Opportunity Information: Apply for PA 07 305
Apply for PA 07 305
- The National Institutes of Health in the environment health sector is offering a public funding opportunity titled "Neurobiology of Migraine (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Dec 5, 2008 and posted on Jan 18, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Special district governments County governments For profit organizations other than small businesses Public and State controlled institutions of higher education.
- Foreign institutions are eligible to apply.
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Opportunity Summary:
The Neurobiology of Migraine (R01) opportunity (Funding Opportunity Number PA-07-305) is a National Institutes of Health (NIH) program announcement led by the National Institute of Neurological Disorders and Stroke (NINDS). It invites research project grant (R01) applications focused on migraine as a neurological disorder, with an emphasis on innovative studies that deepen understanding of the neurobiological mechanisms driving migraine across its different phases. The core goal is to move beyond descriptive observations and into mechanistic explanations of what is happening in the nervous system before, during, and after migraine attacks, including how biological modulators and inherited factors contribute to migraine susceptibility and expression.
Scientifically, the announcement highlights several priority themes. A central focus is the neurobiology underlying the phases of migraine, which commonly include premonitory/prodrome changes, aura in some patients, the headache phase, and postdrome recovery. The FOA is also explicit about interest in neuromodulators, especially sex hormones, recognizing that migraine risk and clinical patterns often differ by sex and can fluctuate with hormonal transitions such as puberty, the menstrual cycle, pregnancy, and menopause. In parallel, it calls attention to genetic influences in migraine pathophysiology, signaling strong interest in projects that link genetic variation to neural circuitry, signaling pathways, neurotransmission, brain excitability, sensory processing, or other biological processes relevant to migraine.
From a funding and structure standpoint, this FOA uses the NIH Research Project Grant (R01) mechanism, which is generally intended for mature, hypothesis-driven projects with well-developed aims, solid preliminary data when appropriate, and a clear plan for producing definitive, publishable outcomes. The announcement notes that it runs in parallel with a companion opportunity of the same scientific scope using the R21 mechanism (PA-07-306), which is typically geared toward earlier-stage, higher-risk exploratory work. Applicants should interpret that pairing as NIH offering two entry points into the same research space: R01 for more established research plans and R21 for more preliminary or proof-of-concept directions.
The number of awards and total funds are not fixed in advance. Instead, the FOA states that awards depend on the availability of funds and the receipt of a sufficient number of high-quality, meritorious applications. In practice, that means funding decisions will be shaped by annual NIH appropriations, NINDS priorities, and peer-review outcomes, rather than a guaranteed award count.
Eligibility is broad and includes many types of domestic applicants, such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit entities (including small businesses and other for-profits), and various units of local government (for example counties, cities/townships, special districts, independent school districts, and public housing/Indian housing authorities). Importantly, foreign institutions are explicitly eligible to apply, which widens the applicant pool to international research organizations capable of conducting strong migraine neuroscience research. The FOA indicates there is no cost-sharing or matching requirement.
Administratively, the opportunity is categorized as discretionary funding and uses the grant funding instrument. It lists multiple receipt dates rather than one single deadline, directing applicants to the full announcement for the specific submission cycles and details. While the posting date is January 18, 2007, the record also includes later administrative dates and an archive date, which generally indicates the announcement was time-limited and eventually retired from active use; applicants would need to confirm whether a current, active successor FOA exists if applying today, but the summary here reflects what this specific PA described.
Finally, the FOA provides a standard NIH support contact route for technical access issues through the NIH Office of Extramural Research (OER) webmaster. For anyone developing an application concept, the practical takeaway is that NINDS was seeking mechanistic, neuroscience-forward migraine research that connects migraine phases to underlying neural processes, explicitly incorporating how sex hormones and genetic factors shape migraine biology, and that it offered the full R01 framework for projects designed to deliver substantial, well-supported advances in the field.
Frequently Asked Questions (FAQs): The Neurobiology of Migraine (R01) - PA-07-305
1) What is the name and funding opportunity number of this grant opportunity?
The opportunity is titled The Neurobiology of Migraine (R01) and the Funding Opportunity Number is PA-07-305.
2) Which agency and NIH institute lead this program announcement?
This is a National Institutes of Health (NIH) program announcement led by the National Institute of Neurological Disorders and Stroke (NINDS).
3) What type of grant mechanism does this opportunity use?
This opportunity uses the NIH Research Project Grant (R01) mechanism.
4) What is the overall scientific goal of PA-07-305?
The main goal is to support innovative research that explains the neurobiological mechanisms driving migraine as a neurological disorder, moving beyond descriptive findings to mechanistic explanations of what is happening in the nervous system before, during, and after migraine attacks.
5) What does "mechanistic" migraine research mean in the context of this FOA?
In this announcement, mechanistic research means studies designed to explain how and why migraine-related nervous system changes occur across the migraine cycle, including how modulators and inherited factors contribute to migraine susceptibility and expression, rather than only documenting symptoms or correlations.
6) Which migraine phases are specifically emphasized?
The announcement emphasizes the neurobiology across migraine phases that commonly include:
- Premonitory/prodrome changes
- Aura (in some patients)
- The headache phase
- Postdrome recovery
7) Does the FOA encourage research that examines what happens before and after the headache itself?
Yes. A core focus is understanding what happens in the nervous system before, during, and after migraine attacks, including phases such as prodrome and postdrome.
8) Are sex hormones and other neuromodulators considered priority topics?
Yes. The FOA explicitly highlights interest in neuromodulators, especially sex hormones, reflecting that migraine risk and clinical patterns often differ by sex and may fluctuate during hormonal transitions.
