Opportunity Information: Apply for PAR 14 272
Apply for PAR 14 272
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 3, 2014 and posted on Jul 3, 2014.
- Applicants must submit their applications by Sep 30, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Independent school districts County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Small businesses Public housing authorities/Indian housing authorities State governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This NIH R01 funding opportunity (PAR-14-272), titled "Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes," supports research focused on the long-term health and developmental effects of medically assisted reproduction. The central motivation is that Assisted Reproductive Technologies (ART) and non-IVF fertility treatments (NIFT) have been used for decades and have resulted in millions of births worldwide, but the field still lacks a clear, comprehensive picture of how these conception methods may shape offspring outcomes across childhood and later life. The announcement emphasizes that understanding both potential risks and potential benefits requires systematic study of long-term biological, physical, developmental, and social outcomes in children conceived through these approaches.
A major gap highlighted in the opportunity is the weakness and inconsistency of existing outcome data infrastructure. Many countries maintain registries that track children conceived through ART, but the data are not collected or analyzed in a uniform way, which makes cross-study comparisons difficult and limits the ability to draw strong conclusions. In addition, most registries do not capture long-term health and developmental information in a way that is detailed or sustained enough to answer questions about later outcomes. The situation is even more limited for NIFT, which has been used longer than ART but generally lacks national registry systems across the world, leaving large blind spots in understanding outcomes associated with non-IVF interventions.
The opportunity also points to the likelihood that outcomes are not uniform across all medically assisted reproduction. Differences may arise based on the specific ART or NIFT methods used, clinical approaches, and treatment protocols. It also notes that parental infertility itself, including the underlying causes of infertility, may contribute to offspring outcomes, meaning research needs to carefully separate the effects of treatment from the effects of the medical conditions that led families to use treatment in the first place. In practice, that framing encourages studies that can disentangle treatment-related factors (procedures, medications, laboratory conditions, embryo handling, timing, or other aspects of care) from confounding factors tied to parental health, genetics, age, and infertility diagnoses.
Administratively, this is a discretionary NIH grant using the R01 research project grant mechanism, and it falls under CFDA 93.865 (Child Health and Human Development Extramural Research), reflecting an emphasis on child health and development. The announcement was posted July 3, 2014, and the original and current closing date listed is September 30, 2016, with an archive date of October 31, 2016, indicating it is no longer active but remains a useful reference for the kind of research NIH sought to stimulate. The announcement specifies no cost sharing or matching requirement.
Eligibility is broad and includes many types of applicants across the public, nonprofit, academic, and private sectors. Eligible applicants include for-profit organizations (including small businesses), nonprofits with or without 501(c)(3) status, public and private institutions of higher education, federal agencies, state and local governments (including county, city or township, special district governments, and independent school districts), and public housing authorities/Indian housing authorities. It also explicitly includes a wide range of mission- and community-focused institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions, along with tribal governments and tribal organizations. Non-U.S. entities (foreign organizations), regional organizations, faith-based or community-based organizations, and U.S. territories or possessions are also listed among eligible applicants, underscoring NIH interest in diverse applicant pools and potentially multinational or comparative research.
Overall, the grant opportunity is designed to push the field beyond short-term perinatal endpoints and toward rigorous long-horizon evidence on how ART and NIFT relate to health trajectories and development. By encouraging mechanistic investigations and improved methods to overcome adverse outcomes, the announcement signals interest not only in documenting associations, but also in understanding why adverse outcomes may occur and how clinical or laboratory practices could be refined to reduce risk and improve long-term wellbeing for children conceived through medically assisted reproduction.
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The opportunity is titled "Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes."
What is the NIH FOA number for this opportunity?
The FOA number is PAR-14-272.
What grant mechanism does this opportunity use?
This is an NIH R01 research project grant opportunity.
What CFDA program is associated with this opportunity?
The opportunity falls under CFDA 93.865, Child Health and Human Development Extramural Research.
What is the main focus of the research supported by this opportunity?
The focus is on long-term health and developmental effects of medically assisted reproduction, including biological, physical, developmental, and social outcomes across childhood and later life.
Which conception approaches are included in the scope of this opportunity?
The scope includes Assisted Reproductive Technologies (ART) and non-IVF fertility treatments (NIFT).
Why is NIH emphasizing long-term outcomes for children conceived through ART and NIFT?
ART and NIFT have been used for decades and have resulted in millions of births worldwide, but the field still lacks a clear, comprehensive understanding of how these conception methods may shape outcomes across childhood and later life.
What kinds of outcomes does the FOA highlight as important to study?
The FOA highlights long-term biological, physical, developmental, and social outcomes, moving beyond short-term perinatal endpoints.
What major data or infrastructure gap does the opportunity identify?
It highlights weaknesses and inconsistencies in outcome data infrastructure, including non-uniform registry data collection and analysis and limited long-term tracking.
What limitations does the FOA note about ART registries?
While many countries maintain registries tracking children conceived through ART, the data are often not collected or analyzed uniformly, making cross-study comparisons difficult. Many registries also do not capture long-term health and developmental information in a detailed or sustained way.
What limitations does the FOA note about NIFT data sources?
