Opportunity Information: Apply for PAR 07 161
Apply for PAR 07 161
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Innovations in Biomedical Computational Science and Technology Initiative (STTR R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.389 National Center for Research Resources 93.396 Cancer Biology Research 93.839 Blood Diseases and Resources Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy, Immunology and Transplantation Research 93.859 Biomedical Research and Research Training 93.866 Aging Research 93.867 Vision Research 93.879 Medical Library Assistance.
- This funding opportunity was created on May 27, 2009 and posted on Dec 12, 2006.
- Applicants must submit their applications by Sep 7, 2009 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Others (see text field entitled Additional Information on Eligibility for clarification).
- Foreign institutions are not eligible to apply. Only United States small business concerns (SBCs) are eligible to submit STTR applications. A small business concern is one that, at the time of award for both Phase I and Phase II awards, meets all of the following criteria 1. Is independently owned and operated, is not dominant in the field of operation in which it is proposing, has a place of business in the United States and operates primarily within the United States or makes a significant contribution to the US economy, and is organized for profit. 2. Is at least 51 owned and controlled by one or more individuals who are citizens of, or permanent resident aliens in, the United States. 3. Has, including its affiliates, an average number of employees for the preceding 12 months not exceeding 500, and meets the other regulatory requirements found in Title 13 Code of Federal Regulations (CFR) Part 121. Business concerns are generally considered to be affiliates of one another when either directly or indirectly, (a) one concern controls or has the power to control the other or (b) a third party/parties controls or has the power to control both.
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Opportunity Summary:
The Innovations in Biomedical Computational Science and Technology Initiative (STTR R41/R42), Funding Opportunity Number PAR 07 161, is a National Institutes of Health (NIH) Small Business Technology Transfer (STTR) grant opportunity focused on accelerating biomedical research by advancing computing methods and tools. The core idea behind the announcement is that modern biomedical science is increasingly driven by large, complex datasets and by the need to model biological systems, and that progress can be significantly sped up when researchers have better computational infrastructure, software, and modeling capabilities. Through this FOA, NIH aims to stimulate innovative, commercially relevant research and development by small businesses working in partnership with nonprofit research institutions.
From a scientific scope standpoint, the FOA targets a broad set of biomedical computational science and technology activities. This includes practical informatics and software engineering work such as database design, improved user-facing graphical interfaces, better ways to query and retrieve data, and more powerful methods for data visualization, manipulation, and integration. It also includes development of integrated analytical tools that allow different datasets, platforms, or workflows to work together more seamlessly, along with tools that support electronic collaboration among researchers. In addition to these informatics tool categories, NIH explicitly includes computational research aimed at building models and simulations of biological processes, spanning structural, functional, integrative, and analytical modeling approaches. In short, applicants are expected to propose computing innovations that directly enable faster, better, or more scalable biomedical discovery.
Mechanistically, this FOA uses the STTR grant mechanisms R41 (Phase I) and R42 (Phase II), and it also allows Fast Track applications that attempt to move efficiently from Phase I proof-of-concept into Phase II development. STTR is designed around formal collaboration between a U.S. small business and a nonprofit research institution, with the intent of transferring technology and expertise in a way that supports both innovation and eventual commercialization or broad adoption. NIH notes that this STTR FOA runs in parallel with an SBIR version of the same scientific scope (PAR 07 160, using R43/R44), and that there are also parallel NIH opportunities using traditional academic research mechanisms with the same scope (PAR 06 410 for R01 and PAR 06 411 for R21). That parallel structure is meant to give similar scientific ideas multiple possible pathways depending on the applicant type and commercialization intent.
Eligibility is restricted to U.S. small business concerns (SBCs); foreign institutions are not eligible to apply. The SBC must meet standard federal small business requirements at the time of award for both Phase I and Phase II. Key requirements include being for-profit, independently owned and operated, not dominant in its field, and having a place of business in the United States while operating primarily in the U.S. or making a significant contribution to the U.S. economy. Ownership and control must be at least 51 percent by one or more U.S. citizens or permanent resident aliens, and the business (including affiliates) must generally have no more than 500 employees on average over the prior 12 months, consistent with the size standards in 13 CFR Part 121 and the affiliated-entity rules.
The FOA is open to qualified Project Directors/Principal Investigators (PDs/PIs) with the expertise and resources to lead the proposed work. NIH emphasizes its standing encouragement for individuals from underrepresented racial and ethnic groups and individuals with disabilities to apply for NIH support. Under STTR rules highlighted in the announcement, the PD/PI may be primarily employed either by the small business or by the partnering nonprofit research institution, as long as there is a formal appointment or documented commitment to the applicant small business that establishes an official relationship. The FOA also allows an applicant SBC to submit multiple applications as long as each proposed project is scientifically distinct.
