Opportunity Information: Apply for RFA HS 14 006
Apply for RFA HS 14 006
- The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "Patient Centered Outcomes Research (PCOR) for Treatment Options in Uterine Fibroids Developing a Prospective Multi Center Practice based Clinical Registry (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes.
- This funding opportunity was created on Sep 30, 2013 and posted on Sep 30, 2013.
- Applicants must submit their applications by Dec 16, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $4,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments State governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Faith based or Community based Organizations Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply.
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Opportunity Summary:
This grant opportunity (RFA HS 14 006) is a discretionary AHRQ funding announcement, developed in partnership with PCORI, focused on building strong, patient-centered evidence about how different uterine fibroid treatments compare for women of childbearing age. The core problem the announcement targets is that, for symptomatic uterine fibroids, patients and clinicians often face a complicated menu of treatment strategies without clear, high-quality comparative evidence on which options best control symptoms while also aligning with a patient s reproductive goals and personal preferences. Because fibroid care decisions frequently involve tradeoffs (for example, symptom relief, recovery time, repeat procedures, and fertility or uterine preservation considerations), AHRQ and PCORI are seeking research designed to help women make more informed, individualized choices rather than relying on limited or inconsistent data.
The mechanism is a P50 grant, and the project is structured around creating a prospective, practice-based, multi-center clinical registry. Instead of a single-site study, the funders want a registry infrastructure that brings together six to ten geographically diverse Clinical Centers, coordinated through a central Registry Research and Data Coordinating Center (RDCC). The RDCC is expected to serve as the hub that designs and maintains the registry, standardizes data collection across sites, supports data quality and governance, and enables the comparative effectiveness analyses that the registry is meant to power. In practical terms, the registry is intended to capture real-world information from routine clinical practice across multiple settings, which increases the usefulness of the findings for everyday decision-making and improves the likelihood that results will generalize to a wide range of patients and care environments.
The research emphasis is on relative effectiveness of treatment options, meaning the registry should be built to compare outcomes across different management strategies used in current care, rather than testing a single intervention in isolation. While the announcement summary does not list specific outcomes, the stated intent is to address both symptom management and patient preferences tied to reproductive options, so the registry should be capable of tracking outcomes that matter to patients as well as clinicians. The ultimate deliverable is evidence that can guide shared decision-making by clarifying which treatments tend to work best for which patients under which circumstances, especially when fertility goals and other personal priorities shape what best means.
In terms of funding and awards, AHRQ anticipated making a single award, with an estimated total funding amount of $4,000,000 and an award ceiling of $4,000,000. There is no cost sharing or matching requirement. The opportunity was posted on September 30, 2013, with an original and final closing date of December 16, 2013, and it was archived on January 16, 2014. The funding activity category is health, and the CFDA number associated with the program is 93.226 (Research on Healthcare Costs, Quality and Outcomes), signaling that the work is expected to support evidence generation relevant to healthcare outcomes and decision-making.
Eligibility is broad across U.S. based public and private institutions and government entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, state governments, county governments, and city or township governments, as well as federally recognized Native American tribal governments and other tribal organizations. The announcement also notes additional eligible applicants such as eligible federal government agencies and faith-based or community-based organizations. Non-U.S. (foreign) entities are explicitly not eligible to apply, which indicates the registry and the participating clinical infrastructure are intended to be U.S. based.
Operationally, applicants would be expected to propose a cohesive, multi-institution partnership that can stand up a registry spanning multiple clinical centers and produce patient-centered comparative evidence. The funders intent to support only one award means the selected application would likely need to demonstrate strong leadership and coordination capacity, clear plans for enrolling and following women prospectively, and a credible approach to collecting standardized data across diverse sites. The announcement points applicants to the full solicitation hosted via the NIH grants guide, and provides NIH Office of Extramural Research webmaster contacts for access or linking issues.
Frequently Asked Questions (FAQs): RFA HS 14 006 (AHRQ/PCORI Uterine Fibroid Treatments Registry, P50)
What is this grant opportunity?
This opportunity (RFA HS 14 006) is a discretionary funding announcement from AHRQ, developed in partnership with PCORI. It supports research to build strong, patient-centered comparative evidence about how different uterine fibroid treatments perform for women of childbearing age.
