Opportunity Information: Apply for PA 13 193
Apply for PA 13 193
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanisms of Alcohol and Nicotine Co Addiction (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Apr 24, 2013 and posted on Apr 12, 2013.
- Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) County governments Public housing authorities/Indian housing authorities State governments For profit organizations other than small businesses Small businesses Public and State controlled institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Special district governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity titled "Mechanisms of Alcohol and Nicotine Co-Addiction (R21)" (Funding Opportunity Number PA 13-193) invited exploratory or early-stage research grant applications aimed at understanding why alcohol use and nicotine use so often occur together and how that pairing becomes mutually reinforcing. The central purpose was to support studies that dig into the neurobiological and behavioral mechanisms that contribute to concurrent alcohol and nicotine co-addiction, meaning the combined, interacting addiction process rather than treating alcohol and tobacco dependence as separate problems. Projects were expected to focus on mechanisms that could explain co-use patterns and escalation, including how alcohol and nicotine may influence each other's rewarding effects, craving, withdrawal, relapse vulnerability, and decision-making processes.
This opportunity used the NIH R21 mechanism, which is designed for novel, high-impact ideas that may still be at an early proof-of-concept stage. As an R21, it generally aligns with shorter, more exploratory projects intended to generate foundational data, clarify biological pathways, or test innovative approaches that could later be expanded in larger studies. The announcement listed an award ceiling of $200,000, reflecting a capped budget structure commonly associated with this type of exploratory NIH grant. Cost sharing or matching was not required, which is typical for NIH research grants and removes a financial barrier for many applicants.
The activity area was health research, and the program aligned with NIH interests spanning both alcohol research and drug abuse/addiction research, as indicated by CFDA numbers 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs). That framing signals that the topic sits at the intersection of alcohol science and broader addiction neuroscience and behavior, and it encourages applicants to consider cross-substance mechanisms rather than single-substance models. In practical terms, this could include studies of shared neural circuitry, overlapping genetic or epigenetic risk, stress and negative affect systems, learning and conditioning processes, or pharmacological interactions where nicotine changes alcohol intake patterns (or vice versa). Behavioral components could involve reinforcement mechanisms, cue reactivity, habit formation, impulsivity, social and environmental drivers, and other factors that contribute to persistent dual use and relapse.
Eligibility was broad and intentionally inclusive. Eligible applicants included many types of U.S. public and private entities such as state, local, and tribal governments; public housing authorities; school districts; special district governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; and for-profit organizations (including small businesses). The opportunity also allowed a wide range of mission-focused institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Importantly, the FOA also permitted non-U.S. entities to apply, including foreign organizations and foreign institutions, and it allowed foreign components under NIH policy, meaning the research could incorporate international sites or collaborators where scientifically justified.
Administratively, the opportunity was posted on April 12, 2013, created on April 24, 2013, and carried an original and final closing date of September 7, 2016. It was archived on October 8, 2016, meaning it is no longer open for new applications under that specific announcement. The sponsoring agency was the National Institutes of Health, and applicants were directed to the full announcement text via the NIH grants guide link. For technical issues accessing the announcement or linking to it, the contact listed was the NIH Office of Extramural Research (OER) webmaster email.
In plain terms, this FOA was meant to push the field toward a clearer, mechanism-based understanding of alcohol and nicotine co-addiction, supporting innovative projects that could explain the biology and behavior behind dual dependence and, over time, inform better prevention and treatment strategies that address both substances together rather than in isolation.
FAQs: Mechanisms of Alcohol and Nicotine Co-Addiction (R21) - NIH (PA 13-193)
What is the title and funding opportunity number for this NIH grant?
The funding opportunity is titled "Mechanisms of Alcohol and Nicotine Co-Addiction (R21)" and the Funding Opportunity Number is PA 13-193.
What is the main purpose of this funding opportunity?
