Opportunity Information: Apply for PAR 11 300
Apply for PAR 11 300
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular and Cellular Substrates of Complex Brain Disorders (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 4, 2014 and posted on Aug 10, 2011.
- Applicants must submit their applications by Aug 5, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Special district governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses For profit organizations other than small businesses Independent school districts Public housing authorities/Indian housing authorities City or township governments Native American tribal governments (Federally recognized) State governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Molecular and Cellular Substrates of Complex Brain Disorders (R21)" (Funding Opportunity Number PAR-11-300) is a National Institutes of Health (NIH) discretionary funding announcement that supports early-stage, exploratory research projects. The core purpose of the FOA is to encourage studies that connect complex brain disorders to the basic building blocks of neuronal function, specifically by discovering how disorder-associated alterations affect fundamental molecular and cellular processes in neurons. In practice, this means the program is aimed at research that moves beyond describing symptoms or broad brain-region changes and instead digs into mechanisms such as how genes, proteins, synapses, signaling pathways, cellular excitability, and other core neuronal functions are altered in ways that may contribute to complex neuropsychiatric or neurobehavioral conditions. The emphasis is on identifying and characterizing mechanistic links between disorder-related changes and the cellular/molecular substrates that underlie how neurons operate.
This opportunity uses the NIH R21 mechanism, which is commonly designed for novel, high-risk/high-reward, or proof-of-concept projects where investigators are testing emerging ideas or generating key preliminary data that could lead to larger studies later. The award ceiling listed for this announcement is $200,000, and the funding instrument type is a grant. There is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds to be eligible.
The activity category is Health, and the program is associated with CFDA numbers 93.242 (Mental Health Research Grants) and 93.273 (Alcohol Research Programs). That combination signals that the scientific scope is relevant to mental health and may also intersect with alcohol-related research areas, consistent with NIH institute portfolios that cover complex brain disorders. The overall intent is to stimulate research that clarifies the molecular and cellular consequences of alterations linked to these disorders, with an eye toward understanding disease biology at a level that can ultimately inform better interventions, targets, or diagnostic approaches, even if immediate clinical applications are not required at the R21 stage.
Eligibility is broad and includes many types of applicant organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with 501(c)(3) status and also nonprofits without 501(c)(3) status, other than institutions of higher education), small businesses, and for-profit organizations (including those other than small businesses). Government entities are also eligible, spanning city or township governments, county governments, state governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments). Additional eligibility information further expands the pool to include Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations). Taken together, the eligibility language indicates NIH intended to encourage diverse institutional participation, including domestic and international research organizations and a wide range of community, academic, governmental, and private-sector applicants.
Key administrative details provided in the source data include a posted date of August 10, 2011, with later record creation activity dated August 4, 2014. The original closing date is listed as September 7, 2014, with a current closing date of August 5, 2014, and an archive date of September 4, 2014. The agency listed is the National Institutes of Health. For applicants or readers who have trouble accessing the full announcement or linking to it, the contact given is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. The additional information link points to the NIH Grants Guide page for the announcement at http://grants.nih.gov/grants/guide/pa-files/PAR-11-300.html.
Overall, this FOA is best understood as NIH support for exploratory neuroscience and neurobiology research focused on mechanism: figuring out how changes associated with complex brain disorders translate into disruptions of the molecular and cellular machinery that neurons use to communicate, adapt, and function. It is structured to enable investigators to pursue new directions and generate foundational mechanistic insights that can later be built into more comprehensive research programs.
Frequently Asked Questions (FAQs)
What is the official title of this grant opportunity?
The opportunity is titled "Molecular and Cellular Substrates of Complex Brain Disorders (R21)."
What is the funding opportunity number (FOA number)?
The Funding Opportunity Number is PAR-11-300.
Which federal agency is offering this opportunity?
The agency listed is the National Institutes of Health (NIH).
What kind of projects is this FOA meant to support?
This FOA supports early-stage, exploratory research projects aimed at connecting complex brain disorders to the fundamental molecular and cellular processes that underlie neuronal function.
What is the core scientific purpose of the FOA?
The main purpose is to encourage studies that discover how disorder-associated alterations affect basic neuronal mechanisms, such as molecular pathways and cellular processes, rather than focusing only on symptoms or broad brain-region changes.
What types of biological mechanisms are emphasized in this program?
The emphasis is on mechanistic links involving core neuronal functions, including how genes, proteins, synapses, signaling pathways, cellular excitability, and other molecular/cellular substrates of neuronal operation are altered in association with complex brain disorders.
