Opportunity Information: Apply for PA 07 304
Apply for PA 07 304
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Novel Approaches to Enhance Animal Stem Cell Research (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.389 National Center for Research Resources 93.396 Cancer Biology Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jan 18, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education Public and State controlled institutions of higher education.
- Foreign institutions are eligible to apply.
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Opportunity Summary:
The NIH funding opportunity "Novel Approaches to Enhance Animal Stem Cell Research (R21)" (Funding Opportunity Number PA-07-304) supports early-stage, high-impact exploratory research aimed at strengthening the use of nonhuman animal stem cells as model biological systems. The main goal is to push forward innovative ways to work with animal stem cells, especially by improving how researchers isolate, identify, and characterize very early stem cell types such as totipotent and multipotent cells from nonhuman biomedical research animal models. A major emphasis is placed on developing new reagents, tools, and techniques that make it easier to distinguish these stem cells from other surrounding cell types and to separate them more cleanly for study. The program is meant to encourage creative, developmental projects that could open up new directions or overcome persistent technical barriers in animal stem cell research.
A clear boundary of this announcement is that studies involving human subjects are not allowed. The focus is strictly on animal-based systems and nonhuman model organisms used in biomedical research. Within that boundary, the scope is intentionally broad, recognizing that projects may differ widely in the kinds of models used, the maturity of the techniques, and the experimental approaches taken. Because applications can vary so much, NIH notes that individual award sizes and project scopes can also vary, and the total number of awards and total funding will depend on the availability of funds and the number of strong applications received.
This FOA uses the NIH Exploratory/Developmental Research Grant mechanism (R21), which is typically designed for novel, potentially transformative ideas that may still be in the proof-of-concept stage. The project period is limited to a maximum of two years, and the R21 under this announcement is not renewable. Budget limits are set at up to $275,000 in direct costs total across the two-year period, with a cap of $200,000 in direct costs in any single year. The opportunity runs in parallel with a separate NIH announcement of the same scientific scope that uses the R01 mechanism (PA-07-303), which is generally intended for more mature, hypothesis-driven projects with a larger scope.
Eligibility is broad and includes many types of institutions and organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and a range of minority-serving institutions such as Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. Nonprofit organizations (both with and without 501(c)(3) status, as long as they are not institutions of higher education in those specific categories) are eligible, as are small businesses and other for-profit organizations (excluding the "other than small business" limitation depending on classification, as listed in the announcement). Importantly, foreign (non-U.S.) organizations are also eligible to apply, which widens participation to international research groups working on relevant animal model stem cell systems.
Administratively, the FOA is categorized as a discretionary grant and is associated with multiple CFDA program areas across health and biomedical research, reflecting how animal stem cell tools can support many disease and biology domains. The announcement was posted January 18, 2007, and it used multiple receipt dates rather than one single deadline, meaning applications could be accepted on several scheduled due dates as described in the full announcement. The award ceiling listed in the source data reflects the yearly direct cost cap (up to $200,000 in a single year), consistent with the two-year total direct cost limit described above.
In practical terms, this opportunity is best suited for teams proposing new enabling methods for animal stem cell science: for example, improved isolation strategies, more precise molecular or functional characterization workflows, better markers or selection systems, or novel separation/purification technologies that increase confidence that the cells being studied are truly totipotent or multipotent. The underlying theme is to build foundational capabilities that make nonhuman stem cell models more powerful, reproducible, and informative for biomedical research, without involving human subjects.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Novel Approaches to Enhance Animal Stem Cell Research (R21)".
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA-07-304.
What is the main purpose of this FOA?
This FOA supports early-stage, high-impact exploratory research intended to strengthen the use of nonhuman animal stem cells as model biological systems. It emphasizes innovative, enabling approaches that can push animal stem cell research forward or break through persistent technical limitations.
What types of projects are most responsive to the scientific goals?
Projects are most responsive when they propose novel approaches to work with nonhuman animal stem cells, especially methods that improve how researchers:
- Isolate stem cells from nonhuman biomedical research animal models
- Identify and distinguish early stem cell types from surrounding cell populations
- Characterize very early stem cell types using improved workflows or assays
- Separate or purify targeted stem cell populations more cleanly for study
Which stem cell types are highlighted as an emphasis area?
The FOA places particular emphasis on very early stem cell types such as totipotent and multipotent cells derived from nonhuman biomedical research animal models.
Does this FOA prioritize tool and reagent development?
Yes. A major emphasis is on developing new reagents, tools, and techniques that make it easier to distinguish specific stem cell populations from other cell types and to separate them more cleanly for downstream study.
Are human subjects allowed under this announcement?
No. The FOA explicitly excludes studies involving human subjects. The focus is strictly on animal-based systems and nonhuman model organisms used in biomedical research.
What grant mechanism does this opportunity use?
