Opportunity Information: Apply for PAR 11 299
Apply for PAR 11 299
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular and Cellular Substrates of Complex Brain Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 4, 2014 and posted on Aug 10, 2011.
- Applicants must submit their applications by Aug 5, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments Independent school districts Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The funding opportunity titled "Molecular and Cellular Substrates of Complex Brain Disorders (R01)" (Funding Opportunity Number PAR 11-299) is a discretionary National Institutes of Health (NIH) research grant program that supports investigator-initiated projects using the R01 mechanism. Its central goal is to push forward basic and translational neuroscience by funding studies that clarify how alterations linked to complex brain disorders affect the core molecular and cellular building blocks of neuronal function. In practice, the FOA is aimed at research that connects disease-associated changes (for example, genetic variation, molecular pathway disruptions, or other biological alterations observed in brain disorders) to concrete effects on how neurons and neural circuits operate at a mechanistic level, with emphasis on fundamental processes that underlie brain function.
The opportunity sits within NIH health research priorities and is associated with CFDA listings 93.242 (Mental Health Research Grants) and 93.273 (Alcohol Research Programs), signaling its relevance to mental health conditions and alcohol-related research areas, among other complex brain disorders. The FOA language points to a discovery-oriented focus: applicants are expected to go beyond describing correlations and instead investigate how disorder-related alterations influence cellular and molecular substrates, such as synaptic function, neuronal signaling, plasticity, gene expression programs, and other core neurobiological mechanisms that can be studied experimentally. The overall intent is to generate mechanistic insight that can deepen understanding of disease biology and potentially inform future diagnostic or therapeutic strategies, even when the immediate work is primarily basic science.
This is a grant program with no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of the award. As an R01, it is generally designed to support substantial, multi-year research projects that have a clear rationale, rigorous approach, and well-justified experimental plan. While the short summary provided does not list specific scientific topics or exclusions, the framing makes it clear that applications should be anchored in molecular and cellular neuroscience and should explicitly tie the proposed mechanistic work to alterations associated with complex brain disorders, rather than studying neuronal function in isolation.
Eligibility is broad and includes a wide range of organizational types. Eligible applicants include for-profit organizations (including small businesses and other than small businesses), nonprofit organizations (both 501(c)(3) and non-501(c)(3) entities), public and private institutions of higher education, and multiple levels of government such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility scope also extends to Native American tribal governments (federally recognized) and tribal organizations (including those other than federally recognized tribal governments). Additional eligible categories specifically called out include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-domestic (non-U.S.) entities (foreign organizations). This wide eligibility reflects NIH’s interest in attracting strong research proposals from diverse institutional settings, including international and regionally focused research organizations where appropriate.
Key administrative details in the source data indicate the program was posted on August 10, 2011, with a later creation date record of August 4, 2014. The original closing date is listed as September 7, 2014, with a current closing date of August 5, 2014, and an archive date of September 4, 2014, meaning the opportunity is historical/archived rather than currently open. Applicants seeking the full announcement and requirements were directed to the NIH grants guide page at http://grants.nih.gov/grants/guide/pa-files/PAR-11-299.html. For access issues or linking problems, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, PAR 11-299 is best understood as an NIH R01 call designed to strengthen mechanistic neuroscience research on complex brain disorders by funding projects that directly test how disorder-related alterations reshape the molecular and cellular machinery that neurons rely on to function.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Molecular and Cellular Substrates of Complex Brain Disorders (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PAR 11-299.
What agency sponsors this opportunity?
This is a National Institutes of Health (NIH) research grant opportunity.
What type of grant mechanism does it use?
It uses the NIH R01 mechanism and supports investigator-initiated research projects.
What is the main purpose of PAR 11-299?
The central goal is to advance basic and translational neuroscience by supporting studies that clarify how alterations associated with complex brain disorders affect the molecular and cellular building blocks of neuronal function.
What kind of research is this FOA trying to fund?
The FOA is aimed at research that links disease-associated changes (such as genetic variation, disrupted molecular pathways, or other biological alterations observed in brain disorders) to concrete, mechanistic effects on how neurons and neural circuits function.
Does the FOA emphasize correlation studies or mechanistic studies?
The FOA emphasizes mechanistic studies. It expects applicants to go beyond describing correlations and to investigate how disorder-related alterations influence molecular and cellular substrates experimentally.
What are examples of "molecular and cellular substrates" mentioned in the opportunity summary?
Examples specifically referenced include synaptic function, neuronal signaling, plasticity, and gene expression programs, as well as other core neurobiological mechanisms that can be studied experimentally.
Is this opportunity focused on basic science, translational science, or both?
It is positioned to push forward both basic and translational neuroscience. The intent includes generating mechanistic insight that can deepen understanding of disease biology and potentially inform future diagnostic or therapeutic strategies, even if the immediate work is primarily basic science.
Do applications need to connect the proposed work to complex brain disorders?
Yes. The framing makes it clear that applications should explicitly tie the proposed mechanistic work to alterations associated with complex brain disorders rather than studying neuronal function in isolation.
Which program areas or CFDA listings are associated with this FOA?
The FOA is associated with CFDA 93.242 (Mental Health Research Grants) and 93.273 (Alcohol Research Programs).
Does this mean the FOA is only for mental health or alcohol research?
The summary indicates relevance to mental health conditions and alcohol-related research areas, among other complex brain disorders. The description also uses broader language around complex brain disorders generally.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
How long and how substantial are projects typically under an R01?
The summary describes the R01 as generally designed to support substantial, multi-year research projects with a clear rationale, a rigorous approach, and a well-justified experimental plan.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including for-profit and nonprofit organizations, public and private institutions of higher education, and multiple levels of government.
