Opportunity Information: Apply for PAR 14 273
Apply for PAR 14 273
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 3, 2014 and posted on Jul 3, 2014.
- Applicants must submit their applications by Sep 30, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Small businesses Private institutions of higher education Special district governments City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts State governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This NIH funding opportunity (PAR-14-273) supports exploratory, high-risk/high-impact research focused on understanding and ultimately reducing adverse outcomes associated with medically assisted reproduction. It targets both Assisted Reproductive Technologies (ART), such as IVF-related approaches, and Non-IVF Fertility Treatments (NIFT), which have been used even longer but are much less consistently tracked. The core motivation is that millions of children have been conceived through these methods worldwide, yet the field still lacks a clear, standardized picture of long-term health and developmental outcomes across different treatments, clinical practices, and patient populations. The announcement emphasizes that evaluating long-term biological, physical, developmental, and social outcomes in offspring is essential for weighing the risks and benefits of these procedures and for improving them.
A major problem highlighted in the announcement is the uneven quality and structure of existing data sources. For ART, some countries maintain national registries, but data collection methods differ widely and many registries do not capture long-term follow-up information, especially on health and development beyond the early years. For NIFT, the gap is even larger: despite long-standing use, there is generally no comparable national-level registry infrastructure worldwide. Because ART and NIFT include a wide range of techniques and clinical decision points, the announcement notes that outcomes may differ depending on the specific method used, how it is implemented, and the clinical context. It also underscores that the underlying causes of parental infertility could independently influence offspring outcomes, meaning research needs to disentangle effects of treatment from effects related to infertility itself.
The opportunity encourages projects that do two related things: first, investigate mechanisms that could explain adverse outcomes in children conceived through ART or NIFT; and second, develop improved methods or strategies to overcome or reduce those adverse outcomes. In practice, that can include innovative study designs to assess long-term outcomes, efforts to build or enhance registries that document ART and NIFT procedures in a more standardized way, and approaches that better link treatment details with longitudinal health and developmental data. The tone of the announcement is intentionally forward-looking: it is not only about documenting risks, but also about enabling better surveillance and generating actionable knowledge that could lead to safer, more effective reproductive care.
Mechanistically oriented work is particularly relevant because it can move the field beyond broad associations toward explanations of why certain adverse outcomes might occur. At the same time, the registry and long-term follow-up emphasis reflects a recognition that many important outcomes may not appear immediately at birth, and that differences in data standards across countries and clinics make it hard to compare findings or draw strong conclusions. The FOA is therefore positioned to stimulate new infrastructure and analytical approaches that improve comparability, quality, and completeness of information for both ART and NIFT.
Administratively, this is an NIH discretionary grant opportunity using the R21 mechanism, which is typically meant for early-stage, exploratory projects that may be more novel or higher risk than standard research grants. The maximum award ceiling listed is $200,000, and there is no cost-sharing or matching requirement. The funding activity falls under CFDA 93.865 (Child Health and Human Development Extramural Research), aligning it with NICHD-related priorities even though the agency name is listed broadly as the National Institutes of Health. The opportunity was posted July 3, 2014, with an original and current closing date of September 30, 2016, and an archive date of October 31, 2016, indicating it is no longer active but remains as a reference for the program’s goals and structure.
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations other than small businesses, and small businesses, as well as a wide range of government entities (city/township, county, state, special district, independent school districts, and public housing authorities). It also explicitly includes tribal governments and tribal organizations, U.S. territories or possessions, and a range of designated institution types such as HBCUs, Hispanic-serving institutions, AANAPISISs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations. Notably, the eligibility list also allows non-U.S. entities (foreign organizations) and regional organizations, reflecting the global nature of ART/NIFT practice and the value of international data and collaborations.
For applicants seeking the full archived announcement and detailed application instructions, NIH provided an additional information link through the NIH grants guide (PAR-14-273) and general support contacts through the NIH Office of Extramural Research webmaster email for technical access and linking issues.
Frequently Asked Questions (FAQs)
What is this NIH funding opportunity (PAR-14-273) about?
This NIH Funding Opportunity Announcement (FOA), PAR-14-273, supports exploratory, high-risk/high-impact research aimed at understanding and ultimately reducing adverse outcomes associated with medically assisted reproduction. It focuses on both Assisted Reproductive Technologies (ART) and Non-IVF Fertility Treatments (NIFT), with an emphasis on long-term health and developmental outcomes in offspring.
Which reproductive methods are included under the scope of this FOA?
