Opportunity Information: Apply for PA 14 138
Apply for PA 14 138
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Neuroimmune Mechanisms of Alcohol Related Disorders (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Mar 3, 2014 and posted on Mar 3, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education City or township governments Special district governments Independent school districts State governments County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Neuroimmune Mechanisms of Alcohol Related Disorders (R21) opportunity (Funding Opportunity Number PA 14 138) is a National Institutes of Health (NIH) discretionary grant solicitation designed to support exploratory and early-stage research on how alcohol exposure changes neuroimmune signaling in the brain and how those changes contribute to alcohol related disorders. It uses the NIH Exploratory/Developmental Research Project Grant mechanism (R21), which is typically aimed at high-impact, innovative studies that generate foundational data, test new concepts, or open up new research directions rather than completing a full, mature research program. The overall intent is to move beyond the observation that alcohol alters neuroimmune markers and pathways, and instead clarify the causal links between altered neuroimmune activity and the brain functional and behavioral changes seen in alcohol dependence and alcohol use disorders.
The scientific focus of the FOA is the intersection of neuroscience and immunology within the central nervous system. Prior work, including studies using animal models as well as analyses of post mortem human brains from individuals with alcoholism, suggests that alcohol exposure can disrupt the brain’s neuroimmune system. What remains uncertain, and what this FOA aims to address, is how those neuroimmune disruptions translate into lasting neuroadaptations, changes in synaptic and circuit function, and behavioral outcomes relevant to dependence. A key motivating idea in the announcement is that neuroimmune molecules are not limited to classical immune roles; they are also expressed in neurons and glial cells and can directly shape synaptic function, neurodevelopmental processes, and neuroendocrine regulation. Because these molecules sit at the crossroads of neuromodulation and neuroinflammation, the FOA frames neuroimmune signaling as a potentially unifying biological pathway for understanding how alcohol produces persistent brain changes that influence craving, reinforcement, stress responsivity, withdrawal-related behaviors, and other clinically relevant phenotypes.
Projects proposed under this FOA are expected to provide fundamental insights into neuroimmune mechanisms that underlie alcohol-induced brain and behavior alterations. In practical terms, that can include mechanistic studies that map how alcohol changes neuroimmune signaling in specific brain regions or cell types, experiments that test whether manipulating particular neuroimmune pathways alters alcohol-related behaviors, or work that connects neuroimmune changes to functional outcomes such as synaptic plasticity, circuit excitability, neurodevelopmental trajectories, or neuroendocrine and stress-axis dysregulation. The FOA explicitly recognizes multiple evidence sources (animal models and human post mortem findings) and encourages research that clarifies the functional significance of neuroimmune changes rather than treating them only as correlates of alcohol exposure.
From an administrative standpoint, this opportunity falls under the NIH health research activity category and is associated with CFDA number 93.273 (Alcohol Research Programs). It does not require cost sharing or matching. The listed award ceiling is $200,000 (as provided in the source data). The FOA was posted and created on March 3, 2014, with an original closing date of May 7, 2017, and it was archived on June 7, 2017. Even though it is archived, the record is useful for understanding NIH priorities and the types of projects NIH has sought in this area, and it can serve as a reference point for similar or successor announcements.
Eligibility is broad and includes a wide range of domestic and non-domestic entities. Eligible applicants include public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (including small businesses), and various levels of government (state, county, city/township, special district). The FOA also lists eligibility for tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, and a variety of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs). Foreign organizations and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are allowed, indicating NIH’s openness to internationally relevant expertise and collaborations in this scientific space.
For applicants seeking the full text and detailed NIH instructions, the FOA points to the NIH grants page at http://grants.nih.gov/grants/guide/pa-files/PA-14-138.html. For technical issues accessing or linking to the announcement, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the Neuroimmune Mechanisms of Alcohol Related Disorders (R21) opportunity?
It is a National Institutes of Health (NIH) discretionary grant solicitation titled "The Neuroimmune Mechanisms of Alcohol Related Disorders (R21)." The Funding Opportunity Number (FON) is PA 14 138. It is designed to support exploratory and early-stage research on how alcohol exposure changes neuroimmune signaling in the brain and how those changes contribute to alcohol related disorders.
Which NIH grant mechanism does this opportunity use?
This opportunity uses the NIH Exploratory/Developmental Research Project Grant mechanism (R21). The R21 mechanism is typically intended for high-impact, innovative studies that generate foundational data, test new concepts, or open new research directions rather than completing a full, mature research program.
What is the overall goal of the FOA?
The overall intent is to move beyond simply observing that alcohol alters neuroimmune markers and pathways. The FOA aims to clarify causal links between altered neuroimmune activity and the brain functional and behavioral changes associated with alcohol dependence and alcohol use disorders.