Are for-profit organizations eligible?
Yes. For-profit organizations are listed as eligible, including small businesses and other than small businesses.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations are eligible, including both 501(c)(3) and non-501(c)(3) entities.
Are colleges and universities eligible?
Yes. Public and private institutions of higher education are listed as eligible.
Are state and local government entities eligible?
Yes. The eligibility list includes state governments and multiple local government types, including county governments, city/township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. Native American tribal governments (federally recognized) are eligible, and tribal organizations are also eligible, including those other than federally recognized tribal governments.
Are minority-serving institutions included in the eligibility list?
Yes. The list specifically mentions Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and other similar categories.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed as eligible.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are specifically called out as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included in the eligibility list.
Are foreign (non-U.S.) organizations eligible?
Yes. Non-domestic (non-U.S.) entities (foreign organizations) are listed as eligible.
Is this funding opportunity currently open?
No. The administrative details indicate it is historical/archived rather than currently open.
What dates indicate that the opportunity is archived?
The source data lists an original closing date of September 7, 2014, a current closing date of August 5, 2014, and an archive date of September 4, 2014. These dates indicate the opportunity is no longer active.
When was the opportunity posted?
The program was posted on August 10, 2011.
Why is there also a later "creation date record" mentioned?
The source data includes a later creation date record of August 4, 2014, in addition to the original posting date.
Where can applicants find the full announcement details?
The full announcement and requirements were directed to the NIH grants guide page at http://grants.nih.gov/grants/guide/pa-files/PAR-11-299.html.
Who is listed as the contact for access issues or linking problems?
The contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the simplest way to describe the intent of PAR 11-299?
It is an NIH R01 call intended to strengthen mechanistic neuroscience research on complex brain disorders by funding projects that directly test how disorder-related alterations reshape the molecular and cellular machinery that neurons rely on to function.
Browse more opportunities from the same category: Health
Next opportunity: Molecular and Cellular Substrates of Complex Brain Disorders (R21)
Previous opportunity: Defense Sciences Research and Technology
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 11 299
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 11 299) also looked into and applied for these:
| Funding Opportunity |
|---|
| Molecular and Cellular Substrates of Complex Brain Disorders (R21) Apply for PAR 11 300 Funding Number: PAR 11 300 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Mentored Career Award for Faculty at Institutions That Promote Diversity (K01) Apply for RFA HL 12 029 Funding Number: RFA HL 12 029 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| International Centers of Excellence for Malaria Research (ICEMR) Competitive Revision (U19) Apply for RFA AI 11 046 Funding Number: RFA AI 11 046 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| 2012 NIH Directors New Innovator Award Program (DP2) Apply for RFA RM 11 005 Funding Number: RFA RM 11 005 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Dimensional Approaches to Research Classification in Psychiatric Disorders (R01) Apply for RFA MH 12 100 Funding Number: RFA MH 12 100 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Emerging Infections Program Apply for CDC RFA CK12 1202 Funding Number: CDC RFA CK12 1202 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $5,000,000 |
| Discovery of Genetic Basis of Mendelian or Monogenic Heart, Lung, and Blood Disorders (X01) Apply for PAR 11 307 Funding Number: PAR 11 307 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Native American Research Centers for Health (NARCH) V and VI Competitive Supplements Apply for HHS 2011 IHS NARCH 0001 Funding Number: HHS 2011 IHS NARCH 0001 Agency: Indian Health Service Category: Health Funding Amount: $700,000 |
| Secondary Analysis of Existing Alcohol Epidemiology Data (R01) Apply for PA 11 308 Funding Number: PA 11 308 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Secondary Analysis of Existing Alcohol Epidemiology Data (R03) Apply for PA 11 309 Funding Number: PA 11 309 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tribal Self Governance Program, Planning Cooperative Agreement Apply for HHS 2011 IHS TSGP 0001 Funding Number: HHS 2011 IHS TSGP 0001 Agency: Indian Health Service Category: Health Funding Amount: $75,000 |
| Tribal Self Governance Program Negotiation Cooperative Agreement Apply for HHS 2011 IHS TSGN 0001 Funding Number: HHS 2011 IHS TSGN 0001 Agency: Indian Health Service Category: Health Funding Amount: $30,000 |
| Tribal Management Grant Program Apply for HHS 2012 IHS TMD 0001 Funding Number: HHS 2012 IHS TMD 0001 Agency: Indian Health Service Category: Health Funding Amount: $100,000 |
| Implementation Science Research to Support Programs under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for APS OAA 11 000002 Funding Number: APS OAA 11 000002 Agency: Agency for International Development Category: Health Funding Amount: $1,800,000 |
| Tracking Electronic Health Record Adoption And Capturing Related Insights in U.S. Hospitals Apply for EP NARRA AHA 11 001 Funding Number: EP NARRA AHA 11 001 Agency: Office of the National Coordinator Category: Health Funding Amount: $204,000 |
| Short Term Research Education Program to Increase Diversity in Health Related Research (R25) Apply for RFA HL 12 031 Funding Number: RFA HL 12 031 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Global Nurse Capacity Building Program Apply for HRSA 12 123 Funding Number: HRSA 12 123 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Innovative Pilot Studies of Novel Mechanism of Action Compounds for Treating Psychiatric Disorders (U01) Apply for PAR 11 316 Funding Number: PAR 11 316 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Exploratory Grant Program in Disease Modification and Prevention in the Epilepsies (P20) Apply for RFA NS 12 006 Funding Number: RFA NS 12 006 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Early Cystic Fibrosis Lung Disease Studies in Humans, NHLBI (R01) Apply for RFA HL 12 035 Funding Number: RFA HL 12 035 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 11 299", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.