9) Which hormonal transitions are mentioned as relevant to migraine research under this opportunity?
The announcement points to hormonal transitions such as puberty, the menstrual cycle, pregnancy, and menopause as biologically relevant contexts for understanding migraine variability and susceptibility.
10) Does this program announcement prioritize genetic factors in migraine?
Yes. The FOA calls attention to genetic influences in migraine pathophysiology and signals strong interest in projects that connect genetic variation to underlying neurobiology.
11) What kinds of neurobiological links to genetics are described as relevant?
The FOA notes interest in linking genetic variation to areas such as:
- Neural circuitry
- Signaling pathways
- Neurotransmission
- Brain excitability
- Sensory processing
- Other biological processes relevant to migraine
12) Is this opportunity intended for mature projects or early exploratory studies?
This FOA is an R01, which is generally intended for mature, hypothesis-driven projects with well-developed aims and a clear plan for producing definitive, publishable outcomes. The summary also notes that solid preliminary data may be expected when appropriate.
13) Is there a related NIH opportunity for more exploratory migraine research?
Yes. This R01 announcement runs in parallel with a companion opportunity of the same scientific scope using the R21 mechanism: PA-07-306, which is typically geared toward earlier-stage, higher-risk exploratory work.
14) How should applicants interpret the relationship between PA-07-305 (R01) and PA-07-306 (R21)?
The pairing indicates NIH provided two entry points into the same research space: an R01 path for more established research plans and an R21 path for more preliminary or proof-of-concept directions.
15) How many awards will be made under this FOA?
The number of awards is not fixed in advance. Awards depend on the availability of funds and the receipt of a sufficient number of high-quality, meritorious applications.
16) Is the total amount of funding predetermined?
No. The FOA indicates total funding is not predetermined and will depend on appropriations, NINDS priorities, and peer-review outcomes.
17) What does it mean that this is discretionary funding using a grant instrument?
Based on the description provided, the opportunity is categorized as discretionary funding and uses the grant funding instrument, meaning awards are competitively made based on merit review and programmatic considerations rather than being guaranteed or formula-based.
18) What types of organizations are eligible to apply?
Eligibility is broad and includes many types of applicants, including:
- Public and private institutions of higher education
- Nonprofit organizations (with or without 501(c)(3) status)
- For-profit entities (including small businesses and other for-profits)
- Units of local government (including counties, cities/townships, special districts, independent school districts, and public housing/Indian housing authorities)
19) Are foreign (non-U.S.) institutions eligible to apply?
Yes. The FOA explicitly states that foreign institutions are eligible, allowing international research organizations to apply.
20) Is cost sharing or matching required?
No. The FOA indicates there is no cost-sharing or matching requirement.
21) Are there multiple deadlines or a single submission deadline?
The opportunity lists multiple receipt dates rather than a single deadline and directs applicants to the full announcement for the specific submission cycles and details.
22) When was this FOA posted, and is it still active?
The posting date listed is January 18, 2007. The record also includes later administrative dates and an archive date, which generally indicates the announcement was time-limited and eventually retired from active use. Anyone looking to apply now would need to confirm whether there is a current, active successor FOA.
23) What is the practical research takeaway for applicants considering this announcement?
NINDS was seeking mechanistic, neuroscience-forward migraine research that connects migraine phases to underlying neural processes and explicitly considers how sex hormones and genetic factors shape migraine biology, using the R01 framework for substantial, well-supported advances.
24) Who is listed as the contact for technical access issues related to the FOA?
The FOA provides a standard NIH support route for technical access issues through the NIH Office of Extramural Research (OER) webmaster.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 305) also looked into and applied for these:
| Funding Opportunity |
|---|
| Neurobiology of Migraine (R21) Apply for PA 07 306 Funding Number: PA 07 306 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Nutrition and Alcohol Related Health Outcomes (R21) Apply for PA 07 405 Funding Number: PA 07 405 Agency: National Institutes of Health Category: Environment Health Funding Amount: $200,000 |
| Short Term Career Development Award in the Environmental Health Sciences for Established Investigators (K18) Apply for PAR 07 402 Funding Number: PAR 07 402 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Research to Action Assessing and Addressing Community Exposures to Environmental Contaminants (R21) Apply for RFA ES 09 001 Funding Number: RFA ES 09 001 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Environmental Health Sciences Core Center Grants (P30) Apply for RFA ES 09 002 Funding Number: RFA ES 09 002 Agency: National Institutes of Health Category: Environment Health Funding Amount: $500,000 |
| Childrens Environmental Health and Disease Prevention Research Centers (P01) Apply for RFA ES 08 002 Funding Number: RFA ES 08 002 Agency: National Institutes of Health Category: Environment Health Funding Amount: $900,000 |
| Childrens Environmental Health and Disease Prevention Research Centers Formative Centers (P20) Apply for RFA ES 08 004 Funding Number: RFA ES 08 004 Agency: National Institutes of Health Category: Environment Health Funding Amount: $500,000 |
| Short Term Career Development Award in the Environmental Health Sciences for Established Investigators (K18) Apply for PAR 09 090 Funding Number: PAR 09 090 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
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| Mechanism for Time Sensitive Research Opportunities in Environmental Health Sciences (R21) Apply for PAR 10 084 Funding Number: PAR 10 084 Agency: National Institutes of Health Category: Environment Health Funding Amount: $200,000 |
| Parkinsons Disease Data Organizing Center PD DOC (U24) Apply for RFA NS 11 001 Funding Number: RFA NS 11 001 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Outstanding New Environmental Scientist Award (ONES) (R01) Apply for RFA ES 10 004 Funding Number: RFA ES 10 004 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
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