Opportunity Information: Apply for RFA DK 09 004
Apply for RFA DK 09 004
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Multiethnic Study of Type 2 Diabetes Genes (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Jan 7, 2009 and posted on Jan 7, 2009.
- Applicants must submit their applications by Mar 18, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Special district governments State governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments City or township governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Multiethnic Study of Type 2 Diabetes Genes (U01) funding opportunity (RFA-DK-09-004) is a National Institutes of Health program led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) aimed at advancing the understanding of the genetics of type 2 diabetes across the diverse populations that make up the United States. The core scientific goal is to confirm and further characterize genetic associations for type 2 diabetes that have already been identified through genome-wide association studies (GWAS). In practical terms, applicants are expected to take signals found in prior GWAS and test, validate, and refine them in multiple ethnic groups, with the intent of determining whether the same genetic risk factors apply broadly across populations, whether the strength of associations differs by ancestry, and whether additional population-specific variants or patterns emerge when the research is expanded beyond a single group.
This announcement uses a U01 cooperative agreement mechanism rather than a standard research project grant. That distinction matters because a U01 generally implies substantial scientific or programmatic involvement by NIH staff during the life of the project. Awards funded under cooperative agreements often operate as coordinated efforts where NIH may help guide priorities, facilitate collaboration across awardees, and support harmonization of methods or data standards, especially when the program’s success depends on multiple teams producing comparable results. For a project focused on confirming GWAS findings in multiethnic cohorts, that cooperative structure is designed to encourage consistency in study design and to make the resulting evidence stronger and easier to compare across different datasets and populations.
In terms of funding scale, NIDDK anticipated investing roughly $20 million total over five years through this initiative, with an expected 5 to 6 awards made under the request for applications. The listing also provides an estimated total funding figure of $4,000,000 and an award ceiling of $500,000, which typically reflects annualized or per-award caps as presented in the opportunity record. The takeaway is that this was intended as a mid-sized, multi-award research program supporting several coordinated projects rather than a single large center grant, with enough overall funding to build a set of complementary studies that collectively strengthen the evidence base for diabetes genetics in the US population.
The opportunity falls under the NIH discretionary grant category and is associated with CFDA numbers 93.172 (Human Genome Research) and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), reflecting its combined emphasis on genomics and diabetes-focused public health. There is no cost sharing or matching requirement, which means applicants were not required to commit non-federal funds as a condition of receiving an award.
Eligibility was broad and included a wide range of organizations that could contribute to population-based genetics research. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (other than small businesses, although small businesses were also listed as eligible), and multiple levels of government entities (state, county, city/township, special district governments, and independent school districts). The announcement also explicitly included tribal governments and tribal organizations, as well as institutions serving populations that are often central to multiethnic research goals, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. Foreign organizations and non-domestic entities were also listed among eligible applicants, along with US territories and possessions, which aligns with the scientific emphasis on diverse populations and the practical reality that relevant cohorts, expertise, or analytic capacity may be distributed across many types of institutions.
Key dates indicate this was a time-limited solicitation posted January 7, 2009, with an original and current closing date of March 18, 2009, and an archive date of April 18, 2009, meaning the competition is no longer active. The full announcement was hosted on the NIH grants site, and contact support was routed through the NIH Office of Extramural Research webmaster for access and linking issues, which is typical for announcements of that era.
Overall, this FOA was designed to move beyond initial discovery signals from GWAS by testing their validity and relevance across multiple US ethnic groups, improving confidence in which genetic associations are truly robust, and helping clarify how genetic risk for type 2 diabetes may vary across populations. By funding several coordinated U01 projects, NIDDK aimed to generate stronger, more generalizable genetic evidence that could ultimately support better biological understanding of diabetes risk and, over time, inform more equitable approaches to prediction, prevention, and treatment.
Frequently Asked Questions (FAQs)
What is the funding opportunity called?
The opportunity is titled The Multiethnic Study of Type 2 Diabetes Genes (U01) and is identified as RFA-DK-09-004.
Which agency is running this program?
This is a National Institutes of Health (NIH) program led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What is the main scientific purpose of this funding opportunity?
The core goal is to confirm and further characterize genetic associations for type 2 diabetes that have already been identified through genome-wide association studies (GWAS), specifically by evaluating those signals across multiple ethnic groups relevant to the diversity of the United States.
What kinds of studies or activities were applicants expected to perform?
Applicants were expected to take previously identified GWAS signals and test, validate, and refine them in multiple ethnic populations. The intent included determining whether:
- the same genetic risk factors apply broadly across populations,
- the strength of associations differs by ancestry, and
- additional population-specific variants or patterns emerge when research extends beyond a single group.
What does it mean that this is a U01 cooperative agreement?
This FOA uses the U01 cooperative agreement mechanism rather than a standard research project grant. A U01 generally indicates substantial NIH scientific or programmatic involvement during the project period. In practice, NIH may help guide priorities, facilitate collaboration among awardees, and support harmonization of methods or data standards so results are comparable across projects and populations.
Why would NIH choose a cooperative agreement for a multiethnic GWAS follow-up effort?
Because the program depends on multiple teams producing results that can be compared across different datasets and populations, the cooperative structure is designed to encourage consistent study design and method harmonization, strengthening the overall evidence base when findings are aggregated or compared.
How much funding was expected for this initiative overall?
NIDDK anticipated investing roughly $20 million total over five years through this initiative.
How many awards were expected?
The program expected to make approximately 5 to 6 awards.
What are the funding figures listed in the opportunity record?
The listing includes an estimated total funding figure of $4,000,000 and an award ceiling of $500,000. As presented in the record, these figures typically reflect annualized and/or per-award caps, while the program narrative indicates an overall initiative investment of about $20 million across five years.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants were not required to contribute non-federal funds as a condition of award.
What type of grant category does this fall under?
This opportunity is described as an NIH discretionary grant program.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.172 (Human Genome Research) and CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Who was eligible to apply?
Eligibility was broad and included many organization types capable of contributing to population-based genetics research, including:
- Public and private institutions of higher education
- Nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits)
- For-profit organizations (including small businesses, as also listed)
- Government entities (state, county, city/township, special district governments, independent school districts)
- Tribal governments and tribal organizations
- US territories and possessions
- Foreign organizations and non-domestic entities
Were minority-serving institutions specifically included?
Yes. The announcement explicitly included institutions and organizations that often play central roles in multiethnic research goals, such as HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Were foreign organizations allowed to apply?
Yes. The eligibility language included foreign organizations and non-domestic entities, consistent with the possibility that relevant cohorts, expertise, or analytic capacity could be based outside the United States.
When was the opportunity posted?
The opportunity was posted on January 7, 2009.
What was the application closing date?
The original and current closing date listed was March 18, 2009.
Is this funding opportunity still active?
No. The opportunity is archived. The archive date is listed as April 18, 2009, indicating the competition is no longer active.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site.
Who was listed as the contact for access or linking issues?
Contact support for access and linking issues was routed through the NIH Office of Extramural Research webmaster, which was typical for announcements of that time.
What is the practical impact this program aimed to have?
By validating GWAS-discovered type 2 diabetes genetic associations across multiple US ethnic groups, the program aimed to produce more robust and generalizable genetic evidence. Over time, that stronger evidence base can support improved biological understanding of diabetes risk and help inform more equitable approaches to prediction, prevention, and treatment.
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