What problem is the grant trying to address?
The announcement targets a major gap in clear, high-quality comparative evidence for symptomatic uterine fibroids. Patients and clinicians often have to choose from many treatment strategies without consistent data showing which options best control symptoms while also fitting a patient’s reproductive goals and personal preferences.
What is the main research focus?
The emphasis is on comparative (relative) effectiveness research. The intent is to compare outcomes across different treatment and management strategies used in current real-world care, rather than evaluating a single intervention in isolation.
Who is the research intended to help?
The work is designed to help women of childbearing age with symptomatic uterine fibroids, along with their clinicians, make more informed and individualized treatment decisions, especially when fertility goals and uterine preservation preferences influence what “best†means.
What mechanism does this funding use?
The mechanism is a P50 grant.
What type of project does the announcement require?
The project is structured around creating a prospective, practice-based, multi-center clinical registry. The registry is intended to collect real-world information from routine clinical practice across multiple settings.
How many clinical sites are expected to participate?
The registry infrastructure is expected to bring together six to ten geographically diverse Clinical Centers.
What is the RDCC and what does it do?
The Registry Research and Data Coordinating Center (RDCC) is the central hub for the project. It is expected to design and maintain the registry, standardize data collection across sites, support data quality and governance, and enable the comparative effectiveness analyses the registry is meant to support.
Is this a single-site study?
No. The announcement specifically calls for a multi-center registry with multiple Clinical Centers coordinated by a central RDCC.
Does the registry have to be prospective?
Yes. The registry is described as prospective, meaning women would be enrolled and followed forward over time as part of routine clinical practice across participating sites.
Why does the funding announcement emphasize “practice-based†and “real-world†data?
The intent is to capture information from routine clinical practice in multiple settings. This is meant to make findings more useful for everyday decision-making and to improve the likelihood that results generalize across a wide range of patients and care environments.
What kinds of outcomes is the registry expected to support?
While specific outcomes are not listed in the summary provided, the stated intent is to address both symptom management and patient preferences tied to reproductive options. The registry should therefore be capable of tracking outcomes that matter to patients as well as clinicians, supporting shared decision-making.
What is the intended end product or deliverable?
The ultimate deliverable is comparative evidence that can guide shared decision-making by clarifying which treatments tend to work best for which patients, under which circumstances, particularly when fertility goals and other personal priorities are central to the decision.
How many awards did AHRQ anticipate making?
AHRQ anticipated making a single award.
How much funding is available?
The estimated total funding amount is $4,000,000, and the award ceiling is $4,000,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
What is the CFDA number for this opportunity?
The CFDA number is 93.226 (Research on Healthcare Costs, Quality and Outcomes).
What is the funding activity category?
The funding activity category is health.
When was the opportunity posted and when did it close?
It was posted on September 30, 2013. The original and final closing date was December 16, 2013.
Is this opportunity still open?
No. The opportunity was archived on January 16, 2014, and the closing date was December 16, 2013.
Who is eligible to apply?
Eligibility is broad for U.S.-based entities, including: public and state-controlled institutions of higher education; private institutions of higher education; state governments; county governments; city or township governments; federally recognized Native American tribal governments; other tribal organizations; eligible federal government agencies; and faith-based or community-based organizations.
Are non-U.S. (foreign) entities eligible?
No. Non-U.S. (foreign) entities are explicitly not eligible to apply, indicating the registry and participating clinical infrastructure are intended to be U.S.-based.
What does an applicant need to be prepared to propose?
Applicants would be expected to propose a cohesive, multi-institution partnership capable of standing up a registry spanning multiple clinical centers and producing patient-centered comparative evidence. Given the plan for a single award, the application would likely need to demonstrate strong leadership and coordination capacity, plans for enrolling and following women prospectively, and a credible approach to standardized data collection across diverse sites.
Where is the full solicitation posted?
The announcement points applicants to the full solicitation hosted via the NIH grants guide.
Who should be contacted for access or linking issues to the solicitation?
The announcement provides NIH Office of Extramural Research webmaster contacts for access or linking issues.
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