Opportunity Information: Apply for RFA DK 14 001

  • The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "NIDDK Cooperative Hematology Specialized Core Centers (U54)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
  • This funding opportunity was created on Jul 3, 2014 and posted on Jul 3, 2014.
  • Applicants must submit their applications by Nov 19, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $4,745,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
  • Eligible applicants include: Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public and State controlled institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments County governments For profit organizations other than small businesses.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The NIDDK Cooperative Hematology Specialized Core Centers (U54) funding opportunity (RFA-DK-14-001) is a National Institutes of Health cooperative agreement designed to build and support national, multidisciplinary centers focused on nonmalignant blood disorders. The central idea is to strengthen the U.S. research ecosystem for benign hematology by concentrating advanced capabilities, specialized expertise, and shared infrastructure in dedicated centers that can serve a wider community of investigators. Rather than funding only individual research projects, this program emphasizes shared resources and coordinated activities that make many projects possible, faster, cheaper, and more reproducible across institutions.

A key purpose of the program is to increase resource sharing and active collaboration across the country. NIDDK is aiming to reduce duplication of expensive efforts by encouraging centers to centralize functions that are costly or technically demanding, such as preparing critical reagents, maintaining state-of-the-art equipment platforms, or running complex, multi-step molecular biology assays. By doing so, the Centers are expected to improve cost effectiveness and raise the quality and consistency of specialized services that individual labs may struggle to sustain on their own.

Each funded Center is required to have a defined structure that includes at least three scientific or technical Cores, a Pilot and Feasibility (PNF) program, and an Enrichment program. The Cores are meant to provide specialized services, technologies, reagents, or other shared capabilities that support multiple investigators and projects. The PNF program is intended to seed new ideas, launch early-stage studies, and help investigators generate preliminary data that can grow into larger, independently funded research programs. The Enrichment program is designed to strengthen the broader scientific environment around the Center, typically by supporting activities that build skills, community, and engagement, and by creating pathways for investigators to connect with the Center and each other.

Career development and workforce building are also built into the rationale for this initiative. By offering access to cutting-edge tools, centralized expertise, and a collaborative setting, the program is positioned as a national resource for scientists early in their careers who are entering the field of nonmalignant hematology research. In practice, this means the Centers are expected not only to operate high-end infrastructure, but also to create opportunities for learning, mentoring, and professional growth through the Center environment and its enrichment activities.

Because this is a U54 cooperative agreement, the relationship with NIDDK is intended to be interactive. Funded Centers will work in cooperation with NIDDK to facilitate collaborations and scientific interactions both within individual Centers and across the network of Centers, as well as with the broader research community. The cooperative model signals that NIH program staff may have a more active role than in typical investigator-initiated grants, particularly in encouraging coordination, sharing, and network-level impact.

From an administrative standpoint, the opportunity was posted July 3, 2014, with an application due date of November 19, 2014, and an archive date of December 20, 2014. The estimated total funding was listed as $4,745,000, with an award ceiling of $1,000,000. There was no cost sharing or matching requirement. The announcement falls under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), reflecting NIDDK’s role and the broader mission area even though the scientific focus here is nonmalignant hematology.

Eligibility is broad and includes many types of U.S.-based organizations, such as public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), state and local governments, tribal governments and tribal organizations, public housing authorities/Indian housing authorities, special district governments, small businesses, and certain for-profit entities (other than small businesses are listed as eligible). The announcement also highlights eligibility for various institution types and communities, including HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and U.S. territories or possessions. Foreign institutions and other non-U.S. entities are not eligible to apply, although non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.

Overall, this FOA is best understood as an infrastructure-and-collaboration driven Center program: it funds a coordinated hub of cores and developmental programs intended to accelerate and elevate nonmalignant hematology research nationwide, reduce costs through shared high-end resources, and build a stronger pipeline of investigators through structured pilot support and enrichment activities.

Frequently Asked Questions (FAQs)

What is the NIDDK Cooperative Hematology Specialized Core Centers (U54) funding opportunity?

It is a National Institutes of Health (NIH) cooperative agreement funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to build and support national, multidisciplinary centers focused on nonmalignant (benign) blood disorders. The opportunity is identified as RFA-DK-14-001.

What is the main goal of this program?

The main goal is to strengthen the U.S. research ecosystem for nonmalignant hematology by concentrating advanced capabilities, specialized expertise, and shared infrastructure in dedicated centers that can serve a broader community of investigators.

