New Technologies for Transient Molecular Complex Characterization (SBIR R43/R44) | Apply Online

Opportunity Summary:

The grant opportunity "New Technologies for Transient Molecular Complex Characterization (SBIR R43/R44)" is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) designed specifically for eligible U.S. small businesses to build and validate new ways to study transient molecular complexes. These are short-lived assemblies of biomolecules (often protein-protein, protein-nucleic acid, or multi-component complexes) that form and break apart quickly as part of normal biology. Because many critical cellular processes depend on these fleeting interactions, the FOA focuses on technology development that can capture, measure, and interpret transient complexes in ways that are not currently possible or not sufficiently robust, sensitive, or high-throughput. The overall goal is to enable clearer insight into how these complexes behave in healthy systems, how they become disrupted in disease, and how they change when exposed to potential therapeutic interventions.

A central emphasis of the program is the development of practical technologies, tools, and processes that make it easier to characterize both the structure and the kinetics of transient complexes. On the structural side, the FOA highlights the need to determine features such as stoichiometry (how many of each component are present), localization (where the complex forms in a cell or system), symmetry, and overall shape. On the kinetic side, the FOA calls attention to measuring how fast complexes assemble and disassemble, how stable they are, and how those properties shift under different biological conditions. The rationale is straightforward: without the ability to reliably observe and quantify transient complexes, many important biological mechanisms remain partially hidden, slowing down progress in understanding disease pathways and in identifying promising diagnostic signals or therapeutic targets.

This FOA uses the SBIR grant mechanisms R43/R44, meaning it supports Phase I and Phase II projects, as well as Fast-Track applications that combine Phase I and Phase II into a single streamlined submission. In practice, Phase I typically supports early proof-of-concept work showing that an approach is feasible, while Phase II generally supports further development, optimization, and demonstration of performance in more realistic or relevant settings. The FOA is positioned as a technology-creation program rather than a purely hypothesis-driven basic science program; applicants are expected to propose concrete development aims that result in a new or significantly improved capability for studying transient molecular complexes, with a path toward broader use in biomedical research and, potentially, clinical translation.

The opportunity is administered under the NIH, with the National Center for Research Resources associated with the listing (CFDA 93.389). It is categorized as a discretionary grant program within the broader health and education activity areas. It does not require cost sharing or matching, which lowers the barrier for small businesses that may not be able to commit non-federal funds. Eligibility is limited to small business concerns, consistent with SBIR rules. The FOA was originally posted on April 7, 2008, with the final closing date listed as May 7, 2011, and it was archived on June 7, 2011, indicating it is no longer open for new submissions under that announcement number.

An important contextual detail is that this SBIR FOA ran in parallel with a companion FOA of identical scientific scope for the STTR program (PA 08-111), which uses R41/R42 mechanisms. The practical takeaway is that NIH offered two closely aligned pathways to pursue the same technology-development goals: one tailored to SBIR-structured small business-led R&D, and another tailored to STTR’s formal collaboration model between a small business and a nonprofit research institution. Applicants would choose the mechanism that best matched their team structure and commercialization plan while targeting the same overarching need: better technologies to capture and characterize transient molecular complexes that underpin normal physiology and contribute to disease.

For reference and follow-up, the source announcement is identified as Funding Opportunity Number PA 08-110, titled exactly as above, with an NIH grants webpage listed as the additional information link. The contact information provided is the NIH Office of Extramural Research (OER) webmaster email for help accessing or linking to the full electronic announcement.

Browse more opportunities from the same agency: National Institutes of Health

Browse more opportunities from the same category: Education Health

Next opportunity: New Technologies for Transient Molecular Complex Characterization (STTR R41/R42)

Previous opportunity: Lab to Marketplace Tools for Brain and Behavioral Research (SBIR R43/R44)

USGrants.org Applicant Portal:

Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.

Apply for PA 08 110

 

[Watch] how do funding administrators access proposals?

Applicants also applied for:

Applicants who have applied for this opportunity (PA 08 110) also looked into and applied for these:

 

Grant application guides and resources

It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!

Apply for Grants

 

 

Premium leads for funding administrators, grant writers, and loan issuers

Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.

If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.

Subscribe to Leads

 

Request more information:

Would you like to learn more about this funding opportunity, similar opportunities to "PA 08 110", eligibility, application service, and/or application tips? Submit an inquiry below:

Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.