Opportunity Information: Apply for PAR 13 370

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "NEI Translational Research Program (TRP) on therapy for Visual Disorders (R24)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.867 Vision Research.
  • This funding opportunity was created on Sep 30, 2013 and posted on Sep 30, 2013.
  • Applicants must submit their applications by Jan 28, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,750,000.00 in funding.
  • Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Private institutions of higher education State governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

The NEI Translational Research Program (TRP) on Therapy for Visual Disorders (R24), Funding Opportunity Number PAR-13-370, is a National Institutes of Health funding opportunity from the National Eye Institute designed to speed up the move from promising lab discoveries to real, clinic-ready therapies for eye diseases and vision disorders. The core idea is straightforward: many of the most promising treatments in vision science, especially modern biologic approaches, are too complex for a single lab to advance efficiently on its own. This program therefore supports the creation and operation of a tightly coordinated, multidisciplinary team that can tackle the scientific, technical, and translational hurdles needed to turn an innovative concept into a therapy that is ready for clinical development.

A defining feature of this opportunity is its emphasis on integrative, team-based translational work rather than isolated basic research. The program expects an expert leader to assemble a collaborative group that blends the right scientific and clinical skills, and to run that group under a clear leadership and management plan. This structure is meant to enable rapid, efficient progress by aligning discovery science with the practical steps required for therapeutic development, such as optimizing a candidate intervention, validating it in appropriate models, addressing delivery challenges, and resolving safety or performance questions that typically slow translation. The TRP is positioned for projects where collaboration is not just helpful but necessary, meaning the work involves specialized expertise and resources that no single research group could reasonably provide alone.

The types of therapeutic pathways highlighted as especially appropriate include biologic interventions and other advanced strategies that often require multiple disciplines to develop. Examples explicitly referenced include gene therapy, cell-based therapy, and pharmacological approaches. In practice, this framing points toward projects where success depends on coordinated input from areas such as ophthalmology, molecular and cellular biology, genetics, pharmacology, bioengineering, imaging, toxicology, animal model development, translational study design, and other supporting specialties. The goal is to create a development-focused environment in which the team can systematically answer the key questions that stand between a laboratory finding and a clinically credible therapeutic candidate.

Administratively, this is a discretionary grant opportunity using the NIH grant mechanism, with the activity aligned to health and vision research (CFDA 93.867). The posted and created date for the announcement is September 30, 2013. The closing date listed is January 28, 2016, with an archive date of February 28, 2016, indicating that this specific announcement is no longer open but serves as a reference point for the program’s intent and structure. The opportunity states there is no cost sharing or matching requirement, which means applicants are not required to contribute a predefined non-federal share as a condition of the award.

In terms of budget, the announcement lists an award ceiling of $1,750,000. This ceiling communicates the maximum amount that can be awarded under the terms described, and it signals that the program is meant to support substantial, coordinated efforts rather than small, single-investigator projects. The award size aligns with the expectation that teams will bring together multiple capabilities, potentially spanning different departments, centers, or partner organizations, and will need sufficient resources to handle the translational work needed for therapy development.

Eligibility is broad across many U.S.-based organization types. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (with the noted exclusions in the listing), small businesses, for-profit organizations (including those other than small businesses), and a wide range of government entities such as city or township governments, county governments, state governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The opportunity also explicitly calls out additional eligible applicants including faith-based or community-based organizations and several categories of institutions that serve specific populations, such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs), along with regional organizations and U.S. territories or possessions. At the same time, it clearly restricts foreign involvement: non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.

For applicants looking for the full official requirements and submission details, the announcement provides an NIH guide link (http://grants.nih.gov/grants/guide/pa-files/PAR-13-370.html). For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

Overall, the TRP (R24) is best understood as a program built to fund organized, leadership-driven translational teams focused on producing therapy-enabling results for visual disorders, particularly where the path to clinical development requires coordinated multidisciplinary expertise and shared resources to overcome complex scientific and technical barriers.

FAQs: NEI Translational Research Program (TRP) on Therapy for Visual Disorders (R24) - PAR-13-370

What is the NEI Translational Research Program (TRP) on Therapy for Visual Disorders (R24)?

It is a National Institutes of Health (NIH) funding opportunity from the National Eye Institute (NEI) intended to accelerate the transition of promising laboratory discoveries into therapies for eye diseases and vision disorders that are ready for clinical development.

