Opportunity Information: Apply for APS OAA 12 000007
Apply for APS OAA 12 000007
- The Agency for International Development in the other (see text field entitled explanation of other category of funding activity for clarification) sector is offering a public funding opportunity titled "Microbicides Research, Development, and Introduction" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 98.001 USAID Foreign Assistance for Programs Overseas.
- This funding opportunity was created on Jul 30, 2012 and posted on Jul 30, 2012.
- Applicants must submit their applications by TBD. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,250,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Elibility requirements included in attached document.
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Opportunity Summary:
The Microbicides Research, Development, and Introduction opportunity (Funding Opportunity Number APS-OAA-12-000007) is a USAID request under an Annual Program Statement designed to move promising vaginal microbicide products and strategies closer to real-world impact. The underlying public health need is straightforward: women and girls in many settings still have limited options they can control to protect themselves from HIV infection. Recent clinical trials in South Africa have tested vaginal microbicides for their ability to reduce HIV acquisition, and this funding opportunity is positioned to build on that momentum by supporting the kinds of research, development, and early introduction work that help translate clinical evidence into scalable prevention tools.
USAID indicates that the award mechanism will be a Cooperative Agreement, meaning USAID expects to have substantial involvement during implementation rather than operating at arm's length. The APS emphasizes creative research and innovative activities that are now considered essential for two major milestones: first, advancing candidate microbicides toward regulatory approval, and second, successfully introducing approved microbicides into service delivery programs. In practical terms, this points to support not only for scientific and clinical advancement, but also for the operational, policy, and programmatic work required to integrate a new prevention commodity into health systems and community settings.
The opportunity is explicitly framed to align with the Principles of the Global Health Initiative (GHI). It highlights promoting research and innovation, using a women- and girl-centered approach, and strengthening and leveraging contributions from multilateral organizations, global health partnerships, and the private sector. It also stresses encouraging country ownership and leadership, which signals that proposals will likely be stronger if they are grounded in local priorities, demonstrate meaningful engagement with national stakeholders, and build sustainable capacity rather than running as externally driven pilots.
Another key theme is health systems strengthening, especially around the building blocks that often determine whether a biomedical innovation actually reaches the people who need it. USAID notes potential contributions to commodities and procurement (such as supply chains, forecasting, and product availability), service delivery (such as integration into clinics or community platforms, provider training, and quality assurance), and leadership and governance (such as policy, coordination, and regulatory readiness). Even though the focus is microbicides, USAID is signaling that it cares about the full pathway from product to program, including the systems that support safe, consistent, and equitable access.
Gender is treated as a central design requirement rather than an add-on. USAID expects gender analyses and other gender considerations to continue informing both the design and implementation of activities supported under its microbicide program. That implies applicants should be prepared to show how their approach responds to gender-related barriers and risks, including norms affecting women's autonomy, ability to negotiate prevention, stigma, intimate partner dynamics, safety concerns, and the realities facing adolescent girls and young women in high-incidence settings.
Environmental compliance is also a condition of award. All funded activities will be subject to USAID environmental requirements, including completion of an Initial Environmental Examination. For applicants, this typically means anticipating how research and program activities will handle issues like biomedical waste management, facility and laboratory practices, and any other operational impacts that USAID environmental review processes commonly cover.
From a funding standpoint, the opportunity lists an award floor of $100,000 and a ceiling of $2,250,000, with no cost sharing or matching requirement. The CFDA reference is 98.001 (USAID Foreign Assistance for Programs Overseas). The posting date and creation date are July 30, 2012, and the closing date is listed as TBD, indicating that applications were likely accepted on a rolling or periodically reviewed basis under APS procedures, with the detailed eligibility rules and submission requirements contained in the attached APS document rather than in the brief synopsis.
Eligibility is described broadly as "Others," with the specific eligibility requirements provided in the attachment. This phrasing commonly indicates that multiple organization types may be eligible (for example, nonprofits, universities, research organizations, or private entities), but that applicants must check the APS text for the exact criteria, any restrictions, and the required documentation. The named point of contact is Kathleen Bumpass, Contracts/Agreement Specialist, at 202-567-5008, for assistance accessing the full announcement or presumably for administrative questions.
Overall, this APS is aimed at closing a critical gap in HIV prevention choices by supporting the next phase of microbicide progress: not just demonstrating efficacy in trials, but doing the additional research, coordination, and system preparation needed for regulatory approval and successful introduction into health programs in ways that prioritize women and girls, strengthen country-led systems, and leverage partnerships across sectors.
Microbicides Research, Development, and Introduction (APS-OAA-12-000007) - FAQs
1) What is this funding opportunity?
This is a USAID funding opportunity titled "Microbicides Research, Development, and Introduction" under an Annual Program Statement (APS). It is designed to move promising vaginal microbicide products and related strategies closer to real-world public health impact, particularly by helping translate clinical trial evidence into scalable HIV prevention tools for women and girls.
2) What public health problem is USAID trying to address?
The opportunity is rooted in the ongoing need for HIV prevention options that women and girls can control. In many settings, women and girls still have limited ability to protect themselves from HIV infection using methods they can initiate and manage.