How is this different from a typical research grant that funds individual projects?

Instead of primarily funding individual stand-alone research projects, this program emphasizes shared resources and coordinated activities (such as scientific/technical cores and developmental programs) that enable multiple research projects to happen more efficiently, at lower cost, and with improved reproducibility across institutions.

What does the program mean by resource sharing and collaboration?

NIDDK is aiming to increase national resource sharing and active collaboration by encouraging centers to centralize functions that are expensive or technically demanding. This approach is intended to reduce duplication of costly efforts and make specialized services broadly available.

What types of centralized functions are centers expected to provide?

Examples mentioned include preparing critical reagents, maintaining state-of-the-art equipment platforms, and running complex, multi-step molecular biology assays. More broadly, cores are expected to provide specialized services, technologies, reagents, or shared capabilities that support multiple investigators and projects.

What are the required structural components of a funded Center?

Each funded Center is required to include at least three scientific or technical Cores, a Pilot and Feasibility (PNF) program, and an Enrichment program.

What are the Cores and what do they do?

Cores are scientific or technical components that provide shared services, specialized technologies, reagents, or other advanced capabilities intended to support multiple investigators and multiple projects, rather than serving only a single lab or a single study.

What is the Pilot and Feasibility (PNF) program?

The PNF program is intended to seed new ideas and launch early-stage studies, helping investigators generate preliminary data that can develop into larger, independently funded research programs.

What is the Enrichment program?

The Enrichment program is designed to strengthen the broader scientific environment around the Center. It typically supports activities that build skills, community, and engagement, and helps create pathways for investigators to connect with the Center and with each other.

Does the program include career development or workforce-building goals?

Yes. The opportunity explicitly ties the Center model to career development and workforce building by positioning the centers as national resources for scientists early in their careers entering nonmalignant hematology research. The centers are expected to create opportunities for learning, mentoring, and professional growth through the Center environment and enrichment activities.

What does it mean that this is a U54 cooperative agreement?

A U54 cooperative agreement is intended to be interactive. Funded Centers will work in cooperation with NIDDK to facilitate collaborations and scientific interactions within Centers, across the network of Centers, and with the broader research community. This cooperative model indicates NIH program staff may have a more active role than in typical investigator-initiated grants, particularly around coordination, sharing, and network-level impact.

Who is the funding agency and what area does CFDA 93.847 cover?

The funding agency is NIDDK, part of NIH. The announcement is under CFDA 93.847, titled "Diabetes, Digestive, and Kidney Diseases Extramural Research," reflecting NIDDK's mission area even though the scientific focus of this opportunity is nonmalignant hematology.

When was this opportunity posted and when were applications due?

The opportunity was posted on July 3, 2014. The application due date was November 19, 2014.

What is the archive date and what does it indicate?

The archive date was December 20, 2014. Based on the information provided, this indicates the announcement was archived after the submission window associated with the listed due date.

How much funding was available and what was the award ceiling?

The estimated total funding was $4,745,000, and the award ceiling was $1,000,000.

Is cost sharing or matching required?

No. The opportunity states there was no cost sharing or matching requirement.

What types of organizations are eligible to apply?

Eligibility is broad and includes many U.S.-based organizations, including public and private institutions of higher education; nonprofits (with and without 501(c)(3) status); state and local governments; tribal governments and tribal organizations; public housing authorities/Indian housing authorities; special district governments; small businesses; and certain for-profit entities (including other-than-small-business for-profit entities, as listed).

Are minority-serving institutions and community-based organizations included in eligibility?

Yes. The announcement highlights eligibility for various institution types and communities, including HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and U.S. territories or possessions.

Are foreign institutions eligible to apply?

No. Foreign institutions and other non-U.S. entities are not eligible to apply, based on the information provided.

Can a U.S. organization include non-domestic or foreign components?

Yes. Non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.

What research area does the Center program focus on?

The program focuses on nonmalignant (benign) blood disorders and is intended to advance research capabilities and collaboration in benign hematology.

What is the overall program concept in plain terms?

This is an infrastructure-and-collaboration-driven Center program. It funds coordinated hubs with multiple cores plus pilot and enrichment activities, with the aim of accelerating nonmalignant hematology research nationwide, reducing costs by sharing high-end resources, improving consistency of specialized services, and strengthening the pipeline of investigators through pilot support and enrichment activities.

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