Opportunity Information: Apply for APS OAA 14 000076
Apply for APS OAA 14 000076
- The Agency for International Development in the other (see text field entitled explanation of other category of funding activity for clarification) sector is offering a public funding opportunity titled "Microbicide Research, Development, and Introduction, Round 3" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 98.001 USAID Foreign Assistance for Programs Overseas.
- This funding opportunity was created on Jul 3, 2014 and posted on Jun 6, 2014.
- Applicants must submit their applications by Jul 11, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $4,000,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Eligibility requirements included in attached document.
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Opportunity Summary:
The funding opportunity titled "Microbicide Research, Development, and Introduction, Round 3" (Funding Opportunity Number APS OAA 14 000076) is a USAID request to support work that helps move HIV prevention microbicides from promising research results toward real-world availability and use, especially for women and girls in developing countries. It is issued by the U.S. Agency for International Development under CFDA 98.001 (USAID Foreign Assistance for Programs Overseas) and uses a Cooperative Agreement funding instrument, which typically means USAID expects substantial involvement during implementation (for example, through technical collaboration, shared planning, or ongoing coordination), rather than simply providing funds with minimal interaction.
The rationale for this call is grounded in a major milestone in HIV prevention research: the CAPRISA 004 clinical trial of 1 percent tenofovir gel. That study, led by South African investigators and supported jointly by USAID and the Government of South Africa, was the first to show proof of concept that a vaginal microbicide could significantly reduce the risk of HIV infection. After that announcement in July 2010, the field shifted from asking whether microbicides could work at all to confronting the next set of practical, high-stakes challenges: confirming safety and effectiveness through additional work, navigating regulatory pathways with national authorities, and preparing health programs and delivery systems to introduce a new prevention technology designed to meet the needs of women in settings with high HIV burden. USAID notes that while research and development of improved and alternative microbicide candidates remains important, this round emphasizes a broader set of activities needed to move the overall program toward product approval and successful introduction.
In plain terms, the opportunity is meant to fund creative research and innovative, problem-solving efforts that accelerate progress along the end-to-end pathway: from late-stage development issues and evidence generation, through regulatory readiness, and into the groundwork required for adoption in real service delivery programs. This reflects a recognition that scientific breakthroughs alone do not automatically translate into public health impact; success also depends on building an evidence base that regulators can rely on, addressing implementation realities, and preparing countries and programs to deliver products effectively and equitably. The ultimate goal described is to fill a critical gap in HIV prevention options by expanding what women and girls can use to protect themselves from infection.
The award size is designed for substantial projects, with an award floor of $1,000,000 and an award ceiling of $4,000,000. The opportunity does not require cost sharing or matching, reducing barriers for organizations that may have strong technical capacity but limited ability to provide additional funds. The opportunity category and activity category are listed as "Other," with the explanation making clear that the scope spans more than classic bench research and includes the wider set of activities needed for regulatory approval and introduction planning.
Key dates indicate a short application window at the time of posting. The opportunity was posted on June 6, 2014, created on July 3, 2014, and had an original closing date of July 9, 2014, later extended to July 11, 2014. The archive date is August 8, 2014, meaning it is no longer open, but the details still matter as a record of USAID priorities and the type of work it sought to support during that period.
Eligibility is listed broadly as "Others," with specific requirements and additional eligibility information referenced as being contained in the attached full announcement. In practice, USAID APS opportunities often attract a range of applicants such as nonprofit organizations, universities, research institutions, and other entities with demonstrated technical and operational capacity, but the definitive rules for this round would be in the attachment referenced in the notice. For applicants or readers who cannot access the full announcement electronically, the notice provides a point of contact: Petrina Williams, Contract Specialist/Agreement Specialist, at 202-567-5368.
Overall, this opportunity signals USAID's intent to invest not just in microbicide discovery, but in the hard transition work that turns a promising HIV prevention technology into something that can be approved, adopted, and delivered at scale, with an explicit focus on expanding prevention choices for women and girls in developing-country contexts.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Microbicide Research, Development, and Introduction, Round 3" and the Funding Opportunity Number is APS OAA 14 000076.
Which U.S. government agency issued this opportunity?
This opportunity was issued by the U.S. Agency for International Development (USAID).
What CFDA number is associated with this funding opportunity?