The scope includes:
- Assisted Reproductive Technologies (ART), such as IVF-related approaches.
- Non-IVF Fertility Treatments (NIFT), which have been used for a long time but are less consistently tracked in standardized systems.
Why does the FOA emphasize long-term outcomes in children?
The announcement highlights that millions of children worldwide have been conceived through ART and NIFT, yet the field still lacks a clear, standardized understanding of long-term biological, physical, developmental, and social outcomes. Long-term follow-up is framed as essential for weighing risks and benefits and for improving the safety and effectiveness of these procedures.
What core problem is the FOA trying to address regarding data?
A major problem identified is the uneven quality and structure of existing data sources. For ART, some countries have registries, but collection methods vary widely and often do not include long-term follow-up. For NIFT, the gap is larger, with generally no comparable national registry infrastructure worldwide.
How do ART registries fall short, according to the announcement?
The FOA notes that while some national registries exist for ART, data collection is not standardized across countries and many registries do not capture long-term outcomes, especially beyond early childhood. This limits comparability and makes it harder to draw strong conclusions across settings.
Why is NIFT specifically highlighted as a tracking gap?
NIFT has been used even longer than many IVF-related approaches, but the FOA states it is much less consistently tracked. In general, there is no national-level registry infrastructure for NIFT worldwide comparable to what exists in some places for ART.
What kinds of research does the FOA encourage?
The opportunity encourages projects that do two related things:
- Investigate mechanisms that could explain adverse outcomes in children conceived through ART or NIFT.
- Develop improved methods or strategies to overcome or reduce those adverse outcomes.
Does the FOA support building or improving registries?
Yes. The FOA explicitly encourages efforts to build or enhance registries that document ART and NIFT procedures in a more standardized way, and approaches that better link treatment details with longitudinal health and developmental data.
What is meant by "mechanistically oriented" research in this FOA?
The announcement emphasizes mechanistic work because it can move the field beyond broad associations and toward explanations of why certain adverse outcomes might occur. This is positioned as a way to generate more actionable knowledge that could lead to safer, more effective reproductive care.
Why does the FOA mention that different methods and clinical practices can lead to different outcomes?
ART and NIFT include a wide range of techniques and clinical decision points. The FOA notes that outcomes may differ depending on which method is used, how it is implemented, and the clinical context in which care is delivered.
How does underlying infertility factor into the research questions?
The FOA underscores that the underlying causes of parental infertility could independently influence offspring outcomes. Because of this, research is expected to disentangle effects of treatment from effects related to infertility itself.
What NIH grant mechanism is used for this opportunity?
This FOA uses the NIH R21 mechanism, which is typically intended for early-stage, exploratory research projects that may be more novel or higher risk than standard research grants.
What is the maximum award amount listed?
The maximum award ceiling listed for this opportunity is $200,000.
Is there a cost-sharing or matching requirement?
No. The FOA indicates there is no cost-sharing or matching requirement.
Which CFDA program is associated with this funding activity?
The funding activity is listed under CFDA 93.865, described as Child Health and Human Development Extramural Research.
Is this opportunity associated with NICHD priorities?
Yes. The FOA aligns with NICHD-related priorities through CFDA 93.865, even though the agency is broadly listed as the National Institutes of Health.
When was the opportunity posted, and when did it close?
The FOA was posted on July 3, 2014. The original and current closing date listed is September 30, 2016. The archive date is October 31, 2016.
Is PAR-14-273 still active?
No. Based on the listed closing date and archive date, the opportunity is no longer active and remains available as an archived reference for the program's goals and structure.
What types of organizations are eligible to apply?
Eligibility is broad and includes:
- Public and private institutions of higher education
- Nonprofit organizations (with or without 501(c)(3) status)
- For-profit organizations other than small businesses
- Small businesses
- Government entities (city/township, county, state, special district, independent school districts, and public housing authorities)
- Tribal governments and tribal organizations
- U.S. territories or possessions
- Designated institution types (including HBCUs, Hispanic-serving institutions, AANAPISISs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions)
- Faith-based or community-based organizations
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility list explicitly includes non-U.S. entities (foreign organizations) and regional organizations, reflecting the global nature of ART and NIFT practice and the value of international data and collaborations.
Where can applicants find the full archived announcement and instructions?
NIH provided an additional information link through the NIH grants guide for PAR-14-273, where the archived announcement and application instructions can be accessed.
Who should be contacted for technical access or linking issues?
The FOA references general support contacts through the NIH Office of Extramural Research webmaster email for technical access and linking issues.
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Previous opportunity: Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R01)
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