Administrative details in the record show this as a discretionary grant opportunity within activity categories that span education, environment, and health, reflecting the broad biomedical relevance of the technologies sought. The FOA was posted December 12, 2006, and it used multiple receipt dates (rather than a single deadline) during its active period, with a listed current closing date of September 7, 2009 and an archive date of October 8, 2009. As with typical NIH opportunities, awards are explicitly contingent on the availability of funds and on receiving a sufficient number of meritorious applications, meaning strong peer review outcomes and programmatic fit are central to funding decisions.
Finally, the opportunity is associated with a wide range of NIH program areas, as reflected by the multiple CFDA numbers listed (covering domains such as human genome research, cancer biology, neuroscience, aging, vision, biomedical research infrastructure, and more). That breadth signals that proposed computational innovations can be relevant across many disease areas and research disciplines, as long as they clearly advance biomedical research through improved computation, data handling, analysis, integration, modeling, simulation, or collaboration tooling.
Frequently Asked Questions (FAQs)
What is the Innovations in Biomedical Computational Science and Technology Initiative (STTR R41/R42)?
It is a National Institutes of Health (NIH) Small Business Technology Transfer (STTR) funding opportunity focused on accelerating biomedical research by supporting advances in computing methods and tools. The emphasis is on innovative, commercially relevant research and development led by a U.S. small business working in formal partnership with a nonprofit research institution.
What is the Funding Opportunity Number for this NIH announcement?
The Funding Opportunity Number (FOA) is PAR 07 161.
What is the main goal of this FOA?
The goal is to speed up biomedical discovery by improving computational infrastructure, software, modeling, simulation, and other data-intensive capabilities that modern biomedical science increasingly depends on.
What kinds of projects are within the scientific scope of this FOA?
The scope is broad and includes biomedical computational science and technology activities such as informatics, software engineering, data handling and integration, collaborative research tools, and computational modeling and simulation of biological processes. Proposed innovations are expected to enable faster, better, or more scalable biomedical research.
Does the FOA support informatics and software engineering work?
Yes. Examples mentioned include database design, improved graphical user interfaces, improved querying and data retrieval, and more powerful approaches for data visualization, manipulation, and integration.
Does the FOA support tools that connect or integrate different datasets or workflows?
Yes. The FOA includes development of integrated analytical tools that allow different datasets, platforms, or workflows to work together more seamlessly.
Are electronic collaboration tools for researchers included in the scope?
Yes. The FOA includes tools that support electronic collaboration among researchers.
Are computational models and simulations of biological processes eligible topics?
Yes. NIH explicitly includes computational research aimed at building models and simulations of biological processes, including structural, functional, integrative, and analytical modeling approaches.
What funding mechanisms does this FOA use?
This opportunity uses the NIH STTR grant mechanisms R41 (Phase I) and R42 (Phase II). It also allows Fast Track applications intended to move efficiently from Phase I proof-of-concept to Phase II development.
What is the difference between Phase I (R41) and Phase II (R42) in this announcement?
Based on the description provided, Phase I is positioned as proof-of-concept work, and Phase II supports further development following successful Phase I outcomes. The FOA also allows Fast Track submissions that combine a plan for both phases.
Who is eligible to apply?
Eligibility is restricted to U.S. small business concerns (SBCs) that meet standard federal small business requirements at the time of award for both Phase I and Phase II.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply under this FOA.
What are the key small business requirements mentioned for eligibility?
The small business must be for-profit, independently owned and operated, not dominant in its field, and have a place of business in the United States while operating primarily in the U.S. or making a significant contribution to the U.S. economy.
What ownership and control requirements apply to the small business?
Ownership and control must be at least 51 percent by one or more U.S. citizens or permanent resident aliens.
Is there an employee-size limit for the applicant business?
Yes. The business (including affiliates) must generally have no more than 500 employees on average over the prior 12 months, consistent with size standards in 13 CFR Part 121 and affiliated-entity rules.
Does this STTR opportunity require a nonprofit research institution partner?
Yes. STTR is designed around formal collaboration between a U.S. small business and a nonprofit research institution, with an intent to transfer technology and expertise and support eventual commercialization or broad adoption.
Who can serve as the Project Director/Principal Investigator (PD/PI) under this STTR FOA?
Qualified PDs/PIs with the expertise and resources to lead the proposed work may serve. Under the STTR rules highlighted here, the PD/PI may be primarily employed either by the small business or by the partnering nonprofit research institution, as long as there is a formal appointment or documented commitment to the applicant small business establishing an official relationship.