The opportunity is associated with CFDA 98.001, listed as "USAID Foreign Assistance for Programs Overseas."
What type of funding instrument is used?
USAID planned to use a Cooperative Agreement.
What does a Cooperative Agreement imply about USAID's role during implementation?
A Cooperative Agreement typically indicates that USAID expects substantial involvement during implementation. The description highlights examples such as technical collaboration, shared planning, and ongoing coordination, rather than a hands-off approach where funds are provided with minimal interaction.
What is the main purpose of the "Round 3" microbicide opportunity?
The purpose is to support work that helps move HIV prevention microbicides from promising research findings toward real-world availability and use, with a particular emphasis on women and girls in developing countries.
What stage of the microbicide pathway does this opportunity emphasize?
This round emphasizes the broader set of activities needed to move toward product approval and successful introduction, including late-stage development issues, evidence generation, regulatory readiness, and groundwork for adoption in real service delivery programs.
How does this opportunity differ from basic or early-stage microbicide research?
While USAID notes that research and development of improved and alternative microbicide candidates remains important, this round is framed around the transition work needed after proof-of-concept results: confirming safety and effectiveness through additional work, navigating regulatory pathways, and preparing programs and delivery systems for introduction.
What research milestone does USAID cite as part of the rationale for this call?
USAID cites the CAPRISA 004 clinical trial of 1 percent tenofovir gel, which was described as the first to show proof of concept that a vaginal microbicide could significantly reduce the risk of HIV infection.
When was the CAPRISA 004 trial result publicly announced, according to the description?
The description notes the announcement occurred in July 2010.
Why does USAID emphasize more than scientific breakthroughs in this funding opportunity?
The opportunity reflects the idea that scientific breakthroughs alone do not automatically translate into public health impact. USAID emphasizes building an evidence base regulators can rely on, addressing implementation realities, and preparing countries and programs to deliver products effectively and equitably.
What kinds of activities are intended to be supported (in plain terms)?
The notice describes funding for creative research and innovative, problem-solving efforts that accelerate progress across the end-to-end pathway: from late-stage development and evidence generation, through regulatory readiness, and into planning and preparation for adoption and delivery in real service delivery programs.
Who is the primary intended beneficiary population highlighted in the notice?
The opportunity explicitly emphasizes expanding HIV prevention choices for women and girls, especially in developing-country contexts with high HIV burden.
What is the ultimate goal of the work USAID sought to support?
The stated ultimate goal is to fill a critical gap in HIV prevention options by expanding what women and girls can use to protect themselves from HIV infection, by helping move microbicides toward approval, adoption, and delivery at scale.
What is the award floor and award ceiling?
The award floor is $1,000,000 and the award ceiling is $4,000,000.
Is cost sharing or matching required?
No. The opportunity states that cost sharing or matching is not required.
What are the opportunity category and activity category?
Both the opportunity category and the activity category are listed as "Other."
Why is the activity category listed as "Other"?
The description explains that the scope spans more than classic bench research and includes the wider set of activities needed for regulatory approval and introduction planning.
When was the opportunity posted and when was it created?
The opportunity was posted on June 6, 2014, and created on July 3, 2014.
What was the original closing date and what was it extended to?
The original closing date was July 9, 2014, and it was extended to July 11, 2014.
Is this funding opportunity currently open?
No. The archive date is August 8, 2014, which indicates the opportunity is no longer open.
How is eligibility described in the notice?
Eligibility is listed broadly as "Others," with additional eligibility information and specific requirements referenced as being contained in the attached full announcement.
Where are the definitive eligibility rules and requirements located?
The notice indicates that specific requirements and additional eligibility information are contained in the attached full announcement referenced in the opportunity.
What types of organizations might typically be interested in USAID APS opportunities like this (as described in the notice)?
The description notes that APS opportunities often attract a range of applicants such as nonprofit organizations, universities, research institutions, and other entities with demonstrated technical and operational capacity, while also emphasizing that the definitive rules for this round would be in the attachment referenced in the notice.
Who is the point of contact for applicants or readers who cannot access the full announcement electronically?
The notice provides a point of contact: Petrina Williams, Contract Specialist/Agreement Specialist.
What contact phone number is provided in the notice?
The phone number provided is 202-567-5368.
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