Opportunity Information: Apply for PA 13 043
Apply for PA 13 043
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Calcium Oxalate Stone Diseases (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Dec 14, 2012 and posted on Dec 14, 2012.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education County governments Independent school districts Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Special district governments Public housing authorities/Indian housing authorities State governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity "Calcium Oxalate Stone Diseases (R01)" (Funding Opportunity Number PA-13-043) is an investigator-initiated research grant announcement designed to stimulate more scientific attention and more new projects focused on oxalate biology and calcium oxalate stone disease. At its core, the FOA aims to grow the field by encouraging researchers to bring fresh ideas and modern methods to understanding how oxalate is produced, handled, and balanced in the body, and how disruptions in those processes lead to stone formation and related disease. The announcement is broad by design and welcomes a wide range of research angles, as long as they meaningfully advance knowledge related to oxalate metabolism, oxalate transport and homeostasis, and the mechanisms, diagnosis, treatment, or prevention of oxalate stone disorders.
This is a discretionary NIH grant mechanism using the R01 funding instrument, meaning it supports full-scale, hypothesis-driven projects that can include basic laboratory science, clinical research, or epidemiological studies. The emphasis on "new and innovative approaches" signals interest in projects that go beyond incremental extensions of prior work, for example by applying emerging technologies, novel model systems, improved biomarkers or diagnostics, or creative study designs that clarify who is at risk, why stones form, and how to prevent recurrence. In practical terms, the FOA positions calcium oxalate stone disease not just as a urology problem, but as a metabolic and kidney-related condition where transporters, diet, gut handling of oxalate, genetic factors, and systemic physiology can all be relevant, and where better prevention and treatment strategies could reduce a high burden of recurrent disease.
The awarding agency is the National Institutes of Health, and the listing is associated with CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), indicating alignment with NIH institutes and programs that support kidney and metabolic research. The opportunity explicitly states there is no cost-sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of the award.
Eligibility is intentionally expansive. Eligible applicants include many types of U.S. public and private institutions and governmental entities, such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses, and for-profit organizations other than small businesses, as well as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The announcement also extends eligibility to a wide range of mission-serving institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations, regional organizations, and eligible federal agencies. Importantly, foreign participation is allowed: non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are permitted, which can matter for collaborations or for studying populations and exposures that are best accessed outside the United States.
From an administrative timeline perspective, the FOA was posted and created on December 14, 2012, and it had an original and current closing date of January 7, 2016, with an archive date of February 7, 2016. That means the specific announcement is no longer active for new submissions under that exact FOA number and dates, but it remains useful as a reference point for the NIH's research priorities in this area and for locating successor opportunities or related NIH program announcements.
For applicants or readers who need the full text and official requirements, the announcement provides an NIH link to the program page (http://grants.nih.gov/grants/guide/pa-files/PA-13-043.html). For access or technical linking issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs): NIH "Calcium Oxalate Stone Diseases (R01)" (PA-13-043)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Calcium Oxalate Stone Diseases (R01)" and it is identified by Funding Opportunity Number (FON) PA-13-043.
Who is the awarding agency?
The awarding agency is the National Institutes of Health (NIH).
What is the purpose of PA-13-043?
The purpose is to stimulate more scientific attention and encourage new investigator-initiated projects focused on oxalate biology and calcium oxalate stone disease, especially projects that meaningfully advance knowledge about oxalate metabolism, oxalate transport and homeostasis, and stone disease mechanisms, diagnosis, treatment, or prevention.
What type of grant mechanism does this opportunity use?
This opportunity uses the NIH R01 funding instrument, which is designed to support full-scale, hypothesis-driven research projects.
Is this an investigator-initiated opportunity?
Yes. It is described as an investigator-initiated research grant announcement, intended to attract new projects and approaches in the field.
What scientific areas does the FOA encourage?
The FOA is broad and welcomes a range of research angles, as long as they advance understanding of oxalate biology and calcium oxalate stone disease. Examples of focus areas mentioned include oxalate production, handling, and balance in the body; oxalate transport and homeostasis; and how disruptions lead to stone formation and related disease.
What kinds of study types are supported under this R01 announcement?
The announcement indicates R01 projects may include basic laboratory science, clinical research, or epidemiological studies, as long as they align with the FOA's goals.
Does NIH signal a preference for any particular approach or style of research?
Yes. The FOA emphasizes "new and innovative approaches" and suggests interest in projects that go beyond incremental extensions of prior work. Examples mentioned include emerging technologies, novel model systems, improved biomarkers or diagnostics, and creative study designs to clarify risk, mechanisms of stone formation, and prevention of recurrence.
Is calcium oxalate stone disease treated as only a urology topic in this FOA?
No. The FOA frames calcium oxalate stone disease more broadly as a metabolic and kidney-related condition, where factors such as transporters, diet, gut handling of oxalate, genetic factors, and systemic physiology may all be relevant.
What CFDA program is this opportunity associated with?
The listing is associated with CFDA 93.847, described as "Diabetes, Digestive, and Kidney Diseases Extramural Research."
Is cost-sharing or matching required?
No. The opportunity explicitly states there is no cost-sharing or matching requirement, so applicants are not required to contribute non-federal funds as a condition of the award.
Which U.S. organizations are eligible to apply?
Eligibility is described as expansive and includes a wide range of U.S. public and private institutions and governmental entities, such as public and state-controlled institutions of higher education; private institutions of higher education; nonprofits (including those with and without 501(c)(3) status); small businesses; for-profit organizations other than small businesses; and various units of government (state, county, city/township, and special district governments), as well as independent school districts and public housing authorities/Indian housing authorities.
Are mission-serving and community-based organizations included in eligibility?
Yes. The FOA includes eligibility for institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also mentions faith-based and community-based organizations, regional organizations, and eligible federal agencies.
Are foreign organizations allowed to apply?
Yes. The opportunity states that non-U.S. entities (foreign organizations and foreign institutions) may apply.
Can non-U.S. components of U.S. organizations participate?
Yes. Non-U.S. components of U.S. organizations are described as eligible.
Are foreign components permitted under NIH policy for this FOA?
Yes. The opportunity indicates that foreign components (as defined by NIH policy) are permitted, which may matter for collaborations or research best conducted outside the United States.
When was this FOA posted?
The FOA was posted (and created) on December 14, 2012.
What were the closing dates and archive date for PA-13-043?
The opportunity had an original and current closing date of January 7, 2016, and an archive date of February 7, 2016.
Is PA-13-043 still active for new submissions?
No. Based on the closing and archive dates provided, the specific announcement is no longer active for new submissions under that exact FOA number and those dates.
Is the FOA still useful even though it is archived?
Yes. The description notes it can still be useful as a reference for NIH research priorities in oxalate biology and calcium oxalate stone disease and for identifying successor opportunities or related program announcements.
Where can applicants or readers find the official FOA text?
The FOA provides an NIH program page link: http://grants.nih.gov/grants/guide/pa-files/PA-13-043.html
Who is listed as the contact for technical or linking issues?
The contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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