Opportunity Information: Apply for RFA AT 15 002
Apply for RFA AT 15 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods Development in Natural Products Chemistry (STTR) (R41)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health.
- This funding opportunity was created on Jun 17, 2014 and posted on Jun 17, 2014.
- Applicants must submit their applications by Sep 10, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $250,000.00 to eligible and selected applicants.
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the following Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity. A small business concern is one that, at the time of award of Phase I and Phase II, meets all of the following criteria 1. Is organized for profit, with a place of business located in the United States, which operates primarily within the United States or which makes a significant contribution to the United States economy through payment of taxes or use of American products, materials or labor 2. Is in the legal form of an individual proprietorship, partnership, limited liability company, corporation, joint venture, association, trust or cooperative, except that where the form is a joint venture, there must be less than 50 percent participation by foreign business entities in the joint venture 3. (i) SBIR and STTR. Be a concern which is more than 50 directly owned and controlled by one or more individuals (who are citizens or permanent resident aliens of the United States), other business concerns (each of which is more than 50 directly owned and controlled by individuals who are citizens or permanent resident aliens of the United States), or any combination of these OR (ii) SBIR only. Be a concern which is more than 50 owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these. No single venture capital operating company, hedge fund, or private equity firm may own more than 50 of the concern OR (iii) SBIR and STTR. Be a joint venture in which each entity to the joint venture must meet the requirements set forth in paragraph 3 (i) or 3 (ii) of this section. A joint venture that includes one or more concerns that meet the requirements of paragraph (ii) of this section must comply with 121.705(b) concerning registration and proposal requirements. 4. Has, including its affiliates, not more than 500 employees.
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Opportunity Summary:
Methods Development in Natural Products Chemistry (STTR) (R41) is a National Institutes of Health (NIH) Small Business Technology Transfer funding opportunity that focuses on removing practical bottlenecks that keep natural products from being more fully used in research and development. The core idea is straightforward: many promising compounds and chemical leads come from plants, microbes, marine organisms, and other natural sources, but the field often stalls because the underlying methods are slow, expensive, unreliable, or difficult to scale. This FOA invites small businesses, working through the STTR mechanism, to build and demonstrate improved tools, workflows, and technologies that make natural products easier to collect, test, isolate, identify, reproduce, and supply in dependable quantities.
The scientific and technical scope centers on method development across the full natural products pipeline. The announcement highlights specific pain points that applicants are expected to tackle, including collection methods (how source materials are obtained, documented, and processed), bioassay approaches (how extracts or fractions are screened and linked to biological activity), isolation and purification strategies (how active compounds are separated from complex mixtures efficiently and reproducibly), dereplication (how to rapidly determine whether a compound is already known so time is not wasted re-discovering it), and challenges related to yield and supply (how to obtain enough material for follow-up studies, validation, or development). In practice, this can include innovations in analytical chemistry workflows, high-throughput fractionation, improved structure elucidation pipelines, data-driven dereplication methods, standardized collection and quality control procedures, or scalable production strategies that address limited natural abundance. The FOA is positioned as enabling infrastructure for natural products science: the goal is not just to find a new compound, but to make the overall process more effective so more compounds can be assessed and advanced.
This is an STTR Phase I opportunity using the R41 grant mechanism, which generally emphasizes early-stage feasibility and proof-of-concept work performed by a small business in formal collaboration with a nonprofit research institution. While the full FOA would spell out the exact STTR partnership requirements, the listing makes clear that only United States small business concerns are eligible to apply, and the intent is to support translational, commercialization-oriented R and D where the small business is developing a method or platform with real-world utility. The funding instrument type is a grant, and it falls under the Health funding activity category with CFDA number 93.213, Research and Training in Complementary and Integrative Health, indicating alignment with NIH interests in complementary and integrative health-related research capabilities and resources. There is no cost sharing or matching requirement indicated, which reduces barriers for small companies that may not have substantial non-federal funding available.
Eligibility is limited to U.S. small business concerns that meet standard size and ownership rules at the time of award for Phase I and Phase II. The company must be for-profit, have a place of business in the United States, and operate primarily in the United States or otherwise make a significant contribution to the U.S. economy. Acceptable legal structures include sole proprietorships, partnerships, LLCs, corporations, joint ventures, associations, trusts, or cooperatives, with additional restrictions on foreign participation in joint ventures. The ownership and control requirements follow federal small business standards, and the business must have no more than 500 employees including affiliates. These conditions are meant to ensure that awards go to truly small entities building technologies that can transition into products, services, or widely adoptable research methods.
From an administrative standpoint, the opportunity was posted on June 17, 2014, with an original and current closing date of September 10, 2014, and an archive date of October 11, 2014, meaning it is no longer accepting applications in its posted form. The estimated total funding listed is $250,000, which typically reflects either the expected overall funds available under the announcement or a rough projection of award volume and size for that cycle. The funding opportunity number is RFA-AT-15-002, and additional details were provided through the NIH Grants Guide link associated with that RFA. For access issues or technical problems with the announcement link, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, this FOA is best understood as a targeted push to modernize the practical chemistry and analytics of natural products research through small business-led innovation, with an emphasis on tools that reduce rediscovery, improve reproducibility, increase throughput, and solve the recurring problem of obtaining adequate, consistent supplies of bioactive natural compounds.
