Opportunity Information: Apply for RFA AT 14 001
Apply for RFA AT 14 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods Development in Natural Products Chemistry (SBIR)(R43)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.350 National Center for Advancing Translational Sciences.
- This funding opportunity was created on Apr 10, 2013 and posted on Apr 10, 2013.
- Applicants must submit their applications by Aug 2, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $225,000.00 in funding.
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
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Opportunity Summary:
The grant opportunity titled "Methods Development in Natural Products Chemistry (SBIR) (R43)" (Funding Opportunity Number RFA-AT-14-001) is a National Institutes of Health (NIH) Small Business Innovative Research (SBIR) solicitation focused on improving the practical, real-world methods needed to fully develop and use natural products for research and potential health applications. In plain terms, NIH is looking for early-stage, high-impact tool and method development projects from small businesses that can remove common bottlenecks in natural products chemistry, especially the technical hurdles that make natural products difficult to study, standardize, and scale.
The central purpose of the announcement is to support projects that tackle problems across the natural-products pipeline, including how natural materials are collected, how they are tested in bioassays, and how active compounds are isolated and purified. It also specifically highlights method needs around "dereplication," meaning approaches that help researchers quickly determine whether a compound is already known so time is not wasted repeatedly rediscovering the same molecules. Beyond identifying and isolating compounds, the FOA is also concerned with yield and supply, which refers to the persistent challenge of obtaining enough material of consistent quality for research, development, and potential downstream translation. Overall, the opportunity is aimed at practical methods that make natural product discovery and development more efficient, reliable, and scalable.
This is an SBIR Phase I-style opportunity under the R43 mechanism, meaning it is intended for feasibility and proof-of-concept work performed by an eligible U.S. small business concern. The funding instrument is a grant (not a contract), the opportunity category is discretionary, and there is no cost sharing or matching requirement stated. The maximum award amount listed is an award ceiling of $225,000, which sets the upper limit for funding under this specific announcement.
Eligibility is limited to small businesses, and the solicitation clearly states that non-U.S. (foreign) entities are not eligible to apply. In addition, non-U.S. components of U.S. organizations are not eligible. However, foreign components may be allowed in some cases as defined by NIH policy, which generally means a U.S. applicant might be able to include certain foreign collaborations or elements if they meet NIH rules and are well-justified, but the applicant organization itself must be domestic and meet SBIR requirements.
From an administrative standpoint, the opportunity was posted on April 10, 2013, with an original and current closing date of August 2, 2013, and an archive date of September 2, 2013. The activity categories referenced include Health-related research and training, specifically tied to CFDA numbers 93.213 (Research and Training in Complementary and Integrative Health) and 93.350 (National Center for Advancing Translational Sciences), which signals that the work is expected to be relevant to NIH interests in advancing translational science and complementary/integrative health research through better enabling technologies and methods.
The sponsor agency is NIH, and the provided additional information link points to the full announcement on the NIH Grants Guide. For technical issues accessing the announcement or linking to it, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the official title and funding opportunity number for this grant?
The opportunity is titled "Methods Development in Natural Products Chemistry (SBIR) (R43)" and the Funding Opportunity Number is RFA-AT-14-001.
Who is sponsoring this opportunity?
The sponsor agency is the National Institutes of Health (NIH).
What type of funding mechanism is this?
This is an NIH Small Business Innovative Research (SBIR) opportunity under the R43 mechanism, which corresponds to a Phase I-style award focused on feasibility and proof-of-concept work.
Is this a grant or a contract?
The funding instrument is a grant, not a contract.
What is the main goal of this SBIR solicitation?
The central goal is to support practical, real-world methods and tool development that make natural products chemistry more efficient, reliable, and scalable. NIH is looking for early-stage, high-impact method development projects from small businesses that remove common technical bottlenecks in natural product discovery and development.
What parts of the natural products pipeline does the announcement emphasize?
The announcement highlights method needs across the natural-products pipeline, including: how natural materials are collected, how they are tested in bioassays, and how active compounds are isolated and purified.
What does "dereplication" mean in the context of this opportunity?
Dereplication refers to methods that help researchers quickly determine whether a compound is already known, so time and resources are not spent repeatedly rediscovering the same molecules.
Does the opportunity address challenges related to yield and supply?
Yes. It specifically notes "yield and supply" as a persistent challenge, meaning obtaining enough material of consistent quality for research, development, and potential downstream translation.
What kind of projects does NIH appear to be looking for?
Based on the description provided, NIH is looking for early-stage, high-impact tool and method development projects that address technical hurdles that make natural products difficult to study, standardize, and scale.
What is the maximum award amount for this announcement?
The maximum award amount listed is an award ceiling of $225,000, which sets the upper limit for funding under this specific announcement.
Is cost sharing or matching required?
No cost sharing or matching requirement is stated for this opportunity.
Who is eligible to apply?
Eligibility is limited to eligible U.S. small business concerns under the SBIR program.
Are non-U.S. (foreign) entities eligible to apply?
No. The solicitation states that non-U.S. (foreign) entities are not eligible to apply.
Can a U.S. applicant include non-U.S. components?
Non-U.S. components of U.S. organizations are not eligible. However, foreign components may be allowed in some cases as defined by NIH policy, generally meaning certain foreign collaborations or elements may be included if they meet NIH rules and are well-justified, while the applicant organization itself must remain domestic and SBIR-eligible.
What is the opportunity category?
The opportunity category is discretionary.
When was this opportunity posted?
The opportunity was posted on April 10, 2013.
What was the closing date for applications?
The original and current closing date listed is August 2, 2013.
When was the opportunity archived?
The archive date listed is September 2, 2013.
What activity categories or program areas are referenced?
The activity categories referenced include health-related research and training, and the announcement is tied to CFDA numbers 93.213 (Research and Training in Complementary and Integrative Health) and 93.350 (National Center for Advancing Translational Sciences).
What do the CFDA numbers suggest about the focus of the work?
They indicate the work is expected to align with NIH interests in advancing translational science and complementary/integrative health research through enabling technologies and improved methods.
Where can applicants find the full announcement?
An additional information link is provided that points to the full announcement on the NIH Grants Guide.
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing the announcement or linking to it, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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