Opportunity Information: Apply for PA 07 312
Apply for PA 07 312
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mental Health Consequences Of Violence And Trauma (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Dec 5, 2008 and posted on Jan 18, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Independent school districts Special district governments State governments County governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Small businesses Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Mental Health Consequences of Violence and Trauma (R01) funding opportunity (PA-07-312) is a National Institutes of Health program led by the National Institute of Mental Health (NIMH) that supports investigator-initiated research on how exposure to violence and traumatic experiences contributes to mental health problems, and how those problems can be prevented, identified earlier, and treated more effectively. The core aim is to strengthen scientific understanding of the causes and developmental pathways (etiology) of trauma- and violence-related psychopathology while also encouraging practical work that improves interventions, services, and prevention strategies for people and communities affected by trauma.
A central theme of the announcement is a strong preference for interdisciplinary research that connects multiple levels of analysis rather than focusing on only one domain. NIMH highlights projects that integrate psychological processes with neurobiological and genetic factors, with the goal of building better risk models for psychopathology after trauma and violence. In practice, this means studies might combine clinical assessment with biological measures and real-world behavioral data to explain why some individuals develop conditions such as PTSD, depression, anxiety, substance use problems, or other trauma-linked outcomes, while others show resilience. The opportunity also emphasizes the use of modern scientific tools and methods, including ecological assessment approaches (for example, capturing symptoms, stress, and context in daily life), neuroimaging methods to examine brain structure and function, and genomic or molecular approaches (the announcement references microarrays) that may help identify biological signatures related to risk or recovery.
Another major priority is the identification of markers that can predict who is most likely to develop significant mental health problems following violence or trauma. NIMH signals interest in highly predictive indicators of pathology that could improve diagnostics, screening, or clinical decision-making. This includes efforts to improve how trauma-related disorders are detected and categorized, and to translate basic findings from behavioral science and neuroscience into applied clinical tools. In other words, the announcement is not only about understanding mechanisms in the lab; it also encourages bridging from foundational research on risk and resilience into real interventions that can be tested and implemented.
On the intervention side, the FOA supports studies that develop and evaluate treatments, preventive approaches, and service-delivery strategies tailored to trauma- and violence-related mental health needs. A specific concern is how to deliver effective care in settings where specialty mental health providers may not be readily available. The announcement calls attention to non-specialty systems such as primary care, where mental health services may need to be provided or coordinated. That focus makes space for research on models of care integration, referral pathways, stepped-care approaches, workforce strategies, and other service innovations that could realistically expand access to evidence-based trauma care.
In terms of award structure, this opportunity uses the NIH Research Project Grant (R01) mechanism, which is typically intended for well-developed projects with substantial scope. The announcement notes that it runs alongside related funding opportunities with similar scientific goals but different grant mechanisms: an R03 small grant (PA-07-313), an R21 exploratory/developmental grant (PA-07-314), and an R34 mechanism for exploratory grants focused on mental health interventions and services (PAR-07-315). Applicants choosing the R01 route should generally be prepared to propose a more mature research plan, with strong preliminary rationale and a clear strategy for producing impactful findings.
Funding decisions under PA-07-312 depend on the availability of funds and the quality and number of applications received, and the announcement does not promise a fixed number of awards. The opportunity is categorized as discretionary and falls under the health funding activity category, with CFDA number 93.242 (Mental Health Research Grants). There is no cost sharing or matching requirement, which is consistent with many NIH research grants.
Eligibility is broad and includes many types of domestic organizations such as state, county, city or township governments; public and private institutions of higher education; nonprofits (including those with and without 501(c)(3) status, other than universities); for-profit organizations (including small businesses and other for-profits); independent school districts; special district governments; public housing authorities/Indian housing authorities; and Native American tribal governments (federally recognized) as well as other tribal organizations. The FOA also states that foreign institutions are eligible to apply, that eligible federal agencies may apply, and that faith-based or community-based organizations can apply, reflecting an intent to support trauma and violence research across many institutional settings and community contexts.
Administratively, the FOA was posted on January 18, 2007, and uses multiple receipt dates (meaning applications are accepted on recurring NIH due dates rather than a single deadline). The full announcement was historically hosted on the NIH grants guide website (PA-07-312), and the NIH Office of Extramural Research (OER) webmaster contact is provided for access or linking issues.
Frequently Asked Questions (FAQs): The Mental Health Consequences of Violence and Trauma (R01) - PA-07-312
What is PA-07-312?