Frequently Asked Questions (FAQs)
What is the "Methods Development in Natural Products Chemistry (STTR) (R41)" opportunity?
It is a National Institutes of Health (NIH) Small Business Technology Transfer (STTR) funding opportunity that supports Phase I (R41) proof-of-concept work focused on improving methods and tools used in natural products chemistry. The intent is to remove practical bottlenecks that make natural products difficult to collect, test, isolate, identify, reproduce, and supply in dependable quantities.
What problem is this funding opportunity trying to solve?
The opportunity targets common, real-world barriers in natural products research and development where progress often slows because methods are too slow, expensive, unreliable, hard to reproduce, or difficult to scale. The goal is to make the overall pipeline more effective so more natural product compounds and chemical leads can be assessed and advanced.
What kinds of natural sources are included under "natural products" in this opportunity?
The opportunity references natural products from sources such as plants, microbes, marine organisms, and other natural sources that can yield promising compounds and chemical leads.
Is this opportunity focused on discovering new compounds or on building better methods?
The emphasis is on method development and enabling infrastructure across the natural products pipeline. While new compounds may be involved in demonstrating a method, the stated goal is not simply to find a new compound but to improve processes so natural products research becomes more effective, reproducible, and scalable.
What stage of STTR funding does this opportunity support?
This is an STTR Phase I opportunity using the R41 grant mechanism, which generally emphasizes early-stage feasibility and proof-of-concept work.
What is the required collaboration model for this opportunity?
The opportunity is offered through the STTR mechanism, which is described as involving a small business working in formal collaboration with a nonprofit research institution.
Who is eligible to apply?
Only United States small business concerns are eligible to apply, subject to standard STTR and federal small business rules at the time of award for Phase I and Phase II.
What basic business characteristics are required for eligibility?
The company must be for-profit, have a place of business in the United States, and operate primarily in the United States or otherwise make a significant contribution to the U.S. economy.
Are there employee limits for eligibility?
Yes. The business must have no more than 500 employees, including affiliates.
What legal business structures are acceptable?
Acceptable legal structures listed include sole proprietorships, partnerships, LLCs, corporations, joint ventures, associations, trusts, or cooperatives, with additional restrictions on foreign participation in joint ventures.
Is cost sharing or matching required?
No cost sharing or matching requirement is indicated for this opportunity.
What specific technical areas or bottlenecks does the FOA highlight?
The announcement highlights pain points applicants are expected to tackle across the natural products pipeline, including collection methods, bioassay approaches, isolation and purification strategies, dereplication, and yield and supply challenges.
What does "collection methods" refer to in this opportunity?
Collection methods refer to how source materials are obtained, documented, and processed so that downstream work can be reliable, traceable, and reproducible.
What does "bioassay approaches" mean here?
Bioassay approaches refer to how extracts or fractions are screened and connected to biological activity, helping determine which samples or components warrant deeper chemical investigation.
What does "isolation and purification strategies" cover?
It covers methods for separating active compounds from complex mixtures efficiently and reproducibly, addressing practical challenges in getting from crude extracts to purified, testable compounds.
What is "dereplication" in the context of this FOA?
Dereplication refers to rapidly determining whether a compound is already known, so research teams do not waste time and resources re-discovering previously identified molecules.
What types of innovations does the FOA suggest are in scope?
Examples described include innovations in analytical chemistry workflows, high-throughput fractionation, improved structure elucidation pipelines, data-driven dereplication methods, standardized collection and quality control procedures, and scalable production strategies that address limited natural abundance.
What does the FOA mean by addressing "yield and supply" challenges?
It means developing ways to obtain enough material for follow-up studies, validation, or development, including strategies that improve access to consistent supplies when natural abundance is limited.
What is the funding instrument type?
The funding instrument type is a grant.
What is the funding activity category?
The listing places it under the Health funding activity category.
What is the CFDA number associated with this opportunity and what does it indicate?
The CFDA number is 93.213, "Research and Training in Complementary and Integrative Health." This indicates alignment with NIH interests related to complementary and integrative health research capabilities and resources.
What is the funding opportunity number?
The funding opportunity number is RFA-AT-15-002.
How much funding is listed for this opportunity?
The estimated total funding listed is $250,000, described as typically reflecting expected overall funds available under the announcement or a rough projection of award volume and size for that cycle.
When was this opportunity posted and what were the key dates?
The opportunity was posted on June 17, 2014. The original and current closing date listed is September 10, 2014, and the archive date is October 11, 2014.
Is this opportunity still open to applications?
No. Based on the posted closing and archive dates, it is no longer accepting applications in its posted form.
Where were additional details provided?
Additional details were provided through the NIH Grants Guide link associated with RFA-AT-15-002.
Who is the listed contact for access issues or technical problems with the announcement link?
The listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall purpose or intended impact of this FOA?
The FOA is a targeted push to modernize the practical chemistry and analytics of natural products research through small business-led innovation, emphasizing tools that reduce rediscovery, improve reproducibility, increase throughput, and solve recurring supply and consistency problems for bioactive natural compounds.
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