What scientific area does the FOA focus on?
The scientific focus is at the intersection of neuroscience and immunology within the central nervous system. Specifically, it centers on neuroimmune signaling in the brain and how alcohol-induced disruption of that signaling contributes to persistent brain changes and behavior relevant to alcohol related disorders.
Why is neuroimmune signaling considered important in alcohol research under this FOA?
Prior studies in animal models and analyses of post mortem human brains from individuals with alcoholism suggest alcohol exposure can disrupt the brain's neuroimmune system. The FOA highlights that neuroimmune molecules are not limited to classical immune roles; they are also expressed in neurons and glial cells and can shape synaptic function, neurodevelopmental processes, and neuroendocrine regulation. Because of this, neuroimmune signaling is framed as a potentially unifying pathway for understanding how alcohol produces persistent brain changes tied to clinically relevant outcomes.
What kinds of research projects are expected to fit this FOA?
Projects are expected to provide fundamental insights into neuroimmune mechanisms underlying alcohol-induced brain and behavior alterations. Examples described in the FOA summary include mechanistic studies mapping how alcohol changes neuroimmune signaling in specific brain regions or cell types, experiments testing whether manipulating particular neuroimmune pathways alters alcohol-related behaviors, and research connecting neuroimmune changes to functional outcomes such as synaptic plasticity, circuit excitability, neurodevelopmental trajectories, or neuroendocrine and stress-axis dysregulation.
Does the FOA emphasize correlation findings or causal mechanisms?
The FOA emphasizes clarifying functional significance and causal links, rather than treating neuroimmune changes only as correlates of alcohol exposure. The goal is to determine how neuroimmune disruptions translate into lasting neuroadaptations, circuit and synaptic changes, and behavioral outcomes relevant to dependence.
What types of evidence sources does the FOA recognize?
The FOA explicitly recognizes multiple evidence sources, including animal models and human post mortem findings. It encourages research that builds on these sources to clarify what neuroimmune changes mean functionally for brain activity and behavior.
What kinds of outcomes or phenotypes are mentioned as relevant to this FOA?
The FOA frames neuroimmune signaling as potentially influencing craving, reinforcement, stress responsivity, withdrawal-related behaviors, and other clinically relevant phenotypes, along with underlying changes in synaptic function, circuit function, neurodevelopment, and neuroendocrine regulation.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.273, listed as Alcohol Research Programs.
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
What is the listed award ceiling for this opportunity?
The listed award ceiling is $200,000 (as provided in the source data).
When was the FOA posted and when did it close?
The FOA was posted and created on March 3, 2014. The original closing date was May 7, 2017.
Is this funding opportunity still active?
No. The record indicates the FOA was archived on June 7, 2017. While archived, it can still be useful as a reference for NIH priorities and for understanding the kinds of projects NIH has sought in this research area, including for similar or successor announcements.
Who is eligible to apply?
Eligibility is broad and includes a wide range of domestic and non-domestic entities. Eligible applicants include public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), for-profit organizations (including small businesses), and various levels of government (state, county, city/township, and special district).
Are tribal governments and tribal organizations eligible?
Yes. The FOA lists eligibility for tribal governments and tribal organizations.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are included in the eligibility list.
Are minority-serving institutions and other designated institution types eligible?
Yes. The FOA lists a variety of institution types as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Are foreign organizations allowed to apply?
Yes. Foreign organizations and foreign institutions are eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
Yes. Non-U.S. components of U.S. organizations are listed as eligible.
Are foreign components allowed under NIH policy?
Yes. The FOA states that foreign components (as defined by NIH policy) are allowed, indicating openness to internationally relevant expertise and collaborations.
Where can the full FOA text and NIH application instructions be found?
The FOA points to the NIH grants page at http://grants.nih.gov/grants/guide/pa-files/PA-14-138.html for the full text and detailed NIH instructions.
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What type of NIH activity category is this opportunity associated with?
It falls under the NIH health research activity category.
How does the FOA describe the role of neuroimmune molecules in the brain?
The FOA notes that neuroimmune molecules can be expressed in neurons and glial cells, and that they can directly influence synaptic function, neurodevelopmental processes, and neuroendocrine regulation, placing them at the crossroads of neuromodulation and neuroinflammation.
What is the practical research direction encouraged by the FOA?
The FOA encourages research that connects alcohol-driven neuroimmune changes to downstream functional consequences in the brain and behavior, including testing whether targeted manipulation of neuroimmune pathways changes alcohol-related behaviors and identifying how specific brain regions or cell types are affected.
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