PA-07-312 is an NIH Funding Opportunity Announcement (FOA) titled "The Mental Health Consequences of Violence and Trauma (R01)". It is a program led by the National Institute of Mental Health (NIMH) to support investigator-initiated research on how exposure to violence and traumatic experiences contributes to mental health problems, and how those problems can be prevented, identified earlier, and treated more effectively.
Which agency leads this funding opportunity?
The opportunity is led by the National Institute of Mental Health (NIMH), part of the National Institutes of Health (NIH).
What is the main purpose of this FOA?
The core aim is to strengthen scientific understanding of the causes and developmental pathways (etiology) of trauma- and violence-related psychopathology, while also encouraging practical work that improves interventions, services, and prevention strategies for people and communities affected by trauma.
What kinds of mental health outcomes are relevant to this FOA?
This FOA is focused on trauma- and violence-linked mental health problems. Examples mentioned include PTSD, depression, anxiety, substance use problems, and other trauma-linked outcomes, including resilience (why some individuals do not develop significant psychopathology following trauma).
Does the FOA emphasize basic research, applied research, or both?
Both. The FOA encourages research that advances mechanistic understanding of risk and resilience (including etiology and developmental pathways) and also supports research designed to improve prevention, early identification, treatment, interventions, and services.
What is meant by "interdisciplinary" in this announcement?
NIMH expresses a strong preference for research that integrates multiple levels of analysis rather than staying within a single domain. That includes connecting psychological processes with neurobiological and genetic factors to build better risk models for psychopathology after trauma and violence.
Are projects that focus on only one domain (for example, only psychological or only biological) encouraged?
The announcement signals a preference for studies that connect multiple levels of analysis. Projects are highlighted as especially responsive when they integrate psychological, neurobiological, and genetic factors instead of focusing narrowly on one domain.
What kinds of scientific tools and methods does the FOA mention?
The FOA highlights modern tools and methods, including:
- Ecological assessment approaches (capturing symptoms, stress, and context in daily life)
- Neuroimaging methods to examine brain structure and function
- Genomic or molecular approaches, including microarrays, to identify biological signatures related to risk or recovery
What types of measures might be combined in a competitive study?
The announcement describes studies that may combine clinical assessment with biological measures and real-world behavioral data, aiming to explain differences in outcomes such as vulnerability versus resilience following trauma or violence exposure.
Is identifying predictors or markers of post-trauma psychopathology a priority?
Yes. A major priority is the identification of markers that can predict who is most likely to develop significant mental health problems after violence or trauma. NIMH notes interest in highly predictive indicators that could improve diagnostics, screening, or clinical decision-making.
Does the FOA support work to improve diagnosis and categorization of trauma-related disorders?
Yes. The FOA includes interest in improving how trauma-related disorders are detected and categorized, and in translating findings from behavioral science and neuroscience into applied clinical tools.
Is the FOA only focused on lab-based research?
No. The FOA explicitly encourages bridging from foundational research on mechanisms of risk and resilience into real interventions that can be tested and implemented.
What kinds of intervention research are supported?
The FOA supports studies that develop and evaluate treatments, preventive approaches, and service-delivery strategies tailored to trauma- and violence-related mental health needs.
Does the FOA address how to deliver care when specialty mental health providers are limited?
Yes. A specific concern is how to deliver effective care in settings where specialty mental health providers may not be readily available. The FOA highlights interest in non-specialty systems such as primary care, where services may need to be provided or coordinated.
What types of service-delivery and access strategies are relevant?
The announcement makes space for research on practical service innovations, including:
- Models of care integration
- Referral pathways
- Stepped-care approaches
- Workforce strategies
- Other approaches that could expand access to evidence-based trauma care
What grant mechanism is used for PA-07-312?
PA-07-312 uses the NIH Research Project Grant (R01) mechanism, typically intended for well-developed projects with substantial scope.
Are there related opportunities with different NIH mechanisms?
Yes. The announcement notes related FOAs with similar scientific goals but different grant mechanisms:
- R03 small grant: PA-07-313
- R21 exploratory/developmental grant: PA-07-314
- R34 exploratory grants focused on mental health interventions and services: PAR-07-315
How does an R01 application differ from those other mechanisms, based on the FOA description?
The FOA indicates that applicants choosing the R01 route should generally be prepared to propose a more mature research plan with substantial scope, supported by a strong preliminary rationale and a clear strategy for producing impactful findings.
Is there a guaranteed number of awards?