3) What types of products are the focus of this APS?
The APS focuses on vaginal microbicides, including candidate products and strategies intended to reduce HIV acquisition. The opportunity is positioned to build on momentum from recent clinical trials (including trials in South Africa) that tested vaginal microbicides for HIV prevention.
4) What is the Funding Opportunity Number?
The Funding Opportunity Number is APS-OAA-12-000007.
5) What kind of award will USAID use for this opportunity?
USAID indicates the award mechanism will be a Cooperative Agreement. This means USAID expects to have substantial involvement during implementation, rather than operating at a distance.
6) What does "substantial involvement" mean in practice?
Because this is a Cooperative Agreement, USAID anticipates playing an active role during implementation. The synopsis does not list the exact form of involvement, but it signals that implementers should expect ongoing collaboration and engagement with USAID compared to more hands-off award types.
7) What are the main goals or milestones USAID wants to support?
The APS highlights two major milestones: (1) advancing candidate microbicides toward regulatory approval, and (2) successfully introducing approved microbicides into service delivery programs.
8) Is this opportunity only about clinical research?
No. While the APS supports research and development, it also points to early introduction work and the operational, policy, and programmatic activities needed to integrate a new prevention commodity into health systems and community settings.
9) What kinds of activities does the APS emphasize?
USAID emphasizes creative research and innovative activities considered essential to progress microbicides from evidence to impact. The synopsis also highlights work across the pathway from product to program, including research, development, regulatory readiness, and introduction planning and implementation support.
10) How does this opportunity align with the Global Health Initiative (GHI)?
The opportunity is explicitly framed to align with the Principles of the Global Health Initiative (GHI). It highlights promoting research and innovation, using a women- and girl-centered approach, and strengthening and leveraging contributions from multilateral organizations, global health partnerships, and the private sector.
11) How important is "country ownership" in this APS?
Country ownership and leadership are stressed as important themes. Proposals are likely to be stronger if they reflect local priorities, include meaningful engagement with national stakeholders, and build sustainable capacity rather than functioning as externally driven pilots.
12) Does USAID expect health systems strengthening components?
Yes. A key theme is health systems strengthening, especially in areas that often determine whether a biomedical innovation reaches the people who need it. USAID signals interest in the systems and structures that support safe, consistent, and equitable access.
13) What health system areas are highlighted?
The synopsis highlights potential contributions to:
- Commodities and procurement: supply chains, forecasting, and product availability
- Service delivery: integration into clinics or community platforms, provider training, and quality assurance
- Leadership and governance: policy, coordination, and regulatory readiness
14) Is gender considered a core requirement?
Yes. Gender is treated as a central design requirement rather than an add-on. USAID expects gender analyses and other gender considerations to inform both design and implementation of activities supported under its microbicide program.
15) What gender-related issues should applicants be prepared to address?
The synopsis indicates applicants should be prepared to address gender-related barriers and risks, including norms affecting women's autonomy, ability to negotiate prevention, stigma, intimate partner dynamics, safety concerns, and the realities facing adolescent girls and young women in high-incidence settings.
16) Are there environmental compliance requirements?
Yes. Environmental compliance is a condition of award. All funded activities will be subject to USAID environmental requirements, including completion of an Initial Environmental Examination.
17) What kinds of environmental issues might be relevant?
Applicants should anticipate operational impacts commonly covered by USAID environmental review processes, such as biomedical waste management, facility and laboratory practices, and other impacts related to research and program activities.
18) What is the funding range for awards under this opportunity?
The opportunity lists an award floor of $100,000 and a ceiling of $2,250,000.
19) Is cost sharing or matching required?
No. The synopsis states there is no cost sharing or matching requirement.
20) What is the CFDA reference for this opportunity?
The CFDA reference is 98.001 (USAID Foreign Assistance for Programs Overseas).
21) When was this opportunity posted?
The posting date and creation date are July 30, 2012.
22) What is the closing date for applications?
The closing date is listed as TBD. This suggests applications may have been accepted on a rolling basis or reviewed periodically under APS procedures, with the definitive details contained in the attached APS document.
23) Who is eligible to apply?
Eligibility is described broadly as "Others," with the specific eligibility requirements provided in the attachment. This commonly indicates multiple organization types may be eligible, but applicants need to consult the APS attachment for the exact criteria, restrictions, and required documentation.
24) Where are the detailed submission requirements and eligibility rules?
The synopsis indicates that detailed eligibility rules and submission requirements are contained in the attached APS document rather than in the brief synopsis.
25) Who is the point of contact for this opportunity?
The named point of contact is Kathleen Bumpass, Contracts/Agreement Specialist, at 202-567-5008. The synopsis notes this contact can help with accessing the full announcement and related administrative questions.
26) What overall outcome is USAID trying to achieve through this APS?
The APS aims to close a critical gap in HIV prevention choices by supporting the next phase of microbicide progress: moving beyond trial results to the additional research, coordination, and system preparation needed for regulatory approval and successful introduction into health programs in ways that prioritize women and girls, strengthen country-led systems, and leverage partnerships across sectors.
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