Opportunity Information: Apply for PA 10 259
Apply for PA 10 259
- The National Institutes of Health in the environment health sector is offering a public funding opportunity titled "Neurobiology of Migraine (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Aug 13, 2010 and posted on Aug 13, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Special district governments County governments Public housing authorities/Indian housing authorities City or township governments Independent school districts Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Neurobiology of Migraine (R21) opportunity (Funding Opportunity Number PA 10 259) is an NIH program announcement designed to push forward early stage, high impact research on how migraine works at the neurobiological level. It is sponsored by several NIH components working together, including the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Environmental Health Sciences (NIEHS), and the NIH Office of Research on Women's Health. The overall aim is to encourage innovative exploratory projects that can open new directions in migraine science, especially where there are gaps in understanding of underlying mechanisms or where new therapeutic angles could emerge.
This announcement specifically calls for R21 applications, meaning it uses the NIH Exploratory/Developmental Grant mechanism. In practice, that points to projects that are novel, potentially higher risk, and focused on generating key proof-of-concept data or testing fresh ideas rather than delivering a fully mature, long-term research program. The scientific scope centers on expanding knowledge of the neurobiological mechanisms that drive migraine headache, with explicit interest in studying neuromodulators and how they shape migraine pathways, as well as examining genetic contributors and environmental factors that may increase susceptibility. A major through-line is identifying and exploring new targets that could eventually support therapy development, whether by clarifying disease pathways, revealing actionable molecular targets, or highlighting modifiable environmental triggers.
The FOA runs in parallel with a companion announcement of the same scientific scope that uses the R01 mechanism (PA 10 258). The R01 track is generally a better fit for more developed, hypothesis-driven programs with substantial preliminary data, while this R21 track is positioned for earlier, exploratory work. Applicants choosing between the two would typically base the decision on how mature the evidence base is and how much work is needed to establish feasibility or validate a new direction.
Funding details are intentionally flexible. There is no cost sharing or matching requirement, and the award structure is described as dependent on available funds and the number of highly rated applications received. Because proposed projects can differ widely in scope and methods, NIH notes that award size and project duration may vary from application to application. The listing includes an award ceiling of $200,000, reinforcing that this is meant to support smaller, developmental efforts rather than large multi-year programs. Ultimately, the total number of awards and the dollars committed are contingent on both appropriations and scientific merit across the applicant pool.
Eligibility is broad and includes many kinds of organizations. Eligible applicants span public and state-controlled institutions of higher education, private higher education institutions, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations (other than small businesses), and multiple levels of government such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The announcement also highlights additional eligible groups such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). It also references eligibility for certain tribal governments and tribal organizations, with details clarified in the full announcement text.
Administratively, the opportunity is categorized as a discretionary grant and is associated with several CFDA numbers reflecting the participating institutes areas, including environmental health (93.113), oral diseases and disorders research (93.121), research related to deafness and communication disorders (93.173), and neurosciences and neurological disorders extramural research programs (93.853). The FOA was posted and created on August 13, 2010, with an original and current closing date of September 7, 2013, and an archive date of October 8, 2013, meaning it is no longer open for new submissions under that specific posting. For those needing the official archived text and full instructions, NIH provided a link to the detailed announcement and points of contact through the NIH Office of Extramural Research webmaster for access or technical issues.
Frequently Asked Questions (FAQs): Neurobiology of Migraine (R21) - PA-10-259
What is the Neurobiology of Migraine (R21) funding opportunity?
The Neurobiology of Migraine (R21) opportunity is an NIH Program Announcement (Funding Opportunity Number PA-10-259) focused on advancing early stage, high-impact research on the neurobiological mechanisms of migraine.
Which NIH components sponsor or participate in this opportunity?
This program announcement is sponsored by multiple NIH components working together, including:
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- National Institute of Dental and Craniofacial Research (NIDCR)
- National Institute of Environmental Health Sciences (NIEHS)
- NIH Office of Research on Women's Health
What is the main goal of PA-10-259?
The overall aim is to encourage innovative, exploratory projects that can open new directions in migraine science, especially in areas where there are gaps in understanding underlying mechanisms or where new therapeutic angles could emerge.
What grant mechanism does this announcement use?
This opportunity uses the NIH R21 Exploratory/Developmental Grant mechanism.
What type of projects are a good fit for an R21 under this announcement?
Projects are expected to be novel and potentially higher risk, with an emphasis on generating key proof-of-concept data or testing fresh ideas rather than running a fully mature, long-term research program.
What scientific topics are within the scope of this migraine R21 program announcement?
