Opportunity Information: Apply for PA 10 258
Apply for PA 10 258
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Neurobiology of Migraine (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Aug 13, 2010 and posted on Aug 13, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities City or township governments Public and State controlled institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Private institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Neurobiology of Migraine (R01) opportunity (Funding Opportunity Number PA 10 258) is a National Institutes of Health (NIH) program announcement designed to push forward research on the underlying brain and nervous system biology of migraine. Led by the National Institute of Neurological Disorders and Stroke (NINDS) and joined by the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Dental and Craniofacial Research (NIDCR), and the National Institute of Environmental Health Sciences (NIEHS), the announcement invites research project grant (R01) applications that take innovative approaches to explaining how migraine starts, spreads, and is maintained at the neurobiological level. A major emphasis is on expanding fundamental understanding of migraine mechanisms while also identifying promising biological targets that could eventually translate into better therapies.
Scientifically, the FOA highlights several priority areas. It encourages studies that clarify neurobiological mechanisms underlying migraine headache, including the pathways, circuits, and signaling systems involved in migraine susceptibility and attack generation. It specifically calls attention to the role of neuromodulators (chemical signaling molecules that shape neuronal activity), as well as genetic and environmental factors that influence risk and expression of migraine. In practical terms, this means the NIH is looking for projects that connect mechanistic insights to new therapeutic directions, whether by identifying novel targets, validating pathways, or developing early-stage strategies that could be leveraged for treatment development.
From a funding and structure standpoint, this announcement uses the NIH Research Project Grant (R01) mechanism, which is typically suited for more mature, hypothesis-driven projects with substantial scope. The FOA runs in parallel with a companion announcement of identical scientific scope that uses the R21 exploratory/developmental mechanism (PA 10 259), which is generally intended for earlier-stage or higher-risk ideas that need initial proof-of-concept. For this R01 FOA, NIH notes that awards depend on the availability of funds and the number of strong applications received. Because migraine research projects can vary widely in approach and scale, the agency anticipates that both the size and duration of awards will vary across funded projects rather than following a single standardized budget or timeline.
Key administrative details include an award ceiling listed as 250,000 (as provided in the opportunity data), no cost sharing or matching requirement, and classification under NIH health-related research funding (CFDA 93.853 for neurosciences/neurological disorders and CFDA 93.173 for deafness and communication disorders research-related activities). The opportunity was posted and created on August 13, 2010, with an original and current closing date of September 7, 2013, and an archive date of October 8, 2013, meaning it is no longer active but remains useful as a reference point for NIH priorities and for locating successor announcements.
Eligibility is broad and includes many organization types: public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, independent school districts, and various local, county, and state government entities. It also includes Native American tribal governments (federally recognized) and tribal organizations (not federally recognized), public housing authorities/Indian housing authorities, and special district governments. Additional eligible applicants explicitly include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), tribally controlled colleges and universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). In short, NIH structured this announcement to attract a wide range of capable research performers, including U.S. and international institutions, to accelerate progress on the biology of migraine and paths toward improved treatments.
For reference, the archived full announcement was linked at http://grants.nih.gov/grants/guide/pa-files/PA-10-258.html, and the NIH Office of Extramural Research (OER) webmaster contacts were provided for access or technical issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs): The Neurobiology of Migraine (R01) - PA-10-258
What is the title of this funding opportunity?
The funding opportunity is titled "The Neurobiology of Migraine (R01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-10-258.
Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) program announcement.
Which NIH Institute(s) lead and participate in the announcement?
The opportunity is led by the National Institute of Neurological Disorders and Stroke (NINDS) and joined by the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Dental and Craniofacial Research (NIDCR), and the National Institute of Environmental Health Sciences (NIEHS).
What type of grant mechanism does this opportunity use?
This announcement uses the NIH Research Project Grant (R01) mechanism.
What is the main purpose of this R01 program announcement?
