Opportunity Information: Apply for PA 11 065
Apply for PA 11 065
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Neuroimmune Mechanisms Of Alcohol Related Disorders (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Dec 8, 2010 and posted on Dec 8, 2010.
- Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Special district governments Independent school districts For profit organizations other than small businesses Private institutions of higher education County governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Neuroimmune Mechanisms Of Alcohol Related Disorders (R21)" (Funding Opportunity Number PA 11-065) was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) within the National Institutes of Health (NIH). It supports the NIH R21 mechanism, which is typically used for exploratory and developmental research projects that can open up new lines of investigation, generate early proof-of-concept data, or test novel ideas that may be too preliminary for larger, longer-term awards. In this case, the focus is on understanding how alcohol exposure affects the brain's neuroimmune system and how those immune-related changes may drive the kinds of brain, behavioral, and functional problems seen in alcohol-related disorders.
At the center of this announcement is the idea that alcohol is not only a substance that alters neurotransmission and behavior in the short term, but also a biological stressor that can meaningfully disrupt immune signaling within the brain. Evidence from animal models and examinations of post-mortem brain tissue from individuals with a history of alcoholism suggests that alcohol exposure can change neuroimmune activity. What remains uncertain, and what this program is trying to push forward, is the causal chain: which neuroimmune factors change, in which brain cells and circuits, at what stages of exposure or withdrawal, and how those changes translate into altered synaptic function, shifts in neurodevelopmental processes, changes in neuroendocrine regulation, neurodegeneration, and ultimately behavior. The FOA emphasizes that neuroimmune molecules are not limited to traditional immune cells. Emerging findings indicate these molecules are expressed in neurons and glial cells as well, and can act as neuromodulators that influence synaptic activity, development, and hormone-related brain functions. That dual role, both in classic neuroinflammation and in day-to-day regulation of neural signaling, is presented as a key reason this area is promising for explaining longer-term alcohol-induced brain adaptations and damage.
The projects encouraged under this announcement are meant to clarify neuroimmune mechanisms that underlie alcohol-induced brain and behavioral changes. In practical terms, that means research that can connect immune-related molecular and cellular events in the nervous system to measurable outcomes such as changes in neural circuit function, cognitive or emotional behaviors relevant to alcohol use disorders, neuroadaptive processes linked to dependence, and neurodegenerative effects associated with chronic exposure. The FOA frames this as a "new framework" for interpreting alcohol-related pathology: instead of treating neuroimmune activity as a side effect of injury, it highlights the possibility that neuroimmune signaling itself can be an active driver of neuroadaptation, neurodegeneration, and behavioral dysfunction.
From an administrative standpoint, this is a discretionary grant program in the health funding category, listed under CFDA number 93.273 (Alcohol Research Programs). The award ceiling is listed as $200,000, and the opportunity does not require cost sharing or matching. The opportunity was posted on December 8, 2010, with an original and current closing date of January 7, 2014, and an archive date of February 7, 2014, meaning it is no longer open but remains as a record of the program’s intent and parameters during that period.
Eligibility is broad and includes many types of organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including both 501(c)(3) and certain nonprofits without 501(c)(3) status), for-profit organizations other than small businesses, and small businesses. Government entities at multiple levels are also eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also lists eligibility for Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments). Additional categories explicitly mentioned include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, U.S. territories or possessions, regional organizations, and even non-U.S. entities (foreign organizations), reflecting NIH's common approach of allowing a wide range of research-capable institutions to compete when the scientific question is a priority.
The full announcement was made available through the NIH grants guide at the provided link (http://grants.nih.gov/grants/guide/pa-files/PA-11-065.html). For technical problems accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. Overall, the opportunity is best understood as an effort by NIAAA to accelerate early-stage, mechanism-driven research that explains how immune-like signaling within the brain interacts with alcohol exposure to produce lasting changes in brain function and behavior, with the long-term goal of improving the scientific foundation for preventing and treating alcohol-related disorders.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The funding opportunity is titled "Neuroimmune Mechanisms Of Alcohol Related Disorders (R21)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-11-065.
Which agency issued this opportunity?
This opportunity was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) within the National Institutes of Health (NIH).
What type of grant mechanism does this opportunity use?
This opportunity supports the NIH R21 mechanism, which is typically used for exploratory and developmental research projects.
