Opportunity Information: Apply for PA 11 064
Apply for PA 11 064
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Neuroimmune Mechanisms Of Alcohol Related Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Dec 8, 2010 and posted on Dec 8, 2010.
- Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Independent school districts State governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Neuroimmune Mechanisms of Alcohol Related Disorders (R01) funding opportunity (PA-11-064) was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) within the National Institutes of Health (NIH) to support Research Project Grant (R01) applications focused on how alcohol exposure affects neuroimmune signaling in the brain and how those changes, in turn, drive alcohol-related brain dysfunction and behavior. The core idea behind the announcement is that a growing body of evidence from animal models and post-mortem human brain studies shows alcohol can substantially alter neuroimmune pathways, but the field still lacks a clear mechanistic understanding of how those immune-related shifts translate into the kinds of neural and behavioral outcomes seen in alcohol use disorders and other alcohol-related conditions. The FOA frames neuroimmune biology not only as a classic inflammation story, but as a broader neuromodulatory system that interacts with synapses, development, and neuroendocrine function.
A key scientific emphasis in the announcement is the emerging recognition that neuroimmune molecules are not limited to traditional immune cells or purely “inflammatory” roles. Instead, many of these molecules are expressed in both neurons and glia and can influence synaptic function, neurodevelopmental processes, and neuroendocrine regulation. Because these same molecules also participate in neuroinflammation, the FOA highlights an integrated framework where neuroimmune factors may help explain multiple alcohol-related outcomes, including neuroadaptation (long-term changes in neural circuitry and signaling that can support craving, tolerance, and dependence), neurodegeneration (damage or loss of neural structure and function), and alcohol-associated behavioral disorders. In practical terms, NIAAA is signaling strong interest in projects that move beyond descriptive findings and instead pinpoint causal mechanisms, pathways, and interactions that connect alcohol exposure to specific neuroimmune changes and then to measurable brain and behavioral endpoints.
The funding mechanism is the NIH R01, meaning it is intended for substantial, hypothesis-driven research projects that can generate foundational, generalizable insights. Applications could involve a range of experimental approaches consistent with the FOA’s topic area, including studies in relevant animal models, translational studies leveraging human tissues such as post-mortem brain, and other designs capable of dissecting cellular and molecular mechanisms in the nervous system. The announcement’s stated goal is that supported studies will produce fundamental insights into neuroimmune mechanisms that underlie alcohol-induced changes in brain function and behavior, which can ultimately inform future prevention and treatment strategies even if the immediate focus is basic or mechanistic science.
From an administrative standpoint, this was a discretionary NIH grant opportunity in the health funding category (CFDA 93.273, Alcohol Research Programs) with no cost sharing or matching requirement. The opportunity was posted and created on December 8, 2010, with an original and final closing date of January 7, 2014, and an archive date of February 7, 2014. While it is archived now, the details remain useful as a snapshot of NIAAA priorities and as a guide to the kind of neuroimmune-alcohol research questions the institute has actively sought to fund.
Eligibility for the FOA was broad and included many organization types commonly eligible for NIH grants. This included public and private institutions of higher education, nonprofits with and without 501(c)(3) status, small businesses, for-profit organizations (other than small businesses), and a variety of government entities (state, county, city/township, special district, independent school districts), as well as public housing authorities/Indian housing authorities. It also explicitly included Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments). Additional eligible applicant categories included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, U.S. territories or possessions, and non-U.S. entities (foreign organizations). The administering agency is NIH, with NIAAA as the issuing institute. The full announcement was linked through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-11-064.html, and the contact listed for technical access issues was the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "The Neuroimmune Mechanisms of Alcohol Related Disorders (R01)" and is identified as PA-11-064.
Which agency and institute issued this announcement?
This funding opportunity was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) within the National Institutes of Health (NIH).
What grant mechanism does this opportunity use?
The funding mechanism is an NIH Research Project Grant (R01), intended for substantial, hypothesis-driven research projects.
What is the main scientific focus of PA-11-064?
The focus is on understanding how alcohol exposure affects neuroimmune signaling in the brain and how those neuroimmune changes contribute to alcohol-related brain dysfunction and behavior.
Why is NIAAA interested in neuroimmune mechanisms in alcohol-related disorders?
The announcement cites growing evidence from animal models and post-mortem human brain studies showing that alcohol can substantially alter neuroimmune pathways, while emphasizing that the field still needs clearer mechanistic explanations linking these immune-related shifts to neural and behavioral outcomes.
Does the FOA frame neuroimmune biology only as inflammation?
No. The FOA frames neuroimmune biology as a broader neuromodulatory system that can interact with synapses, development, and neuroendocrine function, not only as a classic inflammation story.
What types of neuroimmune molecules and cells are emphasized?
The FOA emphasizes that neuroimmune molecules are not limited to traditional immune cells or purely inflammatory roles. Many are expressed in both neurons and glia and can influence synaptic function, neurodevelopmental processes, and neuroendocrine regulation.
What kinds of outcomes is this FOA trying to connect to neuroimmune signaling changes?
The FOA highlights an integrated framework where neuroimmune factors may help explain multiple alcohol-related outcomes, including neuroadaptation, neurodegeneration, and alcohol-associated behavioral disorders.
Is NIAAA looking for descriptive studies or causal mechanism studies?
NIAAA signals strong interest in projects that move beyond descriptive findings and instead identify causal mechanisms, pathways, and interactions that link alcohol exposure to neuroimmune changes and then to measurable brain and behavioral endpoints.
What kinds of research approaches are consistent with this opportunity?
The announcement notes that applications could use a range of experimental approaches consistent with the topic area, including studies in relevant animal models, translational studies using human tissues (such as post-mortem brain), and other designs suited to dissecting cellular and molecular mechanisms in the nervous system.
What is the stated goal of supporting these R01 projects?
The stated goal is to generate fundamental insights into neuroimmune mechanisms underlying alcohol-induced changes in brain function and behavior, which can inform future prevention and treatment strategies, even if the immediate work is basic or mechanistic.
What is the CFDA number and program category for this opportunity?
The opportunity is listed under CFDA 93.273, Alcohol Research Programs.
Is there a cost sharing or matching requirement?
No. The opportunity states there is no cost sharing or matching requirement.
When was this opportunity posted and created?
The opportunity was posted and created on December 8, 2010.
What were the closing dates for applications?
The announcement lists an original and final closing date of January 7, 2014.
Is this funding opportunity still active?
No. It is archived, with an archive date of February 7, 2014.
Who was eligible to apply?
Eligibility was broad and included many NIH-eligible organization types, including public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), small businesses, for-profit organizations (other than small businesses), and multiple government entities (state, county, city/township, special district, independent school districts), as well as public housing authorities/Indian housing authorities.
Were tribal entities eligible to apply?
Yes. The FOA explicitly included Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments).
Were minority-serving institutions and community organizations eligible?
Yes. Additional eligible categories included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, among others.
Could non-U.S. (foreign) organizations apply?
Yes. The eligibility list explicitly included non-U.S. entities (foreign organizations).
Which agency administered the opportunity?
The administering agency was NIH, with NIAAA as the issuing institute.
Where can the full announcement be found?
The full announcement was available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-11-064.html
Who is listed as the contact for technical access issues?
The contact listed for technical access issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Browse more opportunities from the same category: Health
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