Opportunity Information: Apply for PA 07 303
Apply for PA 07 303
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Novel Approaches to Enhance Animal Stem Cell Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.389 National Center for Research Resources 93.396 Cancer Biology Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jan 18, 2007.
- Applicants must submit their applications by Jan 2, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) City or township governments County governments Public housing authorities/Indian housing authorities Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts Public and State controlled institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification).
- Foreign institutions are eligible to apply.
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Opportunity Summary:
The NIH funding opportunity PA 07 303, titled "Novel Approaches to Enhance Animal Stem Cell Research (R01)," supports research projects aimed at strengthening the use of nonhuman animal stem cells as experimental model systems. The main goal is to push the field beyond routine stem cell work by encouraging genuinely innovative ways to find, isolate, and study stem cells in biomedical research animal species. A central emphasis is on totipotent and multipotent stem cells, including efforts to identify where these cells exist in animal tissues, how to reliably obtain them, and how to define their properties in ways that make them more useful and reproducible for research.
The FOA is especially focused on developing new approaches, tools, and enabling technologies. That includes methods to isolate and enrich rare stem cell populations, strategies to characterize them at molecular and functional levels, and the creation of reagents or techniques that can separate stem cells from surrounding or closely related cell types. In practical terms, strong applications would often involve advances in cell sorting or selection, lineage and potency assessment, improved markers and assays, new culture conditions that preserve potency, and other platform-type innovations that help the broader research community study animal stem cells more effectively. The intention is to improve animal stem cell systems so they can better model biology and disease processes, support translational research, and complement other experimental platforms, without relying on human subjects.
A key restriction is that studies involving human subjects are not allowed under this announcement. The work must be based on nonhuman biomedical research animal models, keeping the scientific scope squarely on animal stem cell biology and the development of model systems, reagents, and methodologies for those systems. Applicants proposing any human-subjects component would not fit the eligibility requirements of this FOA.
This opportunity uses the NIH R01 mechanism, meaning it is intended for mature, hypothesis-driven or technology-developing research projects with a scope and timeline appropriate for an R01 award. NIH notes that this FOA runs in parallel with a separate announcement of identical scientific scope that uses the R21 mechanism (PA 07 304), which is typically more exploratory and shorter-term. Applicants would choose the mechanism that best matches the maturity, risk level, and development stage of their proposed work.
NIH does not specify a fixed budget amount per award or a guaranteed number of awards. Instead, award size and project duration are expected to vary depending on what is proposed, and the total number of awards and total dollars committed will depend on factors such as the mix of applications received, scientific merit, project periods requested, and overall costs. There is no cost sharing or matching requirement.
Eligibility is broad and includes many types of domestic applicants, such as public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, excluding higher education where specified), for-profit organizations (including small businesses and other for-profits), independent school districts, and various local and tribal government entities. Importantly, foreign institutions are also eligible to apply, which opens the competition to international research organizations with relevant expertise and animal model capabilities.
The opportunity was posted January 18, 2007, with multiple receipt dates listed in the full announcement, and it ultimately archived February 1, 2010. The funding instrument is a grant, the agency is the National Institutes of Health, and the program is associated with multiple CFDA numbers spanning environmental health, mental health, addiction, cancer biology, child health, aging, vision research, and related biomedical areas, reflecting the broad applicability of improved animal stem cell models across NIH mission areas. The full announcement is available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-07-303.html (spacing corrected from the source listing).
FAQs: NIH PA-07-303 - Novel Approaches to Enhance Animal Stem Cell Research (R01)
What is the title and number of this NIH funding opportunity?
The funding opportunity is NIH PA-07-303, titled "Novel Approaches to Enhance Animal Stem Cell Research (R01)."
What is the main purpose of PA-07-303?
The purpose is to support research projects that strengthen the use of nonhuman animal stem cells as experimental model systems. The emphasis is on pushing the field beyond routine stem cell work by encouraging innovative ways to find, isolate, and study stem cells in biomedical research animal species.
What types of stem cells are emphasized in this FOA?
The FOA places central emphasis on totipotent and multipotent stem cells, including identifying where these cells exist in animal tissues, how to reliably obtain them, and how to define their properties in ways that improve usefulness and reproducibility for research.
What kinds of research activities does the FOA encourage?
It encourages development of new approaches, tools, and enabling technologies for animal stem cell research. Examples described in the opportunity include methods to isolate and enrich rare stem cell populations, strategies to characterize stem cells at molecular and functional levels, and development of reagents or techniques to separate stem cells from surrounding or closely related cell types.
What would be considered a strong application based on the description?
Applications are described as strong when they include platform-type innovations that enable broader and more effective study of animal stem cells. The FOA highlights advances such as improved cell sorting or selection, lineage and potency assessment, improved markers and assays, and new culture conditions that preserve potency.