Does NIH encourage applications from specific groups of investigators?
Yes. NIH emphasizes its standing encouragement for individuals from underrepresented racial and ethnic groups and individuals with disabilities to apply for NIH support.
Can a small business submit more than one application to this FOA?
Yes. The applicant small business may submit multiple applications as long as each proposed project is scientifically distinct.
Is there a related SBIR version of this opportunity?
Yes. NIH notes that this STTR FOA runs in parallel with an SBIR version of the same scientific scope: PAR 07 160, using mechanisms R43/R44.
Are there related NIH opportunities using traditional academic research mechanisms?
Yes. The information provided notes parallel opportunities with the same scope using academic research mechanisms: PAR 06 410 (R01) and PAR 06 411 (R21).
When was this FOA posted, and what were the key dates mentioned?
The FOA was posted on December 12, 2006. It used multiple receipt dates during its active period. The listed current closing date is September 7, 2009, and the archive date is October 8, 2009.
Does this FOA have a single deadline?
No. The description states it used multiple receipt dates rather than a single deadline during its active period.
Are awards guaranteed if an application is submitted?
No. Awards are contingent on the availability of funds and on receiving a sufficient number of meritorious applications, meaning strong peer review outcomes and programmatic fit are central to funding decisions.
How broad is NIH interest in the types of biomedical areas that could benefit from these computational innovations?
The opportunity is associated with many NIH program areas, reflected by multiple CFDA numbers spanning a wide range of domains (for example, human genome research, cancer biology, neuroscience, aging, vision, and biomedical research infrastructure). This signals that projects may be relevant across many disease areas and disciplines, as long as they clearly advance biomedical research through improved computation, data handling, analysis, integration, modeling, simulation, or collaboration tooling.
What is the underlying rationale for NIH offering this initiative?
The FOA is based on the idea that modern biomedical science is increasingly driven by large, complex datasets and by the need to model biological systems, and that better computational infrastructure, software, and modeling capabilities can significantly accelerate progress.
What type of grant opportunity category is this described as?
It is described as a discretionary grant opportunity within activity categories that span education, environment, and health, reflecting broad biomedical relevance for the technologies sought.
Browse more opportunities from the same agency: National Institutes of Health
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Next opportunity: Neurotechnology Research, Development, and Enhancement (SBIR R43/R44)
Previous opportunity: Innovations in Biomedical Computational Science and Technology Initiative (SBIR R43/R44)
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 07 161) also looked into and applied for these:
| Funding Opportunity |
|---|
| Global Research Initiative Program, Basic/Biomedical Sciences (R01) Apply for PAR 07 239 Funding Number: PAR 07 239 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovations in Biomedical Computational Science and Technology (R01) Apply for PAR 09 218 Funding Number: PAR 09 218 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Exploratory Innovations in Biomedical Computational Science and Technology (R21) Apply for PAR 09 219 Funding Number: PAR 09 219 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 09 012 Funding Number: RFA ES 09 012 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Environmental Influences during Windows of Susceptibility in Breast Cancer Risk (U01) Apply for RFA ES 09 009 Funding Number: RFA ES 09 009 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $300,000 |
| Coordinating Center for the Breast Cancer and the Environment Research Program (U01) Apply for RFA ES 09 010 Funding Number: RFA ES 09 010 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $600,000 |
| Limited Competition Continuation of Studies on Early Environmental Exposures and Human Puberty (U01) Apply for RFA ES 09 008 Funding Number: RFA ES 09 008 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $650,000 |
| Enabling Technologies in DNA Repair Research (R21) Apply for PAR 10 016 Funding Number: PAR 10 016 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Limited Competition for the Global Research Initiative Program, Basic/Biomedical Sciences (R01) Apply for PAR 10 278 Funding Number: PAR 10 278 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Deepwater Horizon Disaster Research Consortia Health Impacts and Community Resiliency (U19) Apply for RFA ES 11 006 Funding Number: RFA ES 11 006 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $1,200,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 10 010 Funding Number: RFA ES 10 010 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovative Bioavailability Assays to Assess the Effectiveness of Contaminated Sediment Remediation (R01) Apply for RFA ES 11 005 Funding Number: RFA ES 11 005 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Limited Competition Fogarty International Research Collaboration Basic Biomedical (FIRCA BB) Research Award (R03) Apply for PAR 11 037 Funding Number: PAR 11 037 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (Parent F33) Apply for PA 11 114 Funding Number: PA 11 114 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
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