township governments For profit organizations other than small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities State governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The funding opportunity titled "Mechanisms of Alcohol and Nicotine Co Addiction (R01)" (Funding Opportunity Number PA-13-194) is a National Institutes of Health (NIH) discretionary grant announcement that invited research proposals aimed at understanding why alcohol use and nicotine use so often occur together and what biological and behavioral processes drive that co-addiction. It specifically sought R01 applications, meaning it supported substantial, hypothesis-driven projects that typically involve multi-year research plans and well-developed preliminary rationale. The central focus was on identifying neurobiological and behavioral mechanisms that contribute to concurrent alcohol and nicotine addiction, including how the two substances may interact in the brain and in behavior to increase vulnerability, reinforce continued use, complicate quitting, or worsen relapse risk.

This FOA was positioned within NIH health research programs and mapped to CFDA numbers 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs), reflecting its cross-cutting relevance to both alcohol and drug abuse research portfolios. The goal was not simply to study alcohol or tobacco in isolation, but to prioritize research that treats co-use as its own scientific problem, where shared reward pathways, stress systems, learning and habit circuitry, genetics, developmental factors, and environmental influences may combine to produce patterns of dependence that differ from single-substance addiction. In practical terms, applications could be expected to explore topics such as how nicotine alters alcohol reward or consumption, how alcohol changes nicotine reinforcement, which neurotransmitter systems and neural circuits are jointly affected, and what behavioral phenotypes or decision-making processes predict co-use and relapse.

The eligibility rules were broad and inclusive, allowing participation from a wide range of domestic and international institutions and organizations. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including those with or without 501(c)(3) status), for-profit organizations (including small businesses), and multiple levels of government (state, county, city/township, special district). The FOA also explicitly included various mission-driven and capacity-building institution types, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions, as well as faith-based and community-based organizations. Foreign organizations and foreign institutions were eligible to apply, and non-U.S. components of U.S. organizations were also eligible, with foreign components permitted consistent with NIH policy. No cost sharing or matching was required, which lowered barriers for applicants and is typical for NIH research project grants.

In terms of timing and status, the opportunity was posted on April 12, 2013, created on April 24, 2013, and it had an original and final closing date of September 7, 2016. It was archived on October 8, 2016, meaning it is no longer open for applications, though the archived announcement remains useful as a reference point for the scientific priorities NIH was emphasizing around alcohol and nicotine co-addiction mechanisms during that period. Applicants and readers were directed to the full announcement on the NIH grants website (PA-13-194), and NIH provided general webmaster contact points for technical difficulties accessing or linking to the notice.

Overall, this FOA can be understood as an NIH effort to push the field toward mechanistic, integrated research on co-occurring alcohol and nicotine addiction, recognizing that dual use is common and clinically challenging and that better prevention and treatment strategies depend on understanding the underlying brain and behavioral processes that make co-addiction persist.

Frequently Asked Questions (FAQs)

What is the title and funding opportunity number for this grant?

The opportunity is titled "Mechanisms of Alcohol and Nicotine Co Addiction (R01)" and the Funding Opportunity Number is PA-13-194.

Which agency offered this funding opportunity?

This was a discretionary grant announcement from the National Institutes of Health (NIH).

What type of grant mechanism did this opportunity support?

The announcement specifically sought R01 applications. R01s are intended to support substantial, hypothesis-driven research projects, typically with multi-year research plans and a well-developed rationale.

What was the main purpose of this funding opportunity?

The goal was to support research aimed at understanding why alcohol use and nicotine use so often occur together and to identify the biological and behavioral processes that drive co-addiction.

What did NIH mean by focusing on "co-addiction" rather than single-substance use?

The FOA emphasized studying concurrent alcohol and nicotine use as its own scientific problem, rather than treating alcohol or tobacco use in isolation. It prioritized research on shared or interacting mechanisms that may create patterns of dependence that differ from single-substance addiction.

What kinds of mechanisms were of interest under this FOA?

The central scientific focus was on neurobiological and behavioral mechanisms contributing to concurrent alcohol and nicotine addiction, including how the two substances may interact in the brain and behavior to increase vulnerability, reinforce continued use, complicate quitting, or worsen relapse risk.

What research topics or questions were expected to fit this FOA?

Examples of topics described included: how nicotine alters alcohol reward or consumption; how alcohol changes nicotine reinforcement; which neurotransmitter systems and neural circuits are jointly affected; and what behavioral phenotypes or decision-making processes predict co-use and relapse.

Did the FOA emphasize any particular domains that might contribute to co-use?

Yes. The description highlighted the potential roles of shared reward pathways, stress systems, learning and habit circuitry, genetics, developmental factors, and environmental influences in shaping co-addiction.

Which program areas or CFDA numbers were associated with this opportunity?

The FOA mapped to CFDA 93.273 (Alcohol Research Programs) and CFDA 93.279 (Drug Abuse and Addiction Research Programs), reflecting its relevance across both alcohol and drug abuse research portfolios.

Who was eligible to apply?

Eligibility was broad. Eligible applicants included public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses); and governmental entities such as state, county, city/township, and special district governments.

Were specific institution types explicitly included as eligible?

Yes. The FOA explicitly included Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, and also faith-based and community-based organizations.

Were non-U.S. (foreign) organizations eligible to apply?

Yes. Foreign organizations and foreign institutions were eligible to apply. The FOA also allowed non-U.S. components of U.S. organizations, and foreign components were permitted in a manner consistent with NIH policy.

Was cost sharing or matching required?

No. The FOA stated that no cost sharing or matching was required.

When was this funding opportunity posted and created?

It was posted on April 12, 2013, and created on April 24, 2013.

What were the closing dates for this opportunity?

The original and final closing date listed was September 7, 2016.

Is this funding opportunity still open for applications?

No. The announcement was archived on October 8, 2016, and is no longer open for applications.

If it is archived, why might someone still look at it?

Even though it is closed, the archived notice can still be useful as a reference for understanding NIH scientific priorities during that period related to mechanisms of alcohol and nicotine co-addiction.

Where were applicants directed to find the full announcement?

Applicants and readers were directed to the full announcement on the NIH grants website under PA-13-194.

What kind of contact information was provided for technical issues?

NIH provided general webmaster contact points for technical difficulties accessing or linking to the notice.

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Previous opportunity: Mechanisms of Alcohol and Nicotine Co Addiction (R21)

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