What is the main purpose of this funding opportunity?

The program is designed to speed up translational progress by supporting a tightly coordinated, multidisciplinary team that can address the scientific, technical, and practical hurdles required to move an innovative therapeutic concept toward clinical readiness.

What makes this opportunity different from basic research grants?

A defining feature is its emphasis on integrative, team-based translational work rather than isolated basic research. The focus is on development-oriented steps that help convert a discovery into a clinically credible therapeutic candidate.

Why does the program emphasize a multidisciplinary team?

The opportunity is aimed at projects where collaboration is not optional but necessary. Many advanced therapies for vision disorders (especially biologic approaches) are too complex for a single lab to advance efficiently. The program supports teams that can bring together specialized expertise and resources that no single group could reasonably provide alone.

What kinds of therapeutic approaches are especially appropriate for this program?

The announcement highlights biologic interventions and other advanced strategies, including gene therapy, cell-based therapy, and pharmacological approaches.

What types of work does the program expect teams to do to support therapy development?

Based on the description, the team is expected to align discovery science with practical development needs, such as optimizing a candidate intervention, validating it in appropriate models, addressing delivery challenges, and resolving safety or performance questions that commonly slow translation.

What expertise might be included on a TRP team?

The program anticipates coordinated input from areas such as ophthalmology, molecular and cellular biology, genetics, pharmacology, bioengineering, imaging, toxicology, animal model development, translational study design, and other supporting specialties.

What does "R24" mean in this opportunity?

The activity is an NIH grant mechanism listed as R24 in the announcement. The opportunity frames it as supporting the creation and operation of a coordinated program/team structure for translational research on therapies for visual disorders.

What is the Funding Opportunity Number for this announcement?

The Funding Opportunity Number is PAR-13-370.

Which NIH Institute is sponsoring this opportunity?

The opportunity is from the National Eye Institute (NEI), part of the National Institutes of Health (NIH).

Is this opportunity still open for applications?

No. The announcement lists a closing date of January 28, 2016, and an archive date of February 28, 2016, indicating that this specific announcement is no longer open.

When was this announcement originally posted?

The posted/created date listed is September 30, 2013.

What is the maximum award amount (award ceiling)?

The announcement lists an award ceiling of $1,750,000.

Does the program require cost sharing or matching funds?

No. The opportunity states there is no cost sharing or matching requirement, meaning applicants are not required to contribute a predefined non-federal share as a condition of the award.

What is the CFDA number associated with this opportunity?

The opportunity is aligned with CFDA 93.867.

What organizations are eligible to apply?

Eligibility is broad across many U.S.-based organization types, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (with noted exclusions in the listing), small businesses, and for-profit organizations (including those other than small businesses).

Are government entities eligible to apply?

Yes. The listing includes a wide range of eligible government entities such as city or township governments, county governments, state governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.

Are faith-based or community-based organizations eligible?

Yes. The opportunity explicitly calls out faith-based or community-based organizations as eligible applicants.

Are minority-serving institutions specifically included as eligible applicants?

Yes. The opportunity explicitly includes categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs).

Are U.S. territories or possessions eligible?

Yes. The opportunity mentions U.S. territories or possessions among eligible applicants.

Are foreign organizations eligible to apply?

No. The announcement states that non-U.S. entities are not eligible to apply.

Can a U.S. organization apply if the work involves a non-U.S. component?

No. The opportunity states that non-U.S. components of U.S. organizations are not eligible.

Are foreign components allowed under NIH policy for this opportunity?

No. The announcement states that foreign components (as defined by NIH policy) are not allowed.

What kind of leadership structure does the program expect?

The program expects an expert leader to assemble the collaborative group and run it under a clear leadership and management plan to keep the work coordinated and moving efficiently toward clinical development readiness.

Is this program intended for small, single-investigator projects?

The description and award ceiling suggest it is intended for substantial, coordinated efforts rather than small, single-investigator projects, particularly where multidisciplinary coordination and shared resources are needed.

Where can applicants find the official announcement and full requirements?

The announcement provides an NIH guide link: http://grants.nih.gov/grants/guide/pa-files/PAR-13-370.html.

Who is the contact for technical issues accessing or linking to the announcement?

For technical issues, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

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