The purpose is to advance research on the underlying brain and nervous system biology of migraine, including how migraine starts, spreads, and is maintained at the neurobiological level, while also helping identify promising biological targets that could eventually support improved therapies.
What research topics and scientific areas are emphasized?
The announcement highlights studies that clarify neurobiological mechanisms underlying migraine headache, including relevant pathways, circuits, and signaling systems involved in migraine susceptibility and attack generation.
Does the FOA specifically mention neuromodulators?
Yes. The FOA specifically calls attention to the role of neuromodulators (chemical signaling molecules that shape neuronal activity) in migraine.
Are genetic and environmental factors within scope?
Yes. The FOA encourages research addressing genetic and environmental factors that influence migraine risk and the way migraine is expressed.
Is this FOA focused on basic science, translation to therapy, or both?
Both. A major emphasis is on expanding fundamental understanding of migraine mechanisms while also identifying targets and directions that could eventually translate into better therapies (for example, identifying novel targets, validating pathways, or developing early-stage strategies relevant to treatment development).
Is there a companion funding opportunity related to this one?
Yes. This R01 FOA runs in parallel with a companion announcement of identical scientific scope using the R21 exploratory/developmental mechanism, identified as PA-10-259.
How is the R01 (PA-10-258) positioned relative to the R21 companion (PA-10-259)?
Based on the announcement description, the R01 mechanism is typically suited for more mature, hypothesis-driven projects with substantial scope, while the R21 is generally intended for earlier-stage or higher-risk ideas needing initial proof-of-concept.
What is the award ceiling listed for this opportunity?
The opportunity data lists an award ceiling of 250,000.
Is cost sharing or matching required?
No. The announcement indicates there is no cost sharing or matching requirement.
Will all awards have the same budget size and project period?
No. NIH notes that, because migraine research projects can vary widely in approach and scale, both the size and duration of awards are expected to vary across funded projects rather than follow one standardized budget or timeline.
Are awards guaranteed if an application is submitted?
No. NIH indicates that awards depend on the availability of funds and the number of strong applications received.
What CFDA numbers are associated with this opportunity?
The opportunity is classified under NIH health-related research funding including CFDA 93.853 (neurosciences/neurological disorders) and CFDA 93.173 (deafness and communication disorders research-related activities).
When was this opportunity posted and created?
The opportunity was posted and created on August 13, 2010.
What were the closing date and archive date?
The original and current closing date was September 7, 2013, and the archive date was October 8, 2013.
Is this funding opportunity currently active?
No. Based on the closing and archive dates provided, the opportunity is no longer active, but it may still be useful as a reference point for NIH priorities and for locating successor announcements.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, independent school districts, and various local, county, and state government entities.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes Native American tribal governments (federally recognized) and tribal organizations (not federally recognized).
Are public housing authorities eligible?
Yes. Eligibility includes public housing authorities/Indian housing authorities.
Are special district governments eligible?
Yes. Eligibility includes special district governments.
Are minority-serving institutions and other specifically named institution types eligible?
Yes. The announcement explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and tribally controlled colleges and universities (TCCUs).
Are faith-based and community-based organizations eligible?
Yes. The eligibility list explicitly includes faith-based or community-based organizations.
Are federal agencies eligible to apply?
Yes. The announcement explicitly includes eligible federal agencies.
Are U.S. territories or possessions eligible?
Yes. The eligibility list includes U.S. territories or possessions.
Are non-U.S. (foreign) organizations eligible?
Yes. The eligibility list explicitly includes non-U.S. entities (foreign organizations).
Where can the archived full announcement be found?
The archived full announcement was linked at: http://grants.nih.gov/grants/guide/pa-files/PA-10-258.html
Who should be contacted for access or technical issues related to the announcement?
The NIH Office of Extramural Research (OER) webmaster contact provided for access or technical issues is FBOWebmaster@OD.NIH.GOV.
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