Opportunity Information: Apply for PA 07 389
Apply for PA 07 389
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Neurotechnology Research, Development, and Enhancement (SBIR R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.361 Nursing Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Jan 26, 2009 and posted on Jun 29, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses.
- Foreign institutions are not eligible to apply.
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Opportunity Summary:
The Neurotechnology Research, Development, and Enhancement (SBIR R43/R44) opportunity (Funding Opportunity Number PA 07 389) is a National Institutes of Health (NIH) funding announcement that supports small businesses developing new, or substantially improved, technologies that make neuroscience and behavioral research better, faster, or more informative. The core idea is to accelerate progress in understanding how the brain works in health and disease by backing practical tool-building efforts that researchers and clinicians can actually use. This includes technologies aimed at basic research, clinical research, or even clinical care when the technology supports assessment, diagnosis, monitoring, treatment, or other forms of brain-disorder care.
A key feature of this program is its broad scope. NIH is not restricting applicants to a particular technology area, measurement scale, or scientific approach. Instead, it welcomes a wide range of neurotechnology concepts as long as they clearly enable brain or behavioral research or meaningfully improve existing capabilities. Projects can focus on creating entirely novel tools or making significant enhancements to technologies that already exist, with an emphasis on improvements that matter in real-world use (for example, better sensitivity, higher throughput, improved usability, lower cost, better portability, stronger validation, improved data quality, or expanded functionality).
The FOA explicitly encourages multidisciplinary teams, reflecting how neurotechnology often sits at the intersection of neuroscience, engineering, computer science, materials science, chemistry, clinical practice, and data science. It also signals that NIH is interested in the full spectrum of technology types, including hardware (such as sensors, imaging components, stimulation devices, wearable systems, instrumentation), software (such as analysis pipelines, modeling tools, signal processing, machine learning methods, data management platforms), and wetware (such as reagents, biological constructs, assay systems, cell- or tissue-based platforms), as well as combinations of these. In practice, that means a proposal could range from a new neural recording interface, to an improved behavioral assessment platform, to a better computational method for interpreting neuroimaging or electrophysiology signals, to enabling tools that support translational or clinical neuroscience.
This is an SBIR grant mechanism using the R43/R44 pathway, which is designed specifically for U.S. small business concerns developing innovations with clear research and development aims and a path toward commercialization and broad adoption. The listing shows no cost-sharing or matching requirement, which is typical for SBIR awards. Eligibility is limited to small businesses, and foreign institutions are not eligible to apply. The opportunity was posted June 29, 2007, with multiple receipt dates (meaning NIH accepted applications on repeating submission cycles rather than a single deadline), and it later archived on June 7, 2010, indicating it was a time-bounded announcement with a defined active period.
From an NIH programmatic standpoint, the FOA is associated with multiple CFDA program areas that span the neuroscience and behavioral health landscape, including research related to communication disorders and deafness (93.173), mental health (93.242), alcohol (93.273), drug abuse and addiction (93.279), technological innovations to improve human health (93.286), nursing research (93.361), neurosciences and neurological disorders (93.853), child health and human development (93.865), and aging research (93.866). That mix is a strong hint that NIH intended the solicitation to support enabling technologies relevant across many institutes and disease areas, not just one condition or one research community.
In short, PA 07 389 is a tool-and-technology-focused SBIR opportunity from NIH aimed at helping small businesses build or significantly improve neurotechnology that advances neuroscience and behavioral research and, where appropriate, clinical applications for brain and behavioral disorders. The full announcement and official requirements were provided through the NIH grants page listed in the opportunity record.
Frequently Asked Questions (FAQs)
What is the Neurotechnology Research, Development, and Enhancement (SBIR R43/R44) opportunity?
This is an NIH Small Business Innovation Research (SBIR) funding announcement focused on supporting U.S. small businesses that are developing new, or substantially improved, neurotechnologies. The purpose is to make neuroscience and behavioral research better, faster, or more informative by backing practical tools that researchers and clinicians can actually use.
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is PA 07 389.
What is the main goal of this NIH SBIR program?