What kinds of projects are R21 awards generally meant to support (as described here)?
As described in this announcement, R21 projects are generally intended to:
- Open new lines of investigation
- Generate early proof-of-concept data
- Test novel ideas that may be too preliminary for larger or longer-term awards
What is the scientific focus of this FOA?
The focus is on understanding how alcohol exposure affects the brain's neuroimmune system and how immune-related changes may contribute to brain, behavioral, and functional problems seen in alcohol-related disorders.
How does the FOA frame alcohol in relation to the brain and the immune system?
The FOA emphasizes that alcohol is not only a substance that alters neurotransmission and behavior in the short term, but also a biological stressor that can disrupt immune signaling within the brain.
What evidence does the FOA cite to support interest in neuroimmune effects of alcohol?
The announcement notes evidence from:
- Animal models
- Post-mortem brain tissue from individuals with a history of alcoholism
These lines of evidence suggest that alcohol exposure can change neuroimmune activity.
What key uncertainties is this program trying to address?
The FOA highlights open questions about the causal chain linking alcohol exposure to neuroimmune changes and downstream outcomes, including:
- Which neuroimmune factors change
- In which brain cells and circuits those changes occur
- At what stages of exposure or withdrawal changes emerge
- How these changes translate into altered synaptic function, neurodevelopmental shifts, neuroendocrine regulation, neurodegeneration, and behavior
Are neuroimmune molecules discussed as being limited to traditional immune cells?
No. The FOA emphasizes that neuroimmune molecules are not limited to traditional immune cells. It points to emerging findings that these molecules are expressed in neurons and glial cells and can act as neuromodulators influencing synaptic activity, development, and hormone-related brain functions.
What outcomes or impacts does the FOA encourage projects to connect to neuroimmune mechanisms?
The FOA encourages research that connects immune-related molecular and cellular events in the nervous system to measurable outcomes such as:
- Changes in neural circuit function
- Cognitive or emotional behaviors relevant to alcohol use disorders
- Neuroadaptive processes linked to dependence
- Neurodegenerative effects associated with chronic exposure
How does the FOA describe the broader conceptual goal or "framework" of the research area?
The FOA describes a "new framework" in which neuroimmune signaling is not treated only as a side effect of injury. Instead, neuroimmune activity is presented as potentially being an active driver of:
- Neuroadaptation
- Neurodegeneration
- Behavioral dysfunction
What is the funding category for this opportunity?
The opportunity is listed under the health funding category.
What CFDA number is associated with this program?
The CFDA number is 93.273, labeled Alcohol Research Programs.
What is the award ceiling listed for this opportunity?
The award ceiling is listed as $200,000.
Is cost sharing or matching required?
No. The opportunity states that cost sharing or matching is not required.
When was this opportunity posted?
The opportunity was posted on December 8, 2010.
What were the closing dates for this opportunity?
The original and current closing date listed is January 7, 2014.
Is this opportunity still open?
No. The archive date is listed as February 7, 2014, which indicates the opportunity is no longer open and remains available as a record of the program during that period.
Who is eligible to apply?
Eligibility is broad. The FOA lists many eligible applicant types, including:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits (including 501(c)(3) and certain nonprofits without 501(c)(3) status)
- For-profit organizations (other than small businesses)
- Small businesses
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Native American tribal governments (federally recognized)
- Native American tribal organizations (other than federally recognized tribal governments)
- Alaska Native and Native Hawaiian Serving Institutions
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Faith-based or community-based organizations
- Eligible agencies of the federal government
- U.S. territories or possessions
- Regional organizations
- Non-U.S. entities (foreign organizations)
Are foreign (non-U.S.) organizations eligible?
Yes. The FOA explicitly includes non-U.S. entities (foreign organizations) among eligible applicants.
Where can the full announcement be found?
The full announcement is available through the NIH Grants Guide at:
Who is the contact for technical problems accessing the announcement?
For technical problems accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall intent of this FOA (as described)?
The FOA is described as an effort by NIAAA to accelerate early-stage, mechanism-driven research explaining how immune-like signaling within the brain interacts with alcohol exposure to produce lasting changes in brain function and behavior, with the long-term goal of improving the scientific foundation for preventing and treating alcohol-related disorders.
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