Opportunity Information: Apply for RFA AT 15 003
Apply for RFA AT 15 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods Development in Natural Products Chemistry (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health.
- This funding opportunity was created on Jun 17, 2014 and posted on Jun 17, 2014.
- Applicants must submit their applications by Sep 10, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $10,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the following Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity. A small business concern is one that, at the time of award of Phase I and Phase II, meets all of the following criteria 1. Is organized for profit, with a place of business located in the United States, which operates primarily within the United States or which makes a significant contribution to the United States economy through payment of taxes or use of American products, materials or labor 2. Is in the legal form of an individual proprietorship, partnership, limited liability company, corporation, joint venture, association, trust or cooperative, except that where the form is a joint venture, there must be less than 50 percent participation by foreign business entities in the joint venture 3. (i) SBIR and STTR. Be a concern which is more than 50 directly owned and controlled by one or more individuals (who are citizens or permanent resident aliens of the United States), other business concerns (each of which is more than 50 directly owned and controlled by individuals who are citizens or permanent resident aliens of the United States), or any combination of these OR (ii) SBIR only. Be a concern which is more than 50 owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these. No single venture capital operating company, hedge fund, or private equity firm may own more than 50 of the concern OR (iii) SBIR and STTR. Be a joint venture in which each entity to the joint venture must meet the requirements set forth in paragraph 3 (i) or 3 (ii) of this section. A joint venture that includes one or more concerns that meet the requirements of paragraph (ii) of this section must comply with 121.705(b) concerning registration and proposal requirements. 4. Has, including its affiliates, not more than 500 employees.
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Opportunity Summary:
Methods Development in Natural Products Chemistry (R43/R44) is a National Institutes of Health (NIH) Small Business Innovative Research (SBIR) grant opportunity focused on removing practical bottlenecks that keep natural products from being fully used in research and product development. The announcement targets real-world technical hurdles in natural products chemistry, especially problems tied to how natural materials are collected and processed, how bioassays are run and interpreted, and how active compounds are isolated, purified, and supplied at usable scale. In plain terms, the goal is to fund small businesses that can create or improve methods so that promising compounds from plants, microbes, marine organisms, and other natural sources can be identified more reliably, obtained more efficiently, and produced or sourced in a way that supports downstream research and development.
The technical scope centers on method development across the natural products pipeline. That includes better collection practices (for consistency, stability, and traceability of starting materials), improved bioassay workflows (so activity can be detected and validated with fewer artifacts), and more effective approaches to isolation and purification (to separate complex mixtures, confirm structures, and avoid losing activity during processing). It also emphasizes yield and supply, which are often decisive barriers in natural products work: even when a compound is exciting biologically, it may be present at very low levels, difficult to purify, unstable, or hard to obtain repeatedly from nature. Projects responsive to this FOA would therefore aim to make natural product discovery and development more reproducible and scalable, for example by improving extraction methods, increasing recovery, reducing degradation, enabling higher-throughput fractionation, or creating supply solutions that reduce dependence on limited natural sources.
Administratively, this opportunity is identified as Funding Opportunity Number RFA-AT-15-003, titled "Methods Development in Natural Products Chemistry (R43/R44)." It is a discretionary grant funding instrument under the health funding activity category and is associated with CFDA 93.213, Research and Training in Complementary and Integrative Health. The mechanism is R43/R44, meaning it supports the standard SBIR phased structure: Phase I (R43) generally supports early feasibility and proof-of-concept work, and Phase II (R44) supports more advanced research and development aimed at moving the innovation toward commercialization and broader adoption. The announcement was posted on June 17, 2014, with an original and current closing date of September 10, 2014, and an archive date of October 11, 2014. The estimated total funding amount listed is $10,000,000, and the FOA states there is no cost-sharing or matching requirement, which is typical for SBIR opportunities.
Eligibility is limited to United States small business concerns. To qualify, an applicant must be organized for profit, have a place of business in the United States, and operate primarily in the United States or otherwise make a significant contribution to the U.S. economy through taxes or the use of American products, materials, or labor. The business must fit an allowable legal form (such as a sole proprietorship, partnership, LLC, corporation, joint venture, association, trust, or cooperative), with specific limits on foreign participation in joint ventures. Ownership and control requirements follow SBIR rules, allowing traditional majority ownership by U.S. citizens or permanent resident aliens (alone or through qualifying entities), and also allowing certain SBIR-only majority ownership structures involving multiple venture capital operating companies, hedge funds, or private equity firms, provided no single such entity owns more than 50%. The company, including affiliates, must have no more than 500 employees at the time of award for both Phase I and Phase II.
NIH is the sponsoring agency, and the announcement provides an official information link through the NIH Grants Guide. For access or technical issues with the electronic announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. Overall, the opportunity is designed to stimulate commercially relevant innovation from small businesses that can modernize and strengthen the methodologies behind natural products chemistry, making natural products easier to study, validate, reproduce, and ultimately translate into useful applications.
