Opportunity Information: Apply for RFA HL 13 028
Apply for RFA HL 13 028
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanisms of HIV Related Lung Disease Data Coordinating Center (DCC) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Dec 14, 2012 and posted on Dec 14, 2012.
- Applicants must submit their applications by Mar 19, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments City or township governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Mechanisms of HIV Related Lung Disease Data Coordinating Center (DCC) (U01) funding opportunity (RFA-HL-13-028) is a National Institutes of Health program run through the National Heart, Lung, and Blood Institute (NHLBI). It supports a cooperative agreement award mechanism (U01), meaning the NIH expects to be actively involved alongside the awardee in shaping and overseeing key scientific and operational components rather than simply providing funds and stepping back. The overarching research program this DCC will serve is focused on understanding why and how lung diseases occur and progress in people living with HIV, with an emphasis on defining the cellular and molecular mechanisms involved and considering host genetic factors. The diseases highlighted include HIV-associated chronic obstructive pulmonary disease (COPD) and pulmonary hypertension, though the broader intent is to address HIV-related lung disease mechanisms more generally.
The central purpose of the award is to fund a Data Coordinating Center that acts as the operational and analytical hub for a network of individual U01 clinical and basic research sites. In practice, the DCC is expected to make multi-site collaboration workable by organizing and harmonizing study operations across participating projects. This includes facilitating governance and communication structures such as a Steering Committee and advisory groups, and helping the network develop, refine, and carry out shared (collaborative) protocols and cross-site projects. The DCC role is not limited to data storage; it extends to end-to-end coordination of how collaborative studies are designed and executed so that data coming from different sites can be combined, compared, and analyzed reliably.
On the data side, the DCC is tasked with core coordination functions that typically include building and maintaining systems for data collection and management, establishing common data elements and standards, ensuring data quality control, and supporting consistent documentation and reporting practices across sites. It is also expected to provide safety surveillance support for collaborative projects, which generally involves tracking and coordinating safety-related information in a standardized way appropriate to the studies being conducted. Finally, the DCC is responsible for data analysis for collaborative projects, meaning it should have strong biostatistical and analytical capacity to support network-wide questions, pooled analyses, interim reporting needs, and final study outputs.
Administratively, this opportunity falls under the discretionary category and the health activity area, with CFDA number 93.838 (Lung Diseases Research). It does not require cost sharing or matching funds. The announcement was posted and created on December 14, 2012, with an original and current closing date of March 19, 2013, and an archive date of April 19, 2013. Additional details and the full announcement were made available through the NIH grants guide at the link provided in the notice.
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), state, county, city/township, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations, including federally recognized tribal governments and other tribal entities. The opportunity explicitly notes inclusion of a range of institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, as well as faith-based or community-based organizations and eligible federal agencies. Foreign institutions and non-U.S. entities are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, foreign components as defined by NIH policy are allowed, which typically means limited, clearly justified international elements can be included under specific NIH rules even though the applicant organization itself must be eligible and primarily domestic.
In short, this grant opportunity is aimed at selecting a capable coordinating center to unify a research network studying HIV-related lung disease mechanisms. The DCC is expected to provide the infrastructure and expertise that allow multiple clinical and basic science sites to function like a single integrated program, with consistent protocols, reliable and high-quality shared data, appropriate safety oversight processes, and rigorous cross-site analyses that can answer complex mechanistic questions about HIV-associated pulmonary conditions.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Mechanisms of HIV Related Lung Disease Data Coordinating Center (DCC) (U01)" and is associated with RFA-HL-13-028.
Which federal agency and institute are running this program?
This is a National Institutes of Health (NIH) program run through the National Heart, Lung, and Blood Institute (NHLBI).
What type of award mechanism does this opportunity use?
It uses a cooperative agreement mechanism (U01). Under a U01, NIH expects to be actively involved with the awardee in shaping and overseeing key scientific and operational components, rather than only providing funds.
What is the main purpose of the award?
The main purpose is to fund a Data Coordinating Center (DCC) that serves as the operational and analytical hub for a network of individual U01 clinical and basic research sites focused on HIV-related lung disease mechanisms.
What broader research program will the DCC support?
