Opportunity Information: Apply for RFA HL 10 018
Apply for RFA HL 10 018
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Cardiovascular Outcomes Research Coordinating Unit (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Oct 19, 2009 and posted on Oct 19, 2009.
- Applicants must submit their applications by Jan 21, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $800,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NHLBI Cardiovascular Outcomes Research Coordinating Unit (U01) opportunity (RFA-HL-10-018) is a four-year NIH cooperative agreement designed to fund a single institution or organization to serve as the central Research Coordinating Unit (RCU) for the Centers for Cardiovascular Outcomes Research (CCOR) program. This coordinating unit is meant to be the operational hub that supports and connects three separately funded CCOR research centers (solicited under a companion announcement, RFA-HL-10-008). The overall program focus is cardiovascular outcomes and comparative effectiveness research aimed at questions that matter directly to patients and clinicians, including what drives differences in outcomes and how cardiovascular care can be measured, evaluated, and improved across the full continuum of care.
Within the broader CCOR program, each funded center is expected to run one to two research projects using multidisciplinary teams that may include clinician-researchers, health services researchers, biostatisticians, and health economists. The centers research can be applied (evaluating real-world care and interventions) and/or methodological (improving how outcomes are measured and compared). The outcomes of interest span hard clinical endpoints and patient-centered measures, including cardiovascular mortality, clinical events, cost-effectiveness, and quality of life. In that context, the RCU is not being funded to lead its own standalone outcomes studies, but rather to make the multi-center program function as a coherent, collaborative network with shared processes and aligned outputs.
The RCU role is heavily coordination-oriented and includes facilitating collaboration across the centers, maintaining effective communication channels among the centers and with NHLBI, enabling data sharing, and supporting the production of collaborative manuscripts. A major part of the work involves logistics and governance support: the RCU is expected to plan, arrange, and support meetings of the program Steering Committee and relevant subcommittees, as well as meetings involving investigators and trainees. The RCU also supports oversight and monitoring structures, including organizing meetings for an outcomes or data and safety monitoring board (OSMB or DSMB), reflecting the expectation that some projects may involve prospective studies or other activities that warrant formal monitoring.
This announcement uses the U01 cooperative agreement mechanism, which generally means NHLBI anticipates substantial scientific and/or programmatic involvement during the award period compared with a standard research project grant. In practical terms, the awardee should be prepared to work closely with NHLBI staff and to operate in a coordinated network environment where governance, shared decision-making, and standardized procedures are essential.
NHLBI planned to make one award under this FOA, with an intention to commit up to $800,000 in total costs in FY 2010 for the RCU. The estimated award ceiling listed is $500,000, and final funding depends on the availability of appropriations and the receipt of a sufficient number of high-quality, competitive applications. There is no cost-sharing or matching requirement.
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other for-profits), state governments, federally recognized and other tribal governments and tribal organizations, and a range of mission-focused or designated institutions and entities. These include HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
Key administrative details from the source listing include the posting and creation date of October 19, 2009, an original and current closing date of January 21, 2010, and an archive date of February 21, 2010. The CFDA program number associated with this opportunity is 93.837 (Cardiovascular Diseases Research). The funding activity category is Health, the instrument type is a cooperative agreement, and the anticipated number of awards is one.
Frequently Asked Questions (FAQs)
What is the NHLBI Cardiovascular Outcomes Research Coordinating Unit (U01) opportunity?
This funding opportunity (RFA-HL-10-018) is a four-year NIH/NHLBI cooperative agreement (U01) to support a single institution or organization to serve as the central Research Coordinating Unit (RCU) for the Centers for Cardiovascular Outcomes Research (CCOR) program.
What is the main purpose of the Research Coordinating Unit (RCU)?
The RCU is intended to be the operational hub for the CCOR program. Its main purpose is to support and connect three separately funded CCOR research centers, enabling the overall program to function as a coherent, collaborative network with shared processes and aligned outputs.
How many awards does NHLBI plan to make under this funding opportunity?
NHLBI planned to make one award under this FOA.
How long is the project period?
The opportunity is designed as a four-year cooperative agreement.
Is the RCU expected to conduct its own independent cardiovascular outcomes research projects?
No. The RCU is not being funded to lead its own standalone outcomes studies. Instead, it provides coordination, communication, governance, and network support so the multi-center CCOR program can operate effectively.
How many CCOR research centers will the RCU support?
The RCU supports three separately funded CCOR research centers that are solicited under a companion announcement (RFA-HL-10-008).
What is the overall scientific focus of the CCOR program?
The CCOR program focuses on cardiovascular outcomes and comparative effectiveness research aimed at questions that matter directly to patients and clinicians. This includes understanding what drives differences in outcomes and how cardiovascular care can be measured, evaluated, and improved across the full continuum of care.
What kinds of projects are the CCOR centers expected to run?
Each funded center is expected to run one to two research projects using multidisciplinary teams. The projects may be applied (evaluating real-world care and interventions) and/or methodological (improving how outcomes are measured and compared).
What types of expertise may be involved in CCOR center teams?
The multidisciplinary teams may include clinician-researchers, health services researchers, biostatisticians, and health economists.
What outcomes are of interest in this program?
Outcomes of interest include both hard clinical endpoints and patient-centered measures, such as cardiovascular mortality, clinical events, cost-effectiveness, and quality of life.
What are the core responsibilities of the RCU?
The RCU responsibilities are coordination-oriented and include facilitating collaboration across the centers, maintaining effective communication channels among the centers and with NHLBI, enabling data sharing, and supporting the production of collaborative manuscripts.
What meeting and governance support is the RCU expected to provide?
The RCU is expected to plan, arrange, and support meetings of the program Steering Committee and relevant subcommittees, as well as meetings involving investigators and trainees.
Is the RCU involved in oversight or monitoring activities?
Yes. The RCU supports oversight and monitoring structures, including organizing meetings for an outcomes or data and safety monitoring board (OSMB or DSMB). This reflects that some projects may involve prospective studies or other activities warranting formal monitoring.
What does it mean that this is a U01 cooperative agreement?
The U01 mechanism indicates that NHLBI anticipates substantial scientific and/or programmatic involvement during the award period compared with a standard research project grant. In practice, the awardee should be prepared to work closely with NHLBI staff and operate in a coordinated network environment with governance, shared decision-making, and standardized procedures.
What is the anticipated funding amount?
NHLBI intended to commit up to $800,000 in total costs in FY 2010 for the RCU. The estimated award ceiling listed is $500,000. Final funding depends on the availability of appropriations and the receipt of a sufficient number of high-quality, competitive applications.
Is cost-sharing or matching required?
No. There is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other for-profits); state governments; federally recognized and other tribal governments and tribal organizations; and additional eligible entities such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
What is the CFDA program number for this opportunity?
The CFDA program number associated with this opportunity is 93.837 (Cardiovascular Diseases Research).
What is the funding activity category?
The funding activity category is Health.
What is the instrument type?
The instrument type is a cooperative agreement.
When was this opportunity posted, and what were the key dates?
The posting/creation date is October 19, 2009. The original and current closing date is January 21, 2010. The archive date is February 21, 2010.
How many awards are anticipated?
The anticipated number of awards is one.
What is the relationship between this FOA and the companion announcement?
This FOA funds the central RCU (RFA-HL-10-018). The three CCOR research centers that the RCU supports are solicited under a companion announcement (RFA-HL-10-008).
What kinds of collaboration outputs is the RCU expected to support?
The RCU is expected to support collaborative manuscripts and help align outputs across centers through coordination, data sharing support, and structured communication and governance processes.
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