Is this opportunity focused on creating tools and technologies, or only on biological discovery?
The FOA is especially focused on developing new approaches, tools, and enabling technologies, including reagents, techniques, and methodologies that improve how animal stem cell systems are identified, isolated, characterized, and maintained.
Does PA-07-303 allow studies involving human subjects?
No. Studies involving human subjects are not allowed under this announcement. The work must be based on nonhuman biomedical research animal models.
What happens if a proposal includes any human-subjects component?
The FOA states that applicants proposing any human-subjects component would not fit the eligibility requirements of this announcement.
What is the intended impact of improving animal stem cell model systems?
The intention is to improve animal stem cell systems so they can better model biology and disease processes, support translational research, and complement other experimental platforms, without relying on human subjects.
What funding mechanism does PA-07-303 use?
This opportunity uses the NIH R01 mechanism.
What does it mean that this FOA uses an R01 mechanism?
Based on the FOA description, it is intended for mature, hypothesis-driven or technology-developing research projects with a scope and timeline appropriate for an R01 award.
Is there a related NIH opportunity with the same scientific scope?
Yes. NIH notes that PA-07-303 runs in parallel with a separate announcement of identical scientific scope that uses the R21 mechanism (PA-07-304), which is described as typically more exploratory and shorter-term.
How should an applicant choose between PA-07-303 (R01) and the related R21 announcement?
NIH indicates applicants should choose the mechanism that best matches the maturity, risk level, and development stage of the proposed work (R01 for more mature projects; R21 for more exploratory, shorter-term efforts).
Is there a fixed budget amount per award?
No. NIH does not specify a fixed budget amount per award under this announcement.
Is there a guaranteed number of awards?
No. NIH does not guarantee a set number of awards. The number of awards and total dollars committed depend on factors such as the mix of applications received, scientific merit, project periods requested, and overall costs.
How are award size and project duration determined?
Award size and project duration are expected to vary depending on what is proposed, and NIH indicates outcomes will depend on factors like scientific merit, requested project periods, and overall costs.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic applicants, including public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, excluding higher education where specified), for-profit organizations (including small businesses and other for-profits), independent school districts, and various local and tribal government entities.
Are for-profit organizations eligible?
Yes. The eligibility description includes for-profit organizations, including small businesses and other for-profits.
Are foreign institutions eligible to apply?
Yes. The opportunity explicitly notes that foreign institutions are eligible to apply.
When was this opportunity posted, and what is its current status?
The opportunity was posted on January 18, 2007, and it was archived on February 1, 2010.
Where can the full announcement be found?
The full announcement is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-07-303.html
What is the funding instrument and agency for PA-07-303?
The funding instrument is a grant, and the agency is the National Institutes of Health (NIH).
What NIH mission areas or program areas does this FOA relate to?
The program is associated with multiple CFDA numbers spanning areas such as environmental health, mental health, addiction, cancer biology, child health, aging, vision research, and other biomedical areas, reflecting broad applicability of improved animal stem cell models across NIH mission areas.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 303) also looked into and applied for these:
| Funding Opportunity |
|---|
| Novel Approaches to Enhance Animal Stem Cell Research (R21) Apply for PA 07 304 Funding Number: PA 07 304 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Bioengineering Research Partnerships (BRP)R01 Apply for PAR 07 352 Funding Number: PAR 07 352 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $2,000,000 |
| Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21) Apply for PAR 07 380 Funding Number: PAR 07 380 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Advancing Novel Science in Women s Health Research (ANSWHR) R21 Apply for PAS 07 381 Funding Number: PAS 07 381 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $2,000,000 |
| Advancing Novel Science in Women s Health Research (ANSWHR) (R03) Apply for PAS 07 382 Funding Number: PAS 07 382 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Treating Generalized and Focal Dystonias (R01) Apply for PA 07 397 Funding Number: PA 07 397 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Treating Generalized and Focal Dystonias (R21) Apply for PA 07 398 Funding Number: PA 07 398 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Developmental Pharmacology (R01) Apply for PAR 07 416 Funding Number: PAR 07 416 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination (R03) Apply for PAR 07 417 Funding Number: PAR 07 417 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
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| Methodology and Measurement in the Behavioral and Social Sciences (R01) Apply for PAR 08 212 Funding Number: PAR 08 212 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Methodology and Measurement in the Behavioral and Social Sciences (R21) Apply for PAR 08 213 Funding Number: PAR 08 213 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Methodology and Measurement in the Behavioral and Social Sciences (R03) Apply for PAR 08 214 Funding Number: PAR 08 214 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Fogarty International Research Collaboration Basic Biomedical (FIRCA BB) Research Award (R03) Apply for PAR 08 222 Funding Number: PAR 08 222 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
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