No. The FOA does not promise a fixed number of awards. Funding decisions depend on the availability of funds and the quality and number of applications received.
What funding category does this opportunity fall under?
The opportunity is categorized as discretionary and falls under the health funding activity category.
What is the CFDA number associated with this FOA?
The CFDA number listed is 93.242, titled Mental Health Research Grants.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many types of organizations, including:
- State, county, city, or township governments
- Public and private institutions of higher education
- Nonprofits (with and without 501(c)(3) status, other than universities)
- For-profit organizations (including small businesses and other for-profits)
- Independent school districts
- Special district governments
- Public housing authorities/Indian housing authorities
- Native American tribal governments (federally recognized) and other tribal organizations
- Foreign institutions
- Eligible federal agencies
- Faith-based and community-based organizations
Are foreign institutions allowed to apply?
Yes. The FOA states that foreign institutions are eligible to apply.
Can for-profit entities apply?
Yes. The FOA includes for-profit organizations among eligible applicants, including small businesses and other for-profits.
Can faith-based or community-based organizations apply?
Yes. The FOA explicitly notes that faith-based and community-based organizations can apply.
When was this FOA posted?
The FOA was posted on January 18, 2007.
Is there a single deadline or multiple due dates?
The FOA uses multiple receipt dates, meaning applications are accepted on recurring NIH due dates rather than one single deadline.
Where was the full announcement hosted?
The full announcement was historically hosted on the NIH grants guide website under the identifier PA-07-312.
Who is listed for technical issues related to access or linking?
The opportunity notes the NIH Office of Extramural Research (OER) webmaster contact for access or linking issues.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 312) also looked into and applied for these:
| Funding Opportunity |
|---|
| Mental Health Consequences of Violence and Trauma (R03) Apply for PA 07 313 Funding Number: PA 07 313 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| Mental Health Consequences Of Violence And Trauma (R34) Apply for PAR 07 315 Funding Number: PAR 07 315 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Mental Health Consequences Of Violence And Trauma (R21) Apply for PA 07 314 Funding Number: PA 07 314 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Stress Management Interventions to Reduce Risk of Coronary Artery Disease (R01) Apply for PA 07 322 Funding Number: PA 07 322 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Hyperglycemic Exacerbation of Ischemia/Reperfusion Injury after Ischemic Insult (R01) Apply for PA 07 323 Funding Number: PA 07 323 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Alcohol Use Disorders Treatment, Services Research, and Recovery (R03) Apply for PA 07 215 Funding Number: PA 07 215 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pilot and Feasibility Studies on Oral Health Promotion Research across the Life Span (R21) Apply for PA 07 223 Funding Number: PA 07 223 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Planning Grant for Oral Health Promotion across the Life Span (R21) Apply for PAR 07 224 Funding Number: PAR 07 224 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Oral Health Promotion Research across the Lifespan (R01) Apply for PA 07 225 Funding Number: PA 07 225 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| HIV Treatment Adherence Research (R34) Apply for PAR 07 341 Funding Number: PAR 07 341 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Collaborative Neurological Sciences (CNS) Award (S11) Apply for PAR 07 357 Funding Number: PAR 07 357 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Molecular Mechanisms of Development and Reversal of Alcohol Induced Liver Fibrosis (R01) Apply for PA 07 360 Funding Number: PA 07 360 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Molecular Mechanisms of Development and Reversal of Alcohol Induced Liver Fibrosis (R21) Apply for PA 07 361 Funding Number: PA 07 361 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIBIB Research Revisions to Promote Clinical Resident Research Experiences (Revisions to Currently Active NIBIB R01 and R37 Grants) Apply for PAR 07 363 Funding Number: PAR 07 363 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
| Grants for Basic Research in Glomerular Diseases (R01) Apply for PA 07 367 Funding Number: PA 07 367 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Simian Models For The Oral Biology Of HIV Infection And AIDS Related Oral Complications (R21) Apply for PA 07 369 Funding Number: PA 07 369 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Implicating Noncoding RNAs in the Genetics of Mental Disorders (R01) Apply for PA 07 370 Funding Number: PA 07 370 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Implicating Noncoding RNAs in the Genetics of Mental Disorders (Collaborative R01) Apply for PA 07 371 Funding Number: PA 07 371 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Implicating Noncoding RNAs in the Genetics of Mental Disorders (R21) Apply for PA 07 372 Funding Number: PA 07 372 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Investigator Initiated Multi Site Clinical Trials (R01) Apply for PAR 07 373 Funding Number: PAR 07 373 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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