The central purpose was to support exploratory or early-stage research that explains why alcohol use and nicotine use so often occur together and how the pairing becomes mutually reinforcing. The emphasis was on understanding the combined, interacting co-addiction process rather than treating alcohol dependence and tobacco dependence as separate problems.
What type of research did the FOA seek to support?
The FOA invited studies focused on neurobiological and behavioral mechanisms that contribute to concurrent alcohol and nicotine co-addiction. Projects were expected to investigate mechanisms that could explain co-use patterns and escalation, including how alcohol and nicotine may influence each other's rewarding effects, craving, withdrawal, relapse vulnerability, and decision-making processes.
What does "co-addiction" mean in the context of this opportunity?
In this FOA, co-addiction refers to the combined and interacting addiction process involving both alcohol and nicotine, with attention to how the two substances may jointly shape use patterns, reinforcement, dependence, and relapse risk.
What grant mechanism was used for this opportunity?
This opportunity used the NIH R21 mechanism, which is designed for novel, potentially high-impact ideas that may be at an early proof-of-concept stage. The R21 structure generally aligns with shorter, exploratory projects aimed at generating foundational data, clarifying pathways, or testing innovative approaches that could later be expanded in larger studies.
Was there an award budget cap for this R21 opportunity?
Yes. The announcement listed an award ceiling of $200,000, reflecting a capped budget structure commonly associated with this type of exploratory NIH grant.
Was cost sharing or matching required?
No. Cost sharing or matching was not required.
What is the general activity area for this FOA?
The activity area was health research, specifically focused on alcohol and nicotine co-addiction mechanisms.
How does this FOA align with NIH program areas?
The program sat at the intersection of alcohol research and broader drug abuse/addiction research. This alignment was indicated by CFDA 93.273 (Alcohol Research Programs) and CFDA 93.279 (Drug Abuse and Addiction Research Programs), signaling an interest in cross-substance mechanisms rather than single-substance models.
What kinds of scientific topics were relevant to proposed studies?
Based on the FOA description, relevant topics could include shared neural circuitry, overlapping genetic or epigenetic risk, stress and negative affect systems, learning and conditioning processes, and pharmacological interactions in which nicotine changes alcohol intake patterns or alcohol changes nicotine use patterns.
What kinds of behavioral mechanisms were within scope?
Behavioral components could involve reinforcement mechanisms, cue reactivity, habit formation, impulsivity, social and environmental drivers, and other factors that contribute to persistent dual use and relapse.
Who was eligible to apply?
Eligibility was broad and included many types of U.S. public and private entities, such as state, local, and tribal governments; public housing authorities; school districts; special district governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; and for-profit organizations (including small businesses).
Were minority-serving institutions specifically included as eligible applicants?
Yes. The FOA explicitly allowed a wide range of mission-focused institutions, including HBCUs, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs.
Could non-U.S. organizations apply?
Yes. The FOA permitted non-U.S. entities to apply, including foreign organizations and foreign institutions.
Did the FOA allow foreign components or international collaborations?
Yes. It allowed foreign components under NIH policy, meaning the research could incorporate international sites or collaborators where scientifically justified.
When was this opportunity posted and when did it close?
The opportunity was posted on April 12, 2013, created on April 24, 2013, and had an original and final closing date of September 7, 2016.
Is this funding opportunity still open?
No. It was archived on October 8, 2016, meaning it is no longer open for new applications under that specific announcement.
Who was the sponsoring agency?
The sponsoring agency was the National Institutes of Health (NIH).
Where were applicants directed for the full announcement text?
Applicants were directed to the full announcement text via the NIH grants guide link referenced in the posting.
Who was listed as the contact for technical issues accessing the announcement?
For technical issues accessing the announcement or linking to it, the contact listed was the NIH Office of Extramural Research (OER) webmaster email.
What was the intended long-term impact of the research supported by this FOA?
In practical terms, the FOA aimed to move the field toward a clearer, mechanism-based understanding of alcohol and nicotine co-addiction, supporting innovative projects that could inform better prevention and treatment strategies that address both substances together rather than in isolation.
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