The DCC will support a research program aimed at understanding why and how lung diseases occur and progress in people living with HIV, with emphasis on cellular and molecular mechanisms and consideration of host genetic factors.
Which lung diseases are specifically highlighted in the program description?
The description highlights HIV-associated chronic obstructive pulmonary disease (COPD) and pulmonary hypertension, while also indicating a broader intent to address HIV-related lung disease mechanisms generally.
Is the DCC role limited to data storage?
No. The DCC is expected to support end-to-end coordination for collaborative studies, including helping design and execute shared protocols so that data across sites can be combined, compared, and analyzed reliably.
What does it mean that the DCC is the "operational and analytical hub"?
It means the DCC is expected to make multi-site collaboration workable by organizing and harmonizing study operations across participating projects, while also providing network-wide analytical capacity to support collaborative research questions.
What kinds of network coordination activities are expected from the DCC?
The DCC is expected to facilitate governance and communication structures (such as a Steering Committee and advisory groups) and help the network develop, refine, and carry out shared protocols and cross-site projects.
What data collection and management responsibilities are included?
Core responsibilities include building and maintaining systems for data collection and management, establishing common data elements and standards, and supporting consistent documentation and reporting practices across sites.
What is meant by "common data elements and standards" in this context?
It refers to harmonized definitions, formats, and conventions for data collected across multiple sites so that results can be pooled and compared consistently across the network.
What data quality responsibilities does the DCC have?
The DCC is expected to ensure data quality control across sites, supporting practices that help keep multi-site data accurate, consistent, and reliable for combined analyses.
Is safety surveillance part of the DCC responsibilities?
Yes. The DCC is expected to provide safety surveillance support for collaborative projects, generally meaning standardized tracking and coordination of safety-related information appropriate to the studies being conducted.
What analysis responsibilities does the DCC have?
The DCC is responsible for data analysis for collaborative projects and should have strong biostatistical and analytical capacity to support pooled analyses, network-wide questions, interim reporting needs, and final study outputs.
Who is this DCC intended to work with?
The DCC is intended to work with a network of individual U01 clinical and basic research sites participating in the broader HIV-related lung disease mechanisms program.
What is the CFDA number and program area for this opportunity?
The CFDA number is 93.838, and it falls under Lung Diseases Research.
What are the activity and category designations mentioned?
The opportunity is listed in the health activity area and the discretionary category.
Is cost sharing or matching required?
No. The opportunity states that cost sharing or matching funds are not required.
When was the funding opportunity posted and created?
The announcement was posted and created on December 14, 2012.
What is the application closing date?
The original and current closing date listed is March 19, 2013.
When was the opportunity archived?
The archive date listed is April 19, 2013.
Where can applicants find the full announcement details?
The notice states that additional details and the full announcement were available through the NIH grants guide at the link provided in the notice.
What types of organizations are eligible to apply?
Eligibility is broad and includes U.S.-based public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), and a variety of U.S. governmental entities.
Which government entities are listed as eligible?
Eligible government entities include state governments, county governments, city or township governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations (including federally recognized tribal governments and other tribal entities).
Are specific institution types explicitly mentioned as included?
Yes. The opportunity explicitly notes inclusion of institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, as well as faith-based or community-based organizations and eligible federal agencies.
Are foreign institutions or non-U.S. entities eligible to apply?
No. Foreign institutions and non-U.S. entities are not eligible to apply.
Can a U.S. organization apply if it has a non-U.S. component?
Non-U.S. components of U.S. organizations are not eligible. However, the opportunity notes that foreign components (as defined by NIH policy) are allowed, meaning limited and clearly justified international elements may be included under specific NIH rules even though the applicant organization must be eligible and primarily domestic.
What is the practical goal of funding a DCC for this network?
The practical goal is to unify multiple participating clinical and basic science sites so they can operate as a single integrated program, using consistent protocols and producing shared data that is high quality and suitable for rigorous cross-site analyses.
Why is a DCC important for multi-site HIV-related lung disease research?
Based on the description, the DCC is important because it helps harmonize operations and data across sites, supports governance and collaboration, coordinates safety surveillance for collaborative projects, and enables pooled analyses needed to answer complex mechanistic questions.
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