Does the FOA focus on describing clinical symptoms or brain-region level changes?
No. The focus is on moving beyond symptom descriptions or broad regional changes and instead identifying and characterizing molecular and cellular mechanisms in neurons that are affected by disorder-associated alterations.
What NIH award mechanism does this opportunity use?
This opportunity uses the NIH R21 mechanism.
What does the R21 mechanism imply about the kind of research NIH expects?
R21 awards are commonly designed for novel, high-risk/high-reward, exploratory, or proof-of-concept projects that test emerging ideas and generate key preliminary data that could support larger studies later.
What is the maximum award amount (award ceiling) stated for this announcement?
The award ceiling listed is $200,000.
What is the funding instrument type?
The funding instrument type is a grant.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement stated for this opportunity.
What is the activity category for this funding opportunity?
The activity category is Health.
Which CFDA numbers are associated with this opportunity?
The CFDA numbers listed are 93.242 (Mental Health Research Grants) and 93.273 (Alcohol Research Programs).
Does the scope relate only to mental health, or can it intersect with alcohol research as well?
Based on the CFDA numbers provided, the scope is relevant to mental health and may also intersect with alcohol-related research areas.
Are immediate clinical applications required at the R21 stage?
The description indicates that immediate clinical applications are not required at the R21 stage, with an overall intent to build mechanistic understanding that can ultimately inform interventions, targets, or diagnostics later.
Who is eligible to apply?
Eligibility is broad and includes many organization types across academia, nonprofit, business, government, tribal entities, and more (including non-U.S. entities).
Are public and state-controlled institutions of higher education eligible?
Yes, public and state-controlled institutions of higher education are listed as eligible applicants.
Are private institutions of higher education eligible?
Yes, private institutions of higher education are listed as eligible applicants.
Are nonprofit organizations eligible, including those without 501(c)(3) status?
Yes. The FOA includes nonprofit organizations with 501(c)(3) status and also nonprofits without 501(c)(3) status (other than institutions of higher education).
Are small businesses eligible to apply?
Yes, small businesses are listed as eligible applicants.
Are for-profit organizations eligible, including those that are not small businesses?
Yes. For-profit organizations (including those other than small businesses) are listed as eligible applicants.
Are local government entities eligible (city, township, county)?
Yes. City or township governments and county governments are listed as eligible applicants.
Are state governments eligible?
Yes, state governments are listed as eligible applicants.
Are special district governments eligible?
Yes, special district governments are listed as eligible applicants.
Are independent school districts eligible?
Yes, independent school districts are listed as eligible applicants.
Are public housing authorities and Indian housing authorities eligible?
Yes, public housing authorities/Indian housing authorities are listed as eligible applicants.
Are Native American tribal governments eligible?
Yes. Native American tribal governments (federally recognized) are explicitly included as eligible applicants.
Are Native American tribal organizations eligible even if they are not federally recognized tribal governments?
Yes. Native American tribal organizations (other than federally recognized tribal governments) are explicitly included.
Are minority-serving institutions eligible (HBCUs, Hispanic Serving Institutions, TCCUs)?
Yes. The eligibility information explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are Alaska Native and Native Hawaiian Serving Institutions eligible?
Yes, Alaska Native and Native Hawaiian Serving Institutions are explicitly included.
Are faith-based or community-based organizations eligible?
Yes, faith-based or community-based organizations are included in the expanded eligibility information.
Are U.S. territories or possessions eligible?
Yes, U.S. territories or possessions are explicitly included.
Are regional organizations eligible?
Yes, regional organizations are explicitly included.
Are non-U.S. entities (foreign organizations) eligible to apply?
Yes. Non-U.S. entities (foreign organizations) are explicitly included in the eligibility information.
Where can applicants find the full announcement text?
The additional information link provided points to the NIH Grants Guide page: http://grants.nih.gov/grants/guide/pa-files/PAR-11-300.html
What is the posted date listed for this opportunity?
The posted date provided is August 10, 2011.
What dates are listed for closing and archiving?
The source data lists an original closing date of September 7, 2014, a current closing date of August 5, 2014, and an archive date of September 4, 2014.
Who should be contacted if there are technical issues accessing the announcement link?
The contact listed for access or linking issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
How should this FOA be summarized in plain terms?
It is NIH support for exploratory neuroscience and neurobiology research focused on mechanisms: determining how disorder-associated changes translate into disruptions of the molecular and cellular machinery neurons use to function and communicate, with the goal of generating foundational insights that can later support larger research programs.
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