The scientific scope centers on expanding knowledge of the neurobiological mechanisms that drive migraine headache. Areas explicitly highlighted include:
- Neuromodulators and how they shape migraine pathways
- Genetic contributors to migraine susceptibility
- Environmental factors that may increase susceptibility
- Identification and exploration of new targets that could support therapy development
Does the announcement emphasize therapy development?
It emphasizes identifying and exploring new targets that could eventually support therapy development. This can include clarifying disease pathways, revealing actionable molecular targets, or highlighting modifiable environmental triggers.
Is there a companion funding opportunity for more developed projects?
Yes. This R21 announcement runs in parallel with a companion announcement of the same scientific scope using the R01 mechanism (PA-10-258).
How do I choose between the R21 (PA-10-259) and the R01 (PA-10-258) companion announcement?
Based on the information provided, the R01 track is generally a better fit for more developed, hypothesis-driven programs with substantial preliminary data, while the R21 track is positioned for earlier, exploratory work where feasibility still needs to be established or a new direction needs initial validation.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
How is the award amount determined?
Funding is described as flexible and dependent on available funds and the number of highly rated applications received. NIH notes that award size and project duration may vary from application to application because projects can differ widely in scope and methods.
Is there a funding cap mentioned for this opportunity?
Yes. The listing includes an award ceiling of $200,000, reinforcing that the program is meant to support smaller, developmental efforts rather than large multi-year programs.
How many awards will NIH make under this program announcement?
The total number of awards and the dollars committed are contingent on appropriations and scientific merit across the applicant pool, as well as the number of highly rated applications received.
What types of organizations are eligible to apply?
Eligibility is broad. The eligible applicant organizations listed include:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits with or without 501(c)(3) status
- Small businesses
- For-profit organizations (other than small businesses)
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
Are minority-serving institutions specifically included as eligible applicants?
Yes. The announcement highlights eligibility for several groups, including historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian-serving institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are listed among additional eligible groups.
Are tribal organizations or tribal governments eligible?
The announcement references eligibility for certain tribal governments and tribal organizations, with details clarified in the full announcement text.
Are U.S. territories or possessions eligible?
Yes. The announcement highlights U.S. territories or possessions among additional eligible groups.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The listing includes non-U.S. entities (foreign organizations) as eligible applicants.
What is the assistance type and administrative category of this opportunity?
It is categorized as a discretionary grant.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with several CFDA numbers reflecting participating institutes' areas, including:
- 93.113 (environmental health)
- 93.121 (oral diseases and disorders research)
- 93.173 (deafness and communication disorders research)
- 93.853 (neurosciences and neurological disorders extramural research programs)
When was this funding opportunity posted, and is it still open?
The FOA was posted and created on August 13, 2010. The original and current closing date listed is September 7, 2013, with an archive date of October 8, 2013. That means it is no longer open for new submissions under that specific posting.
Where can applicants find the official archived announcement text and full instructions?
NIH provided a link to the detailed announcement and points of contact through the NIH Office of Extramural Research webmaster for access or technical issues. For exact requirements and instructions, applicants are directed to the official archived FOA text.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 10 259) also looked into and applied for these:
| Funding Opportunity |
|---|
| Methods and Approaches for Detection of Gene Environment Interactions in Human Disease (R21) Apply for PAR 11 032 Funding Number: PAR 11 032 Agency: National Institutes of Health Category: Environment Health Funding Amount: $275,000 |
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| Identification of Biomarkers for Early Detection of Environmentally Induced Mitochondrial Dysfunction (R01) Apply for RFA ES 11 007 Funding Number: RFA ES 11 007 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Research Consortium for 2 Year Bisphenol A Toxicity Study (U01) Apply for RFA ES 10 009 Funding Number: RFA ES 10 009 Agency: National Institutes of Health Category: Environment Health Funding Amount: $150,000 |
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| Environmental Health Sciences Core Center Grants (P30) Apply for RFA ES 11 001 Funding Number: RFA ES 11 001 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Dietary Influence on the Human Health Effects of Environmental Exposures (R21) Apply for RFA ES 11 002 Funding Number: RFA ES 11 002 Agency: National Institutes of Health Category: Environment Health Funding Amount: $150,000 |
| Role of Environmental Chemical Exposures in the Development of Obesity, Type 2 Diabetes and Metabolic Syndrome (R01) Apply for PAR 11 170 Funding Number: PAR 11 170 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Role of Environmental Chemical Exposures in the Development of Obesity, Type 2 Diabetes and Metabolic Syndrome (R21) Apply for PAR 11 171 Funding Number: PAR 11 171 Agency: National Institutes of Health Category: Environment Health Funding Amount: $200,000 |
| SBIR E learning for HAZMAT and Emergency Response (SBIR R43/R44) Apply for RFA ES 11 008 Funding Number: RFA ES 11 008 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
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