Opportunity Information: Apply for RFA AT 14 002
Apply for RFA AT 14 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods Development in Natural Products Chemistry (STTR) (R41)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.350 National Center for Advancing Translational Sciences.
- This funding opportunity was created on Apr 10, 2013 and posted on Apr 10, 2013.
- Applicants must submit their applications by Aug 2, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $225,000.00 in funding.
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
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Opportunity Summary:
The NIH funding opportunity titled "Methods Development in Natural Products Chemistry (STTR) (R41)" (Funding Opportunity Number RFA-AT-14-002) was a discretionary grant program designed to support early-stage, high-impact methods work that makes natural products easier to discover, characterize, and ultimately use. The core purpose of the announcement was to encourage Small Business Technology Transfer (STTR) applications that tackle practical bottlenecks in natural products chemistry, especially the technical hurdles that slow down the transition from a promising natural source to a reproducible, well-characterized, and usable product or lead compound. The FOA focuses on the reality that many natural products efforts stall because the workflow is difficult to scale and standardize, and because the chemistry and biology steps can be slow, expensive, and uncertain without better tools.
A central theme of the opportunity is method development across the full natural products pipeline. That includes improving how natural materials are collected and handled, how bioassays are designed or run to identify meaningful biological activity, and how complex mixtures are processed through isolation and purification. It also highlights the need for better de-replication methods, meaning tools and workflows that quickly determine whether an "active" compound is truly novel or simply a previously known molecule showing up again. De-replication is emphasized because re-isolating known compounds is a major source of wasted time and cost in natural products discovery. The FOA also calls out challenges related to yield and supply, reflecting a common problem where a compound may be biologically interesting but difficult to obtain in sufficient quantity or with consistent quality, which can block further development, validation, and translation.
This was an STTR mechanism using the R41 phase, which generally supports feasibility and proof-of-concept work carried out through a collaboration between a small business concern and a research institution partner. The intent is to push innovations that are ready to be developed into practical, deployable methods, platforms, or services that can be adopted by laboratories, research programs, or downstream development efforts. The announcement sits within NIH's health research mission and is categorized under health as the activity area. It is tied to CFDA numbers 93.213 (Research and Training in Complementary and Integrative Health) and 93.350 (National Center for Advancing Translational Sciences), which signals an interest both in natural products relevant to complementary/integrative health research and in translational approaches that make discoveries more actionable.
From an eligibility standpoint, the applicant organization needed to be a small business. The FOA explicitly excludes non-U.S. (foreign) institutions from applying as the applicant organization, and it also excludes non-U.S. components of U.S. organizations from applying. However, it notes that foreign components, as defined under the NIH Grants Policy Statement, may be allowed, which typically means certain parts of the work can be performed abroad if well-justified and compliant with NIH policy, even though the applicant must be eligible and primarily domestic. No cost sharing or matching was required, reducing barriers for small businesses that may not have substantial non-federal funds available for a feasibility-stage project.
Key administrative details show that this was a time-limited opportunity posted on April 10, 2013, with an original and current closing date of August 2, 2013, and an archive date of September 2, 2013. The award ceiling listed is $225,000, indicating the upper limit of funding expected under this FOA for a single award or for a defined budget period as specified in the full announcement. The sponsoring agency is the National Institutes of Health, and the full FOA was made available through the NIH grants guide at the provided link. For access or technical issues, applicants were directed to contact the NIH Office of Extramural Research (OER) Webmaster via the provided email address.
In practical terms, the opportunity was aimed at enabling technologies and improved workflows that make natural products research more efficient, less redundant, and more scalable. By targeting collection methods, assay integration, separation science, compound identification and novelty screening, and supply/yield constraints, the FOA was structured to fund tools that remove the friction points that commonly prevent natural products from being fully utilized in health-related research and development.
Frequently Asked Questions (FAQs)
What is the name and funding opportunity number for this NIH grant?
