Opportunity Information: Apply for PAR 12 183
Apply for PAR 12 183
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "National Institute on Aging Analysis of Alzheimers Disease Genome Sequencing Project Data U19" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Feb 8, 2013 and posted on May 14, 2012.
- Applicants must submit their applications by May 28, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Independent school districts City or township governments Special district governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institute on Aging (NIA), part of the National Institutes of Health (NIH), issued this funding opportunity to support research teams that will analyze large-scale DNA sequencing data relevant to Alzheimer's disease. The central focus is not generating new sequencing data, but extracting scientific value from existing whole exome sequencing and whole genome sequencing datasets that were produced through the National Human Genome Research Institute (NHGRI) Large Scale Sequencing Program and made available to the Alzheimer's disease research community. In practical terms, the grant is designed to fund coordinated, multi-project efforts that can apply modern statistical genetics, bioinformatics, and computational methods to identify genetic variants, genes, pathways, and biological mechanisms that influence Alzheimer's risk, progression, or related phenotypes.
This opportunity uses the U19 mechanism, which is an NIH cooperative agreement typically intended for large, integrated research programs composed of multiple interrelated projects and cores. Because it is a cooperative agreement rather than a standard grant, applicants should expect substantial scientific involvement from NIH staff during the course of the project. That usually means the funded teams will work in closer partnership with the Institute on priorities, milestones, data-sharing expectations, and program coordination than they would under a traditional investigator-initiated award. The activity category is Health, and the funding falls under CFDA 93.866 (Aging Research). There is no cost sharing or matching requirement.
The announcement was posted May 14, 2012, with key administrative dates showing a current closing date of May 28, 2013 (with an original closing date listed as September 7, 2013) and an archive date of June 28, 2013. The funding opportunity number is PAR-12-183, titled "National Institute on Aging Analysis of Alzheimer's Disease Genome Sequencing Project Data U19." The official NIH guide notice and full details were provided through the NIH grants site at http://grants.nih.gov/grants/guide/pa-files/PAR-12-183.html.
Eligibility for applying is broad and includes many types of U.S.-based organizations. Eligible applicants include state, county, city/township, and special district governments; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits other than institutions of higher education); small businesses; and for-profit organizations other than small businesses. The announcement also explicitly includes various mission-focused institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and U.S. territories or possessions. Foreign institutions (non-U.S. entities) are not eligible to apply; however, non-domestic components of U.S. organizations may participate, and "foreign components" as defined by NIH policy are allowed, meaning certain parts of the work may be conducted abroad under NIH rules as long as the applicant organization itself is eligible and based in the U.S.
Overall, the opportunity is aimed at accelerating Alzheimer's disease genetics and genomics discovery by mobilizing teams capable of rigorous, large-scale analysis of exome and genome sequencing datasets, with the expectation that the resulting findings, methods, and insights will benefit the broader research community and advance understanding of Alzheimer's disease biology. For technical access issues related to the full announcement, NIH listed the NIH Office of Extramural Research (OER) webmaster contact (FBOWebmaster@OD.NIH.GOV) for help with accessing or linking to the funding notice.
Frequently Asked Questions (FAQ)
What is this funding opportunity?
This is a National Institute on Aging (NIA), National Institutes of Health (NIH) funding opportunity to support coordinated research teams that will analyze large-scale DNA sequencing data relevant to Alzheimer's disease. The funding opportunity number is PAR-12-183, titled "National Institute on Aging Analysis of Alzheimer's Disease Genome Sequencing Project Data U19."
Which NIH Institute is offering this opportunity?
The opportunity is offered by the National Institute on Aging (NIA), which is part of the National Institutes of Health (NIH).
What is the main scientific focus of the program?
The central focus is extracting scientific value from existing whole exome sequencing (WES) and whole genome sequencing (WGS) datasets relevant to Alzheimer's disease, using modern statistical genetics, bioinformatics, and computational approaches.
Is this opportunity for generating new sequencing data?
No. The central focus is not generating new sequencing data. It is focused on analyzing existing WES and WGS datasets and deriving new findings, methods, and insights from those data.
What datasets are intended for analysis under this opportunity?
The program is designed to leverage WES and WGS datasets produced through the National Human Genome Research Institute (NHGRI) Large Scale Sequencing Program and made available to the Alzheimer's disease research community.
What kinds of research outputs are expected?
Based on the announcement description, the work is expected to identify genetic variants, genes, pathways, and biological mechanisms that influence Alzheimer's disease risk, progression, or related phenotypes, using rigorous large-scale analyses of existing sequencing datasets.
What types of methods or expertise are relevant for applicants?
The opportunity emphasizes teams capable of applying modern statistical genetics, bioinformatics, and computational methods to large-scale exome and genome sequencing datasets.
What is the award mechanism?
This opportunity uses the U19 mechanism, which is an NIH cooperative agreement typically intended for large, integrated research programs composed of multiple interrelated projects and cores.
What does it mean that this is a cooperative agreement (U19)?
Because it is a cooperative agreement rather than a standard grant, applicants should expect substantial scientific involvement from NIH staff during the course of the project. Funded teams generally work in closer partnership with the Institute on priorities, milestones, data-sharing expectations, and program coordination than under a traditional investigator-initiated award.
What is the activity category and CFDA number?
The activity category is Health, and the funding falls under CFDA 93.866 (Aging Research).
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
When was the announcement posted?
The announcement was posted on May 14, 2012.
What is the closing date listed for this opportunity?
Key administrative dates show a current closing date of May 28, 2013. The information also notes an original closing date listed as September 7, 2013.
What is the archive date?
The archive date is June 28, 2013.
Where can applicants find the official NIH posting and full details?
The official NIH guide notice and full details were provided through the NIH grants site at: http://grants.nih.gov/grants/guide/pa-files/PAR-12-183.html
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based organizations, including state, county, city/township, and special district governments; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits other than institutions of higher education); small businesses; and for-profit organizations other than small businesses.
Are mission-focused institutions (like HBCUs and Tribal Colleges) included in eligibility?
Yes. The announcement explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and U.S. territories or possessions.
Are foreign (non-U.S.) institutions eligible to apply as the applicant organization?
No. Foreign institutions (non-U.S. entities) are not eligible to apply as the applicant organization.
Can parts of the project be performed outside the United States?
Yes, within NIH rules as described in the announcement. Non-domestic components of U.S. organizations may participate, and "foreign components" as defined by NIH policy are allowed, meaning certain parts of the work may be conducted abroad as long as the applicant organization itself is eligible and based in the U.S.
What is the overall program goal?
The opportunity is aimed at accelerating Alzheimer's disease genetics and genomics discovery by mobilizing teams capable of rigorous, large-scale analysis of exome and genome sequencing datasets, with the expectation that resulting findings, methods, and insights will benefit the broader research community and advance understanding of Alzheimer's disease biology.
Who should be contacted for technical access issues with the funding notice?
For technical access issues related to the full announcement, NIH listed the NIH Office of Extramural Research (OER) webmaster contact: FBOWebmaster@OD.NIH.GOV
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