Methods Development in Natural Products Chemistry (R43/R44) - FAQ
What is this funding opportunity?
This is an NIH Small Business Innovative Research (SBIR) grant opportunity titled "Methods Development in Natural Products Chemistry (R43/R44)." It focuses on method development intended to remove practical bottlenecks that limit how fully natural products can be used in research and product development.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AT-15-003.
Which agency is sponsoring the opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What does "R43/R44" mean?
R43/R44 refers to the SBIR phased structure supported by this opportunity. Phase I (R43) generally supports early feasibility and proof-of-concept work, and Phase II (R44) supports more advanced research and development aimed at moving the innovation toward commercialization and broader adoption.
What is the main goal of this SBIR?
The goal is to fund small businesses that can create or improve methods so that promising compounds from natural sources can be identified more reliably, obtained more efficiently, and produced or sourced in ways that support downstream research and development.
What types of natural sources are included?
The description specifically includes plants, microbes, marine organisms, and other natural sources.
What kinds of problems is NIH trying to solve with this FOA?
The FOA targets real-world technical hurdles in natural products chemistry, especially those related to:
- How natural materials are collected and processed
- How bioassays are run and interpreted
- How active compounds are isolated, purified, and supplied at usable scale
What parts of the natural products pipeline are in scope?
The technical scope centers on method development across the pipeline, including improved collection practices, improved bioassay workflows, and improved isolation and purification approaches, with a strong emphasis on yield and supply challenges.
What does "better collection practices" refer to in this announcement?
It refers to collection practices that improve consistency, stability, and traceability of starting materials, so the initial natural material is more reliable and reproducible for later chemical and biological work.
What bioassay-related improvements are relevant to this FOA?
The FOA emphasizes improved bioassay workflows so that biological activity can be detected and validated with fewer artifacts, and so results can be interpreted more reliably.
What isolation and purification needs does this FOA highlight?
The announcement highlights approaches to separate complex mixtures, confirm structures, and avoid losing activity during processing. This includes making isolation and purification more effective and reliable.
Why does the FOA emphasize yield and supply?
Yield and supply are described as decisive barriers in natural products work. Even when a compound looks biologically exciting, it may exist at very low levels, be difficult to purify, be unstable, or be hard to obtain repeatedly from nature. The FOA supports methods that address these issues so downstream research and development can continue.
What are examples of the kinds of method improvements this FOA is looking for?
Examples mentioned include improving extraction methods, increasing recovery, reducing degradation, enabling higher-throughput fractionation, and creating supply solutions that reduce dependence on limited natural sources.
Is this opportunity aimed at commercialization?
Yes. As an SBIR opportunity, it is designed to stimulate commercially relevant innovation from small businesses, and Phase II (R44) is described as supporting R&D aimed at moving innovations toward commercialization and broader adoption.
What is the funding instrument type?
The funding instrument is a discretionary grant.
What is the activity category?
The activity category is listed as health (a health funding activity category).
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 93.213, Research and Training in Complementary and Integrative Health.
How much total funding is estimated for this FOA?
The estimated total funding amount listed is $10,000,000.
Is cost sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement, which is typical for SBIR opportunities.
Who is eligible to apply?
Eligibility is limited to United States small business concerns.
What basic requirements must a small business meet to be eligible?
To qualify, the applicant must be organized for profit, have a place of business in the United States, and operate primarily in the United States or otherwise make a significant contribution to the U.S. economy through taxes or the use of American products, materials, or labor.
What legal forms of business are allowed?
The FOA indicates allowable legal forms such as a sole proprietorship, partnership, LLC, corporation, joint venture, association, trust, or cooperative, with specific limits on foreign participation in joint ventures.
Are there employee-count limits?
Yes. The company, including affiliates, must have no more than 500 employees at the time of award for both Phase I and Phase II.
What ownership and control structures are allowed under this FOA?
Ownership and control follow SBIR rules. The FOA description notes that eligibility can include traditional majority ownership by U.S. citizens or permanent resident aliens (alone or through qualifying entities). It also allows certain SBIR-only majority ownership structures involving multiple venture capital operating companies, hedge funds, or private equity firms, provided no single such entity owns more than 50%.
What are the key dates for this FOA?
The announcement was posted on June 17, 2014. The original and current closing date is September 10, 2014. The archive date is October 11, 2014.
Where is the official information link provided?
The announcement provides an official information link through the NIH Grants Guide.
Who should be contacted for access or technical issues with the electronic announcement?
For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall purpose of this program in plain terms?
In plain terms, it is meant to help small businesses modernize and strengthen the methodologies behind natural products chemistry so natural products can be studied, validated, reproduced, and translated into useful applications more effectively.
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