This FOA uses the NIH Exploratory/Developmental Research Grant (R21) mechanism, which is commonly used for novel, potentially transformative ideas that may still be at the proof-of-concept stage.
How long can an R21 project last under this FOA?
The project period is limited to a maximum of two years.
Is the R21 award under this announcement renewable?
No. The R21 under this FOA is not renewable.
What are the budget limits for this R21?
Budget limits are stated in direct costs as follows:
- Up to $275,000 total direct costs across the two-year period
- No more than $200,000 direct costs in any single year
Why does the announcement mention that award sizes and scopes may vary?
The FOA notes that applications may vary widely in model systems, technical maturity, and approaches. As a result, individual award sizes and project scopes can vary within the stated caps.
How are the total number of awards and total funding determined?
The FOA indicates that the total number of awards and the total funding will depend on availability of funds and the number of meritorious applications received.
Is there a related NIH opportunity with the same scientific scope but a different mechanism?
Yes. This FOA runs in parallel with a separate NIH announcement of the same scientific scope using the R01 mechanism: PA-07-303. The R01 is generally intended for more mature, hypothesis-driven projects with a larger scope.
What types of organizations are eligible to apply?
Eligibility is broad and includes many institution types, including:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Minority-serving institutions (e.g., Hispanic-serving institutions, HBCUs, TCCUs, Alaska Native and Native Hawaiian Serving Institutions)
- Nonprofit organizations (with or without 501(c)(3) status, as described in the announcement)
- Small businesses and other for-profit organizations (as specified in the announcement)
- Foreign (non-U.S.) organizations
Are international (non-U.S.) applicants eligible?
Yes. The FOA explicitly states that foreign (non-U.S.) organizations are eligible, allowing international research groups working with relevant nonhuman animal model stem cell systems to apply.
What is the nature of this grant from an administrative standpoint?
Administratively, the FOA is categorized as a discretionary grant and is associated with multiple CFDA program areas across health and biomedical research, reflecting the broad utility of animal stem cell tools across many domains.
When was this FOA posted?
The announcement was posted on January 18, 2007.
Is there a single application deadline?
No. The FOA used multiple receipt dates rather than one single deadline, meaning applications could be submitted on several scheduled due dates as described in the full announcement.
What kinds of deliverables or outcomes fit the "enabling methods" theme?
Based on the description provided, the opportunity is best suited for teams proposing new enabling capabilities for animal stem cell science, such as:
- Improved isolation strategies for nonhuman stem cells
- More precise molecular or functional characterization workflows
- Better markers or selection systems to distinguish targeted stem cell populations
- Novel separation or purification technologies that increase confidence the cells are truly totipotent or multipotent
How broad is the scientific scope within the nonhuman boundary?
Within the clear boundary that human subjects are not allowed, the scope is described as intentionally broad, recognizing that projects can differ substantially in model organisms, methods, and developmental stage of the approach.
What is the key theme NIH is trying to advance with this program?
The central theme is to build foundational methods and tools that make nonhuman stem cell models more powerful, reproducible, and informative for biomedical research, while staying entirely within animal-based systems.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 304) also looked into and applied for these:
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| Bioengineering Research Partnerships (BRP)R01 Apply for PAR 07 352 Funding Number: PAR 07 352 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $2,000,000 |
| Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21) Apply for PAR 07 380 Funding Number: PAR 07 380 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Advancing Novel Science in Women s Health Research (ANSWHR) R21 Apply for PAS 07 381 Funding Number: PAS 07 381 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $2,000,000 |
| Advancing Novel Science in Women s Health Research (ANSWHR) (R03) Apply for PAS 07 382 Funding Number: PAS 07 382 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Treating Generalized and Focal Dystonias (R01) Apply for PA 07 397 Funding Number: PA 07 397 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Treating Generalized and Focal Dystonias (R21) Apply for PA 07 398 Funding Number: PA 07 398 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Developmental Pharmacology (R01) Apply for PAR 07 416 Funding Number: PAR 07 416 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination (R03) Apply for PAR 07 417 Funding Number: PAR 07 417 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Data Ontologies for Biomedical Research (R01) Apply for PAR 07 425 Funding Number: PAR 07 425 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
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| Methodology and Measurement in the Behavioral and Social Sciences (R21) Apply for PAR 08 213 Funding Number: PAR 08 213 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Methodology and Measurement in the Behavioral and Social Sciences (R03) Apply for PAR 08 214 Funding Number: PAR 08 214 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Fogarty International Research Collaboration Basic Biomedical (FIRCA BB) Research Award (R03) Apply for PAR 08 222 Funding Number: PAR 08 222 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Fogarty International Research Collaboration Behavioral and Social Sciences (FIRCA BSS) Research Award (R03) Apply for PAR 08 223 Funding Number: PAR 08 223 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
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