The opportunity is titled "Methods Development in Natural Products Chemistry (STTR) (R41)" and the Funding Opportunity Number (FON) is RFA-AT-14-002.
What type of grant mechanism is this?
This is an NIH Small Business Technology Transfer (STTR) opportunity using the R41 phase, which is generally intended for feasibility and proof-of-concept work conducted through a collaboration between a small business and a research institution partner.
What is the main purpose of this funding opportunity?
The purpose is to support early-stage, high-impact methods development that makes natural products easier to discover, characterize, and ultimately use. It specifically targets practical bottlenecks in natural products chemistry that slow the transition from a promising natural source to a reproducible, well-characterized, and usable product or lead compound.
What kinds of projects does the FOA encourage?
The FOA encourages STTR applications that develop tools, workflows, platforms, or services that improve efficiency, reduce redundancy, and increase scalability across the natural products pipeline. The emphasis is on innovations that can become practical and deployable for labs, research programs, or downstream development.
Which parts of the natural products pipeline are in scope for methods development?
The FOA highlights method development across the full pipeline, including improving collection and handling of natural materials, bioassay design and execution to identify meaningful biological activity, processing complex mixtures through isolation and purification, and improving compound identification approaches that support novelty screening.
What does the FOA mean by "de-replication," and why is it important?
De-replication refers to tools and workflows that quickly determine whether an "active" compound is truly novel or is a previously known molecule. It is emphasized because re-isolating known compounds is a major source of wasted time and cost in natural products discovery.
Does the FOA address challenges related to yield and supply of natural products?
Yes. The FOA calls out yield and supply constraints as a key challenge, recognizing that biologically interesting compounds can be difficult to obtain in sufficient quantity or with consistent quality, which can prevent further development, validation, and translation.
Who is eligible to apply as the applicant organization?
The applicant organization needed to be a small business.
Are foreign (non-U.S.) institutions eligible to apply as the applicant organization?
No. The FOA explicitly excludes non-U.S. (foreign) institutions from applying as the applicant organization.
Are non-U.S. components of U.S. organizations eligible to apply?
No. The FOA also excludes non-U.S. components of U.S. organizations from applying.
Can any portion of the work be performed outside the United States?
The FOA notes that foreign components (as defined under the NIH Grants Policy Statement) may be allowed. This typically means some work can be performed abroad if it is well-justified and compliant with NIH policy, even though the applicant organization must be eligible and primarily domestic.
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching was required.
What is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
What is the activity area for this funding opportunity?
The activity area is health.
Which CFDA numbers are associated with this FOA?
The opportunity is tied to CFDA 93.213 (Research and Training in Complementary and Integrative Health) and CFDA 93.350 (National Center for Advancing Translational Sciences).
What do the CFDA numbers suggest about NIH priorities for this FOA?
They signal interest in natural products relevant to complementary and integrative health research, as well as translational approaches that make discoveries more actionable.
When was this funding opportunity posted?
The FOA was posted on April 10, 2013.
What were the closing date and archive date?
The original and current closing date was August 2, 2013. The archive date was September 2, 2013.
Is this a currently open funding opportunity?
No. Based on the listed closing and archive dates, this was a time-limited opportunity that has been closed and archived.
What is the award ceiling for this opportunity?
The listed award ceiling is $225,000, indicating the upper limit of funding expected under this FOA for a single award or for a defined budget period as specified in the full announcement.
What kinds of outcomes was NIH trying to enable with this FOA?
The FOA aimed to fund enabling technologies and improved workflows that make natural products research more efficient, less redundant, and more scalable, especially by reducing bottlenecks in collection, assay integration, separation and purification, compound identification and novelty screening, and supply/yield limitations.
Where was the full FOA made available?
The full FOA was made available through the NIH grants guide at the link provided in the announcement.
Who should be contacted for access or technical issues related to the FOA listing?
Applicants were directed to contact the NIH Office of Extramural Research (OER) Webmaster via the provided email address for access or technical issues.
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