The core goal is to accelerate progress in understanding how the brain works in health and disease by supporting tool-building and technology enhancement efforts that enable or meaningfully improve brain and behavioral research. Where appropriate, the supported technologies can also advance clinical applications related to brain and behavioral disorders.
Who is eligible to apply?
Eligibility is limited to U.S. small business concerns (SBIR-eligible small businesses). Foreign institutions are not eligible to apply under this opportunity.
Is cost-sharing or matching required?
No. The opportunity record indicates there is no cost-sharing or matching requirement, which aligns with typical SBIR award structures.
What SBIR mechanisms does this announcement use?
This opportunity uses the SBIR R43/R44 pathway.
What kinds of projects are a fit for this opportunity?
Projects that create entirely novel neurotechnology tools or make substantial improvements to existing technologies are within scope, as long as they clearly enable neuroscience or behavioral research or meaningfully improve existing capabilities in real-world use.
Does the program only support basic research tools, or does it also support clinical applications?
It supports technologies aimed at basic research, clinical research, and can include clinical care applications when the technology supports assessment, diagnosis, monitoring, treatment, or other forms of brain-disorder care.
Is NIH restricting proposals to specific technology areas or measurement scales?
No. A key feature is the broad scope. NIH is not restricting applicants to a particular technology area, measurement scale, or scientific approach, as long as the proposed technology clearly advances brain or behavioral research or meaningfully improves existing capabilities.
What kinds of improvements does NIH consider meaningful?
The announcement emphasizes improvements that matter in real-world use, such as better sensitivity, higher throughput, improved usability, lower cost, better portability, stronger validation, improved data quality, or expanded functionality.
What types of neurotechnology are included (hardware, software, wetware)?
The scope includes hardware, software, and wetware, as well as combinations of these. Examples described include sensors, imaging components, stimulation devices, wearable systems, instrumentation, analysis pipelines, modeling tools, signal processing approaches, machine learning methods, data management platforms, reagents, biological constructs, assay systems, and cell- or tissue-based platforms.
Are multidisciplinary teams encouraged?
Yes. The FOA explicitly encourages multidisciplinary teams, reflecting that neurotechnology often sits at the intersection of neuroscience, engineering, computer science, materials science, chemistry, clinical practice, and data science.
Does the opportunity support both new tools and enhancements to existing tools?
Yes. It welcomes proposals for creating entirely novel tools as well as proposals that substantially enhance existing technologies.
Is commercialization part of the intent of this program?
Yes. As an SBIR R43/R44 opportunity, it is designed for small businesses conducting research and development with a path toward commercialization and broad adoption.
When was this opportunity posted, and is it still active?
The opportunity was posted on June 29, 2007, and it was archived on June 7, 2010, indicating it had a defined active period and is no longer active under that archived announcement.
Did this announcement use a single deadline or multiple submission cycles?
It used multiple receipt dates, meaning NIH accepted applications on repeating submission cycles rather than only a single deadline.
Which NIH program areas (CFDA listings) were associated with this FOA?
The opportunity was associated with multiple CFDA program areas spanning neuroscience and behavioral health, including communication disorders and deafness (93.173), mental health (93.242), alcohol (93.273), drug abuse and addiction (93.279), technological innovations to improve human health (93.286), nursing research (93.361), neurosciences and neurological disorders (93.853), child health and human development (93.865), and aging research (93.866).
What does it mean that multiple CFDAs are listed?
Based on the listing, it signals that NIH intended the solicitation to support enabling technologies that can be relevant across many institutes, research communities, and disease areas, rather than being limited to a single condition or a single NIH institute focus.
Where were the official requirements and full announcement provided?
The full announcement and official requirements were provided through the NIH grants page referenced in the opportunity record.
Browse more opportunities from the same agency: National Institutes of Health
Browse more opportunities from the same category: Education Health Income Security and Social Services
Next opportunity: Neurotechnology Research, Development, and Enhancement (STTR R41/R42)
Previous opportunity: Innovations in Biomedical Computational Science and Technology Initiative (STTR R41/R42)
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Applicants who have applied for this opportunity (PA 07 389) also looked into and applied for these:
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| Obesity Policy Research Evaluation and Measures (R21) Apply for PA 10 028 Funding Number: PA 10 028 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $200,000 |
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