NIFT has generally lacked national registry systems worldwide, creating major blind spots in understanding outcomes associated with non-IVF interventions.
Does the FOA suggest that outcomes may differ across different ART or NIFT methods?
Yes. The FOA notes outcomes may not be uniform and may vary depending on the specific ART or NIFT methods used, clinical approaches, and treatment protocols.
Why does the FOA emphasize separating treatment effects from parental infertility factors?
Because parental infertility itself, including underlying causes of infertility, may contribute to offspring outcomes. The FOA encourages research designs that disentangle effects of treatment from confounding factors tied to parental health, genetics, age, and infertility diagnoses.
What treatment-related factors does the FOA mention as important to disentangle in research?
The FOA points to treatment-related factors such as procedures, medications, laboratory conditions, embryo handling, timing, and other aspects of care.
Is the FOA interested only in documenting associations, or also in understanding mechanisms?
It is interested in both. The opportunity calls for mechanistic investigations and the development of new and improved methods to overcome adverse outcomes, not just documenting associations.
Is this funding opportunity still active?
No. The original and current closing date listed is September 30, 2016, and the archive date is October 31, 2016, indicating the opportunity is no longer active.
When was the announcement posted?
The announcement was posted on July 3, 2014.
Is there a cost sharing or matching requirement?
No. The announcement specifies there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes for-profit organizations (including small businesses), nonprofits (with or without 501(c)(3) status), public and private higher education institutions, federal agencies, state and local governments, and other listed entities.
Are small businesses and for-profit organizations eligible?
Yes. For-profit organizations, including small businesses, are listed as eligible applicants.
Are nonprofits required to have 501(c)(3) status to be eligible?
No. Nonprofits with or without 501(c)(3) status are listed as eligible applicants.
Are public and private colleges and universities eligible?
Yes. Public and private institutions of higher education are included among eligible applicants.
Are government entities eligible to apply?
Yes. Federal agencies, state governments, and local governments (including county, city or township, special district governments, and independent school districts) are listed as eligible.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments, tribal organizations, and tribally controlled colleges and universities are explicitly included among eligible applicants.
Are HBCUs and other minority-serving institutions eligible?
Yes. The FOA explicitly includes HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are listed among eligible applicants.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-U.S. entities (foreign organizations) and regional organizations are listed as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among eligible applicants.
Does the FOA encourage research that improves clinical or laboratory practices?
Yes. By emphasizing mechanisms underlying adverse outcomes and the development of improved methods to overcome them, the FOA signals interest in refining clinical or laboratory practices to reduce risk and improve long-term wellbeing.
What is the overall goal of this FOA in the field of medically assisted reproduction?
The overall goal is to push the field beyond short-term endpoints toward rigorous long-horizon evidence on how ART and NIFT relate to health trajectories and development, including understanding why adverse outcomes may occur and how to improve methods.
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| Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R21) Apply for PAR 14 273 Funding Number: PAR 14 273 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
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| In vivo Methods for Assessing Placental Development and Function (STTR) R41/R42 Apply for RFA HD 15 019 Funding Number: RFA HD 15 019 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $2,000,000 |
| Obstetric Fetal Pharmacology Research Centers (OPRC) (U54) Apply for RFA HD 14 013 Funding Number: RFA HD 14 013 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $4,800,000 |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R01) Apply for PA 14 312 Funding Number: PA 14 312 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R21) Apply for PA 14 311 Funding Number: PA 14 311 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R03) Apply for PA 14 313 Funding Number: PA 14 313 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $50,000 |
| NICHD Consortium for Research on Pediatric Trauma and Injury Prevention (R24) Apply for PAR 14 324 Funding Number: PAR 14 324 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $750,000 |
| Improving Health through Rehabilitation Robotic Technology (R43/R44) Apply for RFA HD 15 001 Funding Number: RFA HD 15 001 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R41) Apply for RFA HD 15 005 Funding Number: RFA HD 15 005 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R43) Apply for RFA HD 15 006 Funding Number: RFA HD 15 006 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (U54) Apply for RFA AR 15 002 Funding Number: RFA AR 15 002 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $1,000,000 |
| Biomarkers of Alzheimers Disease in Down Syndrome (R01) Apply for RFA AG 15 011 Funding Number: RFA AG 15 011 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $2,500,000 |
| Biomedical/Biobehavioral Research Administration Development (BRAD) Award (G11) Apply for PAR 14 333 Funding Number: PAR 14 333 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $85,000 |
| Consortium on Biomarker and Outcome Measures of Social Impairment for Use in Clinical Trials in Autism Spectrum Disorder (U19) Apply for RFA MH 15 800 Funding Number: RFA MH 15 800 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $5,250,000 |
| Studies in Neonatal and Pediatric Resuscitation (R01) Apply for PA 14 350 Funding Number: PA 14 350 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Studies in Neonatal and Pediatric Resuscitation (R03) Apply for PA 14 351 Funding Number: PA 14 351 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $50,000 |
| Studies in Neonatal and Pediatric Resuscitation (R21) Apply for PA 14 349 Funding Number: PA 14 349 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $275,000 |
| Pregnancy in Women with Disabilities (R01) Apply for PAR 14 354 Funding Number: PAR 14 354 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
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